메뉴 건너뛰기




Volumn 106, Issue 6, 2005, Pages 2018-2025

Reduced frequencies and suppressive function of CD4+CD25 hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; COMPLEMENTARY DNA; CYCLOPHOSPHAMIDE; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FLUDARABINE; GAMMA INTERFERON; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR RELATED PROTEIN; INTERLEUKIN 2 RECEPTOR ALPHA; MESSENGER RNA; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

EID: 24744432528     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2005-02-0642     Document Type: Article
Times cited : (460)

References (78)
  • 1
    • 2442484053 scopus 로고    scopus 로고
    • + regulatory T cells for immunologic self-tolerance and negative control of immune responses
    • + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol. 2004;22:531-562.
    • (2004) Annu Rev Immunol , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 2
    • 4043052238 scopus 로고    scopus 로고
    • Regulatory T cells and mechanisms of immune system control
    • O'Garra A, Vieira P. Regulatory T cells and mechanisms of immune system control. Nat Med. 2004;10:801-805.
    • (2004) Nat Med , vol.10 , pp. 801-805
    • O'Garra, A.1    Vieira, P.2
  • 4
    • 85047690488 scopus 로고    scopus 로고
    • An integrated view of suppressor T cell subsets in immunoregulation
    • Jiang H, Chess L. An integrated view of suppressor T cell subsets in immunoregulation. J Clin Invest. 2004;114:1198-1208.
    • (2004) J Clin Invest , vol.114 , pp. 1198-1208
    • Jiang, H.1    Chess, L.2
  • 6
    • 0031939403 scopus 로고    scopus 로고
    • + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells
    • + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J Immunol. 1998;160:1212-1218.
    • (1998) J Immunol , vol.160 , pp. 1212-1218
    • Suri-Payer, E.1    Amar, A.Z.2    Thomton, A.M.3    Shevach, E.M.4
  • 7
    • 0037361819 scopus 로고    scopus 로고
    • Antigen-induced regulatory T cells in autoimmunity
    • von Herrath MG, Harrison LC. Antigen-induced regulatory T cells in autoimmunity. Nat Rev Immunol. 2003;3:223-232.
    • (2003) Nat Rev Immunol , vol.3 , pp. 223-232
    • Von Herrath, M.G.1    Harrison, L.C.2
  • 8
    • 0033571105 scopus 로고    scopus 로고
    • + T cells: A common basis between tumor immunity and autoimmunity
    • + T cells: a common basis between tumor immunity and autoimmunity. J Immunol. 1999;163:5211-5218.
    • (1999) J Immunol , vol.163 , pp. 5211-5218
    • Shimizu, J.1    Yamazaki, S.2    Sakaguchi, S.3
  • 9
    • 0035903324 scopus 로고    scopus 로고
    • Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses
    • Sutmuller RP, van Duivenvoorde LM, van Elsas A, et al. Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J Exp Med. 2001;194:823-832.
    • (2001) J Exp Med , vol.194 , pp. 823-832
    • Sutmuller, R.P.1    Van Duivenvoorde, L.M.2    Van Elsas, A.3
  • 10
    • 0344153890 scopus 로고    scopus 로고
    • + T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination
    • + T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination. J Immunol. 2003;171:5931-5939.
    • (2003) J Immunol , vol.171 , pp. 5931-5939
    • Casares, N.1    Arribillaga, L.2    Sarobe, P.3
  • 11
    • 1642378018 scopus 로고    scopus 로고
    • + regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative
    • + regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative. Eur J Immunol. 2004;34:336-344.
    • (2004) Eur J Immunol , vol.34 , pp. 336-344
    • Ghiringhelli, F.1    Larmonier, N.2    Schmitt, E.3
  • 12
    • 4644342928 scopus 로고    scopus 로고
    • Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells
    • Turk MJ, Guevara-Patino JA, Rizzuto GA, Engelhorn ME, Houghton AN. Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells. J Exp Med. 2004; 200:771-782.
    • (2004) J Exp Med , vol.200 , pp. 771-782
    • Turk, M.J.1    Guevara-Patino, J.A.2    Rizzuto, G.A.3    Engelhorn, M.E.4    Houghton, A.N.5
  • 13
    • 0035525739 scopus 로고    scopus 로고
    • Human CD4(+)CD25(+) cells: A naturally occurring population of regulatory T cells
    • Ng WF, Duggan PJ, Ponchel F, et al. Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. Blood. 2001;98: 2736-2744.
    • (2001) Blood , vol.98 , pp. 2736-2744
    • Ng, W.F.1    Duggan, P.J.2    Ponchel, F.3
  • 14
    • 0035806290 scopus 로고    scopus 로고
    • Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    • Jonuleit H, Schmitt E, Stassen M, Tuettenberg A, KnopJ, EnkAH. Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J Exp Med. 2001;193:1285-1294.
    • (2001) J Exp Med , vol.193 , pp. 1285-1294
    • Jonuleit, H.1    Schmitt, E.2    Stassen, M.3    Tuettenberg, A.4    Knop, J.5    Enk, A.H.6
  • 15
    • 0034679567 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation
    • Read S, Malmstrom V, Powrie F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med. 2000;192:295-302.
    • (2000) J Exp Med , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 16
    • 0034679560 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    • Takahashi T, Tagami T, Yamazaki S, et al. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med. 2000;192:303-310.
    • (2000) J Exp Med , vol.192 , pp. 303-310
    • Takahashi, T.1    Tagami, T.2    Yamazaki, S.3
  • 17
    • 0036195161 scopus 로고    scopus 로고
    • CD4(+)CD25(+) immunoregulatory T cells: Gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
    • McHugh RS, Whitters MJ, Piccirillo CA, et al. CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity. 2002;16:311-323.
    • (2002) Immunity , vol.16 , pp. 311-323
    • McHugh, R.S.1    Whitters, M.J.2    Piccirillo, C.A.3
  • 18
    • 0036170938 scopus 로고    scopus 로고
    • Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    • Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol. 2002;3:135-142.
    • (2002) Nat Immunol , vol.3 , pp. 135-142
    • Shimizu, J.1    Yamazaki, S.2    Takahashi, T.3    Ishida, Y.4    Sakaguchi, S.5
  • 20
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299:1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 22
    • 0036721772 scopus 로고    scopus 로고
    • + splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7
    • + splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. J Immunol. 2002;169:2461-2465.
    • (2002) J Immunol , vol.169 , pp. 2461-2465
    • Szanya, V.1    Ermann, J.2    Taylor, C.3    Holness, C.4    Pathman, C.G.5
  • 23
    • 1542514775 scopus 로고    scopus 로고
    • Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulaton/T cells
    • Takeda I, Ine S, Killeen N, et al. Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulaton/T cells. J Immunol. 2004;172: 3580-3589.
    • (2004) J Immunol , vol.172 , pp. 3580-3589
    • Takeda, I.1    Ine, S.2    Killeen, N.3
  • 27
    • 0034084162 scopus 로고    scopus 로고
    • Regulatory T cells in autoimmmunity
    • Shevach EM. Regulatory T cells in autoimmmunity. Annu Rev Immunol. 2000;18:423-449.
    • (2000) Annu Rev Immunol , vol.18 , pp. 423-449
    • Shevach, E.M.1
  • 29
    • 0242403301 scopus 로고    scopus 로고
    • Quantification of regulatory T cells in patients with systemic lupus erythematosus
    • Crispin JC, Martinez A, Alcocer-Varela J. Quantification of regulatory T cells in patients with systemic lupus erythematosus. J Autoimmun. 2003; 21:273-276.
    • (2003) J Autoimmun , vol.21 , pp. 273-276
    • Crispin, J.C.1    Martinez, A.2    Alcocer-Varela, J.3
  • 30
    • 1342267617 scopus 로고    scopus 로고
    • + T cells in peripheral blood of patients with systemic lupus erythematosus
    • + T cells in peripheral blood of patients with systemic lupus erythematosus. Scand J Immunol. 2004;59:198-202.
    • (2004) Scand J Immunol , vol.59 , pp. 198-202
    • Liu, M.F.1    Wang, C.R.2    Fung, L.L.3    Wu, C.R.4
  • 31
    • 2442618129 scopus 로고    scopus 로고
    • CD4+CD25(bright) regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis
    • de Kleer IM, Wedderburn LR, Taams LS, et al. CD4+CD25(bright) regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis. J Immunol. 2004;172:6435-6443.
    • (2004) J Immunol , vol.172 , pp. 6435-6443
    • De Kleer, I.M.1    Wedderburn, L.R.2    Taams, L.S.3
  • 32
    • 0141461418 scopus 로고    scopus 로고
    • + regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation
    • + regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med. 2003;9:1144-1150.
    • (2003) Nat Med , vol.9 , pp. 1144-1150
    • Edinger, M.1    Hoffmann, P.2    Ermann, J.3
  • 33
    • 0037025943 scopus 로고    scopus 로고
    • Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation
    • Hoffmann P, Ermann J, Edinger M, Fathman CG, Strober S. Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med. 2002;196:389-399.
    • (2002) J Exp Med , vol.196 , pp. 389-399
    • Hoffmann, P.1    Ermann, J.2    Edinger, M.3    Fathman, C.G.4    Strober, S.5
  • 34
    • 0037093217 scopus 로고    scopus 로고
    • The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality
    • Taylor PA, Lees CJ, Blazar BR. The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood. 2002;99:3493-3499.
    • (2002) Blood , vol.99 , pp. 3493-3499
    • Taylor, P.A.1    Lees, C.J.2    Blazar, B.R.3
  • 35
    • 0346690399 scopus 로고    scopus 로고
    • + regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia
    • + regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia. J Clin Invest. 2003;112:1688-1696.
    • (2003) J Clin Invest , vol.112 , pp. 1688-1696
    • Trenado, A.1    Charlotte, F.2    Fisson, S.3
  • 36
    • 0038155128 scopus 로고    scopus 로고
    • + regulatory T-cell levels in patients with melanoma
    • + regulatory T-cell levels in patients with melanoma. Clin Cancer Res. 2003; 9:2551-2559.
    • (2003) Clin Cancer Res , vol.9 , pp. 2551-2559
    • Gray, C.P.1    Arosio, P.2    Hersey, P.3
  • 37
    • 1442283424 scopus 로고    scopus 로고
    • Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma
    • Marshall NA, Christie LE, Munro LR, et al. Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma. Blood. 2004;103:1755-1762.
    • (2004) Blood , vol.103 , pp. 1755-1762
    • Marshall, N.A.1    Christie, L.E.2    Munro, L.R.3
  • 38
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel TJ, Coukos G, Zou L, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med. 2004;10:942-949.
    • (2004) Nat Med , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3
  • 39
    • 0035874949 scopus 로고    scopus 로고
    • Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer
    • Woo EY, Chu CS, Goletz TJ, et al. Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer. Cancer Res. 2001;61: 4766-4772.
    • (2001) Cancer Res , vol.61 , pp. 4766-4772
    • Woo, E.Y.1    Chu, C.S.2    Goletz, T.J.3
  • 40
    • 0141891466 scopus 로고    scopus 로고
    • Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers
    • Ichihara F, Kono K, Takahashi A, Kawaida H, Sugai H, Fujii H. Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers. Clin Cancer Res. 2003;9: 4404-4408.
    • (2003) Clin Cancer Res , vol.9 , pp. 4404-4408
    • Ichihara, F.1    Kono, K.2    Takahashi, A.3    Kawaida, H.4    Sugai, H.5    Fujii, H.6
  • 41
    • 0041386189 scopus 로고    scopus 로고
    • + regulatory T cells in patients with gastrointestinal malignancies: Possible involvement of regulatory T cells in disease progression
    • + regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression. Cancer. 2003;98:1089-1099.
    • (2003) Cancer , vol.98 , pp. 1089-1099
    • Sasada, T.1    Kimura, M.2    Yoshida, Y.3    Kanal, M.4    Takabayashi, A.5
  • 42
    • 0036569127 scopus 로고    scopus 로고
    • Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation
    • Woo EY, Yeh H, Chu CS, et al. Cutting edge: regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation. J Immunol. 2002;168:4272-4276.
    • (2002) J Immunol , vol.168 , pp. 4272-4276
    • Woo, E.Y.1    Yeh, H.2    Chu, C.S.3
  • 43
    • 0036721629 scopus 로고    scopus 로고
    • Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma
    • Liyanage UK, Moore TT, Joo HG, et al. Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. J Immunol. 2002;169:2756-2761.
    • (2002) J Immunol , vol.169 , pp. 2756-2761
    • Liyanage, U.K.1    Moore, T.T.2    Joo, H.G.3
  • 47
    • 0028931830 scopus 로고
    • Advances in the biology and treatment of B-cell chronic lymphocytic leukemia
    • O'Brien S, del Giglio A, Keating M. Advances in the biology and treatment of B-cell chronic lymphocytic leukemia. Blood. 1995;85:307-318.
    • (1995) Blood , vol.85 , pp. 307-318
    • O'Brien, S.1    Del Giglio, A.2    Keating, M.3
  • 48
    • 0028822481 scopus 로고
    • Chronic lymphocytic leukemia
    • Rozman C, Montserrat E. Chronic lymphocytic leukemia. N Engl J Med. 1995;333:1052-1057.
    • (1995) N Engl J Med , vol.333 , pp. 1052-1057
    • Rozman, C.1    Montserrat, E.2
  • 49
    • 0035231585 scopus 로고    scopus 로고
    • New aspects on the pathogenesis, diagnostic procedures, and therapeutic management of chronic lymphocytic leukemia
    • Wendtner CM, Schmitt B, Bergmann M, Rohnisch T, Buhmann R, Hallek M. New aspects on the pathogenesis, diagnostic procedures, and therapeutic management of chronic lymphocytic leukemia. Int J Hematol. 2001;73:32-38.
    • (2001) Int J Hematol , vol.73 , pp. 32-38
    • Wendtner, C.M.1    Schmitt, B.2    Bergmann, M.3    Rohnisch, T.4    Buhmann, R.5    Hallek, M.6
  • 50
    • 85047692890 scopus 로고
    • T-cell functional abnormality in B-chronic lymphocytic leukaemia: Evidence of a defect of the T-helper subset
    • Lauria F, Foa R, Mantovani V, Fierro MT, Catovsky D, Tura S. T-cell functional abnormality in B-chronic lymphocytic leukaemia: evidence of a defect of the T-helper subset. Br J Haematol. 1983;54:277-283.
    • (1983) Br J Haematol , vol.54 , pp. 277-283
    • Lauria, F.1    Foa, R.2    Mantovani, V.3    Fierro, M.T.4    Catovsky, D.5    Tura, S.6
  • 51
    • 0021229875 scopus 로고
    • Discrepancy between phenotypic and functional features of natural killer T-lymphocytes in B-cell chronic lymphocytic leukaemia
    • Foa R, Lauria F, Lusso P, et al. Discrepancy between phenotypic and functional features of natural killer T-lymphocytes in B-cell chronic lymphocytic leukaemia. Br J Haematol. 1984;58:509-516.
    • (1984) Br J Haematol , vol.58 , pp. 509-516
    • Foa, R.1    Lauria, F.2    Lusso, P.3
  • 52
    • 0025084777 scopus 로고
    • Lymphokine-activated killer (LAK) cell activity in B and T chronic lymphoid leukemia: Defective LAK generation and reduced susceptibility of the leukemic cells to allogeneic and autologous LAK effectors
    • Foa R, Fierro MT, Raspadori D, et al. Lymphokine-activated killer (LAK) cell activity in B and T chronic lymphoid leukemia: defective LAK generation and reduced susceptibility of the leukemic cells to allogeneic and autologous LAK effectors. Blood. 1990;76:1349-1354.
    • (1990) Blood , vol.76 , pp. 1349-1354
    • Foa, R.1    Fierro, M.T.2    Raspadori, D.3
  • 53
    • 0023950247 scopus 로고
    • Defective helper function of purified T4 cells and excessive suppressor activity of purified T8 cells in patients with B-cell chronic lymphocytic leukemia. T4 suppressor effector cells are present in certain patients
    • Kunicka JE, Platsoucas CD. Defective helper function of purified T4 cells and excessive suppressor activity of purified T8 cells in patients with B-cell chronic lymphocytic leukemia. T4 suppressor effector cells are present in certain patients. Blood. 1988;71:1551-1560.
    • (1988) Blood , vol.71 , pp. 1551-1560
    • Kunicka, J.E.1    Platsoucas, C.D.2
  • 54
    • 0030846220 scopus 로고    scopus 로고
    • Acquired CD40-ligand deficiency in chronic lymphocytic leukemia
    • Cantwell M, Hua T, Pappas J, Kipps TJ. Acquired CD40-ligand deficiency in chronic lymphocytic leukemia. Nat Med. 1997;3:984-989.
    • (1997) Nat Med , vol.3 , pp. 984-989
    • Cantwell, M.1    Hua, T.2    Pappas, J.3    Kipps, T.J.4
  • 55
    • 0032919212 scopus 로고    scopus 로고
    • Inhibition of T cell/B cell interaction by B-CLL cells
    • Kneitz C, Goller M, Wilhelm M, et al. Inhibition of T cell/B cell interaction by B-CLL cells. Leukemia. 1999;13:98-104.
    • (1999) Leukemia , vol.13 , pp. 98-104
    • Kneitz, C.1    Goller, M.2    Wilhelm, M.3
  • 56
    • 0043092221 scopus 로고    scopus 로고
    • The circulating dendritic cell compartment in patients with chronic lymphocytic leukemia is severely defective and unable to stimulate an effective T-cell response
    • Orsini E, Guarini A, Chiaretti S, Mauro FR, Foa R. The circulating dendritic cell compartment in patients with chronic lymphocytic leukemia is severely defective and unable to stimulate an effective T-cell response. Cancer Res. 2003;63:4497-4506.
    • (2003) Cancer Res , vol.63 , pp. 4497-4506
    • Orsini, E.1    Guarini, A.2    Chiaretti, S.3    Mauro, F.R.4    Foa, R.5
  • 58
    • 0035044207 scopus 로고    scopus 로고
    • Analysis of the expression of critical activation/interaction markers on peripheral blood T cells in B-cell chronic lymphocytic leukaemia: Evidence of immune dysregulatioh
    • Scrivener S, Kaminski ER, Demaine A, Prentice AG. Analysis of the expression of critical activation/interaction markers on peripheral blood T cells in B-cell chronic lymphocytic leukaemia: evidence of immune dysregulatioh. Br J Haematol. 2001;112:959-964.
    • (2001) Br J Haematol , vol.112 , pp. 959-964
    • Scrivener, S.1    Kaminski, E.R.2    Demaine, A.3    Prentice, A.G.4
  • 59
    • 1642497640 scopus 로고    scopus 로고
    • + regulatory T cells and their ligands: Implications for immunotherapy
    • + regulatory T cells and their ligands: implications for immunotherapy. Immunity. 2004; 20:107-118.
    • (2004) Immunity , vol.20 , pp. 107-118
    • Wang, H.Y.1    Lee, D.A.2    Peng, G.3
  • 61
    • 0034613767 scopus 로고    scopus 로고
    • Induction of interleukin 10-producing, non-proliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells
    • Jonuleit H, Schmitt E, Schuler G, Knop J, Enk AH. Induction of interleukin 10-producing, non-proliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med. 2000; 192:1213-1222.
    • (2000) J Exp Med , vol.192 , pp. 1213-1222
    • Jonuleit, H.1    Schmitt, E.2    Schuler, G.3    Knop, J.4    Enk, A.H.5
  • 64
    • 0037099719 scopus 로고    scopus 로고
    • Infectious tolerance: Human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells
    • Jonuleit H, Schmitt E, Kakirman H, Stassen M, Knop J, Enk AH. Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells. J Exp Med. 2002;196:255-260.
    • (2002) J Exp Med , vol.196 , pp. 255-260
    • Jonuleit, H.1    Schmitt, E.2    Kakirman, H.3    Stassen, M.4    Knop, J.5    Enk, A.H.6
  • 65
    • 0035806323 scopus 로고    scopus 로고
    • Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
    • Levings MK, Sangregorio R, Roncarolo MG. Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med. 2001;193:1295-1302.
    • (2001) J Exp Med , vol.193 , pp. 1295-1302
    • Levings, M.K.1    Sangregorio, R.2    Roncarolo, M.G.3
  • 66
    • 3042703866 scopus 로고    scopus 로고
    • TGF-(beta): The perpetrator of immune suppression by regulatory T cells and suicidal T cells
    • Wahl SM, Swisher J, McCartney-Francis N, Chen W. TGF-(beta): the perpetrator of immune suppression by regulatory T cells and suicidal T cells. J Leukoc Biol. 2004;76:15-24.
    • (2004) J Leukoc Biol , vol.76 , pp. 15-24
    • Wahl, S.M.1    Swisher, J.2    McCartney-Francis, N.3    Chen, W.4
  • 67
    • 0035801335 scopus 로고    scopus 로고
    • Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta
    • Nakamura K, Kitani A, Strober W. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med. 2001;194:629-644.
    • (2001) J Exp Med , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 68
    • 0032950743 scopus 로고    scopus 로고
    • Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling
    • Frank DA, Mahajan S, Ritz J. Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling. Nat Med. 1999;5: 444-447.
    • (1999) Nat Med , vol.5 , pp. 444-447
    • Frank, D.A.1    Mahajan, S.2    Ritz, J.3
  • 69
    • 0037174674 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
    • Dudley ME, Wunderlich JR, Robbins PF, et al. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science. 2002;298:850-854.
    • (2002) Science , vol.298 , pp. 850-854
    • Dudley, M.E.1    Wunderlich, J.R.2    Robbins, P.F.3
  • 70
    • 1542309563 scopus 로고    scopus 로고
    • Immunoregulatory T cells in tumor immunity
    • Terabe M, Berzofsky JA. Immunoregulatory T cells in tumor immunity. Curr Opin Immunol. 2004;16:157-162.
    • (2004) Curr Opin Immunol , vol.16 , pp. 157-162
    • Terabe, M.1    Berzofsky, J.A.2
  • 71
    • 1642338649 scopus 로고    scopus 로고
    • Cloning and characterization of GITR ligand
    • Kim JD, Choi BK, Bae JS, et al. Cloning and characterization of GITR ligand. Genes Immun. 2003; 4:564-569.
    • (2003) Genes Immun , vol.4 , pp. 564-569
    • Kim, J.D.1    Choi, B.K.2    Bae, J.S.3
  • 72
    • 0033602151 scopus 로고    scopus 로고
    • Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR
    • Gurney AL, Marsters SA, Huang RM, et al. Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Curr Biol. 1999;9:215-218.
    • (1999) Curr Biol , vol.9 , pp. 215-218
    • Gurney, A.L.1    Marsters, S.A.2    Huang, R.M.3
  • 73
    • 2442429448 scopus 로고    scopus 로고
    • Cutting edge: The natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression
    • Ji HB, Liao G, Faubion WA, et al. Cutting edge: the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression. J Immunol. 2004;172:5823-5827.
    • (2004) J Immunol , vol.172 , pp. 5823-5827
    • Ji, H.B.1    Liao, G.2    Faubion, W.A.3
  • 75
    • 0035903307 scopus 로고    scopus 로고
    • Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells
    • Iellem A, Mariani M, Lang R, et al. Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells. J Exp Med. 2001;194:847-853.
    • (2001) J Exp Med , vol.194 , pp. 847-853
    • Iellem, A.1    Mariani, M.2    Lang, R.3
  • 76
    • 0037105759 scopus 로고    scopus 로고
    • + regulatory T cells in a colorectal carcinoma patient is mediated by transforming growth factor-beta
    • + regulatory T cells in a colorectal carcinoma patient is mediated by transforming growth factor-beta. Cancer Res. 2002;62: 5267-5272.
    • (2002) Cancer Res , vol.62 , pp. 5267-5272
    • Somasundaram, R.1    Jacob, L.2    Swoboda, R.3
  • 77
    • 10444261212 scopus 로고    scopus 로고
    • Development of TGF-beta signalling inhibitors for cancer therapy
    • Yingling JM, Blanchard KL, Sawyer JS. Development of TGF-beta signalling inhibitors for cancer therapy. Nat Rev Drug Discov. 2004;3:1011-1022.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 1011-1022
    • Yingling, J.M.1    Blanchard, K.L.2    Sawyer, J.S.3
  • 78
    • 0034648702 scopus 로고    scopus 로고
    • Regression of metastatic renal-cell carcinoma after non-myeloablative allogeneic peripheral-blood stem-cell transplantation
    • Childs R, Chernoff A, Contentin N, et al. Regression of metastatic renal-cell carcinoma after non-myeloablative allogeneic peripheral-blood stem-cell transplantation. N Engl J Med. 2000;343:750-758.
    • (2000) N Engl J Med , vol.343 , pp. 750-758
    • Childs, R.1    Chernoff, A.2    Contentin, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.