Critical role of AMP-activated protein kinase in the balance between mitophagy and mitochondrial biogenesis in MELAS disease

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1852, Issue 11, 2015, Pages 2535-2553

  Garrido Maraver, Juan ^a,b   Paz, Marina Villanueva ^a,b   Cordero, Mario D ^c   Bautista Lorite, Juan ^d   Oropesa Ávila, Manuel ^a,b   de la Mata, Mario ^a,b   Pavón, Ana Delgado ^a,b   de Lavera, Isabel ^a,b   Alcocer Gómez, Elizabet ^a,b   Galán, Fernando ^e   Ybot González, Patricia ^f   Cotán, David ^a,b   Jackson, Sandra ^g   Sánchez Alcázar, José A ^a,b  

^a CSIC   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSITY OF SEVILLE   (Spain)

^d HOSPITAL QUIRÓN   (Spain)

^e HOSPITAL UNIVERSITARIO VIRGEN MACARENA   (Spain)

^f HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^g UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

Author keywords

AICAR; AMPK; Coenzyme Q10; MELAS syndrome; Mitochondrial biogenesis; Mitophagy; PGC 1

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; UBIDECARENONE;

ARTICLE; BIOGENESIS; CELL ACTIVATION; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME MECHANISM; FIBROBLAST; HETEROPLASMY; HUMAN; HUMAN CELL; MELAS SYNDROME; MITOCHONDRION; MITOPHAGY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 84941687152     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2015.08.027     Document Type: Article

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