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Volumn 428, Issue 2, 2017, Pages 273-282

Wnt/β-catenin signaling in adult mammalian epithelial stem cells

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; WNT PROTEIN;

EID: 85019612996     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2017.05.015     Document Type: Review
Times cited : (123)

References (156)
  • 1
    • 84994097063 scopus 로고    scopus 로고
    • β-catenin-independent roles of Wnt/LRP6 signaling
    • Acebron, S.P., Niehrs, C., β-catenin-independent roles of Wnt/LRP6 signaling. Trends Cell Biol. 26 (2016), 956–967.
    • (2016) Trends Cell Biol. , vol.26 , pp. 956-967
    • Acebron, S.P.1    Niehrs, C.2
  • 2
    • 77956564468 scopus 로고    scopus 로고
    • Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning
    • Ahn, Y., Sanderson, B.W., Klein, O.D., Krumlauf, R., Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning. Development 137 (2010), 3221–3231.
    • (2010) Development , vol.137 , pp. 3221-3231
    • Ahn, Y.1    Sanderson, B.W.2    Klein, O.D.3    Krumlauf, R.4
  • 3
    • 77953697794 scopus 로고    scopus 로고
    • Differential sensitivity of epidermal cell subpopulations to beta-catenin-induced ectopic hair follicle formation
    • Baker, C.M., Verstuyf, A., Jensen, K.B., Watt, F.M., Differential sensitivity of epidermal cell subpopulations to beta-catenin-induced ectopic hair follicle formation. Dev. Biol. 343 (2010), 40–50.
    • (2010) Dev. Biol. , vol.343 , pp. 40-50
    • Baker, C.M.1    Verstuyf, A.2    Jensen, K.B.3    Watt, F.M.4
  • 8
    • 85029781099 scopus 로고    scopus 로고
    • Induced quiescence of Lgr5+ stem cells in intestinal organoids enables differentiation of hormone-producing enteroendocrine cells
    • Basak, O., Beumer, J., Wiebrands, K., Seno, H., van Oudenaarden, A., Clevers, H., Induced quiescence of Lgr5+ stem cells in intestinal organoids enables differentiation of hormone-producing enteroendocrine cells. Cell Stem Cell, 2016.
    • (2016) Cell Stem Cell
    • Basak, O.1    Beumer, J.2    Wiebrands, K.3    Seno, H.4    van Oudenaarden, A.5    Clevers, H.6
  • 10
    • 84896102205 scopus 로고    scopus 로고
    • Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea
    • Bramhall, N.F., Shi, F., Arnold, K., Hochedlinger, K., Edge, A.S., Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea. Stem Cell Rep. 2 (2014), 311–322.
    • (2014) Stem Cell Rep. , vol.2 , pp. 311-322
    • Bramhall, N.F.1    Shi, F.2    Arnold, K.3    Hochedlinger, K.4    Edge, A.S.5
  • 11
    • 0242460440 scopus 로고    scopus 로고
    • Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis
    • Braun, K.M., Niemann, C., Jensen, U.B., Sundberg, J.P., Silva-Vargas, V., Watt, F.M., Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis. Development 130 (2003), 5241–5255.
    • (2003) Development , vol.130 , pp. 5241-5255
    • Braun, K.M.1    Niemann, C.2    Jensen, U.B.3    Sundberg, J.P.4    Silva-Vargas, V.5    Watt, F.M.6
  • 14
    • 0032953231 scopus 로고    scopus 로고
    • A common human skin tumour is caused by activating mutations in beta-catenin
    • Chan, E.F., Gat, U., McNiff, J.M., Fuchs, E., A common human skin tumour is caused by activating mutations in beta-catenin. Nat. Genet 21 (1999), 410–413.
    • (1999) Nat. Genet , vol.21 , pp. 410-413
    • Chan, E.F.1    Gat, U.2    McNiff, J.M.3    Fuchs, E.4
  • 15
    • 0016358918 scopus 로고
    • Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell
    • Cheng, H., Leblond, C.P., Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell. Am. J. Anat. 141 (1974), 461–479.
    • (1974) Am. J. Anat. , vol.141 , pp. 461-479
    • Cheng, H.1    Leblond, C.P.2
  • 16
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling and disease
    • Clevers, H., Nusse, R., Wnt/beta-catenin signaling and disease. Cell 149 (2012), 1192–1205.
    • (2012) Cell , vol.149 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 17
    • 0025313294 scopus 로고
    • Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis
    • Cotsarelis, G., Sun, T.T., Lavker, R.M., Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 61 (1990), 1329–1337.
    • (1990) Cell , vol.61 , pp. 1329-1337
    • Cotsarelis, G.1    Sun, T.T.2    Lavker, R.M.3
  • 20
    • 84896988913 scopus 로고    scopus 로고
    • Beta-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche
    • Deschene, E.R., Myung, P., Rompolas, P., Zito, G., Sun, T.Y., Taketo, M.M., Saotome, I., Greco, V., Beta-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche. Science 343 (2014), 1353–1356.
    • (2014) Science , vol.343 , pp. 1353-1356
    • Deschene, E.R.1    Myung, P.2    Rompolas, P.3    Zito, G.4    Sun, T.Y.5    Taketo, M.M.6    Saotome, I.7    Greco, V.8
  • 21
    • 69049087793 scopus 로고    scopus 로고
    • Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis
    • Driskell, R.R., Giangreco, A., Jensen, K.B., Mulder, K.W., Watt, F.M., Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis. Development 136 (2009), 2815–2823.
    • (2009) Development , vol.136 , pp. 2815-2823
    • Driskell, R.R.1    Giangreco, A.2    Jensen, K.B.3    Mulder, K.W.4    Watt, F.M.5
  • 23
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon, E.R., Vogelstein, B., A genetic model for colorectal tumorigenesis. Cell 61 (1990), 759–767.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 24
    • 35648969554 scopus 로고    scopus 로고
    • Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells
    • Fevr, T., Robine, S., Louvard, D., Huelsken, J., Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells. Mol. Cell Biol. 27 (2007), 7551–7559.
    • (2007) Mol. Cell Biol. , vol.27 , pp. 7551-7559
    • Fevr, T.1    Robine, S.2    Louvard, D.3    Huelsken, J.4
  • 28
    • 0032567078 scopus 로고    scopus 로고
    • De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin
    • Gat, U., DasGupta, R., Degenstein, L., Fuchs, E., De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell 95 (1998), 605–614.
    • (1998) Cell , vol.95 , pp. 605-614
    • Gat, U.1    DasGupta, R.2    Degenstein, L.3    Fuchs, E.4
  • 30
    • 0032556910 scopus 로고    scopus 로고
    • Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
    • Glinka, A., Wu, W., Delius, H., Monaghan, A.P., Blumenstock, C., Niehrs, C., Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 391 (1998), 357–362.
    • (1998) Nature , vol.391 , pp. 357-362
    • Glinka, A.1    Wu, W.2    Delius, H.3    Monaghan, A.P.4    Blumenstock, C.5    Niehrs, C.6
  • 31
    • 71149092489 scopus 로고    scopus 로고
    • Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling
    • Goentoro, L., Kirschner, M.W., Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling. Mol. Cell 36 (2009), 872–884.
    • (2009) Mol. Cell , vol.36 , pp. 872-884
    • Goentoro, L.1    Kirschner, M.W.2
  • 38
    • 0028572556 scopus 로고
    • E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
    • Huelsken, J., Birchmeier, W., Behrens, J., E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J. Cell Biol. 127 (1994), 2061–2069.
    • (1994) J. Cell Biol. , vol.127 , pp. 2061-2069
    • Huelsken, J.1    Birchmeier, W.2    Behrens, J.3
  • 39
    • 0035907041 scopus 로고    scopus 로고
    • beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin
    • Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., Birchmeier, W., beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 105 (2001), 533–545.
    • (2001) Cell , vol.105 , pp. 533-545
    • Huelsken, J.1    Vogel, R.2    Erdmann, B.3    Cotsarelis, G.4    Birchmeier, W.5
  • 41
    • 0021224749 scopus 로고
    • Induction of hair growth by implantation of cultured dermal papilla cells
    • Jahoda, C.A., Horne, K.A., Oliver, R.F., Induction of hair growth by implantation of cultured dermal papilla cells. Nature 311 (1984), 560–562.
    • (1984) Nature , vol.311 , pp. 560-562
    • Jahoda, C.A.1    Horne, K.A.2    Oliver, R.F.3
  • 45
    • 70349838225 scopus 로고    scopus 로고
    • TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling
    • Junge, H.J., Yang, S., Burton, J.B., Paes, K., Shu, X., French, D.M., Costa, M., Rice, D.S., Ye, W., TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling. Cell 139 (2009), 299–311.
    • (2009) Cell , vol.139 , pp. 299-311
    • Junge, H.J.1    Yang, S.2    Burton, J.B.3    Paes, K.4    Shu, X.5    French, D.M.6    Costa, M.7    Rice, D.S.8    Ye, W.9
  • 46
    • 5044244757 scopus 로고    scopus 로고
    • R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis
    • Kazanskaya, O., Glinka, A., del Barco Barrantes, I., Stannek, P., Niehrs, C., Wu, W., R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. Dev. Cell 7 (2004), 525–534.
    • (2004) Dev. Cell , vol.7 , pp. 525-534
    • Kazanskaya, O.1    Glinka, A.2    del Barco Barrantes, I.3    Stannek, P.4    Niehrs, C.5    Wu, W.6
  • 47
    • 0034657419 scopus 로고    scopus 로고
    • Wnt signaling maintains the hair-inducing activity of the dermal papilla
    • Kishimoto, J., Burgeson, R.E., Morgan, B.A., Wnt signaling maintains the hair-inducing activity of the dermal papilla. Genes Dev. 14 (2000), 1181–1185.
    • (2000) Genes Dev. , vol.14 , pp. 1181-1185
    • Kishimoto, J.1    Burgeson, R.E.2    Morgan, B.A.3
  • 50
    • 0031848068 scopus 로고    scopus 로고
    • Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
    • Korinek, V., Barker, N., Moerer, P., van Donselaar, E., Huls, G., Peters, P.J., Clevers, H., Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat. Genet. 19 (1998), 379–383.
    • (1998) Nat. Genet. , vol.19 , pp. 379-383
    • Korinek, V.1    Barker, N.2    Moerer, P.3    van Donselaar, E.4    Huls, G.5    Peters, P.J.6    Clevers, H.7
  • 53
    • 84991781082 scopus 로고    scopus 로고
    • Organoids: modeling development and the stem cell niche in a dish
    • Kretzschmar, K., Clevers, H., Organoids: modeling development and the stem cell niche in a dish. Dev. Cell 38 (2016), 590–600.
    • (2016) Dev. Cell , vol.38 , pp. 590-600
    • Kretzschmar, K.1    Clevers, H.2
  • 54
    • 84947027848 scopus 로고    scopus 로고
    • The androgen receptor antagonizes Wnt/beta-catenin signaling in epidermal stem cells
    • Kretzschmar, K., Cottle, D.L., Schweiger, P.J., Watt, F.M., The androgen receptor antagonizes Wnt/beta-catenin signaling in epidermal stem cells. J. Invest. Dermatol. 135 (2015), 2753–2763.
    • (2015) J. Invest. Dermatol. , vol.135 , pp. 2753-2763
    • Kretzschmar, K.1    Cottle, D.L.2    Schweiger, P.J.3    Watt, F.M.4
  • 55
    • 84908019448 scopus 로고    scopus 로고
    • Markers of epidermal stem cell subpopulations in adult mammalian skin
    • Kretzschmar, K., Watt, F.M., Markers of epidermal stem cell subpopulations in adult mammalian skin. Cold Spring Harb. Perspect. Med., 2014, 4.
    • (2014) Cold Spring Harb. Perspect. Med. , pp. 4
    • Kretzschmar, K.1    Watt, F.M.2
  • 56
    • 84955415508 scopus 로고    scopus 로고
    • Compartmentalized epidermal activation of beta-Catenin differentially affects lineage reprogramming and underlies tumor heterogeneity
    • Kretzschmar, K., Weber, C., Driskell, R.R., Calonje, E., Watt, F.M., Compartmentalized epidermal activation of beta-Catenin differentially affects lineage reprogramming and underlies tumor heterogeneity. Cell Rep. 14 (2016), 269–281.
    • (2016) Cell Rep. , vol.14 , pp. 269-281
    • Kretzschmar, K.1    Weber, C.2    Driskell, R.R.3    Calonje, E.4    Watt, F.M.5
  • 57
    • 0346458662 scopus 로고    scopus 로고
    • Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1
    • Kuhnert, F., Davis, C.R., Wang, H.T., Chu, P., Lee, M., Yuan, J., Nusse, R., Kuo, C.J., Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc. Natl. Acad. Sci. USA 101 (2004), 266–271.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 266-271
    • Kuhnert, F.1    Davis, C.R.2    Wang, H.T.3    Chu, P.4    Lee, M.5    Yuan, J.6    Nusse, R.7    Kuo, C.J.8
  • 59
    • 84945580377 scopus 로고    scopus 로고
    • Lgr6 marks nail stem cells and is required for digit tip regeneration
    • Lehoczky, J.A., Tabin, C.J., Lgr6 marks nail stem cells and is required for digit tip regeneration. Proc. Natl. Acad. Sci. USA 112 (2015), 13249–13254.
    • (2015) Proc. Natl. Acad. Sci. USA , vol.112 , pp. 13249-13254
    • Lehoczky, J.A.1    Tabin, C.J.2
  • 60
    • 0030933978 scopus 로고    scopus 로고
    • Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer
    • Leyns, L., Bouwmeester, T., Kim, S.H., Piccolo, S., De Robertis, E.M., Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Cell 88 (1997), 747–756.
    • (1997) Cell , vol.88 , pp. 747-756
    • Leyns, L.1    Bouwmeester, T.2    Kim, S.H.3    Piccolo, S.4    De Robertis, E.M.5
  • 61
    • 84922542256 scopus 로고    scopus 로고
    • Single-cell analysis of proxy reporter allele-marked epithelial cells establishes intestinal stem cell hierarchy
    • Li, N., Yousefi, M., Nakauka-Ddamba, A., Jain, R., Tobias, J., Epstein, J.A., Jensen, S.T., Lengner, C.J., Single-cell analysis of proxy reporter allele-marked epithelial cells establishes intestinal stem cell hierarchy. Stem Cell Rep. 3 (2014), 876–891.
    • (2014) Stem Cell Rep. , vol.3 , pp. 876-891
    • Li, N.1    Yousefi, M.2    Nakauka-Ddamba, A.3    Jain, R.4    Tobias, J.5    Epstein, J.A.6    Jensen, S.T.7    Lengner, C.J.8
  • 63
    • 44649146885 scopus 로고
    • Dissertatio de fabrica et actione villorum intestinorum tenuium hominis, Leiden
    • Lieberkühn, J.N., 1745. Dissertatio de fabrica et actione villorum intestinorum tenuium hominis, Leiden.
    • (1745)
    • Lieberkühn, J.N.1
  • 65
    • 84962304175 scopus 로고    scopus 로고
    • Axin2 marks quiescent hair follicle bulge stem cells that are maintained by autocrine Wnt/beta-catenin signaling
    • Lim, X., Tan, S.H., Yu, K.L., Lim, S.B., Nusse, R., Axin2 marks quiescent hair follicle bulge stem cells that are maintained by autocrine Wnt/beta-catenin signaling. Proc. Natl. Acad. Sci. USA 113 (2016), E1498–E1505.
    • (2016) Proc. Natl. Acad. Sci. USA , vol.113 , pp. E1498-E1505
    • Lim, X.1    Tan, S.H.2    Yu, K.L.3    Lim, S.B.4    Nusse, R.5
  • 67
    • 2342427631 scopus 로고    scopus 로고
    • Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours
    • Lo Celso, C., Prowse, D.M., Watt, F.M., Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours. Development 131 (2004), 1787–1799.
    • (2004) Development , vol.131 , pp. 1787-1799
    • Lo Celso, C.1    Prowse, D.M.2    Watt, F.M.3
  • 68
    • 77958485383 scopus 로고    scopus 로고
    • Intestinal stem cell replacement follows a pattern of neutral drift
    • Lopez-Garcia, C., Klein, A.M., Simons, B.D., Winton, D.J, Intestinal stem cell replacement follows a pattern of neutral drift. Science 330 (2010), 822–825.
    • (2010) Science , vol.330 , pp. 822-825
    • Lopez-Garcia, C.1    Klein, A.M.2    Simons, B.D.3    D.J, W.4
  • 70
    • 0035902050 scopus 로고    scopus 로고
    • LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
    • Mao, B., Wu, W., Li, Y., Hoppe, D., Stannek, P., Glinka, A., Niehrs, C., LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411 (2001), 321–325.
    • (2001) Nature , vol.411 , pp. 321-325
    • Mao, B.1    Wu, W.2    Li, Y.3    Hoppe, D.4    Stannek, P.5    Glinka, A.6    Niehrs, C.7
  • 71
    • 85002202350 scopus 로고    scopus 로고
    • Distinct capacity for differentiation to inner ear cell types by progenitor cells of the cochlea and vestibular organs
    • McLean, W.J., McLean, D.T., Eatock, R.A., Edge, A.S., Distinct capacity for differentiation to inner ear cell types by progenitor cells of the cochlea and vestibular organs. Development 143 (2016), 4381–4393.
    • (2016) Development , vol.143 , pp. 4381-4393
    • McLean, W.J.1    McLean, D.T.2    Eatock, R.A.3    Edge, A.S.4
  • 72
    • 0035395874 scopus 로고    scopus 로고
    • Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin
    • Merrill, B.J., Gat, U., DasGupta, R., Fuchs, E., Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin. Genes Dev. 15 (2001), 1688–1705.
    • (2001) Genes Dev. , vol.15 , pp. 1688-1705
    • Merrill, B.J.1    Gat, U.2    DasGupta, R.3    Fuchs, E.4
  • 75
    • 0030949463 scopus 로고    scopus 로고
    • Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    • Morin, P.J., Sparks, A.B., Korinek, V., Barker, N., Clevers, H., Vogelstein, B., Kinzler, K.W., Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275 (1997), 1787–1790.
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3    Barker, N.4    Clevers, H.5    Vogelstein, B.6    Kinzler, K.W.7
  • 78
    • 0036023356 scopus 로고    scopus 로고
    • Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours
    • Niemann, C., Owens, D.M., Hulsken, J., Birchmeier, W., Watt, F.M., Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours. Development 129 (2002), 95–109.
    • (2002) Development , vol.129 , pp. 95-109
    • Niemann, C.1    Owens, D.M.2    Hulsken, J.3    Birchmeier, W.4    Watt, F.M.5
  • 79
    • 0141483068 scopus 로고    scopus 로고
    • Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis
    • Niemann, C., Unden, A.B., Lyle, S., Zouboulis Ch, C., Toftgard, R., Watt, F.M., Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis. Proc. Natl. Acad. Sci. USA 100:Suppl 1 (2003), 11873–11880.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 11873-11880
    • Niemann, C.1    Unden, A.B.2    Lyle, S.3    Zouboulis Ch, C.4    Toftgard, R.5    Watt, F.M.6
  • 80
    • 0020216124 scopus 로고
    • Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
    • Nusse, R., Varmus, H.E., Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 31 (1982), 99–109.
    • (1982) Cell , vol.31 , pp. 99-109
    • Nusse, R.1    Varmus, H.E.2
  • 81
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • Nüsslein-Volhard, C., Wieschaus, E., Mutations affecting segment number and polarity in Drosophila. Nature 287 (1980), 795–801.
    • (1980) Nature , vol.287 , pp. 795-801
    • Nüsslein-Volhard, C.1    Wieschaus, E.2
  • 83
    • 0024451982 scopus 로고
    • The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species
    • Ozawa, M., Baribault, H., Kemler, R., The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 8 (1989), 1711–1717.
    • (1989) EMBO J. , vol.8 , pp. 1711-1717
    • Ozawa, M.1    Baribault, H.2    Kemler, R.3
  • 84
    • 84885184673 scopus 로고    scopus 로고
    • The epidermis comprises autonomous compartments maintained by distinct stem cell populations
    • Page, M.E., Lombard, P., Ng, F., Gottgens, B., Jensen, K.B., The epidermis comprises autonomous compartments maintained by distinct stem cell populations. Cell Stem Cell 13 (2013), 471–482.
    • (2013) Cell Stem Cell , vol.13 , pp. 471-482
    • Page, M.E.1    Lombard, P.2    Ng, F.3    Gottgens, B.4    Jensen, K.B.5
  • 85
    • 44649160789 scopus 로고    scopus 로고
    • The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis
    • Palmer, H.G., Anjos-Afonso, F., Carmeliet, G., Takeda, H., Watt, F.M., The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis. PLoS One, 3, 2008, e1483.
    • (2008) PLoS One , vol.3 , pp. e1483
    • Palmer, H.G.1    Anjos-Afonso, F.2    Carmeliet, G.3    Takeda, H.4    Watt, F.M.5
  • 86
    • 2042495252 scopus 로고
    • Ueber die secernirenden Zellen des Dünndarm-Epithels
    • Paneth, J., Ueber die secernirenden Zellen des Dünndarm-Epithels. Arch. für Mikrosk. Anat. 31 (1887), 113–192.
    • (1887) Arch. für Mikrosk. Anat. , vol.31 , pp. 113-192
    • Paneth, J.1
  • 88
    • 0034727078 scopus 로고    scopus 로고
    • An LDL-receptor-related protein mediates Wnt signalling in mice
    • Pinson, K.I., Brennan, J., Monkley, S., Avery, B.J., Skarnes, W.C., An LDL-receptor-related protein mediates Wnt signalling in mice. Nature 407 (2000), 535–538.
    • (2000) Nature , vol.407 , pp. 535-538
    • Pinson, K.I.1    Brennan, J.2    Monkley, S.3    Avery, B.J.4    Skarnes, W.C.5
  • 89
    • 0037829660 scopus 로고    scopus 로고
    • Canonical Wnt signals are essential for homeostasis of the intestinal epithelium
    • Pinto, D., Gregorieff, A., Begthel, H., Clevers, H., Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev. 17 (2003), 1709–1713.
    • (2003) Genes Dev. , vol.17 , pp. 1709-1713
    • Pinto, D.1    Gregorieff, A.2    Begthel, H.3    Clevers, H.4
  • 92
    • 0018034237 scopus 로고
    • The segregation of DNA in epithelial stem cells
    • Potten, C.S., Hume, W.J., Reid, P., Cairns, J., The segregation of DNA in epithelial stem cells. Cell 15 (1978), 899–906.
    • (1978) Cell , vol.15 , pp. 899-906
    • Potten, C.S.1    Hume, W.J.2    Reid, P.3    Cairns, J.4
  • 95
    • 0023653232 scopus 로고
    • The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless
    • Rijsewijk, F., Schuermann, M., Wagenaar, E., Parren, P., Weigel, D., Nusse, R., The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. Cell 50 (1987), 649–657.
    • (1987) Cell , vol.50 , pp. 649-657
    • Rijsewijk, F.1    Schuermann, M.2    Wagenaar, E.3    Parren, P.4    Weigel, D.5    Nusse, R.6
  • 97
    • 84894267586 scopus 로고    scopus 로고
    • In situ identification of bipotent stem cells in the mammary gland
    • Rios, A.C., Fu, N.Y., Lindeman, G.J., Visvader, J.E., In situ identification of bipotent stem cells in the mammary gland. Nature 506 (2014), 322–327.
    • (2014) Nature , vol.506 , pp. 322-327
    • Rios, A.C.1    Fu, N.Y.2    Lindeman, G.J.3    Visvader, J.E.4
  • 99
    • 84864280567 scopus 로고    scopus 로고
    • Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration
    • Rompolas, P., Deschene, E.R., Zito, G., Gonzalez, D.G., Saotome, I., Haberman, A.M., Greco, V., Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration. Nature 487 (2012), 496–499.
    • (2012) Nature , vol.487 , pp. 496-499
    • Rompolas, P.1    Deschene, E.R.2    Zito, G.3    Gonzalez, D.G.4    Saotome, I.5    Haberman, A.M.6    Greco, V.7
  • 101
    • 0029664368 scopus 로고    scopus 로고
    • Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
    • Rubinfeld, B., Albert, I., Porfiri, E., Fiol, C., Munemitsu, S., Polakis, P., Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 272 (1996), 1023–1026.
    • (1996) Science , vol.272 , pp. 1023-1026
    • Rubinfeld, B.1    Albert, I.2    Porfiri, E.3    Fiol, C.4    Munemitsu, S.5    Polakis, P.6
  • 104
    • 46249128798 scopus 로고    scopus 로고
    • Bmi1 is expressed in vivo in intestinal stem cells
    • Sangiorgi, E., Capecchi, M.R., Bmi1 is expressed in vivo in intestinal stem cells. Nat. Genet. 40 (2008), 915–920.
    • (2008) Nat. Genet. , vol.40 , pp. 915-920
    • Sangiorgi, E.1    Capecchi, M.R.2
  • 108
    • 84896596045 scopus 로고    scopus 로고
    • Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF
    • Schuijers, J., Mokry, M., Hatzis, P., Cuppen, E., Clevers, H., Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF. EMBO J. 33 (2014), 146–156.
    • (2014) EMBO J. , vol.33 , pp. 146-156
    • Schuijers, J.1    Mokry, M.2    Hatzis, P.3    Cuppen, E.4    Clevers, H.5
  • 109
    • 22844445934 scopus 로고    scopus 로고
    • SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
    • Semenov, M., Tamai, K., He, X., SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. J. Biol. Chem. 280 (2005), 26770–26775.
    • (2005) J. Biol. Chem. , vol.280 , pp. 26770-26775
    • Semenov, M.1    Tamai, K.2    He, X.3
  • 111
    • 84863660179 scopus 로고    scopus 로고
    • Wnt-responsive Lgr5-expressing stem cells are hair cell progenitors in the cochlea
    • Shi, F., Kempfle, J.S., Edge, A.S., Wnt-responsive Lgr5-expressing stem cells are hair cell progenitors in the cochlea. J. Neurosci. 32 (2012), 9639–9648.
    • (2012) J. Neurosci. , vol.32 , pp. 9639-9648
    • Shi, F.1    Kempfle, J.S.2    Edge, A.S.3
  • 113
    • 21344436821 scopus 로고    scopus 로고
    • Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells
    • Silva-Vargas, V., Lo Celso, C., Giangreco, A., Ofstad, T., Prowse, D.M., Braun, K.M., Watt, F.M., Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells. Dev. Cell 9 (2005), 121–131.
    • (2005) Dev. Cell , vol.9 , pp. 121-131
    • Silva-Vargas, V.1    Lo Celso, C.2    Giangreco, A.3    Ofstad, T.4    Prowse, D.M.5    Braun, K.M.6    Watt, F.M.7
  • 117
    • 0027756014 scopus 로고
    • Association of the APC tumor suppressor protein with catenins
    • Su, L.K., Vogelstein, B., Kinzler, K.W., Association of the APC tumor suppressor protein with catenins. Science 262 (1993), 1734–1737.
    • (1993) Science , vol.262 , pp. 1734-1737
    • Su, L.K.1    Vogelstein, B.2    Kinzler, K.W.3
  • 119
    • 83255193921 scopus 로고    scopus 로고
    • Interconversion between intestinal stem cell populations in distinct niches
    • Takeda, N., Jain, R., LeBoeuf, M.R., Wang, Q., Lu, M.M., Epstein, J.A., Interconversion between intestinal stem cell populations in distinct niches. Science 334 (2011), 1420–1424.
    • (2011) Science , vol.334 , pp. 1420-1424
    • Takeda, N.1    Jain, R.2    LeBoeuf, M.R.3    Wang, Q.4    Lu, M.M.5    Epstein, J.A.6
  • 120
    • 84879150349 scopus 로고    scopus 로고
    • Lgr5 identifies progenitor cells capable of taste bud regeneration after injury
    • Takeda, N., Jain, R., Li, D., Li, L., Lu, M.M., Epstein, J.A., Lgr5 identifies progenitor cells capable of taste bud regeneration after injury. PLoS One, 8, 2013, e66314.
    • (2013) PLoS One , vol.8 , pp. e66314
    • Takeda, N.1    Jain, R.2    Li, D.3    Li, L.4    Lu, M.M.5    Epstein, J.A.6
  • 123
    • 84921629064 scopus 로고    scopus 로고
    • Plasticity within stem cell hierarchies in mammalian epithelia
    • Tetteh, P.W., Farin, H.F., Clevers, H., Plasticity within stem cell hierarchies in mammalian epithelia. Trends Cell Biol. 25 (2015), 100–108.
    • (2015) Trends Cell Biol. , vol.25 , pp. 100-108
    • Tetteh, P.W.1    Farin, H.F.2    Clevers, H.3
  • 125
    • 80054041585 scopus 로고    scopus 로고
    • A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
    • Tian, H., Biehs, B., Warming, S., Leong, K.G., Rangell, L., Klein, O.D., de Sauvage, F.J., A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature 478 (2011), 255–259.
    • (2011) Nature , vol.478 , pp. 255-259
    • Tian, H.1    Biehs, B.2    Warming, S.3    Leong, K.G.4    Rangell, L.5    Klein, O.D.6    de Sauvage, F.J.7
  • 128
    • 84866114887 scopus 로고    scopus 로고
    • Developmental stage and time dictate the fate of Wnt/beta-catenin-responsive stem cells in the mammary gland
    • van Amerongen, R., Bowman, A.N., Nusse, R., Developmental stage and time dictate the fate of Wnt/beta-catenin-responsive stem cells in the mammary gland. Cell Stem Cell 11 (2012), 387–400.
    • (2012) Cell Stem Cell , vol.11 , pp. 387-400
    • van Amerongen, R.1    Bowman, A.N.2    Nusse, R.3
  • 129
    • 0030067337 scopus 로고    scopus 로고
    • Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties
    • Van de Wetering, M., Castrop, J., Korinek, V., Clevers, H., Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties. Mol. Cell Biol. 16 (1996), 745–752.
    • (1996) Mol. Cell Biol. , vol.16 , pp. 745-752
    • Van de Wetering, M.1    Castrop, J.2    Korinek, V.3    Clevers, H.4
  • 131
    • 0026019629 scopus 로고
    • Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box
    • van de Wetering, M., Oosterwegel, M., Dooijes, D., Clevers, H., Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box. EMBO J. 10 (1991), 123–132.
    • (1991) EMBO J. , vol.10 , pp. 123-132
    • van de Wetering, M.1    Oosterwegel, M.2    Dooijes, D.3    Clevers, H.4
  • 136
    • 0027945654 scopus 로고
    • Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice
    • van Genderen, C., Okamura, R.M., Farinas, I., Quo, R.G., Parslow, T.G., Bruhn, L., Grosschedl, R., Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev. 8 (1994), 2691–2703.
    • (1994) Genes Dev. , vol.8 , pp. 2691-2703
    • van Genderen, C.1    Okamura, R.M.2    Farinas, I.3    Quo, R.G.4    Parslow, T.G.5    Bruhn, L.6    Grosschedl, R.7
  • 139
    • 84868149453 scopus 로고    scopus 로고
    • Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/beta-catenin target gene expression
    • Wallmen, B., Schrempp, M., Hecht, A., Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/beta-catenin target gene expression. Nucleic Acids Res. 40 (2012), 9455–9469.
    • (2012) Nucleic Acids Res. , vol.40 , pp. 9455-9469
    • Wallmen, B.1    Schrempp, M.2    Hecht, A.3
  • 140
    • 84939490816 scopus 로고    scopus 로고
    • Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver
    • Wang, B., Zhao, L., Fish, M., Logan, C.Y., Nusse, R., Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver. Nature 524 (2015), 180–185.
    • (2015) Nature , vol.524 , pp. 180-185
    • Wang, B.1    Zhao, L.2    Fish, M.3    Logan, C.Y.4    Nusse, R.5
  • 142
    • 78651467232 scopus 로고    scopus 로고
    • Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice
    • Wang, G.Y., Wang, J., Mancianti, M.L., Epstein, E.H. Jr., Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice. Cancer Cell 19 (2011), 114–124.
    • (2011) Cancer Cell , vol.19 , pp. 114-124
    • Wang, G.Y.1    Wang, J.2    Mancianti, M.L.3    Epstein, E.H.4
  • 143
    • 0030892061 scopus 로고    scopus 로고
    • Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8
    • Wang, S., Krinks, M., Lin, K., Luyten, F.P., Moos, M. Jr., Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8. Cell 88 (1997), 757–766.
    • (1997) Cell , vol.88 , pp. 757-766
    • Wang, S.1    Krinks, M.2    Lin, K.3    Luyten, F.P.4    Moos, M.5
  • 144
    • 68549127162 scopus 로고    scopus 로고
    • Role of beta-catenin in epidermal stem cell expansion, lineage selection, and cancer
    • Watt, F.M., Collins, C.A., Role of beta-catenin in epidermal stem cell expansion, lineage selection, and cancer. Cold Spring Harb. Symp. Quant. Biol. 73 (2008), 503–512.
    • (2008) Cold Spring Harb. Symp. Quant. Biol. , vol.73 , pp. 503-512
    • Watt, F.M.1    Collins, C.A.2
  • 145
    • 0034712109 scopus 로고    scopus 로고
    • Out of Eden: stem cells and their niches
    • Watt, F.M., Hogan, B.L., Out of Eden: stem cells and their niches. Science 287 (2000), 1427–1430.
    • (2000) Science , vol.287 , pp. 1427-1430
    • Watt, F.M.1    Hogan, B.L.2
  • 150
  • 151
    • 84894623720 scopus 로고    scopus 로고
    • Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny
    • Yin, X., Farin, H.F., van Es, J.H., Clevers, H., Langer, R., Karp, J.M., Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny. Nat. Methods 11 (2014), 106–112.
    • (2014) Nat. Methods , vol.11 , pp. 106-112
    • Yin, X.1    Farin, H.F.2    van Es, J.H.3    Clevers, H.4    Langer, R.5    Karp, J.M.6
  • 155
    • 0028935955 scopus 로고
    • Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate
    • Zhou, P., Byrne, C., Jacobs, J., Fuchs, E., Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate. Genes Dev. 9 (1995), 700–713.
    • (1995) Genes Dev. , vol.9 , pp. 700-713
    • Zhou, P.1    Byrne, C.2    Jacobs, J.3    Fuchs, E.4


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