메뉴 건너뛰기




Volumn 2, Issue 4, 2014, Pages 320-331

PD-1 expression on peripheral blood cells increases with stage in renal cell carcinoma patients and is rapidly reduced after surgical tumor resection

Author keywords

[No Author keywords available]

Indexed keywords

PROGRAMMED DEATH 1 RECEPTOR;

EID: 84905496988     PISSN: 23266066     EISSN: 23266074     Source Type: Journal    
DOI: 10.1158/2326-6066.CIR-13-0133     Document Type: Article
Times cited : (138)

References (50)
  • 2
    • 84857034763 scopus 로고    scopus 로고
    • Kidney cancer in 2011: Objectifying risk for localized renal masses
    • Smaldone MC, Uzzo RG. Kidney cancer in 2011: objectifying risk for localized renal masses. Nat Rev Urol 2012; 9: 70-2.
    • (2012) Nat Rev Urol , vol.9 , pp. 70-72
    • Smaldone, M.C.1    Uzzo, R.G.2
  • 3
    • 79960353198 scopus 로고    scopus 로고
    • The role of surgery in the management of early-stage renal cancer
    • Russo P. The role of surgery in the management of early-stage renal cancer. Hematol Oncol Clin North Am 2011; 25: 737-52.
    • (2011) Hematol Oncol Clin North Am , vol.25 , pp. 737-752
    • Russo, P.1
  • 4
    • 80052974211 scopus 로고    scopus 로고
    • Selecting targeted therapies for patients with renal cell carcinoma
    • quiz 1007
    • Plimack ER, Hudes GR. Selecting targeted therapies for patients with renal cell carcinoma. J Natl Compr Canc Netw 2011; 9: 997-1006; quiz 1007.
    • (2011) J Natl Compr Canc Netw , vol.9 , pp. 997-1006
    • Plimack, E.R.1    Hudes, G.R.2
  • 5
    • 84859844667 scopus 로고    scopus 로고
    • Targeted therapeutic strategies for the management of renal cell carcinoma
    • Singer EA, Gupta GN, Srinivasan R. Targeted therapeutic strategies for the management of renal cell carcinoma. Curr Opin Oncol 2012; 24: 284-90.
    • (2012) Curr Opin Oncol , vol.24 , pp. 284-290
    • Singer, E.A.1    Gupta, G.N.2    Srinivasan, R.3
  • 6
    • 84876114298 scopus 로고    scopus 로고
    • Interferon-gamma-induced necrosis: An antitumor biotherapeutic perspective
    • Balachandran S, Adams GP. Interferon-gamma-induced necrosis: an antitumor biotherapeutic perspective. J Interferon Cytokine Res 2013; 33: 171-80.
    • (2013) J Interferon Cytokine Res , vol.33 , pp. 171-180
    • Balachandran, S.1    Adams, G.P.2
  • 7
    • 84880123722 scopus 로고    scopus 로고
    • Salvage-targeted kidney cancer therapy in patients progressing on high-dose Interleukin-2 immunotherapy: The UCLA experience
    • Birkhauser FD, Pantuck AJ, Rampersaud EN, Wang X, Kroeger N, Pouliot F, et al. Salvage-targeted kidney cancer therapy in patients progressing on high-dose interleukin-2 immunotherapy: the UCLA experience. Cancer J 2013; 19: 189-96.
    • (2013) Cancer J , vol.19 , pp. 189-196
    • Birkhauser, F.D.1    Pantuck, A.J.2    Rampersaud, E.N.3    Wang, X.4    Kroeger, N.5    Pouliot, F.6
  • 8
    • 84930479671 scopus 로고    scopus 로고
    • The 20th anniversary of Interleukin-2 therapy: Bimodal role explaining longstanding random induction of complete clinical responses
    • Coventry BJ, Ashdown ML. The 20th anniversary of interleukin-2 therapy: bimodal role explaining longstanding random induction of complete clinical responses. Cancer Manag Res 2012; 4: 215-21.
    • (2012) Cancer Manag Res , vol.4 , pp. 215-221
    • Coventry, B.J.1    Ashdown, M.L.2
  • 9
    • 0036138580 scopus 로고    scopus 로고
    • Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
    • Motzer RJ, Bacik J, Murphy BA, Russo P, Mazumdar M. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol 2002; 20: 289-96.
    • (2002) J Clin Oncol , vol.20 , pp. 289-296
    • Motzer, R.J.1    Bacik, J.2    Murphy, B.A.3    Russo, P.4    Mazumdar, M.5
  • 10
    • 77953747963 scopus 로고    scopus 로고
    • The PD-1 pathway in tolerance and autoimmunity
    • Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev 2010; 236: 219-42.
    • (2010) Immunol Rev , vol.236 , pp. 219-242
    • Francisco, L.M.1    Sage, P.T.2    Sharpe, A.H.3
  • 11
    • 84884561907 scopus 로고    scopus 로고
    • Molecular pathways: Co-expression of immune checkpoint molecules: Signaling pathways and implications for cancer immunotherapy
    • Nirschl CJ, Drake CG. Molecular pathways: co-expression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy. Clin Cancer Res 2013; 19: 4917-24.
    • (2013) Clin Cancer Res , vol.19 , pp. 4917-4924
    • Nirschl, C.J.1    Drake, C.G.2
  • 12
    • 58149461844 scopus 로고    scopus 로고
    • Contributions of PD-1/PD-L1 pathway to interactions of myeloid DCs with T cells in atherosclerosis
    • Lee J, Zhuang Y, Wei X, Shang F, Wang J, Zhang Y, et al. Contributions of PD-1/PD-L1 pathway to interactions of myeloid DCs with T cells in atherosclerosis. J Mol Cell Cardiol 2009; 46: 169-76.
    • (2009) J Mol Cell Cardiol , vol.46 , pp. 169-176
    • Lee, J.1    Zhuang, Y.2    Wei, X.3    Shang, F.4    Wang, J.5    Zhang, Y.6
  • 13
    • 0032736029 scopus 로고    scopus 로고
    • B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and Interleukin-10 secretion
    • Dong H, Zhu G, Tamada K, Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med 1999; 5: 1365-9.
    • (1999) Nat Med , vol.5 , pp. 1365-1369
    • Dong, H.1    Zhu, G.2    Tamada, K.3    Chen, L.4
  • 14
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 2000; 192: 1027-34.
    • (2000) J Exp Med , vol.192 , pp. 1027-1034
    • Freeman, G.J.1    Long, A.J.2    Iwai, Y.3    Bourque, K.4    Chernova, T.5    Nishimura, H.6
  • 16
    • 0035794314 scopus 로고    scopus 로고
    • B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells
    • Tseng SY, Otsuji M, Gorski K, Huang X, Slansky JE, Pai SI, et al. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J Exp Med 2001; 193: 839-46.
    • (2001) J Exp Med , vol.193 , pp. 839-846
    • Tseng, S.Y.1    Otsuji, M.2    Gorski, K.3    Huang, X.4    Slansky, J.E.5    Pai, S.I.6
  • 17
    • 44349150012 scopus 로고    scopus 로고
    • Inhibitory B7-family molecules in the tumour microenvironment
    • Zou W, Chen L. Inhibitory B7-family molecules in the tumour microenvironment. Nat Rev Immunol 2008; 8: 467-77.
    • (2008) Nat Rev Immunol , vol.8 , pp. 467-477
    • Zou, W.1    Chen, L.2
  • 18
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002; 8: 793-800.
    • (2002) Nat Med , vol.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3    Tamura, H.4    Hirano, F.5    Flies, D.B.6
  • 19
    • 33645736792 scopus 로고    scopus 로고
    • Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up
    • Thompson RH, Kuntz SM, Leibovich BC, Dong H, Lohse CM, Webster WS, et al. Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up. Cancer Res 2006; 66: 3381-5.
    • (2006) Cancer Res , vol.66 , pp. 3381-3385
    • Thompson, R.H.1    Kuntz, S.M.2    Leibovich, B.C.3    Dong, H.4    Lohse, C.M.5    Webster, W.S.6
  • 20
    • 34250177269 scopus 로고    scopus 로고
    • PD-1 is expressed by tumor-infiltrating immune cells and is associated with poor outcome for patients with renal cell carcinoma
    • Thompson RH, Dong H, Lohse CM, Leibovich BC, Blute ML, Cheville JC, et al. PD-1 is expressed by tumor-infiltrating immune cells and is associated with poor outcome for patients with renal cell carcinoma. Clin Cancer Res 2007; 13: 1757-61.
    • (2007) Clin Cancer Res , vol.13 , pp. 1757-1761
    • Thompson, R.H.1    Dong, H.2    Lohse, C.M.3    Leibovich, B.C.4    Blute, M.L.5    Cheville, J.C.6
  • 21
    • 79953306651 scopus 로고    scopus 로고
    • Identification of a soluble form of B7-H1 that retains immunosuppressive activity and is associated with aggressive renal cell carcinoma
    • Frigola X, Inman BA, Lohse CM, Krco CJ, Cheville JC, Thompson RH, et al. Identification of a soluble form of B7-H1 that retains immunosuppressive activity and is associated with aggressive renal cell carcinoma. Clin Cancer Res 2011; 17: 1915-23.
    • (2011) Clin Cancer Res , vol.17 , pp. 1915-1923
    • Frigola, X.1    Inman, B.A.2    Lohse, C.M.3    Krco, C.J.4    Cheville, J.C.5    Thompson, R.H.6
  • 22
    • 0038273853 scopus 로고    scopus 로고
    • Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
    • Curiel TJ, Wei S, Dong H, Alvarez X, Cheng P, Mottram P, et al. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat Med 2003; 9: 562-7.
    • (2003) Nat Med , vol.9 , pp. 562-567
    • Curiel, T.J.1    Wei, S.2    Dong, H.3    Alvarez, X.4    Cheng, P.5    Mottram, P.6
  • 23
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T, Minato N. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Nat Acad Sci USA 2002; 99: 12293-7.
    • (2002) Proc Nat Acad Sci USA , vol.99 , pp. 12293-12297
    • Iwai, Y.1    Ishida, M.2    Tanaka, Y.3    Okazaki, T.4    Honjo, T.5    Minato, N.6
  • 26
    • 84879601217 scopus 로고    scopus 로고
    • Programmed death 1 pathway inhibition in metastatic renal cell cancer and prostate cancer
    • Tang PA, Heng DY. Programmed death 1 pathway inhibition in metastatic renal cell cancer and prostate cancer. Curr Oncol Reports 2013; 15: 98-104.
    • (2013) Curr Oncol Reports , vol.15 , pp. 98-104
    • Tang, P.A.1    Heng, D.Y.2
  • 29
    • 70350728941 scopus 로고    scopus 로고
    • Cryopreservation decreases receptor PD-1 and ligand PD-L1 coinhibitory expression on peripheral blood mononuclear cell-derived T cells and monocytes
    • Campbell DE, Tustin NB, Riedel E, Tustin R III, Taylor J, Murray J, et al. Cryopreservation decreases receptor PD-1 and ligand PD-L1 coinhibitory expression on peripheral blood mononuclear cell-derived T cells and monocytes. Clin Vac Immunol 2009; 16: 1648-53.
    • (2009) Clin Vac Immunol , vol.16 , pp. 1648-1653
    • Campbell, D.E.1    Tustin, N.B.2    Riedel, E.3    Tustin, R.4    Taylor, J.5    Murray, J.6
  • 30
    • 85043546248 scopus 로고    scopus 로고
    • Evaluation of bone marrow elements by 'immuno'morphologic characteristics
    • O'Malley DP. Evaluation of bone marrow elements by 'immuno'morphologic characteristics. Advance 2002; 14: 1.
    • (2002) Advance , vol.14 , pp. 1
    • O'Malley, D.P.1
  • 31
    • 50949124847 scopus 로고    scopus 로고
    • Human natural killer cells
    • Caligiuri MA Human natural killer cells. Blood 2008; 112: 461-9.
    • (2008) Blood , vol.112 , pp. 461-469
    • Caligiuri, M.A.1
  • 32
    • 79960884563 scopus 로고    scopus 로고
    • The shedding of CD62L (L-selectin) regulates the acquisition of lytic activity in human tumor reactive T lymphocytes
    • Yang S, Liu F, Wang QJ, Rosenberg SA, Morgan RA. The shedding of CD62L (L-selectin) regulates the acquisition of lytic activity in human tumor reactive T lymphocytes. PloS One 2011; 6: e22560.
    • (2011) PloS One , vol.6
    • Yang, S.1    Liu, F.2    Wang, Q.J.3    Rosenberg, S.A.4    Morgan, R.A.5
  • 33
    • 0026700235 scopus 로고
    • Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
    • Ishida Y, Agata Y, Shibahara K, Honjo T. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J 1992; 11: 3887-95.
    • (1992) EMBO J , vol.11 , pp. 3887-3895
    • Ishida, Y.1    Agata, Y.2    Shibahara, K.3    Honjo, T.4
  • 34
    • 0033693309 scopus 로고    scopus 로고
    • CD8(+) T-cell selection, function, and death in the primary immune response in vivo
    • Callan MF, Fazou C, Yang H, Rostron T, Poon K, Hatton C, et al. CD8(+) T-cell selection, function, and death in the primary immune response in vivo. J Clin Invest 2000; 106: 1251-61.
    • (2000) J Clin Invest , vol.106 , pp. 1251-1261
    • Callan, M.F.1    Fazou, C.2    Yang, H.3    Rostron, T.4    Poon, K.5    Hatton, C.6
  • 35
    • 84879215734 scopus 로고    scopus 로고
    • Manipulating the PD-1 pathway to improve immunity
    • Kamphorst AO, Ahmed R. Manipulating the PD-1 pathway to improve immunity. Curr Opin Immunol 2013; 25: 381-8.
    • (2013) Curr Opin Immunol , vol.25 , pp. 381-388
    • Kamphorst, A.O.1    Ahmed, R.2
  • 36
    • 84872514622 scopus 로고    scopus 로고
    • Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody
    • Lipson EJ, Sharfman WH, Drake CG, Wollner I, Taube JM, Anders RA, et al. Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody. Clin Cancer Res 2013; 19: 462-8.
    • (2013) Clin Cancer Res , vol.19 , pp. 462-468
    • Lipson, E.J.1    Sharfman, W.H.2    Drake, C.G.3    Wollner, I.4    Taube, J.M.5    Anders, R.A.6
  • 37
    • 84901605781 scopus 로고    scopus 로고
    • Phase I/II trial of PD-1 antibody nivolumab with peptide vaccine in patients that failed ipilumumab
    • 9011
    • Weber JS Phase I/II trial of PD-1 antibody nivolumab with peptide vaccine in patients that failed ipilumumab. J Clin Oncol 31, 2013 (suppl; abstr 9011).
    • (2013) J Clin Oncol , vol.31
    • Weber, J.S.1
  • 38
    • 1642368175 scopus 로고    scopus 로고
    • Generation of kidney cancer-specific antitumor immune responses using peripheral blood monocytes transduced with a recombinant adenovirus encoding carbonic anhydrase 9
    • Mukouyama H, Janzen NK, Hernandez JM, Lam JS, Caliliw R, Wang AY, et al. Generation of kidney cancer-specific antitumor immune responses using peripheral blood monocytes transduced with a recombinant adenovirus encoding carbonic anhydrase 9. Clin Cancer Res 2004; 10: 1421-9.
    • (2004) Clin Cancer Res , vol.10 , pp. 1421-1429
    • Mukouyama, H.1    Janzen, N.K.2    Hernandez, J.M.3    Lam, J.S.4    Caliliw, R.5    Wang, A.Y.6
  • 39
    • 0142183464 scopus 로고    scopus 로고
    • Large-scale immunomagnetic selection of CD14+ monocytes to generate dendritic cells for cancer immunotherapy: A phase I study
    • Babatz J, Rollig C, Oelschlagel U, Zhao S, Ehninger G, Schmitz M, et al. Large-scale immunomagnetic selection of CD14+ monocytes to generate dendritic cells for cancer immunotherapy: a phase I study. J Hematotherapy Stem Cell Res 2003; 12: 515-23.
    • (2003) J Hematotherapy Stem Cell Res , vol.12 , pp. 515-523
    • Babatz, J.1    Rollig, C.2    Oelschlagel, U.3    Zhao, S.4    Ehninger, G.5    Schmitz, M.6
  • 40
    • 79955451697 scopus 로고    scopus 로고
    • Dendritic cell based tumor vaccination in prostate and renal cell cancer: A systematic review and meta-analysis
    • Draube A, Klein-Gonzalez N, Mattheus S, Brillant C, Hellmich M, Engert A, et al. Dendritic cell based tumor vaccination in prostate and renal cell cancer: a systematic review and meta-analysis. PLoS One 2011; 6: e18801.
    • (2011) PLoS One , vol.6
    • Draube, A.1    Klein-Gonzalez, N.2    Mattheus, S.3    Brillant, C.4    Hellmich, M.5    Engert, A.6
  • 41
    • 79952761607 scopus 로고    scopus 로고
    • Crosstalk between programmed death-1 and suppressor of cytokine signaling-1 in inhibition of IL-12 production by monocytes/macrophages in hepatitis C virus infection
    • Zhang Y, Ma CJ, Ni L, Zhang CL, Wu XY, Kumaraguru U, et al. Crosstalk between programmed death-1 and suppressor of cytokine signaling-1 in inhibition of IL-12 production by monocytes/macrophages in hepatitis C virus infection. J Immunol 2011; 186: 3093-103.
    • (2011) J Immunol , vol.186 , pp. 3093-3103
    • Zhang, Y.1    Ma, C.J.2    Ni, L.3    Zhang, C.L.4    Wu, X.Y.5    Kumaraguru, U.6
  • 42
    • 79251632920 scopus 로고    scopus 로고
    • PD-1 negatively regulates Interleukin-12 expression by limiting STAT-1 phosphorylation in monocytes/macrophages during chronic hepatitis C virus infection
    • Ma CJ, Ni L, Zhang Y, Zhang CL, Wu XY, Atia AN, et al. PD-1 negatively regulates interleukin-12 expression by limiting STAT-1 phosphorylation in monocytes/macrophages during chronic hepatitis C virus infection. Immunology 2011; 132: 421-31.
    • (2011) Immunology , vol.132 , pp. 421-431
    • Ma, C.J.1    Ni, L.2    Zhang, Y.3    Zhang, C.L.4    Wu, X.Y.5    Atia, A.N.6
  • 43
    • 77950525439 scopus 로고    scopus 로고
    • Programmed death-1-induced Interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection
    • Said EA, Dupuy FP, Trautmann L, Zhang Y, Shi Y, El-Far M, et al. Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection. Nat Med 2010; 16: 452-9.
    • (2010) Nat Med , vol.16 , pp. 452-459
    • Said, E.A.1    Dupuy, F.P.2    Trautmann, L.3    Zhang, Y.4    Shi, Y.5    El-Far, M.6
  • 44
    • 84885420620 scopus 로고    scopus 로고
    • Monocyte chemotactic protein-1 and CC chemokine receptor 2 polymorphisms and prognosis of renal cell carcinoma
    • Liu GX, Zhang X, Li S, Koiiche RD, Sindsceii JH, Song H. Monocyte chemotactic protein-1 and CC chemokine receptor 2 polymorphisms and prognosis of renal cell carcinoma. Tumour Biol 2013; 34: 2741-6.
    • (2013) Tumour Biol , vol.34 , pp. 2741-2746
    • Liu, G.X.1    Zhang, X.2    Li, S.3    Koiiche, R.D.4    Sindsceii, J.H.5    Song, H.6
  • 45
    • 84886945385 scopus 로고    scopus 로고
    • Tumor-associated macrophages subvert T-cell function and correlate with reduced survival in clear cell renal cell carcinoma
    • Dannenmann SR, Thielicke J, Stockli M, Matter C, von Boehmer L, Cecconi V, et al. Tumor-associated macrophages subvert T-cell function and correlate with reduced survival in clear cell renal cell carcinoma. Oncoimmunology 2013; 2: e23562.
    • (2013) Oncoimmunology , vol.2
    • Dannenmann, S.R.1    Thielicke, J.2    Stockli, M.3    Matter, C.4    Von Boehmer, L.5    Cecconi, V.6
  • 46
    • 84880936480 scopus 로고    scopus 로고
    • Single-dose cyclophosphamide synergizes with immune responses to the renal cell cancer vaccine IMA901
    • Walter S, Weinschenk T, Reinhardt C, Singh-Jasuja H. Single-dose cyclophosphamide synergizes with immune responses to the renal cell cancer vaccine IMA901. Oncoimmunology 2013; 2: e22246.
    • (2013) Oncoimmunology , vol.2
    • Walter, S.1    Weinschenk, T.2    Reinhardt, C.3    Singh-Jasuja, H.4
  • 48
    • 84875241223 scopus 로고    scopus 로고
    • Increased PD-1 expression on CD4+ and CD8+ T cells is involved in immune evasion in gastric cancer
    • Saito H, Kuroda H, Matsunaga T, Osaki T, Ikeguchi M. Increased PD-1 expression on CD4+ and CD8+ T cells is involved in immune evasion in gastric cancer. J Surg Oncol 2013; 107: 517-22.
    • (2013) J Surg Oncol , vol.107 , pp. 517-522
    • Saito, H.1    Kuroda, H.2    Matsunaga, T.3    Osaki, T.4    Ikeguchi, M.5
  • 49
    • 77957701558 scopus 로고    scopus 로고
    • The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: A therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody
    • Benson DM Jr, Bakan CE, Mishra A, Hofmeister CC, Efebera Y, Becknell B, et al. The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody. Blood 2010; 116: 2286-94.
    • (2010) Blood , vol.116 , pp. 2286-2294
    • Benson, D.M.1    Bakan, C.E.2    Mishra, A.3    Hofmeister, C.C.4    Efebera, Y.5    Becknell, B.6
  • 50
    • 66149123225 scopus 로고    scopus 로고
    • Impact of epitope escape on PD-1 expression and CD8 t-cell exhaustion during chronic infection
    • Blattman JN, Wherry EJ, Ha SJ. van der Most RG, Ahmed R. Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection. J Virol 2009; 83: 4386-94.
    • (2009) J Virol , vol.83 , pp. 4386-4394
    • Blattman, J.N.1    Wherry, E.J.2    Ha, S.J.3    Van Der Most, R.G.4    Ahmed, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.