메뉴 건너뛰기




Volumn 123, Issue 5, 2014, Pages 678-686

Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; ANTIGENS, CD20; CELL LINE; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; KILLER CELLS, NATURAL; LYMPHOMA; MALE; MICE; RECEPTORS, KIR;

EID: 84894030202     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/Blood-2013-08-519199     Document Type: Article
Times cited : (246)

References (46)
  • 1
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 2012; 12(4):252-264.
    • (2012) Nat Rev Cancer. , vol.12 , Issue.4 , pp. 252-264
    • Pardoll, D.M.1
  • 2
    • 65349119978 scopus 로고    scopus 로고
    • CD28 and CTLA-4 coreceptor expression and signal transduction
    • Rudd CE, Taylor A, Schneider H. CD28 and CTLA-4 coreceptor expression and signal transduction. Immunol Rev. 2009;229(1):12-26.
    • (2009) Immunol Rev. , vol.229 , Issue.1 , pp. 12-26
    • Rudd, C.E.1    Taylor, A.2    Schneider, H.3
  • 3
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010; 363(8):711-723.
    • (2010) N Engl J Med. , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 4
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366(26): 2443-2454.
    • (2012) N Engl J Med. , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 5
    • 84863115998 scopus 로고    scopus 로고
    • Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape
    • Woo SR, Turnis ME, Goldberg MV, et al. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res. 2012;72(4): 917-927.
    • (2012) Cancer Res. , vol.72 , Issue.4 , pp. 917-927
    • Woo, S.R.1    Turnis, M.E.2    Goldberg, M.V.3
  • 6
    • 79955680198 scopus 로고    scopus 로고
    • Natural killer cell-based therapies
    • Romagne F, Vivier E. Natural killer cell-based therapies. F1000 Med-Rep. 2011;3:9.
    • (2011) F1000 Med-Rep. , vol.3 , pp. 9
    • Romagne, F.1    Vivier, E.2
  • 7
    • 84859159747 scopus 로고    scopus 로고
    • NK cell MHC class I specific receptors (KIR): From biology to clinical intervention
    • Thielens A, Vivier E, Romagné F. NK cell MHC class I specific receptors (KIR): From biology to clinical intervention. Curr Opin Immunol. 2012; 24(2):239-245.
    • (2012) Curr Opin Immunol. , vol.24 , Issue.2 , pp. 239-245
    • Thielens, A.1    Vivier, E.2    Romagné, F.3
  • 8
    • 0037086131 scopus 로고    scopus 로고
    • Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
    • Ruggeri L, Capanni M, Urbani E, et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science. 2002;295(5562):2097-2100.
    • (2002) Science. , vol.295 , Issue.5562 , pp. 2097-2100
    • Ruggeri, L.1    Capanni, M.2    Urbani, E.3
  • 9
    • 69249108787 scopus 로고    scopus 로고
    • Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells
    • Romagné F, André P, Spee P, et al. Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells. Blood. 2009;114(13):2667-2677.
    • (2009) Blood. , vol.114 , Issue.13 , pp. 2667-2677
    • Romagné, F.1    André, P.2    Spee, P.3
  • 10
    • 83455220035 scopus 로고    scopus 로고
    • IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect
    • Benson DM Jr, Bakan CE, Zhang S, et al. IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect. Blood. 2011; 118(24):6387-6391.
    • (2011) Blood. , vol.118 , Issue.24 , pp. 6387-6391
    • Benson Jr., D.M.1    Bakan, C.E.2    Zhang, S.3
  • 11
    • 69149105475 scopus 로고    scopus 로고
    • Genetic and antibody-mediated reprogramming of natural killer cell missing-self recognition in vivo
    • Sola C, André P, Lemmers C, et al. Genetic and antibody-mediated reprogramming of natural killer cell missing-self recognition in vivo. Proc Natl Acad Sci USA. 2009;106(31):12879-12884.
    • (2009) Proc Natl Acad Sci USA. , vol.106 , Issue.31 , pp. 12879-12884
    • Sola, C.1    André, P.2    Lemmers, C.3
  • 12
    • 84869856060 scopus 로고    scopus 로고
    • A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission
    • Vey N, Bourhis JH, Boissel N, et al. A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission. Blood. 2012;120(22): 4317-4323.
    • (2012) Blood. , vol.120 , Issue.22 , pp. 4317-4323
    • Vey, N.1    Bourhis, J.H.2    Boissel, N.3
  • 13
    • 0033774970 scopus 로고    scopus 로고
    • Mechanism of cytotoxicity induced by chimeric mouse human monoclonal antibody IDEC-C2B8 in CD20-expressing lymphoma cell lines
    • Flieger D, Renoth S, Beier I, Sauerbruch T, Schmidt-Wolf I. Mechanism of cytotoxicity induced by chimeric mouse human monoclonal antibody IDEC-C2B8 in CD20-expressing lymphoma cell lines. Cell Immunol. 2000;204(1): 55-63.
    • (2000) Cell Immunol. , vol.204 , Issue.1 , pp. 55-63
    • Flieger, D.1    Renoth, S.2    Beier, I.3    Sauerbruch, T.4    Schmidt-Wolf, I.5
  • 14
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
    • Clynes RA, Towers TL, Presta LG, Ravetch JV. Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat Med. 2000; 6(4):443-446.
    • (2000) Nat Med. , vol.6 , Issue.4 , pp. 443-446
    • Clynes, R.A.1    Towers, T.L.2    Presta, L.G.3    Ravetch, J.V.4
  • 15
    • 33645053518 scopus 로고    scopus 로고
    • Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy
    • Hamaguchi Y, Xiu Y, Komura K, Nimmerjahn F, Tedder TF. Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy. J Exp Med. 2006;203(3):743-753.
    • (2006) J Exp Med. , vol.203 , Issue.3 , pp. 743-753
    • Hamaguchi, Y.1    Xiu, Y.2    Komura, K.3    Nimmerjahn, F.4    Tedder, T.F.5
  • 16
    • 51649123832 scopus 로고    scopus 로고
    • Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcgammaRI FcgammaRIII and FcgammaRIV
    • Minard-Colin V, Xiu Y, Poe JC, et al. Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcgammaRI, FcgammaRIII, and FcgammaRIV. Blood. 2008; 112(4):1205-1213.
    • (2008) Blood. , vol.112 , Issue.4 , pp. 1205-1213
    • Minard-Colin, V.1    Xiu, Y.2    Poe, J.C.3
  • 17
    • 0036464719 scopus 로고    scopus 로고
    • Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene
    • Cartron G, Dacheux L, Salles G, Solal-Celigny P, Bardos P, Colombat P, Watier H. Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene. Blood. 2002;99(3):754-758.
    • (2002) Blood. , vol.99 , Issue.3 , pp. 754-758
    • Cartron, G.1    Dacheux, L.2    Salles, G.3    Solal-Celigny, P.4    Bardos, P.5    Colombat, P.6    Watier, H.7
  • 18
    • 0642373290 scopus 로고    scopus 로고
    • Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma
    • Weng WK, Levy R. Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma. J Clin Oncol. 2003;21(21):3940-3947.
    • (2003) J Clin Oncol. , vol.21 , Issue.21 , pp. 3940-3947
    • Weng, W.K.1    Levy, R.2
  • 19
    • 34547769251 scopus 로고    scopus 로고
    • A novel multiparametric flow cytometry-based cytotoxicity assay simultaneously immunophenotypes effector cells: Comparisons to a 4 h 51Cr-release assay
    • Kim GG, Donnenberg VS, Donnenberg AD, Gooding W, Whiteside TL. A novel multiparametric flow cytometry-based cytotoxicity assay simultaneously immunophenotypes effector cells: Comparisons to a 4 h 51Cr-release assay. J Immunol Methods. 2007;325(1-2):51-66.
    • (2007) J Immunol Methods. , vol.325 , Issue.1-2 , pp. 51-66
    • Kim, G.G.1    Donnenberg, V.S.2    Donnenberg, A.D.3    Gooding, W.4    Whiteside, T.L.5
  • 20
    • 10344255635 scopus 로고    scopus 로고
    • CD107a as a functional marker for the identification of natural killer cell activity
    • Alter G, Malenfant JM, Altfeld M. CD107a as a functional marker for the identification of natural killer cell activity. J Immunol Methods. 2004; 294(1-2):15-22.
    • (2004) J Immunol Methods. , vol.294 , Issue.1-2 , pp. 15-22
    • Alter, G.1    Malenfant, J.M.2    Altfeld, M.3
  • 21
    • 52949129499 scopus 로고    scopus 로고
    • Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates
    • Kotecha N, Flores NJ, Irish JM, et al. Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates. Cancer Cell. 2008;14(4): 335-343.
    • (2008) Cancer Cell. , vol.14 , Issue.4 , pp. 335-343
    • Kotecha, N.1    Flores, N.J.2    Irish, J.M.3
  • 22
    • 0035874543 scopus 로고    scopus 로고
    • Augmentation of antitumor effects by NK cell inhibitory receptor blockade in vitro and in vivo
    • Koh CY, Blazar BR, George T, et al. Augmentation of antitumor effects by NK cell inhibitory receptor blockade in vitro and in vivo. Blood. 2001;97(10):3132-3137.
    • (2001) Blood. , vol.97 , Issue.10 , pp. 3132-3137
    • Koh, C.Y.1    Blazar, B.R.2    George, T.3
  • 23
    • 18644363090 scopus 로고    scopus 로고
    • The CD107 mobilization assay: Viable isolation and immunotherapeutic potential of tumor-cytolytic NK cells
    • Uhrberg M. The CD107 mobilization assay: Viable isolation and immunotherapeutic potential of tumor-cytolytic NK cells. Leukemia. 2005;19(5): 707-709.
    • (2005) Leukemia. , vol.19 , Issue.5 , pp. 707-709
    • Uhrberg, M.1
  • 24
    • 77951614830 scopus 로고    scopus 로고
    • Monoclonal antibodies: Versatile platforms for cancer immunotherapy
    • Weiner LM, Surana R, Wang S. Monoclonal antibodies: Versatile platforms for cancer immunotherapy. Nat Rev Immunol. 2010;10(5): 317-327.
    • (2010) Nat Rev Immunol. , vol.10 , Issue.5 , pp. 317-327
    • Weiner, L.M.1    Surana, R.2    Wang, S.3
  • 26
    • 42949157368 scopus 로고    scopus 로고
    • Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer
    • Musolino A, Naldi N, Bortesi B, et al. Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer. J Clin Oncol. 2008;26(11):1789-1796.
    • (2008) J Clin Oncol. , vol.26 , Issue.11 , pp. 1789-1796
    • Musolino, A.1    Naldi, N.2    Bortesi, B.3
  • 27
    • 34548509226 scopus 로고    scopus 로고
    • FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with singleagent cetuximab
    • Zhang W, Gordon M, Schultheis AM, et al. FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with singleagent cetuximab. J Clin Oncol. 2007;25(24): 3712-3718.
    • (2007) J Clin Oncol. , vol.25 , Issue.24 , pp. 3712-3718
    • Zhang, W.1    Gordon, M.2    Schultheis, A.M.3
  • 28
    • 61449239114 scopus 로고    scopus 로고
    • Impact of FcgammaRIIa-FcgammaRIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan
    • Bibeau F, Lopez-Crapez E, Di Fiore F, et al. Impact of FcgammaRIIa-FcgammaRIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan. J Clin Oncol. 2009;27(7):1122-1129.
    • (2009) J Clin Oncol. , vol.27 , Issue.7 , pp. 1122-1129
    • Bibeau, F.1    Lopez-Crapez, E.2    Di Fiore, F.3
  • 29
    • 76749153964 scopus 로고    scopus 로고
    • B-lymphoma cells escape rituximab-triggered elimination by NK cells through increased HLA class I expression
    • Borgerding A, Hasenkamp J, Engelke M, Burkhart N, Trümper L, Wienands J, Glass B. B-lymphoma cells escape rituximab-triggered elimination by NK cells through increased HLA class I expression. Exp Hematol. 2010;38(3):213-221.
    • (2010) Exp Hematol. , vol.38 , Issue.3 , pp. 213-221
    • Borgerding, A.1    Hasenkamp, J.2    Engelke, M.3    Burkhart, N.4    Trümper, L.5    Wienands, J.6    Glass, B.7
  • 30
    • 84865960648 scopus 로고    scopus 로고
    • Unlicensed NK cells target neuroblastoma following anti-GD2 antibody treatment
    • Tarek N, Le Luduec JB, Gallagher MM, et al. Unlicensed NK cells target neuroblastoma following anti-GD2 antibody treatment. J Clin Invest. 2012;122(9):3260-3270.
    • (2012) J Clin Invest. , vol.122 , Issue.9 , pp. 3260-3270
    • Tarek, N.1    Le Luduec, J.B.2    Gallagher, M.M.3
  • 31
    • 84865977956 scopus 로고    scopus 로고
    • When NK cells overcome their lack of education
    • Jaeger BN, Vivier E. When NK cells overcome their lack of education. J Clin Invest. 2012;122(9): 3053-3056.
    • (2012) J Clin Invest. , vol.122 , Issue.9 , pp. 3053-3056
    • Jaeger, B.N.1    Vivier, E.2
  • 32
    • 84869819029 scopus 로고    scopus 로고
    • A phase 1 trial of the anti-KIR antibody IPH2101 in patients with relapsed/refractory multiple myeloma
    • Benson DM Jr, Hofmeister CC, Padmanabhan S, et al. A phase 1 trial of the anti-KIR antibody IPH2101 in patients with relapsed/refractory multiple myeloma. Blood. 2012;120(22): 4324-4333.
    • (2012) Blood. , vol.120 , Issue.22 , pp. 4324-4333
    • Benson Jr., D.M.1    Hofmeister, C.C.2    Padmanabhan, S.3
  • 33
    • 44449090613 scopus 로고    scopus 로고
    • Blocking NK cell inhibitory self-recognition promotes antibodydependent cellular cytotoxicity in a model of anti-lymphoma therapy
    • Binyamin L, Alpaugh RK, Hughes TL, Lutz CT, Campbell KS, Weiner LM. Blocking NK cell inhibitory self-recognition promotes antibodydependent cellular cytotoxicity in a model of anti-lymphoma therapy. J Immunol. 2008;180(9): 6392-6401.
    • (2008) J Immunol. , vol.180 , Issue.9 , pp. 6392-6401
    • Binyamin, L.1    Alpaugh, R.K.2    Hughes, T.L.3    Lutz, C.T.4    Campbell, K.S.5    Weiner, L.M.6
  • 34
    • 79952127072 scopus 로고    scopus 로고
    • Enhancing natural killer (NM) cell mediated killing of non-Hodgkin's lymphoma [abstract]
    • Abstract 2706
    • Srivastava S, Feng H, Zhang S, Liang J, Squiban P, Farag S. Enhancing natural killer (NM) cell mediated killing of non-Hodgkin's lymphoma [abstract]. Blood. 2009;114(22). Abstract 2706.
    • (2009) Blood. , vol.114 , Issue.22
    • Srivastava, S.1    Feng, H.2    Zhang, S.3    Liang, J.4    Squiban, P.5    Farag, S.6
  • 35
    • 77951561987 scopus 로고    scopus 로고
    • Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cellmediated B-cell cytotoxicity
    • Mössner E, Brünker P, Moser S, et al. Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cellmediated B-cell cytotoxicity. Blood. 2010;115(22): 4393-4402.
    • (2010) Blood. , vol.115 , Issue.22 , pp. 4393-4402
    • Mössner, E.1    Brünker, P.2    Moser, S.3
  • 36
    • 34247847914 scopus 로고    scopus 로고
    • Systemic interleukin-2 and adoptive transfer of lymphokineactivated killer cells improves antibody-dependent cellular cytotoxicity in patients with relapsed B-cell lymphoma treated with rituximab
    • Berdeja JG, Hess A, Lucas DM, et al. Systemic interleukin-2 and adoptive transfer of lymphokineactivated killer cells improves antibody-dependent cellular cytotoxicity in patients with relapsed B-cell lymphoma treated with rituximab. Clin Cancer Res. 2007;13(8):2392-2399.
    • (2007) Clin Cancer Res. , vol.13 , Issue.8 , pp. 2392-2399
    • Berdeja, J.G.1    Hess, A.2    Lucas, D.M.3
  • 37
    • 84862493242 scopus 로고    scopus 로고
    • Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells
    • Gill S, Vasey AE, De Souza A, et al. Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells. Blood. 2012;119(24):5758-5768.
    • (2012) Blood. , vol.119 , Issue.24 , pp. 5758-5768
    • Gill, S.1    Vasey, A.E.2    De Souza, A.3
  • 38
    • 33845795327 scopus 로고    scopus 로고
    • A phase 2 study of rituximab in combination with recombinant interleukin-2 for rituximab-refractory indolent non-Hodgkin's lymphoma
    • Khan KD, Emmanouilides C, Benson DM Jr, et al. A phase 2 study of rituximab in combination with recombinant interleukin-2 for rituximab-refractory indolent non-Hodgkin's lymphoma. Clin Cancer Res. 2006;12(23):7046-7053.
    • (2006) Clin Cancer Res. , vol.12 , Issue.23 , pp. 7046-7053
    • Khan, K.D.1    Emmanouilides, C.2    Benson Jr., D.M.3
  • 39
    • 51649123319 scopus 로고    scopus 로고
    • Lenalidomide enhances natural killer cell and monocytemediated antibody-dependent cellular cytotoxicity of rituximab-treated CD201 tumor cells
    • Wu L, Adams M, Carter T, et al. Lenalidomide enhances natural killer cell and monocytemediated antibody-dependent cellular cytotoxicity of rituximab-treated CD201 tumor cells. Clin Cancer Res. 2008;14(14):4650-4657.
    • (2008) Clin Cancer Res. , vol.14 , Issue.14 , pp. 4650-4657
    • Wu, L.1    Adams, M.2    Carter, T.3
  • 40
    • 84894028239 scopus 로고    scopus 로고
    • A phase I trial of the anti-inhibitory KIR antibody IPH2101 and lenalidomide in multiple myeloma: Interim results [abstract]
    • Abstract 4058
    • Benson DM Jr, Cohen AD, Munshi NC, et al. A phase I trial of the anti-inhibitory KIR antibody, IPH2101, and lenalidomide in multiple myeloma: Interim results [abstract]. Blood. 2012;120(21). Abstract 4058.
    • (2012) Blood. , vol.120 , Issue.21
    • Benson Jr., D.M.1    Cohen, A.D.2    Munshi, N.C.3
  • 41
    • 50949132226 scopus 로고    scopus 로고
    • Fc-dependent expression of CD137 on human NK cells: Insights into "agonistic" effects of anti-CD137 monoclonal antibodies
    • Lin W, Voskens CJ, Zhang X, et al. Fc-dependent expression of CD137 on human NK cells: Insights into "agonistic" effects of anti-CD137 monoclonal antibodies. Blood. 2008;112(3):699-707.
    • (2008) Blood. , vol.112 , Issue.3 , pp. 699-707
    • Lin, W.1    Voskens, C.J.2    Zhang, X.3
  • 42
    • 0032535119 scopus 로고    scopus 로고
    • NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies
    • Melero I, Johnston JV, Shufford WW, Mittler RS, Chen L. NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cell Immunol. 1998;190(2):167-172.
    • (1998) Cell Immunol. , vol.190 , Issue.2 , pp. 167-172
    • Melero, I.1    Johnston, J.V.2    Shufford, W.W.3    Mittler, R.S.4    Chen, L.5
  • 43
    • 0037108355 scopus 로고    scopus 로고
    • Signaling through NK cell-associated CD137 promotes both helper function for CD81 cytolytic T cells and responsiveness to IL-2 but not cytolytic activity
    • Wilcox RA, Tamada K, Strome SE, Chen L. Signaling through NK cell-associated CD137 promotes both helper function for CD81 cytolytic T cells and responsiveness to IL-2 but not cytolytic activity. J Immunol. 2002;169(8): 4230-4236.
    • (2002) J Immunol. , vol.169 , Issue.8 , pp. 4230-4236
    • Wilcox, R.A.1    Tamada, K.2    Strome, S.E.3    Chen, L.4
  • 44
    • 77956593114 scopus 로고    scopus 로고
    • Human gammadelta T lymphocytes induce robust NK cell-mediated antitumor cytotoxicity through CD137 engagement
    • Maniar A, Zhang X, Lin W, Gastman BR, Pauza CD, Strome SE, Chapoval AI. Human gammadelta T lymphocytes induce robust NK cell-mediated antitumor cytotoxicity through CD137 engagement. Blood. 2010;116(10): 1726-1733.
    • (2010) Blood. , vol.116 , Issue.10 , pp. 1726-1733
    • Maniar, A.1    Zhang, X.2    Lin, W.3    Gastman, B.R.4    Pauza, C.D.5    Strome, S.E.6    Chapoval, A.I.7
  • 45
    • 79952124960 scopus 로고    scopus 로고
    • CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies
    • Kohrt HE, Houot R, Goldstein MJ, et al. CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies. Blood. 2011;117(8): 2423-2432.
    • (2011) Blood. , vol.117 , Issue.8 , pp. 2423-2432
    • Kohrt, H.E.1    Houot, R.2    Goldstein, M.J.3
  • 46
    • 79955570584 scopus 로고    scopus 로고
    • Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy
    • Stagg J, Loi S, Divisekera U, et al. Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy. Proc Natl Acad Sci USA. 2011;108(17): 7142-7147.
    • (2011) Proc Natl Acad Sci USA. , vol.108 , Issue.17 , pp. 7142-7147
    • Stagg, J.1    Loi, S.2    Divisekera, U.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.