메뉴 건너뛰기




Volumn 12, Issue 5, 2015, Pages 558-565

FOXP3+ regulatory T cells and their functional regulation

Author keywords

autoimmune diseases; FOXP3; immunosuppressive activity; Treg cells

Indexed keywords

CD4 ANTIGEN; CD45RA ANTIGEN; CYCLOPHOSPHAMIDE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 35; INTERLEUKIN 7 RECEPTOR; MESSENGER RNA; NEUROPILIN 1; RAPAMYCIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR HELIOS; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT1; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG; FORKHEAD TRANSCRIPTION FACTOR;

EID: 84932642481     PISSN: 16727681     EISSN: 20420226     Source Type: Journal    
DOI: 10.1038/cmi.2015.10     Document Type: Review
Times cited : (215)

References (92)
  • 1
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155: 1151-1164.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 2
    • 74049164847 scopus 로고    scopus 로고
    • Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    • Wing K, Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol 2010; 11: 7-13.
    • (2010) Nat Immunol , vol.11 , pp. 7-13
    • Wing, K.1    Sakaguchi, S.2
  • 3
    • 77950349016 scopus 로고    scopus 로고
    • Th17 and regulatory T cells in mediating and restraining inflammation
    • Littman DR, Rudensky AY. Th17 and regulatory T cells in mediating and restraining inflammation. Cell 2010; 140: 845-858.
    • (2010) Cell , vol.140 , pp. 845-858
    • Littman, D.R.1    Rudensky, A.Y.2
  • 4
    • 79251500661 scopus 로고    scopus 로고
    • Phenotypical and functional specialization of FOXP31 regulatory T cells
    • Campbell DJ, Koch MA. Phenotypical and functional specialization of FOXP31 regulatory T cells. Nat Rev Immunol 2011; 11: 119-130.
    • (2011) Nat Rev Immunol , vol.11 , pp. 119-130
    • Campbell, D.J.1    Koch, M.A.2
  • 5
    • 67649170980 scopus 로고    scopus 로고
    • Foxp31 regulatory T cells: Differentiation, specification, subphenotypes
    • Feuerer M, Hill JA, Mathis D, Benoist C. Foxp31 regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol 2009; 10: 689-695.
    • (2009) Nat Immunol , vol.10 , pp. 689-695
    • Feuerer, M.1    Hill, J.A.2    Mathis, D.3    Benoist, C.4
  • 6
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD41CD251 regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD41CD251 regulatory T cells. Nat Immunol 2003; 4: 330-336.
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 7
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 8
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD41CD251 T regulatory cells
    • Khattri R, Cox T, Yasayko SA, Ramsdell F. An essential role for Scurfin in CD41CD251 T regulatory cells. Nat Immunol 2003; 4: 337-342.
    • (2003) Nat Immunol , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 9
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 2001; 27: 68-73.
    • (2001) Nat Genet , vol.27 , pp. 68-73
    • Brunkow, M.E.1    Jeffery, E.W.2    Hjerrild, K.A.3    Paeper, B.4    Clark, L.B.5    Yasayko, S.A.6
  • 10
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    • Bennett CL, Christie J, Ramsdell F, Brunkow ME, Ferguson PJ, Whitesell L et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 2001; 27: 20-21.
    • (2001) Nat Genet , vol.27 , pp. 20-21
    • Bennett, C.L.1    Christie, J.2    Ramsdell, F.3    Brunkow, M.E.4    Ferguson, P.J.5    Whitesell, L.6
  • 11
    • 84874232301 scopus 로고    scopus 로고
    • Helios1 and Helios2 cells coexist within the natural FOXP31 T regulatory cell subset in humans
    • Himmel ME, MacDonald KG, Garcia RV, Steiner TS, Levings MK. Helios1 and Helios2 cells coexist within the natural FOXP31 T regulatory cell subset in humans. J Immunol 2013; 190: 2001-2008.
    • (2013) J Immunol , vol.190 , pp. 2001-2008
    • Himmel, M.E.1    MacDonald, K.G.2    Garcia, R.V.3    Steiner, T.S.4    Levings, M.K.5
  • 12
    • 77951638740 scopus 로고    scopus 로고
    • Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp31 T regulatory cells
    • Thornton AM, Korty PE, Tran DQ, Wohlfert EA, Murray PE, Belkaid Y et al. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp31 T regulatory cells. J Immunol 2010; 184: 3433-3441.
    • (2010) J Immunol , vol.184 , pp. 3433-3441
    • Thornton, A.M.1    Korty, P.E.2    Tran, D.Q.3    Wohlfert, E.A.4    Murray, P.E.5    Belkaid, Y.6
  • 13
    • 84867901322 scopus 로고    scopus 로고
    • Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo
    • S1-S19
    • Yadav M, Louvet C, Davini D, Gardner JM, Martinez-Llordella M, Bailey-Bucktrout S et al. Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo. J Exp Med 2012; 209: 1713-1722, S1-S19.
    • (2012) J Exp Med , vol.209 , pp. 1713-1722
    • Yadav, M.1    Louvet, C.2    Davini, D.3    Gardner, J.M.4    Martinez-Llordella, M.5    Bailey-Bucktrout, S.6
  • 14
    • 84891838421 scopus 로고    scopus 로고
    • Pathogenic conversion of Foxp31 T cells into TH17 cells in autoimmune arthritis
    • Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T et al. Pathogenic conversion of Foxp31 T cells into TH17 cells in autoimmune arthritis. Nat Med 2014; 20: 62-68.
    • (2014) Nat Med , vol.20 , pp. 62-68
    • Komatsu, N.1    Okamoto, K.2    Sawa, S.3    Nakashima, T.4    Oh-Hora, M.5    Kodama, T.6
  • 15
    • 84891112617 scopus 로고    scopus 로고
    • TGF-betamediated Foxp3 gene expression is cooperatively regulated by Stat5, Creb, and AP-1 through CNS2
    • Ogawa C, Tone Y, Tsuda M, Peter C, Waldmann H, Tone M. TGF-betamediated Foxp3 gene expression is cooperatively regulated by Stat5, Creb, and AP-1 through CNS2. J Immunol 2013; 192: 475-483.
    • (2013) J Immunol , vol.192 , pp. 475-483
    • Ogawa, C.1    Tone, Y.2    Tsuda, M.3    Peter, C.4    Waldmann, H.5    Tone, M.6
  • 16
    • 76749133610 scopus 로고    scopus 로고
    • Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
    • Zheng Y, Josefowicz S, Chaudhry A, Peng XP, Forbush K, Rudensky AY. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 2010; 463: 808-812.
    • (2010) Nature , vol.463 , pp. 808-812
    • Zheng, Y.1    Josefowicz, S.2    Chaudhry, A.3    Peng, X.P.4    Forbush, K.5    Rudensky, A.Y.6
  • 17
    • 34447265236 scopus 로고    scopus 로고
    • CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: A role for DNA methylation
    • Kim HP, Leonard WJ. CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation. J Exp Med 2007; 204: 1543-1551.
    • (2007) J Exp Med , vol.204 , pp. 1543-1551
    • Kim, H.P.1    Leonard, W.J.2
  • 18
  • 19
    • 66949171924 scopus 로고    scopus 로고
    • Functional delineation and differentiation dynamics of human CD41 T cells expressing the FoxP3 transcription factor
    • Miyara M, Yoshioka Y, Kitoh A, Shima T, Wing K, Niwa A et al. Functional delineation and differentiation dynamics of human CD41 T cells expressing the FoxP3 transcription factor. Immunity 2009; 30: 899-911.
    • (2009) Immunity , vol.30 , pp. 899-911
    • Miyara, M.1    Yoshioka, Y.2    Kitoh, A.3    Shima, T.4    Wing, K.5    Niwa, A.6
  • 21
    • 70049113279 scopus 로고    scopus 로고
    • CD41 regulatory T cells control TH17 responses in a Stat3-dependent manner
    • Chaudhry A, Rudra D, Treuting P, Samstein RM, Liang Y, Kas A et al. CD41 regulatory T cells control TH17 responses in a Stat3-dependent manner. Science 2009; 326: 986-991.
    • (2009) Science , vol.326 , pp. 986-991
    • Chaudhry, A.1    Rudra, D.2    Treuting, P.3    Samstein, R.M.4    Liang, Y.5    Kas, A.6
  • 22
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    • Koch MA, Tucker-Heard G, Perdue NR, Killebrew JR, Urdahl KB, Campbell DJ. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol 2009; 10: 595-602.
    • (2009) Nat Immunol , vol.10 , pp. 595-602
    • Koch, M.A.1    Tucker-Heard, G.2    Perdue, N.R.3    Killebrew, J.R.4    Urdahl, K.B.5    Campbell, D.J.6
  • 23
    • 62649165369 scopus 로고    scopus 로고
    • Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses
    • Zheng Y, Chaudhry A, Kas A, deRoos P, Kim JM, Chu TT et al. Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses. Nature 2009; 458: 351-356.
    • (2009) Nature , vol.458 , pp. 351-356
    • Zheng, Y.1    Chaudhry, A.2    Kas, A.3    deRoos, P.4    Kim, J.M.5    Chu, T.T.6
  • 24
    • 84923035090 scopus 로고    scopus 로고
    • Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance
    • Yu F, Sharma S, Edwards J, FeigenbaumL, Zhu J. Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance. Nat Immunol 2015; 16: 197-206.
    • (2015) Nat Immunol , vol.16 , pp. 197-206
    • Yu, F.1    Sharma, S.2    Edwards, J.3    Feigenbauml Zhu, J.4
  • 25
    • 78049318852 scopus 로고    scopus 로고
    • Developmental plasticity of Foxp31 regulatory T cells
    • Hori S. Developmental plasticity of Foxp31 regulatory T cells. Curr Opin Immunol 2010; 22: 575-582.
    • (2010) Curr Opin Immunol , vol.22 , pp. 575-582
    • Hori, S.1
  • 27
    • 65449125930 scopus 로고    scopus 로고
    • Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions
    • Duarte JH, Zelenay S, Bergman ML, Martins AC, Demengeot J. Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions. Eur J Immunol 2009; 39: 948-955.
    • (2009) Eur J Immunol , vol.39 , pp. 948-955
    • Duarte, J.H.1    Zelenay, S.2    Bergman, M.L.3    Martins, A.C.4    Demengeot, J.5
  • 28
    • 62449202866 scopus 로고    scopus 로고
    • Preferential generation of follicularB helper T cells from Foxp31 T cells in gut Peyers patches
    • Tsuji M, Komatsu N, Kawamoto S, Suzuki K, Kanagawa O, Honjo T et al. Preferential generation of follicularB helper T cells from Foxp31 T cells in gut Peyers patches. Science 2009; 323: 1488-1492.
    • (2009) Science , vol.323 , pp. 1488-1492
    • Tsuji, M.1    Komatsu, N.2    Kawamoto, S.3    Suzuki, K.4    Kanagawa, O.5    Honjo, T.6
  • 29
    • 70350464351 scopus 로고    scopus 로고
    • Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
    • Murai M, Turovskaya O, Kim G, Madan R, Karp CL, Cheroutre H et al. Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat Immunol 2009; 10: 1178-1184.
    • (2009) Nat Immunol , vol.10 , pp. 1178-1184
    • Murai, M.1    Turovskaya, O.2    Kim, G.3    Madan, R.4    Karp, C.L.5    Cheroutre, H.6
  • 30
    • 69049107358 scopus 로고    scopus 로고
    • Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
    • Zhou X, Bailey-Bucktrout SL, Jeker LT, Penaranda C, Martinez-Llordella M, Ashby M et al. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol 2009; 10: 1000-1007.
    • (2009) Nat Immunol , vol.10 , pp. 1000-1007
    • Zhou, X.1    Bailey-Bucktrout, S.L.2    Jeker, L.T.3    Penaranda, C.4    Martinez-Llordella, M.5    Ashby, M.6
  • 31
    • 84882683958 scopus 로고    scopus 로고
    • The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3
    • Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y et al. The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. Immunity 2013; 39: 272-285.
    • (2013) Immunity , vol.39 , pp. 272-285
    • Chen, Z.1    Barbi, J.2    Bu, S.3    Yang, H.Y.4    Li, Z.5    Gao, Y.6
  • 32
    • 71749113619 scopus 로고    scopus 로고
    • T cell receptor CDR3 sequence but not recognition characteristics distinguish autoreactive effector and Foxp31 regulatory T cells
    • Liu X, Nguyen P, Liu W, Cheng C, Steeves M, Obenauer JC et al. T cell receptor CDR3 sequence but not recognition characteristics distinguish autoreactive effector and Foxp31 regulatory T cells. Immunity 2009; 31: 909-920.
    • (2009) Immunity , vol.31 , pp. 909-920
    • Liu, X.1    Nguyen, P.2    Liu, W.3    Cheng, C.4    Steeves, M.5    Obenauer, J.C.6
  • 34
    • 60549115770 scopus 로고    scopus 로고
    • Heterogeneity of natural Foxp31 T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity
    • Komatsu N, Mariotti-Ferrandiz ME, Wang Y, Malissen B, Waldmann H, Hori S. Heterogeneity of natural Foxp31 T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc Natl Acad Sci USA 2009; 106: 1903-1908.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 1903-1908
    • Komatsu, N.1    Mariotti-Ferrandiz, M.E.2    Wang, Y.3    Malissen, B.4    Waldmann, H.5    Hori, S.6
  • 35
    • 84891838421 scopus 로고    scopus 로고
    • Pathogenic conversion of Foxp31 T cells into TH17 cells in autoimmune arthritis
    • Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T et al. Pathogenic conversion of Foxp31 T cells into TH17 cells in autoimmune arthritis. Nat Med 2013; 20: 62-68.
    • (2013) Nat Med , vol.20 , pp. 62-68
    • Komatsu, N.1    Okamoto, K.2    Sawa, S.3    Nakashima, T.4    Oh-Hora, M.5    Kodama, T.6
  • 36
    • 55149094300 scopus 로고    scopus 로고
    • Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells
    • Koenen HJ, Smeets RL, Vink PM, van Rijssen E, Boots AM, Joosten I. Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells. Blood 2008; 112: 2340-2352.
    • (2008) Blood , vol.112 , pp. 2340-2352
    • Koenen, H.J.1    Smeets, R.L.2    Vink, P.M.3    Van Rijssen, E.4    Boots, A.M.5    Joosten, I.6
  • 38
    • 33646578505 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD41 CD251 regulatory T-cellmediated suppression
    • Oderup C, Cederbom L, Makowska A, Cilio CM, Ivars F. Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD41 CD251 regulatory T-cellmediated suppression. Immunology 2006; 118: 240-249.
    • (2006) Immunology , vol.118 , pp. 240-249
    • Oderup, C.1    Cederbom, L.2    Makowska, A.3    Cilio, C.M.4    Ivars, F.5
  • 39
    • 0347480215 scopus 로고    scopus 로고
    • CD40 ligation releases immature dendritic cells from the control of regulatory CD41CD251 T cells
    • Serra P, Amrani A, Yamanouchi J, Han B, Thiessen S, Utsugi T et al. CD40 ligation releases immature dendritic cells from the control of regulatory CD41CD251 T cells. Immunity 2003; 19: 877-889.
    • (2003) Immunity , vol.19 , pp. 877-889
    • Serra, P.1    Amrani, A.2    Yamanouchi, J.3    Han, B.4    Thiessen, S.5    Utsugi, T.6
  • 40
    • 44449110691 scopus 로고    scopus 로고
    • Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II
    • Liang B, Workman C, Lee J, Chew C, Dale BM, Colonna L et al. Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II. J Immunol 2008; 180: 5916-5926.
    • (2008) J Immunol , vol.180 , pp. 5916-5926
    • Liang, B.1    Workman, C.2    Lee, J.3    Chew, C.4    Dale, B.M.5    Colonna, L.6
  • 41
    • 40249108222 scopus 로고    scopus 로고
    • Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition
    • Sarris M, Andersen KG, Randow F, Mayr L, Betz AG. Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition. Immunity 2008; 28: 402-413.
    • (2008) Immunity , vol.28 , pp. 402-413
    • Sarris, M.1    Andersen, K.G.2    Randow, F.3    Mayr, L.4    Betz, A.G.5
  • 42
    • 28544444024 scopus 로고    scopus 로고
    • Resolution of airway inflammation and hyperreactivity after in vivo transfer ofCD41CD251 regulatory T cells is interleukin 10 dependent
    • Kearley J, Barker JE, Robinson DS, Lloyd CM. Resolution of airway inflammation and hyperreactivity after in vivo transfer ofCD41CD251 regulatory T cells is interleukin 10 dependent. J Exp Med 2005; 202: 1539-1547.
    • (2005) J Exp Med , vol.202 , pp. 1539-1547
    • Kearley, J.1    Barker, J.E.2    Robinson, D.S.3    Lloyd, C.M.4
  • 43
    • 0033523607 scopus 로고    scopus 로고
    • An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    • Asseman C, Mauze S, Leach MW, Coffman RL, Powrie F. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 1999; 190: 995-1004.
    • (1999) J Exp Med , vol.190 , pp. 995-1004
    • Asseman, C.1    Mauze, S.2    Leach, M.W.3    Coffman, R.L.4    Powrie, F.5
  • 44
    • 0035801335 scopus 로고    scopus 로고
    • Cell contact-dependent immunosuppression by CD41CD251 regulatory T cells is mediated by cell surface-bound transforming growth factor beta
    • Nakamura K, Kitani A, Strober W. Cell contact-dependent immunosuppression by CD41CD251 regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med 2001; 194: 629-644.
    • (2001) J Exp Med , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 45
    • 0141703239 scopus 로고    scopus 로고
    • CD41CD251 T regulatory cells control anti-islet CD81 T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes
    • Green EA, Gorelik L, McGregor CM, Tran EH, Flavell RA. CD41CD251 T regulatory cells control anti-islet CD81 T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. Proc Natl Acad Sci USA 2003; 100: 10878-10883.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10878-10883
    • Green, E.A.1    Gorelik, L.2    McGregor, C.M.3    Tran, E.H.4    Flavell, R.A.5
  • 46
    • 36549030784 scopus 로고    scopus 로고
    • The inhibitory cytokine IL-35 contributes to regulatory T-cell function
    • Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 2007; 450: 566-569.
    • (2007) Nature , vol.450 , pp. 566-569
    • Collison, L.W.1    Workman, C.J.2    Kuo, T.T.3    Boyd, K.4    Wang, Y.5    Vignali, K.M.6
  • 48
    • 0031821875 scopus 로고    scopus 로고
    • CD41CD251 immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin2 production
    • Thornton AM, Shevach EM. CD41CD251 immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin2 production. J Exp Med 1998; 188: 287-296.
    • (1998) J Exp Med , vol.188 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2
  • 49
    • 4644369302 scopus 로고    scopus 로고
    • Interleukin-2 is essential for CD41CD251 regulatory T cell function
    • de la Rosa M, Rutz S, Dorninger H, Scheffold A. Interleukin-2 is essential for CD41CD251 regulatory T cell function. Eur J Immunol 2004; 34: 2480-2488.
    • (2004) Eur J Immunol , vol.34 , pp. 2480-2488
    • De La Rosa, M.1    Rutz, S.2    Dorninger, H.3    Scheffold, A.4
  • 50
    • 34250376423 scopus 로고    scopus 로고
    • Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression
    • Bopp T, Becker C, Klein M, Klein-Hessling S, Palmetshofer A, Serfling E et al. Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. J Exp Med 2007; 204: 1303-1310.
    • (2007) J Exp Med , vol.204 , pp. 1303-1310
    • Bopp, T.1    Becker, C.2    Klein, M.3    Klein-Hessling, S.4    Palmetshofer, A.5    Serfling, E.6
  • 51
    • 34250351459 scopus 로고    scopus 로고
    • Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    • Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med 2007; 204: 1257-1265.
    • (2007) J Exp Med , vol.204 , pp. 1257-1265
    • Deaglio, S.1    Dwyer, K.M.2    Gao, W.3    Friedman, D.4    Usheva, A.5    Erat, A.6
  • 52
    • 33750832563 scopus 로고    scopus 로고
    • T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 59-adenosine monophosphate to adenosine
    • Kobie JJ, Shah PR, Yang L, Rebhahn JA, Fowell DJ, Mosmann TR. T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 59-adenosine monophosphate to adenosine. J Immunol 2006; 177: 6780-6786.
    • (2006) J Immunol , vol.177 , pp. 6780-6786
    • Kobie, J.J.1    Shah, P.R.2    Yang, L.3    Rebhahn, J.A.4    Fowell, D.J.5    Mosmann, T.R.6
  • 53
    • 34248379172 scopus 로고    scopus 로고
    • FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression
    • Li B, Samanta A, Song X, Iacono, KT, Bembas K, Tao R et al. FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc Natl Acad Sci USA 2007; 104: 4571-4576.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 4571-4576
    • Li, B.1    Samanta, A.2    Song, X.3    Iacono, K.T.4    Bembas, K.5    Tao, R.6
  • 54
    • 84907588706 scopus 로고    scopus 로고
    • PIM1 kinase phosphorylates the human transcription factor FOXP3 at serine 422 to negatively regulate its activity under inflammation
    • Li Z, Lin F, Zhuo C, Deng G, Chen Z, Yin S et al. PIM1 kinase phosphorylates the human transcription factor FOXP3 at serine 422 to negatively regulate its activity under inflammation. J Biol Chem 2014; 289: 26872-26881.
    • (2014) J Biol Chem , vol.289 , pp. 26872-26881
    • Li, Z.1    Lin, F.2    Zhuo, C.3    Deng, G.4    Chen, Z.5    Yin, S.6
  • 55
    • 84882592280 scopus 로고    scopus 로고
    • Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity
    • van Loosdregt J, Fleskens V, Fu J, Brenkman AB, Bekker CP, Pals CE et al. Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity. Immunity 2013; 39: 259-271.
    • (2013) Immunity , vol.39 , pp. 259-271
    • Van Loosdregt, J.1    Fleskens, V.2    Fu, J.3    Brenkman, A.B.4    Bekker, C.P.5    Pals, C.E.6
  • 56
    • 80052277906 scopus 로고    scopus 로고
    • Control of TH17/Treg balance by hypoxia-inducible factor 1
    • Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y et al. Control of TH17/Treg balance by hypoxia-inducible factor 1. Cell 2011; 146: 772-784.
    • (2011) Cell , vol.146 , pp. 772-784
    • Dang, E.V.1    Barbi, J.2    Yang, H.Y.3    Jinasena, D.4    Yu, H.5    Zheng, Y.6
  • 58
    • 84863229506 scopus 로고    scopus 로고
    • Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells
    • Kwon HS, Lim HW, Wu J, Schnolzer M, Verdin E, Ott M. Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. J Immunol 2012; 188: 2712-2721.
    • (2012) J Immunol , vol.188 , pp. 2712-2721
    • Kwon, H.S.1    Lim, H.W.2    Wu, J.3    Schnolzer, M.4    Verdin, E.5    Ott, M.6
  • 59
    • 84883164348 scopus 로고    scopus 로고
    • Foxp3 protein stability is regulated by cyclin-dependent kinase 2
    • Morawski PA, Mehra P, Chen C, Bhatti T, Wells AD. Foxp3 protein stability is regulated by cyclin-dependent kinase 2. J Biol Chem 2013; 288: 24494-24502.
    • (2013) J Biol Chem , vol.288 , pp. 24494-24502
    • Morawski, P.A.1    Mehra, P.2    Chen, C.3    Bhatti, T.4    Wells, A.D.5
  • 60
    • 84875153425 scopus 로고    scopus 로고
    • Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNFalpha in rheumatoid arthritis
    • Nie H, Zheng Y, Li R, Guo TB, He D, Fang L et al Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNFalpha in rheumatoid arthritis. Nat Med2013; 19: 322-328.
    • (2013) Nat Med , vol.19 , pp. 322-328
    • Nie, H.1    Zheng, Y.2    Li, R.3    Guo, T.B.4    He, D.5    Fang, L.6
  • 62
    • 34547821980 scopus 로고    scopus 로고
    • FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease
    • Li B, Samanta A, Song X, Iacono KT, Brennan P, Chatila TA et al. FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease. Int Immunol 2007; 19: 825-835.
    • (2007) Int Immunol , vol.19 , pp. 825-835
    • Li, B.1    Samanta, A.2    Song, X.3    Iacono, K.T.4    Brennan, P.5    Chatila, T.A.6
  • 63
    • 84863212714 scopus 로고    scopus 로고
    • Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function
    • Song X, Li B, Xiao Y, Chen C, Wang Q, Liu Y et al. Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function. Cell Rep 2012; 1: 665-675.
    • (2012) Cell Rep , vol.1 , pp. 665-675
    • Song, X.1    Li, B.2    Xiao, Y.3    Chen, C.4    Wang, Q.5    Liu, Y.6
  • 64
    • 84866548843 scopus 로고    scopus 로고
    • Transcription factor Foxp3 and its protein partners form a complex regulatory network
    • Rudra D, deRoos P, Chaudhry A, Niec RE, Arvey A, SamsteinRMet al. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Nat Immunol 2012; 13: 1010-1019.
    • (2012) Nat Immunol , vol.13 , pp. 1010-1019
    • Rudra, D.1    deRoos, P.2    Chaudhry, A.3    Niec, R.E.4    Arvey, A.5    Samstein, R.M.6
  • 65
    • 33747801470 scopus 로고    scopus 로고
    • IL-2 regulates FOXP3 expression in human CD41CD251 regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo
    • Zorn E, Nelson EA, Mohseni M, Porcheray F, Kim H, Litsa D et al. IL-2 regulates FOXP3 expression in human CD41CD251 regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood 2006; 108: 1571-1579.
    • (2006) Blood , vol.108 , pp. 1571-1579
    • Zorn, E.1    Nelson, E.A.2    Mohseni, M.3    Porcheray, F.4    Kim, H.5    Litsa, D.6
  • 66
    • 70349741295 scopus 로고    scopus 로고
    • Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP31 regulatory T cells
    • Kitoh A, Ono, M, Naoe, Y, Ohkura, N, Yamaguchi, T, Yaguchi H et al. Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP31 regulatory T cells. Immunity 2009; 31: 609-620.
    • (2009) Immunity , vol.31 , pp. 609-620
    • Kitoh, A.1    Ono, M.2    Naoe, Y.3    Ohkura, N.4    Yamaguchi, T.5    Yaguchi, H.6
  • 67
    • 73949090725 scopus 로고    scopus 로고
    • C-Rel is required for the development of thymic Foxp31 CD4 regulatory T cells
    • Isomura I, Palmer S, Grumont RJ, Bunting K, Hoyne G, Wilkinson N et al. c-Rel is required for the development of thymic Foxp31 CD4 regulatory T cells. J Exp Med 2009; 206: 3001-3014.
    • (2009) J Exp Med , vol.206 , pp. 3001-3014
    • Isomura, I.1    Palmer, S.2    Grumont, R.J.3    Bunting, K.4    Hoyne, G.5    Wilkinson, N.6
  • 68
    • 71749094333 scopus 로고    scopus 로고
    • Development of Foxp31 regulatory t cells is driven by the c-Rel enhanceosome
    • Ruan, Q, Kameswaran, V, Tone, Y, Li, L, Liou, HC, Greene, MI et al. Development of Foxp31 regulatory t cells is driven by the c-Rel enhanceosome. Immunity 2009; 31: 932-940.
    • (2009) Immunity , vol.31 , pp. 932-940
    • Ruan, Q.1    Kameswaran, V.2    Tone, Y.3    Li, L.4    Liou, H.C.5    Greene, M.I.6
  • 69
    • 71749088574 scopus 로고    scopus 로고
    • Nuclear factorkappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor
    • Long M, Park SG, Strickland I, Hayden MS, Ghosh S. Nuclear factorkappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. Immunity 2009; 31: 921-931.
    • (2009) Immunity , vol.31 , pp. 921-931
    • Long, M.1    Park, S.G.2    Strickland, I.3    Hayden, M.S.4    Ghosh, S.5
  • 70
    • 34548755672 scopus 로고    scopus 로고
    • DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP31 conventional T cells
    • Baron U, Floess S, Wieczorek G, Baumann K, Grutzkau A, Dong J et al. DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP31 conventional T cells. Eur J Immunol 2007; 37: 2378-2389.
    • (2007) Eur J Immunol , vol.37 , pp. 2378-2389
    • Baron, U.1    Floess, S.2    Wieczorek, G.3    Baumann, K.4    Grutzkau, A.5    Dong, J.6
  • 72
    • 58849118836 scopus 로고    scopus 로고
    • Epigenetic control of FOXP3 expression: The key to a stable regulatory T-cell lineage?
    • Huehn J, Polansky JK, Hamann A. Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage? Nat Rev Immunol 2009; 9: 83-89.
    • (2009) Nat Rev Immunol , vol.9 , pp. 83-89
    • Huehn, J.1    Polansky, J.K.2    Hamann, A.3
  • 73
    • 84891838421 scopus 로고    scopus 로고
    • Pathogenic conversion of Foxp31 T cells into TH17 cells in autoimmune arthritis
    • Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T et al. Pathogenic conversion of Foxp31 T cells into TH17 cells in autoimmune arthritis. Nat Med 2006; 20: 62-68.
    • (2006) Nat Med , vol.20 , pp. 62-68
    • Komatsu, N.1    Okamoto, K.2    Sawa, S.3    Nakashima, T.4    Oh-Hora, M.5    Kodama, T.6
  • 74
    • 52949138267 scopus 로고    scopus 로고
    • TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3
    • Samanta A, Li B, Song X, Bembas K, Zhang G, Katsumata M et al. TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3. Proc Natl Acad Sci USA 2008; 105: 14023-14027.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 14023-14027
    • Samanta, A.1    Li, B.2    Song, X.3    Bembas, K.4    Zhang, G.5    Katsumata, M.6
  • 75
    • 84883767441 scopus 로고    scopus 로고
    • Inhibition of p300 impairs Foxp31 T regulatory cell function and promotes antitumor immunity
    • Liu Y, Wang L, Predina J, Han R, Beier UH, Wang, LC et al. Inhibition of p300 impairs Foxp31 T regulatory cell function and promotes antitumor immunity. Nat Med 2013; 19: 1173-1177.
    • (2013) Nat Med , vol.19 , pp. 1173-1177
    • Liu, Y.1    Wang, L.2    Predina, J.3    Han, R.4    Beier, U.H.5    Wang, L.C.6
  • 76
    • 75449114277 scopus 로고    scopus 로고
    • Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice
    • de Zoeten EF, Wang L, Sai H, Dillmann WH, Hancock WW. Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice. Gastroenterology 2010; 138: 583-594.
    • (2010) Gastroenterology , vol.138 , pp. 583-594
    • De Zoeten, E.F.1    Wang, L.2    Sai, H.3    Dillmann, W.H.4    Hancock, W.W.5
  • 77
    • 79952274915 scopus 로고    scopus 로고
    • Sirtuin-1 targeting promotes Foxp31 T-regulatory cell function and prolongs allograft survival
    • Beier UH, Wang L, Bhatti TR, Liu Y, Han R, Ge G et al. Sirtuin-1 targeting promotes Foxp31 T-regulatory cell function and prolongs allograft survival. Mol Cell Biol 2011; 31: 1022-1029.
    • (2011) Mol Cell Biol , vol.31 , pp. 1022-1029
    • Beier, U.H.1    Wang, L.2    Bhatti, T.R.3    Liu, Y.4    Han, R.5    Ge, G.6
  • 78
    • 0034791090 scopus 로고    scopus 로고
    • Ubiquitin enters the new millennium
    • Pickart CM. Ubiquitin enters the new millennium. Mol Cell 2001; 8: 499-504.
    • (2001) Mol Cell , vol.8 , pp. 499-504
    • Pickart, C.M.1
  • 80
    • 84885402966 scopus 로고    scopus 로고
    • Phosphorylation of FOXP3 by LCK downregulates MMP9 expression and represses cell invasion
    • Nakahira K, Morita A, Kim NS, Yanagihara I. Phosphorylation of FOXP3 by LCK downregulates MMP9 expression and represses cell invasion. PLoS One 2013; 8: e77099.
    • (2013) PLoS One , vol.8 , pp. e77099
    • Nakahira, K.1    Morita, A.2    Kim, N.S.3    Yanagihara, I.4
  • 81
    • 78751696183 scopus 로고    scopus 로고
    • Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics
    • Brunstein CG, Miller JS, Cao Q, McKenna DH, Hippen KL, Curtsinger J et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood 2011; 117: 1061-1070.
    • (2011) Blood , vol.117 , pp. 1061-1070
    • Brunstein, C.G.1    Miller, J.S.2    Cao, Q.3    McKenna, D.H.4    Hippen, K.L.5    Curtsinger, J.6
  • 82
    • 79953809817 scopus 로고    scopus 로고
    • Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
    • Di Ianni M, Falzetti F, Carotti A, Terenzi A, Castellino F, Bonifacio E et al. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood 2011; 117: 3921-3928.
    • (2011) Blood , vol.117 , pp. 3921-3928
    • Di Ianni, M.1    Falzetti, F.2    Carotti, A.3    Terenzi, A.4    Castellino, F.5    Bonifacio, E.6
  • 83
    • 79956260076 scopus 로고    scopus 로고
    • Regulatory T cells: Customizing for the clinic
    • Wang X, Lu L, Jiang S. Regulatory T cells: customizing for the clinic. Sci Transl Med 2011; 3: 83ps19.
    • (2011) Sci Transl Med , vol.3 , pp. 83ps19
    • Wang, X.1    Lu, L.2    Jiang, S.3
  • 84
    • 77955642823 scopus 로고    scopus 로고
    • CD41CD251 regulatory T cell depletion improves the graftversus-tumor effect of donor lymphocytes after allogeneic hematopoietic stem cell transplantation
    • Maury S, Lemoine FM, Hicheri Y, Rosenzwajg M, Badoual C, CheraiM et al. CD41CD251 regulatory T cell depletion improves the graftversus-tumor effect of donor lymphocytes after allogeneic hematopoietic stem cell transplantation. Sci Transl Med 2010; 2: 41ra52.
    • (2010) Sci Transl Med , vol.2 , pp. 41ra52
    • Maury, S.1    Lemoine, F.M.2    Hicheri, Y.3    Rosenzwajg, M.4    CheraiM, B.C.5
  • 85
    • 84924248653 scopus 로고    scopus 로고
    • Post-transplant highdose cyclophosphamide for the prevention of graft-versus-host disease: A review
    • in press
    • Al-Homsi AS, Roy TS, Cole K, Feng Y, Duffner U. Post-transplant highdose cyclophosphamide for the prevention of graft-versus-host disease: a review. Biol Blood Marrow Transplant 2014; in press.
    • (2014) Biol Blood Marrow Transplant
    • Al-Homsi, A.S.1    Roy, T.S.2    Cole, K.3    Feng, Y.4    Duffner, U.5
  • 86
    • 84870654815 scopus 로고    scopus 로고
    • Post-transplantation cyclophosphamide for tolerance induction in HLA-haploidentical bone marrow transplantation
    • Luznik L, ODonnell PV, Fuchs EJ. Post-transplantation cyclophosphamide for tolerance induction in HLA-haploidentical bone marrow transplantation. Semin Oncol 2012; 39: 683-693.
    • (2012) Semin Oncol , vol.39 , pp. 683-693
    • Luznik, L.1    ODonnell, P.V.2    Fuchs, E.J.3
  • 87
    • 84919350755 scopus 로고    scopus 로고
    • Sirolimus-based graft-versus-host disease prophylaxis promotes the in vivo expansion of regulatory T cells and permits peripheral blood stem cell transplantation from haploidentical donors
    • Peccatori J, Forcina A, Clerici D, Crocchiolo R, Vago L, Stanghellini MT et al. Sirolimus-based graft-versus-host disease prophylaxis promotes the in vivo expansion of regulatory T cells and permits peripheral blood stem cell transplantation from haploidentical donors. Leukemia 2014; in press.
    • (2014) Leukemia
    • Peccatori, J.1    Forcina, A.2    Clerici, D.3    Crocchiolo, R.4    Vago, L.5    Stanghellini, M.T.6
  • 88
    • 84890082174 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide
    • Kanakry CG, Ganguly S, Zahurak M, Bolanos-Meade J, Thoburn C, Perkins B et al. Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide. Sci Transl Med 2013; 5: 211ra157.
    • (2013) Sci Transl Med , vol.5 , pp. 211ra157
    • Kanakry, C.G.1    Ganguly, S.2    Zahurak, M.3    Bolanos-Meade, J.4    Thoburn, C.5    Perkins, B.6
  • 89
    • 33845379986 scopus 로고    scopus 로고
    • Rapamycin promotes expansion of functional CD41CD251FOXP31 regulatory T cells of both healthy subjects and type 1 diabetic patients
    • Battaglia M, Stabilini A, Migliavacca B, Horejs-Hoeck J, Kaupper T, Roncarolo MG. Rapamycin promotes expansion of functional CD41CD251FOXP31 regulatory T cells of both healthy subjects and type 1 diabetic patients J Immunol2006; 177: 8338-8347.
    • (2006) J Immuno L , vol.177 , pp. 8338-8347
    • Battaglia, M.1    Stabilini, A.2    Migliavacca, B.3    Horejs-Hoeck, J.4    Kaupper, T.5    Roncarolo, M.G.6
  • 90
    • 70349310093 scopus 로고    scopus 로고
    • De novo generation and enhanced suppression of humanCD41CD251 regulatory T cells by retinoic acid
    • Wang J, Huizinga TW, Toes RE. De novo generation and enhanced suppression of humanCD41CD251 regulatory T cells by retinoic acid. J Immunol 2009; 183: 4119-4126.
    • (2009) J Immunol , vol.183 , pp. 4119-4126
    • Wang, J.1    Huizinga, T.W.2    Toes, R.E.3
  • 91
    • 78049373227 scopus 로고    scopus 로고
    • Cutting edge: All-trans retinoic acid sustains the stability and function of natural regulatory T cells in an inflammatory milieu
    • Zhou X, Kong N, Wang J, Fan H, Zou H, Horwitz D et al. Cutting edge: all-trans retinoic acid sustains the stability and function of natural regulatory T cells in an inflammatory milieu. J Immunol 2010; 185: 2675-2679.
    • (2010) J Immunol , vol.185 , pp. 2675-2679
    • Zhou, X.1    Kong, N.2    Wang, J.3    Fan, H.4    Zou, H.5    Horwitz, D.6
  • 92
    • 84906308941 scopus 로고    scopus 로고
    • Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions
    • Lu L, Lan Q, Li Z, Zhou X, Gu J, Li Q et al. Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions. Proc Natl Acad Sci USA 2014; 111: E3432-E3440.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. E3432-E3440
    • Lu, L.1    Lan, Q.2    Li, Z.3    Zhou, X.4    Gu, J.5    Li, Q.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.