Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 52, 2015, Pages 15988-15993

  Yin, Jie ^a   Leavenworth, Jianmei W ^b,c   Li, Yang ^a   Luo, Qi ^a   Xie, Huafeng ^b,d,e   Liu, Xinhua ^a   Huang, Shan ^a   Yan, Han ^a   Fu, Zheng ^a   Zhang, Liyun Y ^f   Zhang, Litao ^g   Hao, Junwei ^a   Wu, Xudong ^a   Deng, Xianming ^h   Roberts, Charles W M ^b,c,e   Orkin, Stuart H ^b,c,d,e,i   Cantor, Harvey ^b,c   Wang, Xi ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d HARVARD STEM CELL INSTITUTE   (United States)

^e BOSTON CHILDREN S HOSPITAL   (United States)

^f Shanxi Dayi Hospital   (China)

^g TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^h XIAMEN UNIVERSITY   (China)

ⁱ HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Epigenetic regulation; Hematopoietic stem and progenitor cells; Histone modification; Innate immunity; NKG2D

Indexed keywords

CD34 ANTIGEN; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR3; DNA BINDING PROTEIN; HISTONE METHYLTRANSFERASE; INTERLEUKIN 15 RECEPTOR; INTERLEUKIN 2 RECEPTOR BETA; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR; NATURAL KILLER CELL RECEPTOR NKG2D; POLYCOMB GROUP PROTEIN; POLYCOMB REPRESSIVE COMPLEX 2; T LYMPHOCYTE RECEPTOR BETA CHAIN; TRANSCRIPTION FACTOR EZH2; EZH2 PROTEIN, MOUSE; HISTONE LYSINE METHYLTRANSFERASE; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY K;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER IMMUNOTHERAPY; CELL DIFFERENTIATION; CELL FUNCTION; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME INHIBITION; EPIGENETICS; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL; HISTONE MODIFICATION; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROGENY; REGULATORY MECHANISM; STEM CELL; TUMOR CELL; UPREGULATION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL LINEAGE; CELL PROLIFERATION; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENETICS; IMMUNOBLOTTING; K-562 CELL LINE; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; TUMOR CELL LINE;

ANIMALS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL LINEAGE; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; ENHANCER OF ZESTE HOMOLOG 2 PROTEIN; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HEMATOPOIETIC STEM CELLS; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; IMMUNOBLOTTING; INTERLEUKIN-2 RECEPTOR BETA SUBUNIT; K562 CELLS; KILLER CELLS, NATURAL; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K; POLYCOMB REPRESSIVE COMPLEX 2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84952682714     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1521740112     Document Type: Article

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