Human NK cells in acute myeloid leukaemia patients: Analysis of NK cell-activating receptors and their ligands

Cancer Immunology, Immunotherapy

Volumn 60, Issue 8, 2011, Pages 1195-1205

  Sanchez Correa, Beatriz ^a   Morgado, Sara ^a   Gayoso, Inmaculada ^b   Bergua, Juan M ^c   Casado, Javier G ^a   Arcos, Maria Jose ^c   Bengochea, Maria Luisa ^c   Duran, Esther ^a   Solana, Rafael ^b   Tarazona, Raquel ^a  

^a UNIVERSITY OF EXTREMADURA   (Spain)

^b UNIVERSITY OF CÓRDOBA   (Spain)

^c HOSPITAL SAN PEDRO DE ALCÁNTARA   (Spain)

Author keywords

DNAM 1; Leukaemia; NCR; NK cells; NKG2D; PIVAC 10

Indexed keywords

ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; BINDING PROTEIN; CD244 ANTIGEN; CD48 ANTIGEN; CD6 ANTIGEN; CD94 ANTIGEN; DNAX ACCESSORY MOLECULE 1 PROTEIN; GLYCOPROTEIN; HLA E ANTIGEN; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MEMBRANE PROTEIN; MHC CLASS I CHAIN RELATED GEN A; MHC CLASS I CHAIN RELATED GEN B; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3; NATURAL KILLER CELL RECEPTOR; NATURAL KILLER CELL RECEPTOR NKG2D; UL 16 BINDING PROTEIN; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; AGING; BLAST CELL; CYTOTOXICITY; DOWN REGULATION; HUMAN; LEUKEMIA CELL; LIGAND BINDING; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW;

ANIMALS; CYTOTOXICITY, IMMUNOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOMODULATION; IMMUNOTHERAPY; KILLER CELLS, NATURAL; LEUKEMIA, MYELOID, ACUTE; LIGANDS; RECEPTORS, NATURAL KILLER CELL; SIGNAL TRANSDUCTION; TUMOR ESCAPE;

EID: 79960918744     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-011-1050-2     Document Type: Review

References (76)

1. N Anfossi P Andre S Guia CS Falk S Roetynck CA Stewart V Breso C Frassati D Reviron D Middleton F Romagne S Ugolini E Vivier 2006 Human NK cell education by inhibitory receptors for MHC class I Immunity 25 331 342 16901727 10.1016/j.immuni.2006.06.013 1:CAS:528:DC%2BD28XpvVGjsrc%3D (Pubitemid 44224147)
2. NK Bjorkstrom HG Ljunggren JK Sandberg 2010 CD56 negative NK cells: origin, function, and role in chronic viral disease Trends Immunol 31 401 406 20829113 10.1016/j.it.2010.08.003
3. KS Boles SE Stepp M Bennett V Kumar PA Mathew 2001 2B4 (CD244) and CS1: novel members of the CD2 subset of the immunoglobulin superfamily molecules expressed on natural killer cells and other leukocytes Immunol Rev 181 234 249 11513145 10.1034/j.1600-065X.2001.1810120.x 1:CAS:528:DC%2BD3MXmsF2iu7k%3D (Pubitemid 32703411)
4. F Borrego M Masilamani AI Marusina X Tang JE Coligan 2006 The CD94/NKG2 family of receptors: from molecules and cells to clinical relevance Immunol Res 35 263 278 17172651 10.1385/IR:35:3:263 1:CAS:528:DC%2BD28Xht1OjsbbN (Pubitemid 46020727)
5. C Bottino R Castriconi D Pende P Rivera M Nanni B Carnemolla C Cantoni J Grassi S Marcenaro N Reymond M Vitale L Moretta M Lopez A Moretta 2003 Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule J Exp Med 198 557 567 12913096 10.1084/jem.20030788 1:CAS:528:DC%2BD3sXms1Wis7c%3D (Pubitemid 37040390)
6. CS Brandt M Baratin EC Yi J Kennedy Z Gao B Fox B Haldeman CD Ostrander T Kaifu C Chabannon A Moretta R West W Xu E Vivier SD Levin 2009 The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans J Exp Med 206 1495 1503 19528259 10.1084/jem.20090681 1:CAS:528:DC%2BD1MXos1eisL8%3D
7. Braun M, Muller B, Ter MD, Raffegerst S, Simm B, Wilde S, Spranger S, Ellwart J, Mosetter B, Umansky L, Lerchl T, Schendel DJ, Falk CS (2010) The CD6 scavenger receptor is differentially expressed on a CD56 natural killer cell subpopulation and contributes to natural killer-derived cytokine and chemokine secretion. J Innate Immun E-pub ahead of print
8. YT Bryceson EO Long 2008 Line of attack: NK cell specificity and integration of signals Curr Opin Immunol 20 344 352 18439809 10.1016/j.coi.2008.03.005 1:CAS:528:DC%2BD1cXns1aht7k%3D
9. SJ Burgess K Maasho M Masilamani S Narayanan F Borrego JE Coligan 2008 The NKG2D receptor: immunobiology and clinical implications Immunol Res 40 18 34 18193361 10.1007/s12026-007-0060-9 1:CAS:528:DC%2BD1cXivVyjsrY%3D (Pubitemid 351378033)
10. KS Campbell AK Purdy 2011 Structure/function of human killer cell immunoglobulin-like receptors: lessons from polymorphisms, evolution, crystal structures and mutations Immunology 132 315 325 21214544 10.1111/j.1365-2567. 2010.03398.x 1:CAS:528:DC%2BC3MXislGjt7w%3D
11. M Carlsten BC Baumann M Simonsson M Jadersten AM Forsblom C Hammarstedt YT Bryceson HG Ljunggren E Hellstrom-Lindberg KJ Malmberg 2010 Reduced DNAM-1 expression on bone marrow NK cells associated with impaired killing of CD34+ blasts in myelodysplastic syndrome Leukemia 24 1607 1616 20613786 10.1038/leu.2010.149 1:CAS:528:DC%2BC3cXhtFaiu7%2FE
12. M Carlsten H Norell YT Bryceson I Poschke K Schedvins HG Ljunggren R Kiessling KJ Malmberg 2009 Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells J Immunol 183 4921 4930 19801517 10.4049/jimmunol.0901226 1:CAS:528:DC%2BD1MXht1WhsLnL
13. JG Casado G Pawelec S Morgado B Sanchez-Correa E Delgado I Gayoso E Duran R Solana R Tarazona 2009 Expression of adhesion molecules and ligands for activating and costimulatory receptors involved in cell-mediated cytotoxicity in a large panel of human melanoma cell lines Cancer Immunol Immunother 58 1517 1526 19259667 10.1007/s00262-009-0682-y 1:CAS:528:DC%2BD1MXnslentrk%3D
14. M Champsaur LL Lanier 2010 Effect of NKG2D ligand expression on host immune responses Immunol Rev 235 267 285 20536569 1:CAS:528:DC%2BC3cXnt1Kjt78%3D
15. A Chan DL Hong A Atzberger S Kollnberger AD Filer CD Buckley A McMichael T Enver P Bowness 2007 CD56bright human NK cells differentiate into CD56dim cells: role of contact with peripheral fibroblasts J Immunol 179 89 94 17579025 1:CAS:528:DC%2BD2sXmsF2nsrk%3D (Pubitemid 46986521)
16. RT Costello S Sivori E Marcenaro M Lafage-Pochitaloff MJ Mozziconacci D Reviron JA Gastaut D Pende D Olive A Moretta 2002 Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia Blood 99 3661 3667 11986221 10.1182/blood.V99.10.3661 1:CAS:528:DC%2BD38XjvVGnsLc%3D (Pubitemid 34534536)
17. E Derhovanessian R Solana A Larbi G Pawelec 2008 Immunity, ageing and cancer Immun Ageing 5 11 18816370 10.1186/1742-4933-5-11
18. S Diermayr H Himmelreich B Durovic A Mathys-Schneeberger U Siegler U Langenkamp J Hofsteenge A Gratwohl A Tichelli M Paluszewska W Wiktor-Jedrzejczak CP Kalberer A Wodnar-Filipowicz 2008 NKG2D ligand expression in AML increases in response to HDAC inhibitor valproic acid and contributes to allorecognition by NK-cell lines with single KIR-HLA class I specificities Blood 111 1428 1436 17993609 10.1182/blood-2007-07-101311 1:CAS:528:DC%2BD1cXhvFejtbY%3D (Pubitemid 351213430)
19. RA Eagle J Trowsdale 2007 Promiscuity and the single receptor: NKG2D Nat Rev Immunol 7 737 744 17673918 10.1038/nri2144 1:CAS:528:DC%2BD2sXpsV2qtLk%3D (Pubitemid 47327391)
20. YM El-Sherbiny JL Meade TD Holmes D McGonagle SL Mackie AW Morgan G Cook S Feyler SJ Richards FE Davies GJ Morgan GP Cook 2007 The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells Cancer Res 67 8444 8449 17875681 10.1158/0008-5472.CAN-06-4230 1:CAS:528:DC%2BD2sXhtVCit7zN (Pubitemid 47437416)
21. M Elishmereni F Levi-Schaffer 2011 CD48: a co-stimulatory receptor of immunity Int J Biochem Cell Biol 43 25 28 20833258 10.1016/j.biocel.2010.09.001 1:CAS:528:DC%2BC3cXhsF2itr%2FK
22. PK Epling-Burnette F Bai JS Painter DE Rollison HR Salih M Krusch J Zou E Ku B Zhong D Boulware L Moscinski S Wei JY Djeu AF List 2007 Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors Blood 109 4816 4824 17341666 10.1182/blood-2006-07-035519 1:CAS:528:DC%2BD2sXmt1Oguro%3D (Pubitemid 46827777)
23. SS Farag MA Caligiuri 2006 Human natural killer cell development and biology Blood Rev 20 123 137 16364519 10.1016/j.blre.2005.10.001 1:CAS:528:DC%2BD28Xlt1ejtL0%3D (Pubitemid 43786166)
24. C Fauriat S Just-Landi F Mallet C Arnoulet D Sainty D Olive RT Costello 2007 Deficient expression of NCR in NK cells from acute myeloid leukemia: Evolution during leukemia treatment and impact of leukemia cells in NCRdull phenotype induction Blood 109 323 330 16940427 10.1182/blood-2005-08-027979 1:CAS:528:DC%2BD2sXivVyru7o%3D (Pubitemid 46053073)
25. Gayoso I, Sanchez-Correa B, Campos C, Alonso C, Pera A, Casado JG, Morgado S, Tarazona R, Solana R (2011) Immunosenescence of human natural killer cells. J Innate Immun E-pub ahead of print
26. S Gilfillan CJ Chan M Cella NM Haynes AS Rapaport KS Boles DM Andrews MJ Smyth M Colonna 2008 DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors J Exp Med 205 2965 2973 19029380 10.1084/jem.20081752 1:CAS:528:DC%2BD1MXosFCh
27. V Groh J Wu C Yee T Spies 2002 Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation Nature 419 734 738 12384702 10.1038/nature01112 1:CAS:528:DC%2BD38XnvVyrt7o%3D (Pubitemid 35177960)
28. ML Hecht B Rosental T Horlacher O Hershkovitz JL De Paz C Noti S Schauer A Porgador PH Seeberger 2009 Natural cytotoxicity receptors NKp30, NKp44 and NKp46 bind to different heparan sulfate/heparin sequences J Proteome Res 8 712 720 19196184 10.1021/pr800747c 1:CAS:528:DC%2BD1MXht1OhtbY%3D
29. W Held M Kijima GS Angelov S Bessoles 2011 The function of natural killer cells: education, reminders and some good memories Curr Opin Immunol 23 228 233 21159498 10.1016/j.coi.2010.11.008 1:CAS:528:DC%2BC3MXkt1KisbY%3D
30. EJ Jabbour E Estey HM Kantarjian 2006 Adult acute myeloid leukemia Mayo Clin Proc 81 247 260 16471082 10.4065/81.2.247 (Pubitemid 43205780)
31. P Kalinski RB Mailliard A Giermasz HJ Zeh P Basse DL Bartlett JM Kirkwood MT Lotze RB Herberman 2005 Natural killer-dendritic cell cross-talk in cancer immunotherapy Expert Opin Biol Ther 5 1303 1315 16197336 10.1517/14712598.5.10. 1303 1:CAS:528:DC%2BD2MXhtVGjsLrN (Pubitemid 41503042)
32. S Kim J Poursine-Laurent SM Truscott L Lybarger YJ Song L Yang AR French JB Sunwoo S Lemieux TH Hansen WM Yokoyama 2005 Licensing of natural killer cells by host major histocompatibility complex class I molecules Nature 436 709 713 16079848 10.1038/nature03847 1:CAS:528:DC%2BD2MXmvFentbc%3D (Pubitemid 41117274)
33. T Lakshmikanth S Burke TH Ali S Kimpfler F Ursini L Ruggeri M Capanni V Umansky A Paschen A Sucker D Pende V Groh R Biassoni P Hoglund M Kato K Shibuya D Schadendorf A Anichini S Ferrone A Velardi K Karre A Shibuya E Carbone F Colucci 2009 NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo J Clin Invest 119 1251 1263 19349689 10.1172/JCI36022 1:CAS:528:DC%2BD1MXlsFyrtr4%3D
34. HG Ljunggren K Karre 1990 In search of the 'missing self: MHC molecules and NK cell recognition Immunol Today 11 237 244 2201309 10.1016/0167-5699(90) 90097-S 1:CAS:528:DyaK3cXls12rsbc%3D (Pubitemid 20198988)
35. KJ Malmberg YT Bryceson M Carlsten S Andersson A Bjorklund NK Bjorkstrom BC Baumann C Fauriat E Alici MS Dilber HG Ljunggren 2008 NK cell-mediated targeting of human cancer and possibilities for new means of immunotherapy Cancer Immunol Immunother 57 1541 1552 18317755 10.1007/s00262-008-0492-7 1:CAS:528:DC%2BD1cXovFyitr4%3D
36. SO Mathew KK Rao JR Kim ND Bambard PA Mathew 2009 Functional role of human NK cell receptor 2B4 (CD244) isoforms Eur J Immunol 39 1632 1641 19499526 10.1002/eji.200838733 1:CAS:528:DC%2BD1MXntFCitL8%3D
37. D Mavilio G Lombardo J Benjamin D Kim D Follman E Marcenaro MA O'Shea A Kinter C Kovacs A Moretta AS Fauci 2005 Characterization of CD56-/CD16+ natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals Proc Natl Acad Sci USA 102 2886 2891 15699323 10.1073/pnas.0409872102 1:CAS:528:DC%2BD2MXitVSksbY%3D (Pubitemid 40299886)
38. RW McGilvray RA Eagle NF Watson A Al-Attar G Ball I Jafferji J Trowsdale LG Durrant 2009 NKG2D ligand expression in human colorectal cancer reveals associations with prognosis and evidence for immunoediting Clin Cancer Res 15 6993 7002 19861434 10.1158/1078-0432.CCR-09-0991 1:CAS:528:DC%2BD1MXhtl2ktLnN
39. ME McNerney KM Lee V Kumar 2005 2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8+ T cells Mol Immunol 42 489 494 15607804 10.1016/j.molimm.2004.07.032 1:CAS:528:DC%2BD2cXhtVyktrjP (Pubitemid 39655959)
40. R Mendez N Aptsiauri CA Del I Maleno T Cabrera F Ruiz-Cabello F Garrido A Garcia-Lora 2009 HLA and melanoma: multiple alterations in HLA class I and II expression in human melanoma cell lines from ESTDAB cell bank Cancer Immunol Immunother 58 1507 1515 19340423 10.1007/s00262-009-0701-z 1:CAS:528: DC%2BD1MXnslent7s%3D
41. Morgado S, Sanchez-Correa B, Casado JG, Duran E, Gayoso I, Labella F, Solana R, Tarazona R (2011) NK cell recognition and killing of melanoma cells is controlled by multiple activating receptor-ligand interactions. J Innate Immun E-pub ahead of print
42. E Naumova A Mihaylova M Ivanova S Mihailova 2007 Impact of KIR/HLA ligand combinations on immune responses in malignant melanoma Cancer Immunol Immunother 56 95 100 16547704 10.1007/s00262-006-0151-9 1:CAS:528: DC%2BD28Xht1elsb3P (Pubitemid 44812451)
43. Nguyen S, Beziat V, Roos-Weil D, Vieillard V (2011) Role of natural killer cells in hematopoietic stem cell transplantation: myth or reality? J Innate Immun E-pub ahead of print
44. P Nowbakht MC Ionescu A Rohner CP Kalberer E Rossy L Mori D Cosman LG De A Wodnar-Filipowicz 2005 Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias Blood 105 3615 3622 15657183 10.1182/blood-2004-07-2585 1:CAS:528:DC%2BD2MXjvFejt7w%3D (Pubitemid 40628208)
45. SF Ofori-Acquah JA King 2008 Activated leukocyte cell adhesion molecule: a new paradox in cancer Transl Res 151 122 128 18279810 10.1016/j.trsl.2007.09. 006 1:CAS:528:DC%2BD1cXitVentL0%3D (Pubitemid 351221436)
46. MT Orr LL Lanier 2010 Natural killer cell education and tolerance Cell 142 847 856 20850008 10.1016/j.cell.2010.08.031 1:CAS:528:DC%2BC3cXhtFyitb%2FP
47. G Pawelec R Solana 2008 Are cancer and ageing different sides of the same coin? Conference on Cancer and Ageing EMBO Rep 9 234 238 18259218 10.1038/embor.2008.12 1:CAS:528:DC%2BD1cXislSntbs%3D (Pubitemid 351330986)
48. D Pende C Bottino R Castriconi C Cantoni S Marcenaro P Rivera GM Spaggiari A Dondero B Carnemolla N Reymond MC Mingari M Lopez L Moretta A Moretta 2005 PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis Mol Immunol 42 463 469 15607800 10.1016/j.molimm.2004.07.028 1:CAS:528:DC%2BD2cXhtVyktrvI (Pubitemid 39655955)
49. D Pende C Cantoni P Rivera M Vitale R Castriconi S Marcenaro M Nanni R Biassoni C Bottino A Moretta L Moretta 2001 Role of NKG2D in tumor cell lysis mediated by human NK cells: cooperation with natural cytotoxicity receptors and capability of recognizing tumors of nonepithelial origin Eur J Immunol 31 1076 1086 11298332 10.1002/1521-4141(200104)31:4<1076::AID-IMMU1076>3.0.CO;2-Y 1:CAS:528:DC%2BD3MXivFyjsrw%3D (Pubitemid 32331612)
50. D Pende GM Spaggiari S Marcenaro S Martini P Rivera A Capobianco M Falco E Lanino I Pierri R Zambello A Bacigalupo MC Mingari A Moretta L Moretta 2005 Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112) Blood 105 2066 2073 15536144 10.1182/blood-2004-09-3548 1:CAS:528:DC%2BD2MXitVOnsbk%3D (Pubitemid 40731793)
51. E Peralbo O DelaRosa I Gayoso ML Pita R Tarazona R Solana 2006 Decreased frequency and proliferative response of invariant Valpha24Vbeta11 natural killer T (iNKT) cells in healthy elderly Biogerontology 7 483 492 16953330 10.1007/s10522-006-9063-5 1:CAS:528:DC%2BD28XhtlaqsrnM
52. SE von Pogge VR Simhadri B von Tresckow S Sasse KS Reiners HP Hansen A Rothe B Boll VL Simhadri P Borchmann PJ McKinnon M Hallek A Engert 2007 Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells Immunity 27 965 974 10.1016/j.immuni.2007.10.010 (Pubitemid 350251218)
53. L Ruggeri M Capanni E Urbani K Perruccio WD Shlomchik A Tosti S Posati D Rogaia F Frassoni F Aversa MF Martelli A Velardi 2002 Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants Science 295 2097 2100 11896281 10.1126/science.1068440 1:CAS:528: DC%2BD38Xit1Ohurs%3D (Pubitemid 34229476)
54. HR Salih H Antropius F Gieseke SZ Lutz L Kanz HG Rammensee A Steinle 2003 Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia Blood 102 1389 1396 12714493 10.1182/blood-2003-01-0019 1:CAS:528:DC%2BD3sXmsFWkt7w%3D (Pubitemid 36988048)
55. HR Salih S Holdenrieder A Steinle 2008 Soluble NKG2D ligands: prevalence, release, and functional impact Front Biosci 13 3448 3456 18508446 10.2741/2939 1:CAS:528:DC%2BD1cXnsVKqtr0%3D (Pubitemid 351594695)
56. CJ Sanchez TT Le A Boehrer B Knoblauch J Imbert D Olive RT Costello 2011 Natural killer cells and malignant haemopathies: a model for the interaction of cancer with innate immunity Cancer Immunol Immunother 60 1 13 20697893 10.1007/s00262-010-0898-x 1:CAS:528:DC%2BC3MXht12gt78%3D
57. Sanchez-Correa B, Gayoso I, Bergua JM, Casado JG, Morgado S, Solana R, Tarazona R (2011) Decreased expression of DNAM-1 on NK cells from acute myeloid leukemia patients. Immunol Cell Biol E-pub ahead of print
58. S Sivori S Parolini M Falco E Marcenaro R Biassoni C Bottino L Moretta A Moretta 2000 2B4 functions as a co-receptor in human NK cell activation Eur J Immunol 30 787 793 10741393 10.1002/1521-4141(200003)30:3<787::AID- IMMU787>3.0.CO;2-I 1:CAS:528:DC%2BD3cXhvVChur4%3D (Pubitemid 30216250)
59. R Solana JG Casado E Delgado O DelaRosa J Marin E Duran G Pawelec R Tarazona 2007 Lymphocyte activation in response to melanoma: interaction of NK-associated receptors and their ligands Cancer Immunol Immunother 56 101 109 16485126 10.1007/s00262-006-0141-y 1:CAS:528:DC%2BD28Xht1elsb3O (Pubitemid 44812452)
60. R Solana G Pawelec R Tarazona 2006 Aging and innate immunity Immunity 24 491 494 16713963 10.1016/j.immuni.2006.05.003 1:CAS:528:DC%2BD28XlsFWqsLk%3D (Pubitemid 43728154)
61. JC Sun JN Beilke LL Lanier 2009 Adaptive immune features of natural killer cells Nature 457 557 561 19136945 10.1038/nature07665 1:CAS:528:DC%2BD1MXhtFOmsbo%3D
62. MJ Szczepanski M Szajnik A Welsh KA Foon TL Whiteside M Boyiadzis 2010 Interleukin-15 enhances natural killer cell cytotoxicity in patients with acute myeloid leukemia by upregulating the activating NK cell receptors Cancer Immunol Immunother 59 73 79 19526239 10.1007/s00262-009-0724-5 1:CAS:528: DC%2BD1MXht1OnsL%2FO
63. S Tahara-Hanaoka K Shibuya H Kai A Miyamoto Y Morikawa N Ohkochi S Honda A Shibuya 2006 Tumor rejection by the poliovirus receptor family ligands of the DNAM-1 (CD226) receptor Blood 107 1491 1496 16249389 10.1182/blood-2005-04-1684 1:CAS:528:DC%2BD28XhsFemtrk%3D (Pubitemid 43242386)
64. R Tarazona JG Casado O DelaRosa J Torre-Cisneros JL Villanueva B Sanchez MD Galiani R Gonzalez R Solana J Pena 2002 Selective depletion of CD56(dim) NK cell subsets and maintenance of CD56(bright) NK cells in treatment-naive HIV-1-seropositive individuals J Clin Immunol 22 176 183 12078859 10.1023/A:1015476114409 1:CAS:528:DC%2BD38Xks1Ghtr8%3D (Pubitemid 34596941)
65. SK Tripathy PA Keyel L Yang JT Pingel TP Cheng A Schneeberger WM Yokoyama 2008 Continuous engagement of a self-specific activation receptor induces NK cell tolerance J Exp Med 205 1829 1841 18606857 10.1084/jem.20072446 1:CAS:528:DC%2BD1cXpsFOjsL4%3D
66. SV Vaidya PA Mathew 2006 Of mice and men: different functions of the murine and human 2B4 (CD244) receptor on NK cells Immunol Lett 105 180 184 16621032 10.1016/j.imlet.2006.02.006 1:CAS:528:DC%2BD28XltlGrtL0%3D (Pubitemid 43816090)
67. A Velardi L Ruggeri A Moretta L Moretta 2002 NK cells: a lesson from mismatched hematopoietic transplantation Trends Immunol 23 438 444 12200065 10.1016/S1471-4906(02)02284-6 1:CAS:528:DC%2BD38XmsVekur0%3D (Pubitemid 35015187)
68. S Verheyden M Bernier C Demanet 2004 Identification of natural killer cell receptor phenotypes associated with leukemia Leukemia 18 2002 2007 15470487 10.1038/sj.leu.2403525 1:CAS:528:DC%2BD2cXhtVSmsrnK (Pubitemid 40028427)
69. S Verheyden C Demanet 2006 Susceptibility to myeloid and lymphoid leukemia is mediated by distinct inhibitory KIR-HLA ligand interactions Leukemia 20 1437 1438 16761016 10.1038/sj.leu.2404279 1:CAS:528:DC%2BD28XntVWlu7Y%3D (Pubitemid 44084059)
70. S Verheyden C Demanet 2008 NK cell receptors and their ligands in leukemia Leukemia 22 249 257 18046448 10.1038/sj.leu.2405040 1:CAS:528:DC%2BD1cXhvVyltLo%3D (Pubitemid 351250528)
71. S Verheyden S Ferrone A Mulder FH Claas R Schots B De Moerloose Y Benoit C Demanet 2009 Role of the inhibitory KIR ligand HLA-Bw4 and HLA-C expression levels in the recognition of leukemic cells by natural Killer cells Cancer Immunol Immunother 58 855 865 18841361 10.1007/s00262-008-0601-7 1:CAS:528:DC%2BD1MXjvFOitLw%3D
72. MR Verneris JS Miller 2009 The phenotypic and functional characteristics of umbilical cord blood and peripheral blood natural killer cells Br J Haematol 147 185 191 19796267 10.1111/j.1365-2141.2009.07768.x 1:CAS:528: DC%2BD1MXhtlyns7fP
73. E Vivier JA Nunes F Vely 2004 Natural killer cell signaling pathways Science 306 1517 1519 15567854 10.1126/science.1103478 1:CAS:528: DC%2BD2cXhtVeqtrzK (Pubitemid 39564941)
74. E Vivier DH Raulet A Moretta MA Caligiuri L Zitvogel LL Lanier WM Yokoyama S Ugolini 2011 Innate or adaptive immunity? The example of natural killer cells Science 331 44 49 21212348 10.1126/science.1198687 1:CAS:528:DC%2BC3MXpslCh
75. I Waldhauer A Steinle 2008 NK cells and cancer immunosurveillance Oncogene 27 5932 5943 18836474 10.1038/onc.2008.267 1:CAS:528:DC%2BD1cXhtF2msbnE
76. Wehner R, Dietze K, Bachmann M, Schmitz M (2011) The bidirectional crosstalk between human dendritic cells and natural killer cells. J Innate Immun E-pub ahead of print