ER stress activates the NLRP3 inflammasome via an UPR-independent pathway

Cell Death and Disease

Volumn 3, Issue 1, 2012, Pages

  Menu, P ^a   Mayor, A ^a   Zhou, R ^a,b   Tardivel, A ^a   Ichijo, H ^c   Mori, K ^d   Tschopp, J ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^c UNIVERSITY OF TOKYO   (Japan)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

Endoplasmic reticulum stress; Innate immunity; Macrophages; NLRP3 inflammasome

Indexed keywords

CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; OXYGEN DERIVATIVE; REACTIVE OXYGEN METABOLITE; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; PHORBOL 13 ACETATE 12 MYRISTATE; POTASSIUM; SMALL INTERFERING RNA; TUNICAMYCIN;

ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; POTASSIUM TRANSPORT; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; ANIMAL; BIOSYNTHESIS; CELL DIFFERENTIATION; CELL LINE; DRUG EFFECT; GENE EXPRESSION; GENETICS; IMMUNOLOGY; INFLAMMATION; LENTIVIRINAE; METABOLISM; MOUSE; MOUSE MUTANT;

ANIMALS; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL LINE; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; HUMANS; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-1BETA; LENTIVIRUS; MICE; MICE, KNOCKOUT; POTASSIUM; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; TUNICAMYCIN; UNFOLDED PROTEIN RESPONSE;

EID: 84856857478     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2011.132     Document Type: Article

References (23)

1. Dinarello CA. Blocking interleukin-1b in acute and chronic autoinflammatory diseases. J Intern Med 2011; 269: 16-28.
2. Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010; 140: 900-917.
3. Hotamisligil GS, Erbay E. Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol 2008; 8: 923-934.
4. Schroder K, Tschopp J. The inflammasomes. Cell 2010; 140: 821-832.
5. Ting JPY, Duncan JA, Lei Y. How the noninflammasome NLRs function in the innate immune system. Science 2010; 327: 286-290.
6. Agostini L, Martinon F, Burns K, Mcdermott MF, Hawkins PN, Tschopp J. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 2004; 20: 319-325. (Pubitemid 38388233)
7. Latz E. The inflammasomes: mechanisms of activation and function. Curr Opin Immunol 2010; 22: 28-33.
8. Tschopp J, Schroder K. NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nat Rev Immunol 2010; 10: 210-215.
9. Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011; 469: 221-225.
10. Hu P, Han Z, Couvillon AD, Kaufman RJ, Exton JH. Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Mol Cell Biol 2006; 26: 3071-3084.
11. Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP et al. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 2000; 287: 664-666. (Pubitemid 30070916)
12. Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol 2011; 29: 415-445.
13. Dinarello CA. Anti-inflammatory agents: present and future. Cell 2010; 140: 935-950.
14. Bulua AC, Simon A, Maddipati R, Pelletier M, Park H, Kim K-Y et al. Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J Exp Med 2011; 208: 519-533.
15. McDermott MF, Aksentijevich I, Galon J, McDermott EM, Ogunkolade BW, Centola M et al. Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. Cell 1999; 97: 133-144. (Pubitemid 29165896)
16. Obici L, Meini A, Cattalini M, Chicca S, Galliani M, Donadei S et al. Favourable and sustained response to anakinra in tumour necrosis factor receptor-associated periodic syndrome (TRAPS) with or without AA amyloidosis. Ann Rheum Dis 2011; 70: 1511-1512.
17. Papin S, Cuenin S, Agostini L, Martinon F, Werner S, Beer H-D et al. The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing. Cell Death Differ 2007; 14: 1457-1466. (Pubitemid 47096500)
18. Pétrilli V, Papin S, Dostert C, Mayor A, Martinon F, Tschopp J. Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ 2007; 14: 1583-1589. (Pubitemid 47278844)
19. Martinon F, Pétrilli V, Mayor A, Tardivel A, Tschopp J. Gout- uric acid crystals activate the NALP3 inflammasome. Nature 2006; 440: 237-241. (Pubitemid 43372104)
20. Mariathasan S, Weiss DS, Newton K, Mcbride J, O'rourke K, Roose-Girma M et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 2006; 440: 228-232. (Pubitemid 43372102)
21. Yamamoto K, Sato T, Matsui T, Sato M, Okada T, Yoshida H et al. Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1. Dev Cell 2007; 13: 365-376. (Pubitemid 47308680)
22. Tobiume K, Matsuzawa A, Takahashi T, Nishitoh H, Morita K, Takeda K et al. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep 2001; 2: 222-228. (Pubitemid 32273301)
23. Didierlaurent A, Brissoni B, Velin D, Aebi N, Tardivel A, Käslin E et al. Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide. Mol Cell Biol 2006; 26: 735-742. (Pubitemid 43146471)