Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer

OncoImmunology

Volumn 5, Issue 4, 2016, Pages

  Berchem, Guy ^a,b   Noman, Muhammad Zaeem ^a   Bosseler, Manon ^b   Paggetti, Jerome ^b   Baconnais, Sonia ^c   Le cam, Eric ^c   Nanbakhsh, Arash ^a   Moussay, Etienne ^b   Mami Chouaib, Fathia ^a   Janji, Bassam ^b   Chouaib, Salem ^a  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b LUXEMBOURG INSTITUTE OF HEALTH   (Luxembourg)

^c UMR 8126   (France)

Author keywords

Hypoxia; LAMP 1; microvesicles; miR 23a; natural killer cells; NKG2D; TGF

Indexed keywords

MICRORNA; MICRORNA 23A; NATURAL KILLER CELL RECEPTOR NKG2D; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ARTICLE; CELL FUNCTION; CONTROLLED STUDY; CYTOTOXICITY ASSAY; FLOW CYTOMETRY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HYPOXIA; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; LUCIFERASE ASSAY; MEMBRANE MICROPARTICLE; METASTASIS; NATURAL KILLER CELL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; TRANSMISSION ELECTRON MICROSCOPY; TUMOR INVASION; TUMOR MICROENVIRONMENT;

EID: 84962861045     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.1080/2162402X.2015.1062968     Document Type: Article

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