β-catenin and hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells

Developmental Cell

Volumn 9, Issue 1, 2005, Pages 121-131

  Silva Vargas, Violeta ^a   Lo Celso, Cristina ^a   Giangreco, Adam ^a   Ofstad, Tyler ^a   Prowse, David M ^a,b   Braun, Kristin M ^a   Watt, Fiona M ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BIOLOGICAL MARKER; SONIC HEDGEHOG PROTEIN;

ANIMAL TISSUE; ARTICLE; CELL DIVISION; CELL MIGRATION; CLONOGENESIS; EPIDERMIS; HAIR FOLLICLE; HAIR GROWTH; KERATINOCYTE; MELANOCYTE; MOUSE; MOUSE STRAIN; NONHUMAN; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEBACEOUS GLAND; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; UPREGULATION; WILD TYPE;

ANIMALS; BETA CATENIN; CELL DIFFERENTIATION; CYTOSKELETAL PROTEINS; EPIDERMIS; FEMALE; GENE DOSAGE; HAIR FOLLICLE; HEDGEHOG PROTEINS; KERATINOCYTES; MICE; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SEBACEOUS GLANDS; SIGNAL TRANSDUCTION; STEM CELLS; TAMOXIFEN; TRANS-ACTIVATORS; TRANSGENES;

ERINACEIDAE; MUS MUSCULUS;

EID: 21344436821     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.devcel.2005.04.013     Document Type: Article

References (39)

1. I. Arnold F.M. Watt c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny Curr. Biol. 11 2001 558-568
2. K.M. Braun C. Niemann U.B. Jensen J.P. Sundberg V. Silva-Vargas F.M. Watt Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis Development 130 2003 5241-5255
3. M. Duman-Scheel L. Weng S. Xin W. Du Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E Nature 417 2002 299-304
4. K.J. Fernandes I.A. McKenzie P. Mill K.M. Smith M. Akhavan F. Barnabe-Heider J. Biernaskie A. Junek N.R. Kobayashi J.G. Toma et al. A dermal niche for multipotent adult skin-derived precursor cells Nat. Cell Biol. 6 2004 1082-1093
5. E. Fuchs T. Tumbar G. Guasch Socializing with the neighbors: Stem cells and their niche Cell 116 2004 769-778
6. U. Gat R. DasGupta L. Degenstein E. Fuchs De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin Cell 95 1998 605-614
7. S. Ghazizadeh L.B. Taichman Multiple classes of stem cells in cutaneous epithelium: A lineage analysis of adult mouse skin EMBO J. 20 2001 1215-1222
8. K.U. Hong S.D. Reynolds S. Watkins E. Fuchs B.R. Stripp Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium Am. J. Pathol. 164 2004 577-588
9. P.H. Jones S. Harper F.M. Watt Stem cell patterning and fate in human epidermis Cell 80 1995 83-93
10. M.F. Kielman M. Rindapaa C. Gaspar N. van Poppel C. Breukel S. van Leeuwen M.M. Taketo S. Roberts R. Smits R. Fodde Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling Nat. Genet. 32 2002 594-605
11. M. Lako L. Armstrong P.M. Cairns S. Harris N. Hole C.A. Jahoda Hair follicle dermal cells repopulate the mouse haematopoietic system J. Cell Sci. 115 2002 3967-3974
12. N.M. Le Douarin E. Dupin Multipotentiality of the neural crest Curr. Opin. Genet. Dev. 13 2003 529-536
13. B.Y. Liu S.P. McDermott S.S. Khwaja C.M. Alexander The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells Proc. Natl. Acad. Sci. USA 101 2004 4158-4163
14. C. Lo Celso D.M. Prowse F.M. Watt Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours Development 131 2004 1787-1799
15. M.J. Marvin J. Dahlstrand U. Lendahl R.D. McKay A rod end deletion in the intermediate filament protein nestin alters its subcellular localization in neuroepithelial cells of transgenic mice J. Cell Sci. 111 1998 1951-1961
16. S.G. Megason A.P. McMahon A mitogen gradient of dorsal midline Wnts organizes growth in the CNS Development 129 2002 2087-2098
17. B.J. Merrill U. Gat R. DasGupta E. Fuchs Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin Genes Dev 15 2001 1688-1705
18. S.E. Millar Molecular mechanisms regulating hair follicle development J. Invest. Dermatol. 118 2002 216-225
19. R.J. Morris Y. Liu L. Marles Z. Yang C. Trempus S. Li J.S. Lin J.A. Sawicki G. Cotsarelis Capturing and profiling adult hair follicle stem cells Nat. Biotechnol. 22 2004 411-417
20. C. Niemann F.M. Watt Designer skin: Lineage commitment in postnatal epidermis Trends Cell Biol. 12 2002 185-192
21. E.K. Nishimura S.A. Jordan H. Oshima H. Yoshida M. Osawa M. Moriyama I.J. Jackson Y. Barrandon Y. Miyachi S. Nishikawa Dominant role of the niche in melanocyte stem-cell fate determination Nature 416 2002 854-860
22. T.G. Oliver L.L. Grasfeder A.L. Carroll C. Kaiser C.L. Gillingham S.M. Lin R. Wickramasinghe M.P. Scott R.J. Wechsler-Reya Transcriptional profiling of the Sonic hedgehog response: A critical role for N-myc in proliferation of neuronal precursors Proc. Natl. Acad. Sci. USA 100 2003 7331-7336
23. A.E. Oro K. Higgins Hair cycle regulation of Hedgehog signal reception Dev. Biol. 255 2003 238-248
24. H. Oshima A. Rochat C. Kedzia K. Kobayashi Y. Barrandon Morphogenesis and renewal of hair follicles from adult multipotent stem cells Cell 104 2001 233-245
25. D.J. Pearton C. Ferraris D. Dhouailly Transdifferentiation of corneal epithelium: Evidence for a linkage between the segregation of epidermal stem cells and the induction of hair follicles during embryogenesis Int. J. Dev. Biol. 48 2004 197-201
26. C.S. Potten R.J. Morris Epithelial stem cells in vivo J. Cell Sci. Suppl. 10 1988 45-62
27. T. Reya A.W. Duncan L. Ailles J. Domen D.C. Scherer K. Willert L. Hintz R. Nusse I.L. Weissman A role for Wnt signalling in self-renewal of haematopoietic stem cells Nature 423 2003 409-414
28. M.R. Romero J.M. Carroll F.M. Watt Analysis of cultured keratinocytes from a transgenic mouse model of psoriasis: Effects of suprabasal integrin expression on keratinocyte adhesion, proliferation and terminal differentiation Exp. Dermatol. 8 1999 53-67
29. P. Soriano Generalized lacZ expression with the ROSA26 Cre reporter strain Nat. Genet. 21 1999 70-71
30. J. Taipale P.A. Beachy The Hedgehog and Wnt signalling pathways in cancer Nature 411 2001 349-354
31. G. Taylor M.S. Lehrer P.J. Jensen T.T. Sun R.M. Lavker Involvement of follicular stem cells in forming not only the follicle but also the epidermis Cell 102 2000 451-461
32. C.S. Trempus R.J. Morris C.D. Bortner G. Cotsarelis R.S. Faircloth J.M. Reece R.W. Tennant Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34 J. Invest. Dermatol. 120 2003 501-511
33. T. Tumbar G. Guasch V. Greco C. Blanpain W.E. Lowry M. Rendl E. Fuchs Defining the epithelial stem cell niche in skin Science 303 2004 359-363
34. G.R. van den Brink S.A. Bleuming J.C. Hardwick B.L. Schepman G.J. Offerhaus J.J. Keller C. Nielsen W. Gaffield S.J. van Deventer D.J. Roberts M.P. Peppelenbosch Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation Nat. Genet. 36 2004 277-282
35. D. Van Mater F.T. Kolligs A.A. Dlugosz E.R. Fearon Transient activation of beta-catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice Genes Dev. 17 2003 1219-1224
36. V. Vasioukhin L. Degenstein B. Wise E. Fuchs The magical touch: Genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin Proc. Natl. Acad. Sci. USA 96 1999 8551-8556
37. A.J. Wagers I.L. Weissman Plasticity of adult stem cells Cell 116 2004 639-648
38. F.M. Watt Role of integrins in regulating epidermal adhesion, growth and differentiation EMBO J. 21 2002 3919-3926
39. A.J. Zhu F.M. Watt β-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion Development 126 1999 2285-2298