The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 42, 2009, Pages 17858-17863

  Stanietsky, Noa ^a   Simic, Hrvoje ^b   Arapovic, Jurica ^b   Toporik, Amir ^c   Levy, Ofer ^c   Novik, Amit ^c   Levine, Zurit ^c   Beiman, Meirav ^c   Dassa, Liat ^c   Achdout, Hagit ^a   Stern Ginossar, Noam ^a   Tsukerman, Pinhas ^a   Jonjic, Stipan ^b   Mandelboim, Ofer ^a  

^a HEBREW UNIVERSITY   (Israel)

^b UNIVERSITY OF RIJEKA   (Croatia)

^c Compugen Ltd ^*  (Israel)

Author keywords

Inhibitory receptors; Natural killers

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NECTIN 2; POLIOVIRUS RECEPTOR RELATED PROTEIN; POLIOVIRUS RECEPTOR RELATED PROTEIN 3; PROTEIN; PROTEIN TIGIT; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE; TUMOR CELL;

ANIMALS; CELL ADHESION MOLECULES; CELL LINE; CYTOTOXICITY, IMMUNOLOGIC; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; INTERLEUKIN-2 RECEPTOR BETA SUBUNIT; KILLER CELLS, NATURAL; LIGANDS; LYMPHOCYTE SUBSETS; MICE; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECEPTORS, IMMUNOLOGIC; RECEPTORS, VIRUS; RECOMBINANT PROTEINS;

EID: 70449597272     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0903474106     Document Type: Article

References (42)

1. Schwartz RH (1992) Costimulation of T lymphocytes: The role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 71:1065-1068.
2. Vivier E, Tomasello E, Baratin M, Walzer T, Ugolini S (2008) Functions of natural killer cells. Nat Immunol 9:503-510.
3. Lanier LL (2008) Up on the tightrope: Natural killer cell activation and inhibition. Nat Immunol 9:495-502. (Pubitemid 351560518)
4. Cantoni C, et al. (1999) Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells. Eur J Immunol 29:3148-3159. (Pubitemid 29484205)
5. Markel G, et al. (2002) CD66a interactions between human melanoma and NK cells: A novel class IMHC-independent inhibitory mechanism of cytotoxicity. J Immunol 168:2803-2810. (Pubitemid 34211659)
6. Kumar V, McNerney ME (2005) A new self: MHC-class-I-independent natural-killer-cell self-tolerance. Nat Rev Immunol 5:363-374. (Pubitemid 40685986)
7. Lebbink RJ, Meyaard L (2007) Non-MHC ligands for inhibitory immune receptors: Novel insights and implications for immune regulation. Mol Immunol 44:2153-2164.
8. Stern N, et al. (2005) Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1. J Immunol 174:6692-6701. (Pubitemid 40705631)
9. Arnon TI, et al. (2005) Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus. Nat Immunol 6:515-523.
10. Pogge von Strandmann E, et al. (2007) Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells. Immunity 27:965-974. (Pubitemid 350251218)
11. Brandt CS, et al. (2009) The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans. J Exp Med 206:1495-1503.
12. Mandelboim O, et al. (2001) Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells. Nature 409:1055-1060. (Pubitemid 32204059)
13. Arnon TI, et al. (2001) Recognition of viral hemagglutinins by NKp44 but not by NKp30. Eur J Immunol 31:2680-2689.
14. Vivier E, Tomasello E, Paul P (2002) Lymphocyte activation via NKG2D: Towards a new paradigm in immune recognition? Curr Opin Immunol 14:306-311. (Pubitemid 34327971)
15. Welte S, Kuttruff S, Waldhauer I, Steinle A (2006) Mutual activation of natural killer cells and monocytes mediated by NKp80-AICL interaction. Nat Immunol 7:1334-1342. (Pubitemid 46111255)
16. Bottino C, et al. (2003) Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. J Exp Med 198:557-567. (Pubitemid 37040390)
17. Fuchs A, Cella M, Giurisato E, Shaw AS, Colonna M (2004) Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). J Immunol 172:3994-3998. (Pubitemid 38375210)
18. Yu X, et al. (2009) The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat Immunol 10:48-57.
19. Chuang SS, et al. (2000) 2B4 stimulation of YT cells induces natural killer cell cytolytic function and invasiveness. Immunology 100:378-383.
20. Maeda A, et al. (1999) Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1. Oncogene 18:2291-2297. (Pubitemid 29192706)
21. Muta T, et al. (1994) A 13-amino-acid motif in the cytoplasmic domain of Fc gamma RIIB modulates B-cell receptor signalling. Nature 369:340.
22. Gilfillan S, et al. (2008) DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors. J Exp Med 205:2965-2973.
23. Masson D, et al. (2001) Overexpression of the CD155 gene in human colorectal carcinoma. Gut 49:236-240. (Pubitemid 32675118)
24. Fuchs A, Colonna M (2006) The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance. Semin Cancer Biol 16:359-366. (Pubitemid 44311500)
25. Freistadt MS, Fleit HB, Wimmer E (1993) Poliovirus receptor on human blood cells: A possible extraneural site of poliovirus replication. Virology 195:798-803. (Pubitemid 23226207)
26. Linsley PS, Clark EA, Ledbetter JA (1990) T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc Natl Acad Sci USA 87:5031-5035. (Pubitemid 20224266)
27. Linsley PS, et al. (1991) CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med 174:561-569.
28. Freeman GJ, et al. (1993) Cloning of B7-2: A CTLA-4 counter-receptor that costimulates human T cell proliferation. Science 262:909-911. (Pubitemid 24014081)
29. Azuma M, et al. (1993) B70 antigen is a second ligand for CTLA-4 and CD28. Nature 366:76-79. (Pubitemid 23345240)
30. Brunet JF, et al. (1987) A new member of the immunoglobulin superfamily-CTLA-4. Nature 328:267-270.
31. Moretta L, Moretta A (2004) Killer immunoglobulin-like receptors. Curr Opin Immunol 16:626-633.
32. Biassoni R, et al. (1996) The human leukocyte antigen (HLA)-C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions. J Exp Med 183:645-650. (Pubitemid 26060796)
33. Katz G, et al. (2004) MHC class I-independent recognition of NK-activating receptor KIR2DS4. J Immunol 173:1819-1825. (Pubitemid 38971615)
34. Biassoni R, et al. (1997) Role of amino acid position 70 in the binding affinity of p50.1 and p58.1 receptors for HLA-Cw4 molecules. Eur J Immunol 27:3095-3099. (Pubitemid 28018001)
35. Vales-Gomez M, Reyburn HT, Erskine RA, Strominger J (1998) Differential binding to HLA-C of p50-activating and p58-inhibitory natural killer cell receptors. Proc Natl Acad Sci USA 95:14326-14331. (Pubitemid 28549366)
36. Sloan KE, et al. (2004) CD155/PVR plays a key role in cell motility during tumor cell invasion and migration. BMC Cancer 4:73.
37. El-Sherbiny YM, et al. (2007) The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells. Cancer Res 67:8444-8449.
38. Pende D, et al. (2005) PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis. Mol Immunol 42:463-469. (Pubitemid 39655955)
39. Castriconi R, et al. (2004) Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: Critical role of DNAX accessory molecule-1-poliovirus receptor interaction. Cancer Res 64:9180-9184. (Pubitemid 39665534)
40. Pende D, et al. (2005) Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: Evidence for the involvement of the poliovirus receptor (CD155) and nectin-2 (CD112). Blood 105:2066-2073. (Pubitemid 40731793)
41. Iguchi-Manaka A, et al. (2008) Accelerated tumor growth in mice deficient in DNAM-1 receptor. J Exp Med 205:2959-2964.
42. Achdout H, et al. (2003) Enhanced recognition of human NK receptors after influenza virus infection. J Immunol 171:915-923. (Pubitemid 36871405)