메뉴 건너뛰기




Volumn 8, Issue JUN, 2017, Pages

NK cell exhaustion

Author keywords

Chronic infections; Immune checkpoints; Immune evasion; Immunotherapy; Tumors

Indexed keywords

CELL PROLIFERATION; CYTOTOXICITY; DOWN REGULATION; EXHAUSTION; EXOSOME; HUMAN; HUMAN CELL; HYPOXIA; IMMUNE RESPONSE; NATURAL KILLER CELL; PROTEIN EXPRESSION; PROTEIN PROCESSING; REGULATORY T LYMPHOCYTE; REVIEW; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT;

EID: 85021748454     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2017.00760     Document Type: Review
Times cited : (230)

References (122)
  • 1
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • Wherry EJ. T cell exhaustion. Nat Immunol (2011) 12:492-9. doi:10.1038/ni.2035
    • (2011) Nat Immunol , vol.12 , pp. 492-499
    • Wherry, E.J.1
  • 2
    • 84928771999 scopus 로고    scopus 로고
    • T cell exclusion, immune privilege, and the tumor microenvironment
    • Joyce JA, Fearon DT. T cell exclusion, immune privilege, and the tumor microenvironment. Science (2015) 348:74-80. doi:10.1126/science.aaa6204
    • (2015) Science , vol.348 , pp. 74-80
    • Joyce, J.A.1    Fearon, D.T.2
  • 3
    • 84937837169 scopus 로고    scopus 로고
    • Molecular and cellular insights into T cell exhaustion
    • Wherry EJ, Kurachi M. Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol (2015) 15:486-99. doi:10.1038/nri3862
    • (2015) Nat Rev Immunol , vol.15 , pp. 486-499
    • Wherry, E.J.1    Kurachi, M.2
  • 4
    • 77953760548 scopus 로고    scopus 로고
    • Transcription factor regulation of CD8+ T-cell memory and exhaustion
    • Angelosanto JM, Wherry EJ. Transcription factor regulation of CD8+ T-cell memory and exhaustion. Immunol Rev (2010) 236:167-75. doi:10.1111/j.1600-065X.2010.00927.x
    • (2010) Immunol Rev , vol.236 , pp. 167-175
    • Angelosanto, J.M.1    Wherry, E.J.2
  • 5
    • 84928774156 scopus 로고    scopus 로고
    • The future of immune checkpoint therapy
    • Sharma P, Allison JP. The future of immune checkpoint therapy. Science (2015) 348:56-61. doi:10.1126/science.aaa8172
    • (2015) Science , vol.348 , pp. 56-61
    • Sharma, P.1    Allison, J.P.2
  • 6
    • 85012023606 scopus 로고    scopus 로고
    • The principles of engineering immune cells to treat cancer
    • Lim WA, June CH. The principles of engineering immune cells to treat cancer. Cell (2017) 168:724-40. doi:10.1016/j.cell.2017.01.016
    • (2017) Cell , vol.168 , pp. 724-740
    • Lim, W.A.1    June, C.H.2
  • 7
    • 84928759208 scopus 로고    scopus 로고
    • Adoptive cell transfer as personalized immunotherapy for human cancer
    • Rosenberg SA, Restifo NP. Adoptive cell transfer as personalized immunotherapy for human cancer. Science (2015) 348:62-8. doi:10.1126/science.aaa4967
    • (2015) Science , vol.348 , pp. 62-68
    • Rosenberg, S.A.1    Restifo, N.P.2
  • 9
    • 0016746934 scopus 로고
    • Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors, II. Characterization of effector cells
    • Herberman RB, Nunn ME, Holden HT, Lavrin DH. Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells. Int J Cancer (1975) 16:230-9. doi:10.1002/ijc.2910160204
    • (1975) Int J Cancer , vol.16 , pp. 230-239
    • Herberman, R.B.1    Nunn, M.E.2    Holden, H.T.3    Lavrin, D.H.4
  • 10
    • 0016762220 scopus 로고
    • "Natural" killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype
    • Kiessling R, Klein E, Wigzell H. "Natural" killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype. Eur J Immunol (1975) 5:112-7. doi:10.1002/eji.1830050208
    • (1975) Eur J Immunol , vol.5 , pp. 112-117
    • Kiessling, R.1    Klein, E.2    Wigzell, H.3
  • 11
    • 84858784892 scopus 로고    scopus 로고
    • Targeting natural killer cells and natural killer T cells in cancer
    • Vivier E, Ugolini S, Blaise D, Chabannon C, Brossay L. Targeting natural killer cells and natural killer T cells in cancer. Nat Rev Immunol (2012) 12:239-52. doi:10.1038/nri3174
    • (2012) Nat Rev Immunol , vol.12 , pp. 239-252
    • Vivier, E.1    Ugolini, S.2    Blaise, D.3    Chabannon, C.4    Brossay, L.5
  • 12
    • 84892777868 scopus 로고    scopus 로고
    • Mature cytotoxic CD56(bright)/CD16(+) natural killer cells can infiltrate lymph nodes adjacent to metastatic melanoma
    • Messaoudene M, Fregni G, Fourmentraux-Neves E, Chanal J, Maubec E, Mazouz-Dorval S, et al. Mature cytotoxic CD56(bright)/CD16(+) natural killer cells can infiltrate lymph nodes adjacent to metastatic melanoma. Cancer Res (2014) 74:81-92. doi:10.1158/0008-5472.CAN-13-1303
    • (2014) Cancer Res , vol.74 , pp. 81-92
    • Messaoudene, M.1    Fregni, G.2    Fourmentraux-Neves, E.3    Chanal, J.4    Maubec, E.5    Mazouz-Dorval, S.6
  • 13
    • 0030902366 scopus 로고    scopus 로고
    • The prognostic significance of intratumoral natural killer cells in patients with colorectal carcinoma
    • Coca S, Perez-Piqueras J, Martinez D, Colmenarejo A, Saez MA, Vallejo C, et al. The prognostic significance of intratumoral natural killer cells in patients with colorectal carcinoma. Cancer (1997) 79:2320-8. doi:10.1002/(SICI)1097-0142(19970615)79:12
    • (1997) Cancer , vol.79 , pp. 2320-2328
    • Coca, S.1    Perez-Piqueras, J.2    Martinez, D.3    Colmenarejo, A.4    Saez, M.A.5    Vallejo, C.6
  • 14
    • 0034676249 scopus 로고    scopus 로고
    • Clinical impact of intratumoral natural killer cell and dendritic cell infiltration in gastric cancer
    • Ishigami S, Natsugoe S, Tokuda K, Nakajo A, Xiangming C, Iwashige H, et al. Clinical impact of intratumoral natural killer cell and dendritic cell infiltration in gastric cancer. Cancer Lett (2000) 159:103-8. doi:10.1016/S0304-3835(00)00542-5
    • (2000) Cancer Lett , vol.159 , pp. 103-108
    • Ishigami, S.1    Natsugoe, S.2    Tokuda, K.3    Nakajo, A.4    Xiangming, C.5    Iwashige, H.6
  • 15
    • 0036136050 scopus 로고    scopus 로고
    • Prognostic significance of tumor infiltrating natural killer cells subset CD57 in patients with squamous cell lung cancer
    • Villegas FR, Coca S, Villarrubia VG, Jimenez R, Chillon MJ, Jareno J, et al. Prognostic significance of tumor infiltrating natural killer cells subset CD57 in patients with squamous cell lung cancer. Lung Cancer (2002) 35:23-8. doi:10.1016/S0169-5002(01)00292-6
    • (2002) Lung Cancer , vol.35 , pp. 23-28
    • Villegas, F.R.1    Coca, S.2    Villarrubia, V.G.3    Jimenez, R.4    Chillon, M.J.5    Jareno, J.6
  • 16
    • 85016108598 scopus 로고    scopus 로고
    • Tumor-associated monocytes/macrophages impair NK-cell function via TGFbeta1 in human gastric cancer
    • Peng LS, Zhang JY, Teng YS, Zhao YL, Wang TT, Mao FY, et al. Tumor-associated monocytes/macrophages impair NK-cell function via TGFbeta1 in human gastric cancer. Cancer Immunol Res (2017) 5:248-56. doi:10.1158/2326-6066.CIR-16-0152
    • (2017) Cancer Immunol Res , vol.5 , pp. 248-256
    • Peng, L.S.1    Zhang, J.Y.2    Teng, Y.S.3    Zhao, Y.L.4    Wang, T.T.5    Mao, F.Y.6
  • 17
    • 84907743365 scopus 로고    scopus 로고
    • NK cell phenotypic modulation in lung cancer environment
    • Jin S, Deng Y, Hao JW, Li Y, Liu B, Yu Y, et al. NK cell phenotypic modulation in lung cancer environment. PLoS One (2014) 9:e109976. doi:10.1371/journal.pone.0109976
    • (2014) PLoS One , vol.9
    • Jin, S.1    Deng, Y.2    Hao, J.W.3    Li, Y.4    Liu, B.5    Yu, Y.6
  • 18
    • 0141924778 scopus 로고    scopus 로고
    • Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function
    • Stetson DB, Mohrs M, Reinhardt RL, Baron JL, Wang ZE, Gapin L, et al. Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J Exp Med (2003) 198:1069-76. doi:10.1084/jem.20030630
    • (2003) J Exp Med , vol.198 , pp. 1069-1076
    • Stetson, D.B.1    Mohrs, M.2    Reinhardt, R.L.3    Baron, J.L.4    Wang, Z.E.5    Gapin, L.6
  • 19
    • 0032560475 scopus 로고    scopus 로고
    • Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice
    • Kaplan DH, Shankaran V, Dighe AS, Stockert E, Aguet M, Old LJ, et al. Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc Natl Acad Sci U S A (1998) 95:7556-61. doi:10.1073/pnas.95.13.7556
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 7556-7561
    • Kaplan, D.H.1    Shankaran, V.2    Dighe, A.S.3    Stockert, E.4    Aguet, M.5    Old, L.J.6
  • 20
    • 10744220243 scopus 로고    scopus 로고
    • Natural killer cells activated by MHC class I(low) targets prime dendritic cells to induce protective CD8 T cell responses
    • Mocikat R, Braumuller H, Gumy A, Egeter O, Ziegler H, Reusch U, et al. Natural killer cells activated by MHC class I(low) targets prime dendritic cells to induce protective CD8 T cell responses. Immunity (2003) 19:561-9. doi:10.1016/S1074-7613(03)00264-4
    • (2003) Immunity , vol.19 , pp. 561-569
    • Mocikat, R.1    Braumuller, H.2    Gumy, A.3    Egeter, O.4    Ziegler, H.5    Reusch, U.6
  • 21
    • 13444262764 scopus 로고    scopus 로고
    • Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming
    • Martin-Fontecha A, Thomsen LL, Brett S, Gerard C, Lipp M, Lanzavecchia A, et al. Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming. Nat Immunol (2004) 5:1260-5. doi:10.1038/ni1138
    • (2004) Nat Immunol , vol.5 , pp. 1260-1265
    • Martin-Fontecha, A.1    Thomsen, L.L.2    Brett, S.3    Gerard, C.4    Lipp, M.5    Lanzavecchia, A.6
  • 22
    • 0036779576 scopus 로고    scopus 로고
    • Functional significance of the perforin/granzyme cell death pathway
    • Trapani JA, Smyth MJ. Functional significance of the perforin/granzyme cell death pathway. Nat Rev Immunol (2002) 2:735-47. doi:10.1038/nri911
    • (2002) Nat Rev Immunol , vol.2 , pp. 735-747
    • Trapani, J.A.1    Smyth, M.J.2
  • 23
    • 0029616324 scopus 로고
    • Perforin dependence of natural killer cell-mediated tumor control in vivo
    • van den Broek MF, Kagi D, Zinkernagel RM, Hengartner H. Perforin dependence of natural killer cell-mediated tumor control in vivo. Eur J Immunol (1995) 25:3514-6. doi:10.1002/eji.1830251246
    • (1995) Eur J Immunol , vol.25 , pp. 3514-3516
    • van den Broek, M.F.1    Kagi, D.2    Zinkernagel, R.M.3    Hengartner, H.4
  • 26
    • 0028962125 scopus 로고
    • Fas-mediated cytotoxicity by freshly isolated natural killer cells
    • Arase H, Arase N, Saito T. Fas-mediated cytotoxicity by freshly isolated natural killer cells. J Exp Med (1995) 181:1235-8. doi:10.1084/jem.181.3.1235
    • (1995) J Exp Med , vol.181 , pp. 1235-1238
    • Arase, H.1    Arase, N.2    Saito, T.3
  • 27
    • 0033567099 scopus 로고    scopus 로고
    • Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells
    • Kayagaki N, Yamaguchi N, Nakayama M, Takeda K, Akiba H, Tsutsui H, et al. Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells. J Immunol (1999) 163:1906-13.
    • (1999) J Immunol , vol.163 , pp. 1906-1913
    • Kayagaki, N.1    Yamaguchi, N.2    Nakayama, M.3    Takeda, K.4    Akiba, H.5    Tsutsui, H.6
  • 28
    • 33750689486 scopus 로고    scopus 로고
    • Effector and regulatory events during natural killer-dendritic cell interactions
    • Moretta L, Ferlazzo G, Bottino C, Vitale M, Pende D, Mingari MC, et al. Effector and regulatory events during natural killer-dendritic cell interactions. Immunol Rev (2006) 214:219-28. doi:10.1111/j.1600-065X.2006.00450.x
    • (2006) Immunol Rev , vol.214 , pp. 219-228
    • Moretta, L.1    Ferlazzo, G.2    Bottino, C.3    Vitale, M.4    Pende, D.5    Mingari, M.C.6
  • 29
    • 84900860181 scopus 로고    scopus 로고
    • Cross-talks between natural killer cells and distinct subsets of dendritic cells
    • Ferlazzo G, Morandi B. Cross-talks between natural killer cells and distinct subsets of dendritic cells. Front Immunol (2014) 5:159. doi:10.3389/fimmu.2014.00159
    • (2014) Front Immunol , vol.5 , pp. 159
    • Ferlazzo, G.1    Morandi, B.2
  • 30
    • 84875528678 scopus 로고    scopus 로고
    • Controlling natural killer cell responses: integration of signals for activation and inhibition
    • Long EO, Kim HS, Liu D, Peterson ME, Rajagopalan S. Controlling natural killer cell responses: integration of signals for activation and inhibition. Annu Rev Immunol (2013) 31:227-58. doi:10.1146/annurev-immunol-020711-075005
    • (2013) Annu Rev Immunol , vol.31 , pp. 227-258
    • Long, E.O.1    Kim, H.S.2    Liu, D.3    Peterson, M.E.4    Rajagopalan, S.5
  • 31
    • 11144299492 scopus 로고    scopus 로고
    • NK cell recognition
    • Lanier LL. NK cell recognition. Annu Rev Immunol (2005) 23:225-74. doi:10.1146/annurev.immunol.23.021704.115526
    • (2005) Annu Rev Immunol , vol.23 , pp. 225-274
    • Lanier, L.L.1
  • 32
    • 33947590063 scopus 로고    scopus 로고
    • Whatever turns you on: accessory-cell-dependent activation of NK cells by pathogens
    • Newman KC, Riley EM. Whatever turns you on: accessory-cell-dependent activation of NK cells by pathogens. Nat Rev Immunol (2007) 7:279-91. doi:10.1038/nri2057
    • (2007) Nat Rev Immunol , vol.7 , pp. 279-291
    • Newman, K.C.1    Riley, E.M.2
  • 34
    • 85002406507 scopus 로고    scopus 로고
    • Intratumoral natural killer cells show reduced effector and cytolytic properties and control the differentiation of effector Th1 cells
    • Paul S, Kulkarni N, Shilpi, Lal G. Intratumoral natural killer cells show reduced effector and cytolytic properties and control the differentiation of effector Th1 cells. Oncoimmunology (2016) 5:e1235106. doi:10.1080/2162402X.2016.1235106
    • (2016) Oncoimmunology , vol.5
    • Paul, S.1    Kulkarni, N.2    Shilpi Lal, G.3
  • 35
    • 84885514189 scopus 로고    scopus 로고
    • Comprehensive analysis of the percentage of surface receptors and cytotoxic granules positive natural killer cells in patients with pancreatic cancer, gastric cancer, and colorectal cancer
    • Peng YP, Zhu Y, Zhang JJ, Xu ZK, Qian ZY, Dai CC, et al. Comprehensive analysis of the percentage of surface receptors and cytotoxic granules positive natural killer cells in patients with pancreatic cancer, gastric cancer, and colorectal cancer. J Transl Med (2013) 11:262. doi:10.1186/1479-5876-11-262
    • (2013) J Transl Med , vol.11 , pp. 262
    • Peng, Y.P.1    Zhu, Y.2    Zhang, J.J.3    Xu, Z.K.4    Qian, Z.Y.5    Dai, C.C.6
  • 36
    • 85021778078 scopus 로고    scopus 로고
    • High NKG2A expression contributes to NK cell exhaustion and predicts a poor prognosis of patients with liver cancer
    • Sun C, Xu J, Huang Q, Huang M, Wen H, Zhang C, et al. High NKG2A expression contributes to NK cell exhaustion and predicts a poor prognosis of patients with liver cancer. Oncoimmunology (2017) 6:e1264562. doi:10.1080/2162402X.2016.1264562
    • (2017) Oncoimmunology , vol.6
    • Sun, C.1    Xu, J.2    Huang, Q.3    Huang, M.4    Wen, H.5    Zhang, C.6
  • 37
    • 80051675837 scopus 로고    scopus 로고
    • Profound coordinated alterations of intratumoral NK cell phenotype and function in lung carcinoma
    • Platonova S, Cherfils-Vicini J, Damotte D, Crozet L, Vieillard V, Validire P, et al. Profound coordinated alterations of intratumoral NK cell phenotype and function in lung carcinoma. Cancer Res (2011) 71:5412-22. doi:10.1158/0008-5472.CAN-10-4179
    • (2011) Cancer Res , vol.71 , pp. 5412-5422
    • Platonova, S.1    Cherfils-Vicini, J.2    Damotte, D.3    Crozet, L.4    Vieillard, V.5    Validire, P.6
  • 38
    • 80052346280 scopus 로고    scopus 로고
    • Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity
    • Mamessier E, Sylvain A, Thibult ML, Houvenaeghel G, Jacquemier J, Castellano R, et al. Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity. J Clin Invest (2011) 121:3609-22. doi:10.1172/JCI45816
    • (2011) J Clin Invest , vol.121 , pp. 3609-3622
    • Mamessier, E.1    Sylvain, A.2    Thibult, M.L.3    Houvenaeghel, G.4    Jacquemier, J.5    Castellano, R.6
  • 39
    • 84862493242 scopus 로고    scopus 로고
    • Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells
    • Gill S, Vasey AE, De Souza A, Baker J, Smith AT, Kohrt HE, et al. Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells. Blood (2012) 119:5758-68. doi:10.1182/blood-2012-03-415364
    • (2012) Blood , vol.119 , pp. 5758-5768
    • Gill, S.1    Vasey, A.E.2    De Souza, A.3    Baker, J.4    Smith, A.T.5    Kohrt, H.E.6
  • 40
    • 85021768153 scopus 로고    scopus 로고
    • NK cell function is markedly impaired in patients with chronic lymphocytic leukaemia but is preserved in patients with small lymphocytic lymphoma
    • Parry HM, Stevens T, Oldreive C, Zadran B, McSkeane T, Rudzki Z, et al. NK cell function is markedly impaired in patients with chronic lymphocytic leukaemia but is preserved in patients with small lymphocytic lymphoma. Oncotarget (2016) 7:68513-26. doi:10.18632/oncotarget.12097
    • (2016) Oncotarget , vol.7 , pp. 68513-685126
    • Parry, H.M.1    Stevens, T.2    Oldreive, C.3    Zadran, B.4    McSkeane, T.5    Rudzki, Z.6
  • 41
    • 84861208923 scopus 로고    scopus 로고
    • TGF-beta1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence
    • Sun C, Fu B, Gao Y, Liao X, Sun R, Tian Z, et al. TGF-beta1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence. PLoS Pathog (2012) 8:e1002594. doi:10.1371/journal.ppat.1002594
    • (2012) PLoS Pathog , vol.8
    • Sun, C.1    Fu, B.2    Gao, Y.3    Liao, X.4    Sun, R.5    Tian, Z.6
  • 42
    • 80053152866 scopus 로고    scopus 로고
    • Activating NK cell receptor expression/function (NKp30, NKp46, DNAM-1) during chronic viraemic HCV infection is associated with the outcome of combined treatment
    • Bozzano F, Picciotto A, Costa P, Marras F, Fazio V, Hirsch I, et al. Activating NK cell receptor expression/function (NKp30, NKp46, DNAM-1) during chronic viraemic HCV infection is associated with the outcome of combined treatment. Eur J Immunol (2011) 41:2905-14. doi:10.1002/eji.201041361
    • (2011) Eur J Immunol , vol.41 , pp. 2905-2914
    • Bozzano, F.1    Picciotto, A.2    Costa, P.3    Marras, F.4    Fazio, V.5    Hirsch, I.6
  • 44
    • 84995756454 scopus 로고    scopus 로고
    • PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma
    • Beldi-Ferchiou A, Lambert M, Dogniaux S, Vely F, Vivier E, Olive D, et al. PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma. Oncotarget (2016) 7:72961-77. doi:10.18632/oncotarget.12150
    • (2016) Oncotarget , vol.7 , pp. 72961-72977
    • Beldi-Ferchiou, A.1    Lambert, M.2    Dogniaux, S.3    Vely, F.4    Vivier, E.5    Olive, D.6
  • 45
    • 84905496988 scopus 로고    scopus 로고
    • PD-1 expression on peripheral blood cells increases with stage in renal cell carcinoma patients and is rapidly reduced after surgical tumor resection
    • MacFarlane AW, Jillab M, Plimack ER, Hudes GR, Uzzo RG, Litwin S, et al. PD-1 expression on peripheral blood cells increases with stage in renal cell carcinoma patients and is rapidly reduced after surgical tumor resection. Cancer Immunol Res (2014) 2:320-31. doi:10.1158/2326-6066.CIR-13-0133
    • (2014) Cancer Immunol Res , vol.2 , pp. 320-331
    • MacFarlane, A.W.1    Jillab, M.2    Plimack, E.R.3    Hudes, G.R.4    Uzzo, R.G.5    Litwin, S.6
  • 46
    • 77957701558 scopus 로고    scopus 로고
    • The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody
    • Benson DM Jr, Bakan CE, Mishra A, Hofmeister CC, Efebera Y, Becknell B, et al. The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody. Blood (2010) 116:2286-94. doi:10.1182/blood-2010-02-271874
    • (2010) Blood , vol.116 , pp. 2286-2294
    • Benson, D.M.1    Bakan, C.E.2    Mishra, A.3    Hofmeister, C.C.4    Efebera, Y.5    Becknell, B.6
  • 47
    • 84863393455 scopus 로고    scopus 로고
    • Decreased NKp46 and NKG2D and elevated PD-1 are associated with altered NK-cell function in pediatric transplant patients with PTLD
    • Wiesmayr S, Webber SA, Macedo C, Popescu I, Smith L, Luce J, et al. Decreased NKp46 and NKG2D and elevated PD-1 are associated with altered NK-cell function in pediatric transplant patients with PTLD. Eur J Immunol (2012) 42:541-50. doi:10.1002/eji.201141832
    • (2012) Eur J Immunol , vol.42 , pp. 541-550
    • Wiesmayr, S.1    Webber, S.A.2    Macedo, C.3    Popescu, I.4    Smith, L.5    Luce, J.6
  • 48
    • 84977656292 scopus 로고    scopus 로고
    • Identification of a subset of human natural killer cells expressing high levels of programmed death 1: a phenotypic and functional characterization
    • Pesce S, Greppi M, Tabellini G, Rampinelli F, Parolini S, Olive D, et al. Identification of a subset of human natural killer cells expressing high levels of programmed death 1: a phenotypic and functional characterization. J Allergy Clin Immunol (2017) 139:335-46.e3. doi:10.1016/j.jaci.2016.04.025
    • (2017) J Allergy Clin Immunol , vol.139 , pp. 335-346
    • Pesce, S.1    Greppi, M.2    Tabellini, G.3    Rampinelli, F.4    Parolini, S.5    Olive, D.6
  • 49
    • 84879315928 scopus 로고    scopus 로고
    • Blocking the natural killer cell inhibitory receptor NKG2A increases activity of human natural killer cells and clears hepatitis B virus infection in mice
    • Li F, Wei H, Wei H, Gao Y, Xu L, Yin W, et al. Blocking the natural killer cell inhibitory receptor NKG2A increases activity of human natural killer cells and clears hepatitis B virus infection in mice. Gastroenterology (2013) 144:392-401. doi:10.1053/j.gastro.2012.10.039
    • (2013) Gastroenterology , vol.144 , pp. 392-401
    • Li, F.1    Wei, H.2    Wei, H.3    Gao, Y.4    Xu, L.5    Yin, W.6
  • 50
    • 84954229415 scopus 로고    scopus 로고
    • The Galectin-9/Tim-3 pathway is involved in the regulation of NK cell function at the maternal-fetal interface in early pregnancy
    • Li YH, Zhou WH, Tao Y, Wang SC, Jiang YL, Zhang D, et al. The Galectin-9/Tim-3 pathway is involved in the regulation of NK cell function at the maternal-fetal interface in early pregnancy. Cell Mol Immunol (2016) 13:73-81. doi:10.1038/cmi.2014.126
    • (2016) Cell Mol Immunol , vol.13 , pp. 73-81
    • Li, Y.H.1    Zhou, W.H.2    Tao, Y.3    Wang, S.C.4    Jiang, Y.L.5    Zhang, D.6
  • 51
    • 77549086947 scopus 로고    scopus 로고
    • T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates natural killer cell suppression in chronic hepatitis B
    • Ju Y, Hou N, Meng J, Wang X, Zhang X, Zhao D, et al. T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates natural killer cell suppression in chronic hepatitis B. J Hepatol (2010) 52:322-9. doi:10.1016/j.jhep.2009.12.005
    • (2010) J Hepatol , vol.52 , pp. 322-329
    • Ju, Y.1    Hou, N.2    Meng, J.3    Wang, X.4    Zhang, X.5    Zhao, D.6
  • 52
    • 33745601681 scopus 로고    scopus 로고
    • Tumor growth impedes natural-killer-cell maturation in the bone marrow
    • Richards JO, Chang X, Blaser BW, Caligiuri MA, Zheng P, Liu Y. Tumor growth impedes natural-killer-cell maturation in the bone marrow. Blood (2006) 108:246-52. doi:10.1182/blood-2005-11-4535
    • (2006) Blood , vol.108 , pp. 246-252
    • Richards, J.O.1    Chang, X.2    Blaser, B.W.3    Caligiuri, M.A.4    Zheng, P.5    Liu, Y.6
  • 53
    • 80053444892 scopus 로고    scopus 로고
    • Human leukocyte antigen E contributes to protect tumor cells from lysis by natural killer cells
    • Lo Monaco E, Tremante E, Cerboni C, Melucci E, Sibilio L, Zingoni A, et al. Human leukocyte antigen E contributes to protect tumor cells from lysis by natural killer cells. Neoplasia (2011) 13:822-30. doi:10.1593/neo.101684
    • (2011) Neoplasia , vol.13 , pp. 822-830
    • Lo Monaco, E.1    Tremante, E.2    Cerboni, C.3    Melucci, E.4    Sibilio, L.5    Zingoni, A.6
  • 54
    • 79955847224 scopus 로고    scopus 로고
    • CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia
    • Coles SJ, Wang EC, Man S, Hills RK, Burnett AK, Tonks A, et al. CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia. Leukemia (2011) 25:792-9. doi:10.1038/leu.2011.1
    • (2011) Leukemia , vol.25 , pp. 792-799
    • Coles, S.J.1    Wang, E.C.2    Man, S.3    Hills, R.K.4    Burnett, A.K.5    Tonks, A.6
  • 55
    • 84860337409 scopus 로고    scopus 로고
    • Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity
    • Ndhlovu LC, Lopez-Verges S, Barbour JD, Jones RB, Jha AR, Long BR, et al. Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity. Blood (2012) 119:3734-43. doi:10.1182/blood-2011-11-392951
    • (2012) Blood , vol.119 , pp. 3734-3743
    • Ndhlovu, L.C.1    Lopez-Verges, S.2    Barbour, J.D.3    Jones, R.B.4    Jha, A.R.5    Long, B.R.6
  • 56
    • 84859192882 scopus 로고    scopus 로고
    • Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9
    • Gleason MK, Lenvik TR, McCullar V, Felices M, O'Brien MS, Cooley SA, et al. Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9. Blood (2012) 119:3064-72. doi:10.1182/blood-2011-06-360321
    • (2012) Blood , vol.119 , pp. 3064-3072
    • Gleason, M.K.1    Lenvik, T.R.2    McCullar, V.3    Felices, M.4    O'Brien, M.S.5    Cooley, S.A.6
  • 58
    • 55749098643 scopus 로고    scopus 로고
    • Neutralization of tumor-derived soluble glucocorticoid-induced TNFR-related protein ligand increases NK cell anti-tumor reactivity
    • Baltz KM, Krusch M, Baessler T, Schmiedel BJ, Bringmann A, Brossart P, et al. Neutralization of tumor-derived soluble glucocorticoid-induced TNFR-related protein ligand increases NK cell anti-tumor reactivity. Blood (2008) 112:3735-43. doi:10.1182/blood-2008-03-143016
    • (2008) Blood , vol.112 , pp. 3735-3743
    • Baltz, K.M.1    Krusch, M.2    Baessler, T.3    Schmiedel, B.J.4    Bringmann, A.5    Brossart, P.6
  • 59
    • 84923053706 scopus 로고    scopus 로고
    • Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack
    • Gur C, Ibrahim Y, Isaacson B, Yamin R, Abed J, Gamliel M, et al. Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack. Immunity (2015) 42:344-55. doi:10.1016/j.immuni.2015.01.010
    • (2015) Immunity , vol.42 , pp. 344-355
    • Gur, C.1    Ibrahim, Y.2    Isaacson, B.3    Yamin, R.4    Abed, J.5    Gamliel, M.6
  • 60
    • 70449597272 scopus 로고    scopus 로고
    • The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
    • Stanietsky N, Simic H, Arapovic J, Toporik A, Levy O, Novik A, et al. The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proc Natl Acad Sci U S A (2009) 106:17858-63. doi:10.1073/pnas.0903474106
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 17858-17863
    • Stanietsky, N.1    Simic, H.2    Arapovic, J.3    Toporik, A.4    Levy, O.5    Novik, A.6
  • 62
    • 84903470168 scopus 로고    scopus 로고
    • T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-gamma production of natural killer cells via beta-arrestin 2-mediated negative signaling
    • Li M, Xia P, Du Y, Liu S, Huang G, Chen J, et al. T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-gamma production of natural killer cells via beta-arrestin 2-mediated negative signaling. J Biol Chem (2014) 289:17647-57. doi:10.1074/jbc.M114.572420
    • (2014) J Biol Chem , vol.289 , pp. 17647-17657
    • Li, M.1    Xia, P.2    Du, Y.3    Liu, S.4    Huang, G.5    Chen, J.6
  • 63
    • 84899490367 scopus 로고    scopus 로고
    • T-cell Ig and ITIM domain regulates natural killer cell activation in murine acute viral hepatitis
    • Bi J, Zhang Q, Liang D, Xiong L, Wei H, Sun R, et al. T-cell Ig and ITIM domain regulates natural killer cell activation in murine acute viral hepatitis. Hepatology (2014) 59:1715-25. doi:10.1002/hep.26968
    • (2014) Hepatology , vol.59 , pp. 1715-1725
    • Bi, J.1    Zhang, Q.2    Liang, D.3    Xiong, L.4    Wei, H.5    Sun, R.6
  • 64
    • 84946049691 scopus 로고    scopus 로고
    • Estrogen upregulates MICA/B expression in human non-small cell lung cancer through the regulation of ADAM17
    • Ren J, Nie Y, Lv M, Shen S, Tang R, Xu Y, et al. Estrogen upregulates MICA/B expression in human non-small cell lung cancer through the regulation of ADAM17. Cell Mol Immunol (2015) 12:768-76. doi:10.1038/cmi.2014.101
    • (2015) Cell Mol Immunol , vol.12 , pp. 768-776
    • Ren, J.1    Nie, Y.2    Lv, M.3    Shen, S.4    Tang, R.5    Xu, Y.6
  • 65
    • 79960918744 scopus 로고    scopus 로고
    • Human NK cells in acute myeloid leukaemia patients: analysis of NK cell-activating receptors and their ligands
    • Sanchez-Correa B, Morgado S, Gayoso I, Bergua JM, Casado JG, Arcos MJ, et al. Human NK cells in acute myeloid leukaemia patients: analysis of NK cell-activating receptors and their ligands. Cancer Immunol Immunother (2011) 60:1195-205. doi:10.1007/s00262-011-1050-2
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 1195-1205
    • Sanchez-Correa, B.1    Morgado, S.2    Gayoso, I.3    Bergua, J.M.4    Casado, J.G.5    Arcos, M.J.6
  • 67
    • 79961023938 scopus 로고    scopus 로고
    • A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans
    • Tsuboi S, Sutoh M, Hatakeyama S, Hiraoka N, Habuchi T, Horikawa Y, et al. A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans. EMBO J (2011) 30:3173-85. doi:10.1038/emboj.2011.215
    • (2011) EMBO J , vol.30 , pp. 3173-3185
    • Tsuboi, S.1    Sutoh, M.2    Hatakeyama, S.3    Hiraoka, N.4    Habuchi, T.5    Horikawa, Y.6
  • 68
    • 84875498856 scopus 로고    scopus 로고
    • Development and maintenance of regulatory T cells
    • Ohkura N, Kitagawa Y, Sakaguchi S. Development and maintenance of regulatory T cells. Immunity (2013) 38:414-23. doi:10.1016/j.immuni.2013.03.002
    • (2013) Immunity , vol.38 , pp. 414-423
    • Ohkura, N.1    Kitagawa, Y.2    Sakaguchi, S.3
  • 69
    • 84932642481 scopus 로고    scopus 로고
    • FOXP3+ regulatory T cells and their functional regulation
    • Li Z, Li D, Tsun A, Li B. FOXP3+ regulatory T cells and their functional regulation. Cell Mol Immunol (2015) 12:558-65. doi:10.1038/cmi.2015.10
    • (2015) Cell Mol Immunol , vol.12 , pp. 558-565
    • Li, Z.1    Li, D.2    Tsun, A.3    Li, B.4
  • 70
    • 84941125254 scopus 로고    scopus 로고
    • The role of all-trans retinoic acid in the biology of Foxp3+ regulatory T cells
    • Liu ZM, Wang KP, Ma J, Guo Zheng S. The role of all-trans retinoic acid in the biology of Foxp3+ regulatory T cells. Cell Mol Immunol (2015) 12:553-7. doi:10.1038/cmi.2014.133
    • (2015) Cell Mol Immunol , vol.12 , pp. 553-557
    • Liu, Z.M.1    Wang, K.P.2    Ma, J.3    Guo Zheng, S.4
  • 71
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science (2003) 299:1057-61. doi:10.1126/science.1079490
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 72
    • 24744432528 scopus 로고    scopus 로고
    • Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine
    • Beyer M, Kochanek M, Darabi K, Popov A, Jensen M, Endl E, et al. Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine. Blood (2005) 106:2018-25. doi:10.1182/blood-2005-02-0642
    • (2005) Blood , vol.106 , pp. 2018-2025
    • Beyer, M.1    Kochanek, M.2    Darabi, K.3    Popov, A.4    Jensen, M.5    Endl, E.6
  • 73
    • 84946015206 scopus 로고    scopus 로고
    • Hepatitis C virus core protein triggers expansion and activation of CD4(+)CD25(+) regulatory T cells in chronic hepatitis C patients
    • Zhai N, Chi X, Li T, Song H, Li H, Jin X, et al. Hepatitis C virus core protein triggers expansion and activation of CD4(+)CD25(+) regulatory T cells in chronic hepatitis C patients. Cell Mol Immunol (2015) 12:743-9. doi:10.1038/cmi.2014.119
    • (2015) Cell Mol Immunol , vol.12 , pp. 743-749
    • Zhai, N.1    Chi, X.2    Li, T.3    Song, H.4    Li, H.5    Jin, X.6
  • 74
    • 26844464792 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner
    • Ghiringhelli F, Menard C, Terme M, Flament C, Taieb J, Chaput N, et al. CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner. J Exp Med (2005) 202:1075-85. doi:10.1084/jem.20051511
    • (2005) J Exp Med , vol.202 , pp. 1075-1085
    • Ghiringhelli, F.1    Menard, C.2    Terme, M.3    Flament, C.4    Taieb, J.5    Chaput, N.6
  • 75
    • 85016111488 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells
    • Gabrilovich DI. Myeloid-derived suppressor cells. Cancer Immunol Res (2017) 5:3-8. doi:10.1158/2326-6066.CIR-16-0297
    • (2017) Cancer Immunol Res , vol.5 , pp. 3-8
    • Gabrilovich, D.I.1
  • 76
    • 59849126377 scopus 로고    scopus 로고
    • Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1
    • Li H, Han Y, Guo Q, Zhang M, Cao X. Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1. J Immunol (2009) 182:240-9. doi:10.4049/jimmunol.182.1.240
    • (2009) J Immunol , vol.182 , pp. 240-249
    • Li, H.1    Han, Y.2    Guo, Q.3    Zhang, M.4    Cao, X.5
  • 77
    • 34248342290 scopus 로고    scopus 로고
    • Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host
    • Liu C, Yu S, Kappes J, Wang J, Grizzle WE, Zinn KR, et al. Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host. Blood (2007) 109:4336-42. doi:10.1182/blood-2006-09-046201
    • (2007) Blood , vol.109 , pp. 4336-4342
    • Liu, C.1    Yu, S.2    Kappes, J.3    Wang, J.4    Grizzle, W.E.5    Zinn, K.R.6
  • 78
    • 84962018955 scopus 로고    scopus 로고
    • Hepatitis C virus-induced myeloid-derived suppressor cells suppress NK cell IFN-gamma production by altering cellular metabolism via arginase-1
    • Goh CC, Roggerson KM, Lee HC, Golden-Mason L, Rosen HR, Hahn YS. Hepatitis C virus-induced myeloid-derived suppressor cells suppress NK cell IFN-gamma production by altering cellular metabolism via arginase-1. J Immunol (2016) 196:2283-92. doi:10.4049/jimmunol.1501881
    • (2016) J Immunol , vol.196 , pp. 2283-2292
    • Goh, C.C.1    Roggerson, K.M.2    Lee, H.C.3    Golden-Mason, L.4    Rosen, H.R.5    Hahn, Y.S.6
  • 79
    • 84936092900 scopus 로고    scopus 로고
    • Intratumoral dendritic cells in the anti-tumor immune response
    • Liu Y, Cao X. Intratumoral dendritic cells in the anti-tumor immune response. Cell Mol Immunol (2015) 12:387-90. doi:10.1038/cmi.2014.130
    • (2015) Cell Mol Immunol , vol.12 , pp. 387-390
    • Liu, Y.1    Cao, X.2
  • 80
    • 84920514940 scopus 로고    scopus 로고
    • The origin and function of tumor-associated macrophages
    • Liu Y, Cao X. The origin and function of tumor-associated macrophages. Cell Mol Immunol (2015) 12:1-4. doi:10.1038/cmi.2014.83
    • (2015) Cell Mol Immunol , vol.12 , pp. 1-4
    • Liu, Y.1    Cao, X.2
  • 81
    • 73949125660 scopus 로고    scopus 로고
    • Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity
    • Balsamo M, Scordamaglia F, Pietra G, Manzini C, Cantoni C, Boitano M, et al. Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity. Proc Natl Acad Sci U S A (2009) 106:20847-52. doi:10.1073/pnas.0906481106
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 20847-20852
    • Balsamo, M.1    Scordamaglia, F.2    Pietra, G.3    Manzini, C.4    Cantoni, C.5    Boitano, M.6
  • 82
    • 84858153171 scopus 로고    scopus 로고
    • Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO
    • Li T, Yang Y, Hua X, Wang G, Liu W, Jia C, et al. Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO. Cancer Lett (2012) 318:154-61. doi:10.1016/j.canlet.2011.12.020
    • (2012) Cancer Lett , vol.318 , pp. 154-161
    • Li, T.1    Yang, Y.2    Hua, X.3    Wang, G.4    Liu, W.5    Jia, C.6
  • 83
    • 31144451576 scopus 로고    scopus 로고
    • Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function
    • Liu C, Yu S, Zinn K, Wang J, Zhang L, Jia Y, et al. Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function. J Immunol (2006) 176:1375-85. doi:10.4049/jimmunol.176.3.1375
    • (2006) J Immunol , vol.176 , pp. 1375-1385
    • Liu, C.1    Yu, S.2    Zinn, K.3    Wang, J.4    Zhang, L.5    Jia, Y.6
  • 84
    • 47249144117 scopus 로고    scopus 로고
    • Human tumor-derived exosomes down-modulate NKG2D expression
    • Clayton A, Mitchell JP, Court J, Linnane S, Mason MD, Tabi Z. Human tumor-derived exosomes down-modulate NKG2D expression. J Immunol (2008) 180:7249-58. doi:10.4049/jimmunol.180.11.7249
    • (2008) J Immunol , vol.180 , pp. 7249-7258
    • Clayton, A.1    Mitchell, J.P.2    Court, J.3    Linnane, S.4    Mason, M.D.5    Tabi, Z.6
  • 85
    • 80052384534 scopus 로고    scopus 로고
    • Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor-beta1
    • Szczepanski MJ, Szajnik M, Welsh A, Whiteside TL, Boyiadzis M. Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor-beta1. Haematologica (2011) 96:1302-9. doi:10.3324/haematol.2010.039743
    • (2011) Haematologica , vol.96 , pp. 1302-1309
    • Szczepanski, M.J.1    Szajnik, M.2    Welsh, A.3    Whiteside, T.L.4    Boyiadzis, M.5
  • 86
    • 84962861045 scopus 로고    scopus 로고
    • Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-beta and miR23a transfer
    • Berchem G, Noman MZ, Bosseler M, Paggetti J, Baconnais S, Le Cam E, et al. Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-beta and miR23a transfer. Oncoimmunology (2016) 5:e1062968. doi:10.1080/2162402X.2015.1062968
    • (2016) Oncoimmunology , vol.5
    • Berchem, G.1    Noman, M.Z.2    Bosseler, M.3    Paggetti, J.4    Baconnais, S.5    Le Cam, E.6
  • 87
    • 33745082823 scopus 로고    scopus 로고
    • Role of transforming growth factor-beta in hematologic malignancies
    • Dong M, Blobe GC. Role of transforming growth factor-beta in hematologic malignancies. Blood (2006) 107:4589-96. doi:10.1182/blood-2005-10-4169
    • (2006) Blood , vol.107 , pp. 4589-4596
    • Dong, M.1    Blobe, G.C.2
  • 88
    • 0037388134 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells
    • Castriconi R, Cantoni C, Della Chiesa M, Vitale M, Marcenaro E, Conte R, et al. Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells. Proc Natl Acad Sci U S A (2003) 100:4120-5. doi:10.1073/pnas.0730640100
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4120-4125
    • Castriconi, R.1    Cantoni, C.2    Della Chiesa, M.3    Vitale, M.4    Marcenaro, E.5    Conte, R.6
  • 90
    • 84908141221 scopus 로고    scopus 로고
    • HIF transcription factors, inflammation, and immunity
    • Palazon A, Goldrath AW, Nizet V, Johnson RS. HIF transcription factors, inflammation, and immunity. Immunity (2014) 41:518-28. doi:10.1016/j.immuni.2014.09.008
    • (2014) Immunity , vol.41 , pp. 518-528
    • Palazon, A.1    Goldrath, A.W.2    Nizet, V.3    Johnson, R.S.4
  • 91
    • 84878404499 scopus 로고    scopus 로고
    • Hypoxia induced impairment of NK cell cytotoxicity against multiple myeloma can be overcome by IL-2 activation of the NK cells
    • Sarkar S, Germeraad WT, Rouschop KM, Steeghs EM, van Gelder M, Bos GM, et al. Hypoxia induced impairment of NK cell cytotoxicity against multiple myeloma can be overcome by IL-2 activation of the NK cells. PLoS One (2013) 8:e64835. doi:10.1371/journal.pone.0064835
    • (2013) PLoS One , vol.8
    • Sarkar, S.1    Germeraad, W.T.2    Rouschop, K.M.3    Steeghs, E.M.4    van Gelder, M.5    Bos, G.M.6
  • 92
    • 84885765605 scopus 로고    scopus 로고
    • Hypoxia downregulates the expression of activating receptors involved in NK-cell-mediated target cell killing without affecting ADCC
    • Balsamo M, Manzini C, Pietra G, Raggi F, Blengio F, Mingari MC, et al. Hypoxia downregulates the expression of activating receptors involved in NK-cell-mediated target cell killing without affecting ADCC. Eur J Immunol (2013) 43:2756-64. doi:10.1002/eji.201343448
    • (2013) Eur J Immunol , vol.43 , pp. 2756-2764
    • Balsamo, M.1    Manzini, C.2    Pietra, G.3    Raggi, F.4    Blengio, F.5    Mingari, M.C.6
  • 93
    • 0035874543 scopus 로고    scopus 로고
    • Augmentation of antitumor effects by NK cell inhibitory receptor blockade in vitro and in vivo
    • Koh CY, Blazar BR, George T, Welniak LA, Capitini CM, Raziuddin A, et al. Augmentation of antitumor effects by NK cell inhibitory receptor blockade in vitro and in vivo. Blood (2001) 97:3132-7. doi:10.1182/blood.V97.10.3132
    • (2001) Blood , vol.97 , pp. 3132-3137
    • Koh, C.Y.1    Blazar, B.R.2    George, T.3    Welniak, L.A.4    Capitini, C.M.5    Raziuddin, A.6
  • 94
    • 84894030202 scopus 로고    scopus 로고
    • Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies
    • Kohrt HE, Thielens A, Marabelle A, Sagiv-Barfi I, Sola C, Chanuc F, et al. Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies. Blood (2014) 123:678-86. doi:10.1182/blood-2013-08-519199
    • (2014) Blood , vol.123 , pp. 678-686
    • Kohrt, H.E.1    Thielens, A.2    Marabelle, A.3    Sagiv-Barfi, I.4    Sola, C.5    Chanuc, F.6
  • 95
    • 69249108787 scopus 로고    scopus 로고
    • Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells
    • Romagne F, Andre P, Spee P, Zahn S, Anfossi N, Gauthier L, et al. Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells. Blood (2009) 114:2667-77. doi:10.1182/blood-2009-02-206532
    • (2009) Blood , vol.114 , pp. 2667-2677
    • Romagne, F.1    Andre, P.2    Spee, P.3    Zahn, S.4    Anfossi, N.5    Gauthier, L.6
  • 96
    • 83455220035 scopus 로고    scopus 로고
    • IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect
    • Benson DM Jr, Bakan CE, Zhang S, Collins SM, Liang J, Srivastava S, et al. IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect. Blood (2011) 118:6387-91. doi:10.1182/blood-2011-06-360255
    • (2011) Blood , vol.118 , pp. 6387-6391
    • Benson, D.M.1    Bakan, C.E.2    Zhang, S.3    Collins, S.M.4    Liang, J.5    Srivastava, S.6
  • 97
    • 84990913687 scopus 로고    scopus 로고
    • Therapeutic CD94/NKG2A blockade improves natural killer cell dysfunction in chronic lymphocytic leukemia
    • McWilliams EM, Mele JM, Cheney C, Timmerman EA, Fiazuddin F, Strattan EJ, et al. Therapeutic CD94/NKG2A blockade improves natural killer cell dysfunction in chronic lymphocytic leukemia. Oncoimmunology (2016) 5:e1226720. doi:10.1080/2162402X.2016.1226720
    • (2016) Oncoimmunology , vol.5
    • Mc Williams, E.M.1    Mele, J.M.2    Cheney, C.3    Timmerman, E.A.4    Fiazuddin, F.5    Strattan, E.J.6
  • 98
    • 84925743331 scopus 로고    scopus 로고
    • Balancing natural killer cell activation through paired receptors
    • Martinet L, Smyth MJ. Balancing natural killer cell activation through paired receptors. Nat Rev Immunol (2015) 15:243-54. doi:10.1038/nri3799
    • (2015) Nat Rev Immunol , vol.15 , pp. 243-254
    • Martinet, L.1    Smyth, M.J.2
  • 99
    • 1642394991 scopus 로고    scopus 로고
    • Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155)
    • Fuchs A, Cella M, Giurisato E, Shaw AS, Colonna M. Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). J Immunol (2004) 172:3994-8. doi:10.4049/jimmunol.172.7.3994
    • (2004) J Immunol , vol.172 , pp. 3994-3998
    • Fuchs, A.1    Cella, M.2    Giurisato, E.3    Shaw, A.S.4    Colonna, M.5
  • 100
    • 84899099175 scopus 로고    scopus 로고
    • The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions
    • Chan CJ, Martinet L, Gilfillan S, Souza-Fonseca-Guimaraes F, Chow MT, Town L, et al. The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions. Nat Immunol (2014) 15:431-8. doi:10.1038/ni.2850
    • (2014) Nat Immunol , vol.15 , pp. 431-438
    • Chan, C.J.1    Martinet, L.2    Gilfillan, S.3    Souza-Fonseca-Guimaraes, F.4    Chow, M.T.5    Town, L.6
  • 101
    • 84962449276 scopus 로고    scopus 로고
    • Suppression of metastases using a new lymphocyte checkpoint target for cancer immunotherapy
    • Blake SJ, Stannard K, Liu J, Allen S, Yong MC, Mittal D, et al. Suppression of metastases using a new lymphocyte checkpoint target for cancer immunotherapy. Cancer Discov (2016) 6:446-59. doi:10.1158/2159-8290.CD-15-0944
    • (2016) Cancer Discov , vol.6 , pp. 446-459
    • Blake, S.J.1    Stannard, K.2    Liu, J.3    Allen, S.4    Yong, M.C.5    Mittal, D.6
  • 102
    • 84988726239 scopus 로고    scopus 로고
    • Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells
    • Antonangeli F, Soriani A, Ricci B, Ponzetta A, Benigni G, Morrone S, et al. Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells. Oncoimmunology (2016) 5:e1218105. doi:10.1080/2162402X.2016.1218105
    • (2016) Oncoimmunology , vol.5
    • Antonangeli, F.1    Soriani, A.2    Ricci, B.3    Ponzetta, A.4    Benigni, G.5    Morrone, S.6
  • 103
    • 85010712127 scopus 로고    scopus 로고
    • Low-dose bortezomib increases the expression of NKG2D and DNAM-1 ligands and enhances induced NK and gammadelta T cell-mediated lysis in multiple myeloma
    • Niu C, Jin H, Li M, Zhu S, Zhou L, Jin F, et al. Low-dose bortezomib increases the expression of NKG2D and DNAM-1 ligands and enhances induced NK and gammadelta T cell-mediated lysis in multiple myeloma. Oncotarget (2017) 8:5954-64. doi:10.18632/oncotarget.13979
    • (2017) Oncotarget , vol.8 , pp. 5954-5964
    • Niu, C.1    Jin, H.2    Li, M.3    Zhu, S.4    Zhou, L.5    Jin, F.6
  • 105
    • 53949108746 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors sensitize tumour cells for cytotoxic effects of natural killer cells
    • Schmudde M, Braun A, Pende D, Sonnemann J, Klier U, Beck JF, et al. Histone deacetylase inhibitors sensitize tumour cells for cytotoxic effects of natural killer cells. Cancer Lett (2008) 272:110-21. doi:10.1016/j.canlet.2008.06.027
    • (2008) Cancer Lett , vol.272 , pp. 110-121
    • Schmudde, M.1    Braun, A.2    Pende, D.3    Sonnemann, J.4    Klier, U.5    Beck, J.F.6
  • 106
    • 84879115465 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase-3 increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of STAT3
    • Fionda C, Malgarini G, Soriani A, Zingoni A, Cecere F, Iannitto ML, et al. Inhibition of glycogen synthase kinase-3 increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of STAT3. J Immunol (2013) 190:6662-72. doi:10.4049/jimmunol.1201426
    • (2013) J Immunol , vol.190 , pp. 6662-6672
    • Fionda, C.1    Malgarini, G.2    Soriani, A.3    Zingoni, A.4    Cecere, F.5    Iannitto, M.L.6
  • 107
    • 38949113714 scopus 로고    scopus 로고
    • Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma
    • Shi J, Tricot GJ, Garg TK, Malaviarachchi PA, Szmania SM, Kellum RE, et al. Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma. Blood (2008) 111:1309-17. doi:10.1182/blood-2007-03-078535
    • (2008) Blood , vol.111 , pp. 1309-1317
    • Shi, J.1    Tricot, G.J.2    Garg, T.K.3    Malaviarachchi, P.A.4    Szmania, S.M.5    Kellum, R.E.6
  • 108
    • 84959484636 scopus 로고    scopus 로고
    • Enhancement of tumor cell susceptibility to natural killer cell activity through inhibition of the PI3K signaling pathway
    • Bommarito D, Martin A, Forcade E, Nastke MD, Ritz J, Bellucci R. Enhancement of tumor cell susceptibility to natural killer cell activity through inhibition of the PI3K signaling pathway. Cancer Immunol Immunother (2016) 65:355-66. doi:10.1007/s00262-016-1804-y
    • (2016) Cancer Immunol Immunother , vol.65 , pp. 355-366
    • Bommarito, D.1    Martin, A.2    Forcade, E.3    Nastke, M.D.4    Ritz, J.5    Bellucci, R.6
  • 110
    • 85014676832 scopus 로고    scopus 로고
    • Human fused NKG2D-IL-15 protein controls xenografted human gastric cancer through the recruitment and activation of NK cells
    • Chen Y, Chen B, Yang T, Xiao W, Qian L, Ding Y, et al. Human fused NKG2D-IL-15 protein controls xenografted human gastric cancer through the recruitment and activation of NK cells. Cell Mol Immunol (2017) 14:293-307. doi:10.1038/cmi.2015.81
    • (2017) Cell Mol Immunol , vol.14 , pp. 293-307
    • Chen, Y.1    Chen, B.2    Yang, T.3    Xiao, W.4    Qian, L.5    Ding, Y.6
  • 111
    • 85012300511 scopus 로고    scopus 로고
    • TGFbetaR1 blockade with galunisertib (LY2157299) enhances anti-neuroblastoma activity of the anti-GD2 antibody dinutuximab (ch14.18) with natural killer cells
    • Tran HC, Wan Z, Sheard MA, Sun J, Jackson JR, Malvar J, et al. TGFbetaR1 blockade with galunisertib (LY2157299) enhances anti-neuroblastoma activity of the anti-GD2 antibody dinutuximab (ch14.18) with natural killer cells. Clin Cancer Res (2017) 23:804-13. doi:10.1158/1078-0432.CCR-16-1743
    • (2017) Clin Cancer Res , vol.23 , pp. 804-813
    • Tran, H.C.1    Wan, Z.2    Sheard, M.A.3    Sun, J.4    Jackson, J.R.5    Malvar, J.6
  • 112
    • 68649096424 scopus 로고    scopus 로고
    • A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection
    • Shin H, Blackburn SD, Intlekofer AM, Kao C, Angelosanto JM, Reiner SL, et al. A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection. Immunity (2009) 31:309-20. doi:10.1016/j.immuni.2009.06.019
    • (2009) Immunity , vol.31 , pp. 309-320
    • Shin, H.1    Blackburn, S.D.2    Intlekofer, A.M.3    Kao, C.4    Angelosanto, J.M.5    Reiner, S.L.6
  • 113
    • 84977471548 scopus 로고    scopus 로고
    • T-bet and eomesodermin in NK cell development, maturation, and function
    • Simonetta F, Pradier A, Roosnek E. T-bet and eomesodermin in NK cell development, maturation, and function. Front Immunol (2016) 7:241. doi:10.3389/fimmu.2016.00241
    • (2016) Front Immunol , vol.7 , pp. 241
    • Simonetta, F.1    Pradier, A.2    Roosnek, E.3
  • 114
    • 85018769485 scopus 로고    scopus 로고
    • Metabolic instruction of immunity
    • Buck MD, Sowell RT, Kaech SM, Pearce EL. Metabolic instruction of immunity. Cell (2017) 169:570-86. doi:10.1016/j.cell.2017.04.004
    • (2017) Cell , vol.169 , pp. 570-586
    • Buck, M.D.1    Sowell, R.T.2    Kaech, S.M.3    Pearce, E.L.4
  • 115
    • 85017233046 scopus 로고    scopus 로고
    • Impact of metabolism on T-cell differentiation and function and cross talk with tumor microenvironment
    • Kouidhi S, Elgaaied AB, Chouaib S. Impact of metabolism on T-cell differentiation and function and cross talk with tumor microenvironment. Front Immunol (2017) 8:270. doi:10.3389/fimmu.2017.00270
    • (2017) Front Immunol , vol.8 , pp. 270
    • Kouidhi, S.1    Elgaaied, A.B.2    Chouaib, S.3
  • 116
    • 85018784034 scopus 로고    scopus 로고
    • What fuels natural killers Metabolism and NK cell responses
    • Gardiner CM, Finlay DK. What fuels natural killers Metabolism and NK cell responses. Front Immunol (2017) 8:367. doi:10.3389/fimmu.2017.00367
    • (2017) Front Immunol , vol.8 , pp. 367
    • Gardiner, C.M.1    Finlay, D.K.2
  • 117
    • 84997706268 scopus 로고    scopus 로고
    • Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor PD-1 are an early driver of CD8(+) T cell exhaustion
    • Bengsch B, Johnson AL, Kurachi M, Odorizzi PM, Pauken KE, Attanasio J, et al. Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor PD-1 are an early driver of CD8(+) T cell exhaustion. Immunity (2016) 45:358-73. doi:10.1016/j.immuni.2016.07.008
    • (2016) Immunity , vol.45 , pp. 358-373
    • Bengsch, B.1    Johnson, A.L.2    Kurachi, M.3    Odorizzi, P.M.4    Pauken, K.E.5    Attanasio, J.6
  • 118
    • 84904725488 scopus 로고    scopus 로고
    • The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells
    • Marcais A, Cherfils-Vicini J, Viant C, Degouve S, Viel S, Fenis A, et al. The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells. Nat Immunol (2014) 15:749-57. doi:10.1038/ni.2936
    • (2014) Nat Immunol , vol.15 , pp. 749-757
    • Marcais, A.1    Cherfils-Vicini, J.2    Viant, C.3    Degouve, S.4    Viel, S.5    Fenis, A.6
  • 119
    • 84905973739 scopus 로고    scopus 로고
    • Transcriptional and epigenetic networks of helper T and innate lymphoid cells
    • Shih HY, Sciume G, Poholek AC, Vahedi G, Hirahara K, Villarino AV, et al. Transcriptional and epigenetic networks of helper T and innate lymphoid cells. Immunol Rev (2014) 261:23-49. doi:10.1111/imr.12208
    • (2014) Immunol Rev , vol.261 , pp. 23-49
    • Shih, H.Y.1    Sciume, G.2    Poholek, A.C.3    Vahedi, G.4    Hirahara, K.5    Villarino, A.V.6
  • 120
    • 84994364943 scopus 로고    scopus 로고
    • Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
    • Pauken KE, Sammons MA, Odorizzi PM, Manne S, Godec J, Khan O, et al. Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade. Science (2016) 354:1160-5. doi:10.1126/science.aaf2807
    • (2016) Science , vol.354 , pp. 1160-1165
    • Pauken, K.E.1    Sammons, M.A.2    Odorizzi, P.M.3    Manne, S.4    Godec, J.5    Khan, O.6
  • 122
    • 84952682714 scopus 로고    scopus 로고
    • Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity
    • Yin J, Leavenworth JW, Li Y, Luo Q, Xie H, Liu X, et al. Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity. Proc Natl Acad Sci U S A (2015) 112:15988-93. doi:10.1073/pnas.1521740112
    • (2015) Proc Natl Acad Sci USA , vol.112 , pp. 15988-15993
    • Yin, J.1    Leavenworth, J.W.2    Li, Y.3    Luo, Q.4    Xie, H.5    Liu, X.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.