Alternative Wnt pathways and receptors

Cold Spring Harbor Perspectives in Biology

Volumn 4, Issue 10, 2012, Pages

  van Amerongen, Renée ^a,b  

^a STANFORD UNIVERSITY   (United States)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DISHEVELLED PROTEINS; FRIZZLED PROTEIN; LIGAND; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL; ARTICLE; CELL POLARITY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; VERTEBRATE; WNT SIGNALING PATHWAY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL POLARITY; FRIZZLED RECEPTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; LIGANDS; PHOSPHOPROTEINS; RECEPTORS, WNT; VERTEBRATES; WNT SIGNALING PATHWAY;

EID: 84863918668     PISSN: None     EISSN: 19430264     Source Type: Journal    
DOI: 10.1101/cshperspect.a007914     Document Type: Article

References (196)

1. Abu-Elmagd M, Garcia-Morales C, Wheeler GN. 2006. Frizzled7 mediates canonical Wnt signaling in neural crest induction. Dev Biol 298: 285-298.
2. Adler PN. 1992. The genetic control of tissue polarity in Drosophila. Bioessays 14: 735-741.
3. Afzal AR, Rajab A, Fenske CD, Oldridge M, Elanko N, Ternes-Pereira E, Tuysuz B, Murday VA, Patton MA, Wilkie AO, et al. 2000. Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2. Nat Genet 25: 419-422.
4. Andersson ER, Bryjova L, Biris K, Yamaguchi TP, Arenas E, Bryja V. 2010. Genetic interaction between Lrp6 and Wnt5a during mouse development. Dev Dyn 239: 237-245.
5. Antic D, Stubbs JL, Suyama K, Kintner C, Scott MP, Axelro JD. 2010. Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis. PLoS ONE 5: e8999.
6. Axelrod JD, Miller JR, Shulman JM, Moon RT, Perrimon N. 1998. Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity andWingless signaling pathways. Genes Dev 12: 2610-2622.
7. Baker NE. 1987. Molecular cloning of sequences fromwingless, a segment polarity gene in Drosophila: The spatial distribution of a transcript in embryos. EMBO J 6: 1765-1773.
8. Bayly R, Axelrod JD. 2011. Pointing in the right direction: New developments in the field of planar cell polarity. Nat Rev Genet 12: 385-391.
9. Berndt JD, Aoyagi A, Yang P, Anastas JN, Tang L, Moon RT. 2011. Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/b-catenin signaling. J Cell Biol 194: 737-750.
10. Bhanot P, Brink M, Samos CH, Hsieh JC, Wang Y, Macke JP, Andrew D, Nathans J, Nusse R. 1996. A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature 382: 225-230.
11. Bhanot P, Fish M, Jemison JA, Nusse R, Nathans J, Cadiga KM. 1999. Frizzled and Dfrizzled-2 function as redundant receptors forWingless during Drosophila embryonic development. Development 126: 4175-4186.
12. Bhat KM. 1998. frizzled and frizzled 2 play a partially redundant role inWingless signaling and have similar requirements to Wingless in neurogenesis. Cell 95: 1027-1036.
13. Bilic J, Huang YL, Davidson G, Zimmermann T, Crucia CM, Bienz M, Niehrs C. 2007. Wnt induces LRP6 signalosomes and promotes Dishevelled-dependent LRP6 phosphorylation. Science 316: 1619-1622.
14. Billiard J, Way DS, Seestaller-Wehr LM, Moran RA, Mangin A, Bodine PV. 2005. The orphan receptor tyrosine kinase Ror2 modulates canonical Wnt signaling in osteoblastic cells. Mol Endocrinol 19: 90-101.
15. Boutros M, Paricio N, Strutt DI, Mlodzik M. 1998. Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 94: 109-118.
16. Boutros M, Mihaly J, Bouwmeester T, Mlodzik M. 2000. Signaling specificity by Frizzled receptors in Drosophila. Science 288: 1825-1828.
17. Carreira-Barbosa F, Concha ML, Takeuchi M, Ueno N, Wilso SW, Tada M. 2003. Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish. Development 130: 4037-4046.
18. Cervantes S, Yamaguchi TP, Hebrok M. 2009. Wnt5a is essential for intestinal elongation in mice. Dev Biol 326: 285-294.
19. Cha SW, Tadjuidje E, Tao Q, Wylie C, Heasman J. 2008. Wnt5a and Wnt11 interact in a maternal Dkk1-regulated fashion to activate both canonical and non-canonical signaling in Xenopus axis formation. Development 135: 3719-3729.
20. Cha SW, Tadjuidje E, White J, Wells J, Mayhew C, Wylie C, Heasman J. 2009. Wnt11/5a complex formation caused by tyrosine sulfation increases canonical signaling activity. Curr Biol 19: 1573-1580.
21. Chen WS, Antic D, Matis M, Logan CY, Povelones M, Anderso GA, Nusse R, Axelrod JD. 2008. Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling. Cell 133: 1093-1105.
22. ChoiKW, Benzer S. 1994. Rotation of photoreceptor clusters in the developing Drosophila eye requires the nemo gene. Cell 78: 125-136.
23. 2+ signaling pathway. Dev Biol 244: 342-357.
24. Curtin JA, Quint E, Tsipouri V, Arkell RM, Cattanach B, Copp AJ, Henderson DJ, Spurr N, Stanier P, Fisher EM, et al. 2003. Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse. Curr Biol 13: 1129-1133.
25. Dabdoub A, Kelley MW. 2005. Planar cell polarity and a potential role for a Wnt morphogen gradient in stereociliary bundle orientation in the mammalian inner ear. J Neurobiol 64: 446-457.
26. Dabdoub A, Donohue MJ, Brennan A, Wolf V, Montcouquiol M, Sassoon DA, Hseih JC, Rubin JS, Salinas PC, Kelley MW. 2003. Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea. Development 130: 2375-2384.
27. Darken RS, Scola AM, Rakeman AS, Das G, Mlodzik M, Wilson PA. 2002. The planar polarity gene strabismus regulates convergent extension movements in Xenopus. EMBO J 21: 976-985.
28. Das G, Jenny A, Klein TJ, Eaton S, Mlodzik M. 2004. Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes. Development 131: 4467-4476.
29. Davidson LA, Keller RE. 1999. Neural tube closure in Xenopus laevis involves medial migration, directed protrusive activity, cell intercalation and convergent extension. Development 126: 4547-4556.
30. Deans MR, AnticD, Suyama K, ScottMP, Axelrod JD, Goodric LV. 2007. Asymmetric distribution of Prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear. J Neurosci 27: 3139-3147.
31. Devenport D, Fuchs E. 2008. Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles. Nat Cell Biol 10: 1257-1268.
32. Djiane A, Riou J, Umbhauer M, Boucaut J, ShiD. 2000. Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis. Development 127: 3091-3100.
33. Du SJ, Purcell SM, Christian JL, McGrew LL, Moon RT. 1995. Identification of distinct classes and functional domains of Wnts through expression of wild-type and chimeric proteins in Xenopus embryos. Mol Cell Biol 15: 2625-2634.
34. Endo M, Nishita M, Minami Y. 2012. Analysis of Wnt/planar cell polarity pathway in cultured cells. Methods Mol Biol 839: 201-214.
35. Etheridge SL, Ray S, Li S, Hamblet NS, Lijam N, Tsang M, Greer J, Kardos N, Wang J, Sussman DJ, et al. 2008. Murine Dishevelled 3 functions in redundant pathways with Dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet 4: e1000259.
36. Feike AC, Rachor K, Gentzel M, Schambony A. 2010. Wnt5a/Ror2-induced upregulation of xPAPC requires xShcA. Biochem Biophys Res Commun 400: 500-506.
37. Fiedler M, Mendoza-Topaz C, Rutherford TJ, Mieszczane J, Bienz M. 2011. Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating b-catenin. ProcNatl Aca Sci 108: 1937-1942.
38. Fossat N, Jones V, Khoo PL, Bogani D, Hardy A, Steiner K, Mukhopadhyay M, Westphal H, Nolan PM, Arkell R, et al. 2011. Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo. Development 138: 667-676.
39. Fukuda T, Chen L, Endo T, Tang L, LuD, Castro JE, Widhop GF II, Rassenti LZ, Cantwell MJ, Prussak CE, et al. 2008. Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a. Proc Natl Acad Sci 105: 3047-3052.
40. Gao B, Song H, Bishop K, Elliot G, Garrett L, English MA, Andre P, Robinson J, Sood R, Minami Y, et al. 2011. Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2. Dev Cell 20: 163-176.
41. Gentile A, Lazzari L, Benvenuti S, Trusolino L, Comogli PM. 2011. Ror1 is a pseudokinase that is crucial forMetdriven tumorigenesis. Cancer Res 71: 3132-3141.
42. Gleason JE, Szyleyko EA, Eisenmann DM. 2006. Multiple redundant Wnt signaling components function in two processes during C. elegans vulval development. Dev Biol 298: 442-457.
43. Goodrich LV, Strutt D. 2011. Principles of planar polarity in animal development. Development 138: 1877-1892.
44. Gray RS, Abitua PB, Wlodarczyk BJ, Szabo-Rogers HL, Blanchard O, Lee I, Weiss GS, Liu KJ, Marcotte EM, Wallingfor JB, et al. 2009. The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development. Nat Cell Biol 11: 1225-1232.
45. Gray RS, Roszko I, Solnica-Krezel L. 2011. Planar cell polarity: Coordinating morphogenetic cell behaviors with embryonic polarity. Dev Cell 21: 120-133.
46. Green JL, Inoue T, Sternberg PW. 2007. The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway. Development 134: 4053-4062.
47. Green JL, Inoue T, Sternberg PW. 2008. Opposing Wnt pathways orient cell polarity during organogenesis. Cell 134: 646-656.
48. Guder C, Philipp I, Lengfeld T, Watanabe H, Hobmayer B, Holstein TW. 2006. The Wnt code: Cnidarians signal the way. Oncogene 25: 7450-7460.
49. Guo N, Hawkins C, Nathans J. 2004. Frizzled6 controls hair patterning in mice. Proc Natl Acad Sci 101: 9277-9281.
50. Habas R, Kato Y, He X. 2001. Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. Cell 107: 843-854.
51. Habas R, Dawid IB, He X. 2003. Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation. Genes Dev 17: 295-309.
52. Hamblet NS, Lijam N, Ruiz-Lozano P, Wang J, Yang Y, Lu Z, Mei L, Chien KR, Sussman DJ, Wynshaw-Boris A. 2002. Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development 129: 5827-5838.
53. Harris KE, Beckendorf SK. 2007. Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration. Development 134: 2017-2025.
54. He X, Saint-Jeannet JP, Wang Y, Nathans J, Dawid I, Varmu H. 1997. A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science 275: 1652-1654.
55. Heisenberg CP, Tada M, Rauch GJ, Saude L, Concha ML, Geisler R, Stemple DL, Smith JC, Wilson SW. 2000. Silberblick/Wnt11 mediates convergent extensionmovements during zebrafish gastrulation. Nature 405: 76-81.
56. Hertzano R, Montcouquiol M, Rashi-Elkeles S, Elkon R, Yucel R, Frankel WN, Rechavi G, Moroy T, Friedma TB, Kelley MW, et al. 2004. Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene. Hum Mol Genet 13: 2143-2153.
57. HeydeckW, Liu A. 2011. PCPeffector proteins inturned and fuzzy play nonredundant roles in the patterning but not convergent extension of mammalian neural tube. De Dyn 240: 1938-1948.
58. Ho HY, Susman MW, Bikoff JB, Ryu YK, Jonas AM, Hu L, Kuruvilla R, Greenberg ME. 2012. Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis. Proc Natl Acad Sci 109: 4044-4051.
59. Holmen SL, Salic A, Zylstra CR, Kirschner MW, William BO. 2002. A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate b-catenindependent signaling. J Biol Chem 277: 34727-34735.
60. Inoue T, Oz HS, Wiland D, Gharib S, Deshpande R, Hill RJ, Katz WS, Sternberg PW. 2004. C. elegans LIN-18 is a Ryk ortholog and functions in parallel to LIN-17/Frizzled in Wnt signaling. Cell 118: 795-806.
61. Janssen R, Le Gouar M, Pechmann M, Poulin F, Bolognesi R, Schwager EE, Hopfen C, Colbourne JK, Budd GE, Brow SJ, et al. 2010. Conservation, loss, and redeployment of Wnt ligands in protostomes: Implications for understanding the evolution of segment formation. BMC Evol Biol 10: 374.
62. Jenny A. 2010. Planar cell polarity signaling in the Drosophila eye. Curr Top Dev Biol 93: 189-227.
63. Jenny A, Reynolds-Kenneally J, Das G, Burnett M, Mlodzi M. 2005. Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding. Nat Cell Biol 7: 691-697.
64. Jue SF, Bradley RS, Rudnicki JA, Varmus HE, Brown AM. 1992. The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells. Mol Cell Biol 12: 321-328.
65. Karner CM, Chirumamilla R, Aoki S, Igarashi P, Wallingfor JB, Carroll TJ. 2009. Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis. Nat Genet 41: 793-799.
66. Katanaev VL, Ponzielli R, Semeriva M, Tomlinson A. 2005. Trimeric G protein-dependent frizzled signaling in Drosophila. Cell 120: 111-122.
67. Keeble TR, Halford MM, Seaman C, Kee N, Macheda M, Anderson RB, Stacker SA, Cooper HM. 2006. The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum. J Neurosci 26: 5840-5848.
68. Keller R, Danilchik M. 1988. Regional expression, pattern and timing of convergence and extension during gastrulation of Xenopus laevis. Development 103: 193-209.
69. Keller RE, Danilchik M, Gimlich R, Shih J. 1985. The function and mechanismof convergent extension during gastrulation of Xenopus laevis. J Embryol Exp Morphol 89: 185-209.
70. Kennerdell JR, Carthew RW. 1998. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the Wingless pathway. Cell 95: 1017-1026.
71. Kibar Z, Vogan KJ, Groulx N, Justice MJ, UnderhillDA, Gro P. 2001. Ltap, a mammalian homolog of Drosophila Strabismus/ Van Gogh, is altered in the mouse neural tube mutant Loop-tail. Nat Genet 28: 251-255.
72. Kibar Z, Salem S, Bosoi CM, Pauwels E, De Marco P, Merell E, Bassuk AG, Capra V, Gros P. 2011. Contribution of VANGL2 mutations to isolated neural tube defects. Clin Genet 80: 76-82.
73. Kilian B, Mansukoski H, Barbosa FC, Ulrich F, Tada M, Heisenberg CP. 2003. The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mech Dev 120: 467-476.
74. Kim GH, Han JK. 2005. JNK and ROKa function in the noncanonical Wnt/RhoA signaling pathway to regulate Xenopus convergent extension movements. Dev Dyn 232: 958-968.
75. Kim GH, Her JH, Han JK. 2008. Ryk cooperates with Frizzled 7 to promote Wnt11-mediated endocytosis and is essential for Xenopus laevis convergent extension movements. J Cell Biol 182: 1073-1082.
76. Kockel L, Zeitlinger J, Staszewski LM, Mlodzik M, Bohman D. 1997. Jun in Drosophila development: Redundant and nonredundant functions and regulation by two MAPK signal transduction pathways. Genes Dev 11: 1748-1758.
77. Krasnow RE, Adler PN. 1994. A single frizzled protein has a dual function in tissue polarity. Development 120: 1883-1893.
78. 2+/ calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus. J Biol Chem 275: 12701-12711.
79. 2+ signaling. Mech Dev 106: 61-76.
80. Lee H, Adler PN. 2002. The function of the Frizzled pathway in the Drosophila wing is dependent on Inturned an Fuzzy. Genetics 160: 1535-1547.
81. Le Floch N, Rivat C, De Wever O, Bruyneel E, Mareel M, Dale T, Gespach C. 2005. The proinvasive activity of Wnt-2 is mediated through a noncanonical Wnt pathway coupled to GSK-3b and c-Jun/AP-1 signaling. FASEB J 19: 144-146.
82. Li L, Yuan H, Xie W, Mao J, Caruso AM, McMahon A, Sussman DJ, Wu D. 1999. Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells. J Biol Chem 274: 129-134.
83. Li C, Chen H, Hu L, Xing Y, Sasaki T, Villosis MF, Li J, Nishita M, Minami Y, Minoo P. 2008. Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2. BMC Mol Biol 9: 11.
84. Lin S, Baye LM, Westfall TA, Slusarski DC. 2010. Wnt5b-Ryk pathway provides directional signals to regulate gastrulation movement. J Cell Biol 190: 263-278.
85. Liu X, Liu T, Slusarski DC, Yang-Snyder J, Malbon CC, Moon RT, Wang H. 1999. Activation of a Frizzled-2/badrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells vi Gao and Gat. Proc Natl Acad Sci 96: 14383-14388.
86. Liu Y, Shi J, Lu CC, Wang ZB, Lyuksyutova AI, Song XJ, Zo Y. 2005. Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract. Nat Neurosci 8: 1151-1159.
87. Liu Y, Ross JF, Bodine PV, Billiard J. 2007. Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3b phosphorylation and promotes osteoblast differentiation and bone formation. Mol Endocrinol 21: 3050-3061.
88. Liu Y, Rubin B, Bodine PV, Billiard J. 2008. Wnt5a induces homodimerization and activation of Ror2 receptor tyrosine kinase. J Cell Biochem 105: 497-502.
89. LuW, Yamamoto V, Ortega B, Baltimore D. 2004. Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell 119: 97-108.
90. Lyu J, Yamamoto V, LuW. 2008. Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis. Dev Cell 15: 773-780.
91. Lyu J, Wesselschmidt RL, Lu W. 2009. Cdc37 regulates Ryk signaling by stabilizing the cleaved Ryk intracellular domain. J Biol Chem 284: 12940-12948.
92. 2+ non-canonical pathway. J Biol Chem 282: 28980-28990.
93. Ma L, Wang Y, Malbon CC, Wang HY. 2010. Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling. J Mol Signal 5: 19.
94. MacLeod RJ, Hayes M, Pacheco I. 2007. Wnt5a secretion stimulated by the extracellular calcium-sensing receptor inhibits defective Wnt signaling in colon cancer cells. Am J Physiol Gastrointest Liver Physiol 293: G403-G411.
95. Marinissen MJ, Chiariello M, Tanos T, BernardO, Narumiy S, Gutkind JS. 2004. The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis. Mol Cell 14: 29-41.
96. Matsuda T, Suzuki H, Oishi I, Kani S, Kuroda Y, Komori T, Sasaki A, Watanabe K, Minami Y. 2003. The receptor tyrosine kinase Ror2 associates with the melanoma-associated antigen (MAGE) family protein Dlxin-1 and regulates its intracellular distribution. J Biol Chem 278: 29057-29064.
97. Matthews HK, Marchant L, Carmona-Fontaine C, Kuriyam S, Larrain J, Holt MR, Parsons M, Mayor R. 2008. Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA. Development 135: 1771-1780.
98. Maung SM, Jenny A. 2011. Planar cell polarity in Drosophila. Organogenesis 7: 165-179.
99. McMahon AP, Moon RT. 1989. Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis. Cell 58: 1075-1084.
100. Medina A, Reintsch W, Steinbeisser H. 2000. Xenopus frizzled 7 can act in canonical and non-canonical Wnt signaling pathways: Implications on early patterning and morphogenesis. Mech Dev 92: 227-237.
101. Mikels AJ, Nusse R. 2006. Purified Wnt5a protein activates or inhibits b-catenin-TCF signaling depending on receptor context. PLoS Biol 4: e115.
102. Mikels A, Minami Y, Nusse R. 2009. Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling. J Biol Chem 284: 30167-30176.
103. Moeller H, Jenny A, Schaeffer HJ, Schwarz-Romond T, Mlodzik M, Hammerschmidt M, Birchmeier W. 2006. Diversin regulates heart formation and gastrulation movements in development. Proc Natl Acad Sci 103: 15900-15905.
104. Montcouquiol M, Rachel RA, Lanford PJ, Copeland NG, Jenkins NA, Kelley MW. 2003. Identification of Vangl2 and Scrb1 as planar polarity genes in mammals. Nature 423: 173-177.
105. Montcouquiol M, Sans N, Huss D, Kach J, Dickman JD, Forge A, Rachel RA, Copeland NG, Jenkins NA, Bogan D, et al. 2006. Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. J Neurosci 26: 5265-5275.
106. Moon RT, Campbell RM, Christian JL, McGrew LL, Shih J, Fraser S. 1993. Xwnt-5A: A maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis. Development 119: 97-111.
107. Moriguchi T, Kawachi K, Kamakura S, Masuyama N, Yamanak H, Matsumoto K, Kikuchi A, Nishida E. 1999. Distinct domains of mouse dishevelled are responsible for the c-Jun N-terminal kinase/stress-activated protein kinase activation and the axis formation in vertebrates. J Biol Chem 274: 30957-30962.
108. Nemeth MJ, Topol L, Anderson SM, Yang Y, Bodine DM. 2007. Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation. Proc Nat Acad Sci 104: 15436-15441.
109. Nishita M, Itsukushima S, Nomachi A, Endo M, Wang Z, Inaba D, Qiao S, Takada S, Kikuchi A, Minami Y. 2010. Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization. Mol Cell Biol 30: 3610-3619.
110. Noordermeer J, Klingensmith J, Perrimon N, Nusse R. 1994. dishevelled and armadillo act in the Wingless signalling pathway in Drosophila. Nature 367: 80-83.
111. Ohkawara B, Niehrs C. 2011. An ATF2-based luciferase reporter to monitor non-canonical Wnt signaling in Xenopus embryos. Dev Dyn 240: 188-194.
112. Oishi I, Takeuchi S, Hashimoto R, Nagabukuro A, Ueda T, Liu ZJ, Hatta T, Akira S, Matsuda Y, Yamamura H, et al. 1999. Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: Implications in development and function of the nervous system. Genes Cells 4: 41-56.
113. Oishi I, Suzuki H, Onishi N, Takada R, Kani S, Ohkawara B, Koshida I, Suzuki K, Yamada G, Schwabe GC, et al. 2003. The receptor tyrosine kinase Ror2 is involved in noncanonical Wnt5a/JNK signalling pathway. Genes Cells 8: 645-654.
114. Paganoni S, Bernstein J, Ferreira A. 2010. Ror1-Ror2 complexes modulate synapse formation in hippocampal neurons. Neuroscience 165: 1261-1274.
115. Park TJ, Haigo SL, Wallingford JB. 2006. Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling. Nat Genet 38: 303-311.
116. Penzo-Mendez A, Umbhauer M, Djiane A, Boucaut JC, Riou JF. 2003. Activation of Gbg signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation. Dev Biol 257: 302-314.
117. PersonAD, Beiraghi S, Sieben CM, Hermanson S, Neumann AN, Robu ME, Schleiffarth JR, Billington CJ Jr, Va Bokhoven H, Hoogeboom JM, et al. 2010. WNT5A mutations in patients with autosomal dominant Robinow syndrome. Dev Dyn 239: 327-337.
118. Phillips HM, Murdoch JN, Chaudhry B, Copp AJ, Henderso DJ. 2005. Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract. Circ Res 96: 292-299.
119. Qian D, Jones C, Rzadzinska A, Mark S, Zhang X, Steel KP, Dai X, Chen P. 2007. Wnt5a functions in planar cell polarity regulation in mice. Dev Biol 306: 121-133.
120. Rijsewijk F, Schuermann M, Wagenaar E, Parren P, WeigelD, Nusse R. 1987. The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. Cell 50: 649-657.
121. Roarty K, Baxley SE, Crowley MR, Frost AR, Serra R. 2009. Loss of TGF-b or Wnt5a results in an increase in Wnt/bcatenin activity and redirects mammary tumour phenotype. Breast Cancer Res 11: R19.
122. Rosso SB, Sussman D, Wynshaw-Boris A, Salinas PC. 2005. Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development. Nat Neurosci 8: 34-42.
123. Rothbacher U, Laurent MN, Deardorff MA, Klein PS, Ch KW, Fraser SE. 2000. Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis. EMBO J 19: 1010-1022.
124. Rulifson EJ, Wu CH, Nusse R. 2000. Pathway specificity by the bifunctional receptor Frizzled is determined by affinity for Wingless. Mol Cell 6: 117-126.
125. Sakurai M, Aoki T, Yoshikawa S, Santschi LA, Saito H, End K, Ishikawa K, Kimura K, Ito K, Thomas JB, et al. 2009. Differentially expressed Drl and Drl-2 play opposing roles in Wnt5 signaling during Drosophila olfactory system development. J Neurosci 29: 4972-4980.
126. Saldanha J, Singh J, Mahadevan D. 1998. Identification of a Frizzled-like cysteine rich domain in the extracellular region of developmental receptor tyrosine kinases. Protei Sci 7: 1632-1635.
127. Sammar M, Stricker S, Schwabe GC, Sieber C, Hartung A, Hanke M, Oishi I, Pohl J, Minami Y, SebaldW, et al. 2004. Modulation of GDF5/BRI-b signalling through interactionwith the tyrosine kinase receptor Ror2. Genes Cells 9: 1227-1238.
128. Sammar M, Sieber C, Knaus P. 2009. Biochemical and functional characterization of the Ror2/BRIb receptor complex. Biochem Biophys Res Commun 381: 1-6.
129. Saneyoshi T, Kume S, Amasaki Y, Mikoshiba K. 2002. The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos. Nature 417: 295-299.
130. Sato A, Yamamoto H, Sakane H, Koyama H, Kikuchi A. 2010. Wnt5a regulates distinct signalling pathways by binding to Frizzled2. EMBO J 29: 41-54.
131. Schulte G. 2010. International Union of Basic and Clinical Pharmacology. LXXX. The class Frizzled receptors. Pharmacol Rev 62: 632-667.
132. Schwabe GC, Trepczik B, Suring K, Brieske N, Tucker AS, Sharpe PT, Minami Y, Mundlos S. 2004. Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome. Dev Dyn 229: 400-410.
133. SchwarzerW, Witte F, Rajab A, Mundlos S, Stricker S. 2009. A gradient of ROR2 protein stability and membrane localization confers brachydactyly type B or Robinow syndrome phenotypes. Hum Mol Genet 18: 4013-4021.
134. Schwarz-Romond T, Fiedler M, Shibata N, Butler PJ, Kikuch A, Higuchi Y, Bienz M. 2007a. The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization. Nat Struct Mol Biol 14: 484-492.
135. Schwarz-Romond T, Metcalfe C, Bienz M. 2007b. Dynamic recruitment of axin by Dishevelled protein assemblies. J Cell Sci 120: 2402-2412.
136. Seo JH, Zilber Y, Babayeva S, Liu J, Kyriakopoulos P, D Marco P, Merello E, Capra V, Gros P, Torban E. 2011. Mutations in the planar cell polarity gene, Fuzzy, are associated with neural tube defects in humans. Hu Mol Genet 20: 4324-4333.
137. Shabani M, Asgarian-Omran H, Vossough P, Sharifian RA, Faranoush M, Ghragozlou S, Khoshnoodi J, Roohi A, Jeddi-Tehrani M, Mellstedt H, et al. 2008. Expression profile of orphan receptor tyrosine kinase (ROR1) and Wilms' tumor gene 1 (WT1) in different subsets of B-cell acute lymphoblastic leukemia. Leuk Lymphoma 49: 1360-1367.
138. Shafer B, Onishi K, Lo C, Colakoglu G, Zou Y. 2011. Vangl2 promotes Wnt/planar cell polarity-like signaling by antagonizing Dvl1-mediated feedback inhibition in growth cone guidance. Dev Cell 20: 177-191.
139. Sheldahl LC, Park M, Malbon CC, Moon RT. 1999. Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner. Curr Biol 9: 695-698.
140. 2+ flux, PKC, and CamKII in vertebrate embryos. J Cell Biol 161: 769-777.
141. Shimizu H, Julius MA, Giarre M, Zheng Z, Brown AM, Kitajewski J. 1997. Transformation by Wnt family proteins correlates with regulation of b-catenin. Cell Growt Differ 8: 1349-1358.
142. Shimizu K, Sato M, Tabata T. 2011. The Wnt5/planar cell polarity pathway regulates axonal development of the Drosophila mushroom body neuron. J Neurosci 31: 4944-4954.
143. Siegfried E, Chou TB, Perrimon N. 1992. wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate. Cell 71: 1167-1179.
144. Siegfried E, Wilder EL, Perrimon N. 1994. Components of Wingless signalling in Drosophila. Nature 367: 76-80.
145. Slusarski DC, Corces VG, Moon RT. 1997a. Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature 390: 410-413.
146. 2+ signaling by Wnt-5A. Dev Biol 182: 114-120.
147. Sokol S, Christian JL, Moon RT, Melton DA. 1991. Injected Wnt RNA induces a complete body axis in Xenopus embryos. Cell 67: 741-752.
148. Song H, Hu J, Chen W, Elliott G, Andre P, Gao B, Yang Y. 2010. Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning. Nature 466: 378-382.
149. Stoick-Cooper CL, Weidinger G, Riehle KJ, Hubbert C, MajorMB, Fausto N, Moon RT. 2007. Distinct Wnt signaling pathways have opposing roles in appendage regeneration. Development 134: 479-489.
150. Strutt DI, Weber U, Mlodzik M. 1997. The role of RhoA in tissue polarity and Frizzled signalling. Nature 387: 292-295.
151. Sumanas S, Strege P, Heasman J, Ekker SC. 2000. The putative Wnt receptor Xenopus frizzled-7 functions upstream of b-catenin in vertebrate dorsoventral mesoderm patterning. Development 127: 1981-1990.
152. Tahinci E, Thorne CA, Franklin JL, Salic A, Christian KM, Lee LA, Coffey RJ, Lee E. 2007. Lrp6 is required for convergent extension during Xenopus gastrulation. Development 134: 4095-4106.
153. Taillebourg E, Moreau-Fauvarque C, Delaval K, Dura JM. 2005. In vivo evidence for a regulatory role of the kinase activity of the linotte/derailed receptor tyrosine kinase, a Drosophila Ryk ortholog. Dev Genes Evol 215: 158-163.
154. Tao Q, Yokota C, Puck H, Kofron M, Birsoy B, Yan D, Asashim M, Wylie CC, Lin X, Heasman J. 2005. Maternal Wnt11 activates the canonical Wnt signaling pathway required for axis formation in Xenopus embryos. Cell 120: 857-871.
155. Thorpe CJ, Moon RT. 2004. nemo-like kinase is an essential co-activator of Wnt signaling during early zebrafish development. Development 131: 2899-2909.
156. Topol L, Jiang X, Choi H, Garrett-Beal L, Carolan PJ, Yang Y. 2003. Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent b-catenin degradation. J Cell Biol 162: 899-908.
157. Torban E, Wang HJ, Groulx N, Gros P. 2004. Independent mutations in mouseVangl2 that cause neural tube defects in looptail mice impair interaction with members of th Dishevelled family. J Biol Chem 279: 52703-52713.
158. Torban E, Patenaude AM, Leclerc S, Rakowiecki S, Gauthie S, Andelfinger G, Epstein DJ, Gros P. 2008. Genetic interaction between members of the Vangl family causes neural tube defects in mice. Proc Natl Acad Sci 105: 3449-3454.
159. Torres MA, Yang-Snyder JA, Purcell SM, DeMarais AA, McGrew LL, Moon RT. 1996. Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development. J Cell Biol 133: 1123-1137.
160. Tree DR, Shulman JM, Rousset R, Scott MP, Gubb D, Axelro JD. 2002. Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling. Cell 109: 371-381.
161. Tufan AC, Daumer KM, DeLise AM, Tuan RS. 2002. AP-1 transcription factor complex is a target of signals from bothWnT-7a and N-cadherin-dependent cell-cell adhesion complex during the regulation of limb mesenchymal chondrogenesis. Exp Cell Res 273: 197-203.
162. van Amerongen R, Nusse R. 2009. Towards an integrated view of Wnt signaling in development. Development 136: 3205-3214.
163. van Bokhoven H, Celli J, Kayserili H, van Beusekom E, Balci S, BrusselW, Skovby F, Kerr B, Percin EF, Akarsu N, et al. 2000. Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome. Nat Genet 25: 423-426.
164. van deWetering M, Cavallo R, Dooijes D, van Beest M, van Es J, Loureiro J, Ypma A, Hursh D, Jones T, Bejsovec A, et al. 1997. Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell 88: 789-799.
165. van Wijk NV, Witte F, Feike AC, Schambony A, Birchmeie W, Mundlos S, Stricker S. 2009. The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling. Biochem Biophys Res Commun 390: 211-216.
166. Veeman MT, Slusarski DC, Kaykas A, Louie SH, Moon RT. 2003. Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Curr Biol 13: 680-685.
167. 2+-mobilization in Human Embryonic Kidney 293 cells. Cell Signal 21: 22-33.
168. Verkaar F, Blankesteijn WM, Smits JF, Zaman GJ. 2010. b-Galactosidase enzyme fragment complementation for the measurement of Wnt/b-catenin signaling. FASEB J 24: 1205-1217.
169. Vinson CR, Conover S, Adler PN. 1989. A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains. Nature 338: 263-264.
170. Wallingford JB, Harland RM. 2001. Xenopus dishevelled signaling regulates both neural and mesodermal convergent extension: Parallel forces elongating the body axis. Development 128: 2581-2592.
171. Wallingford JB, Rowning BA, Vogeli KM, Rothbacher U, Fraser SE, Harland RM. 2000. Dishevelled controls cell polarity during Xenopus gastrulation. Nature 405: 81-85.
172. Wang J, Mark S, Zhang X, QianD, Yoo SJ, Radde-Gallwitz K, Zhang Y, Lin X, Collazo A, Wynshaw-Boris A, et al. 2005. Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway. Nat Genet 37: 980-985.
173. Wang J, Hamblet NS, Mark S, Dickinson ME, Brinkman BC, Segil N, Fraser SE, Chen P, Wallingford JB, Wynshaw-Boris A. 2006a. Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development 133: 1767-1778.
174. Wang Y, Guo N, Nathans J. 2006b. The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells. J Neurosci 26: 2147-2156.
175. Wang Y, Chang H, Nathans J. 2010. When whorls collide: The development of hair patterns in frizzled 6 mutant mice. Development 137: 4091-4099.
176. Warga RM, Kimmel CB. 1990. Cell movements during epiboly and gastrulation in zebrafish. Development 108: 569-580.
177. Weber U, Paricio N, Mlodzik M. 2000. Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye. Development 127: 3619-3629.
178. Wilson PA, Oster G, Keller R. 1989. Cell rearrangement and segmentation in Xenopus: Direct observation of cultured explants. Development 105: 155-166.
179. Winkel A, Stricker S, Tylzanowski P, Seiffart V, Mundlos S, Gross G, Hoffmann A. 2008. Wnt-ligand-dependent interaction of TAK1 (TGF-b-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wntsignalling. Cell Signal 20: 2134-2144.
180. Winklbauer R, Medina A, Swain RK, Steinbeisser H. 2001. Frizzled-7 signalling controls tissue separation during Xenopus gastrulation. Nature 413: 856-860.
181. Witte F, Bernatik O, Kirchner K, Masek J, Mahl A, Krejci P, Mundlos S, Schambony A, Bryja V, Stricker S. 2010. Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2. FASEB J 24: 2417-2426.
182. Wong LL, Adler PN. 1993. Tissue polarity genes of Drosophila regulate the subcellular location for prehair initiation in pupal wing cells. J Cell Biol 123: 209-221.
183. Wong GT, Gavin BJ, McMahon AP. 1994. Differential transformation of mammaryepithelial cells by Wnt genes. Mo Cell Biol 14: 6278-6286.
184. Wouda RR, Bansraj MR, de Jong AW, Noordermeer JN, Fradkin LG. 2008. Src family kinases are required for WNT5 signaling through the Derailed/RYK receptor in the Drosophila embryonic central nervous system. Development 135: 2277-2287.
185. Wu M, Herman MA. 2006. A novel noncanonical Wnt pathway is involved in the regulation of the asymmetric B cell division in C. elegans. Dev Biol 293: 316-329.
186. Wu J, Mlodzik M. 2008. The frizzled extracellular domain is a ligand for Van Gogh/Stbm during nonautonomous planar cell polarity signaling. Dev Cell 15: 462-469.
187. Wu J, Klein TJ, Mlodzik M. 2004. Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity. PLoS Biol 2: e158.
188. Yamada M, Udagawa J, Matsumoto A, Hashimoto R, Hatt T, Nishita M, Minami Y, Otani H. 2010. Ror2 is required for midgut elongation during mouse development. Dev Dyn 239: 941-953.
189. Yamaguchi TP, Bradley A, McMahon AP, Jones S. 1999. A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development 126: 1211-1223.
190. Yamamoto S, NishimuraO, Misaki K, Nishita M, Minami Y, Yonemura S, Tarui H, Sasaki H. 2008. Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev Cell 15: 23-36.
191. Yamanaka H, Moriguchi T, Masuyama N, Kusakabe M, Hanafus H, Takada R, Takada S, Nishida E. 2002. JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates. EMBO Rep 3: 69-75.
192. Yates LL, Schnatwinkel C, Murdoch JN, Bogani D, Formstone CJ, Townsend S, Greenfield A, Niswander LA, Dea CH. 2010. The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis. Hum Mo Genet 19: 2251-2267.
193. Yoshikawa S, McKinnon RD, Kokel M, Thomas JB. 2003. Wnt-mediated axon guidance via the Drosophila Derailed receptor. Nature 422: 583-588.
194. Zeng H, Hoover AN, Liu A. 2010. PCP effector gene Inturned is an important regulator of cilia formation and embryonic development in mammals. Dev Biol 339: 418-428.
195. Zhang Y, Levin M. 2009. Left-right asymmetry in the chick embryo requires core planar cell polarity protein Vangl2. Genesis 47: 719-728.
196. Zinovyeva AY, Yamamoto Y, Sawa H, Forrester WC. 2008. Complex network of Wnt signaling regulates neuronal migrations during Caenorhabditis elegans development. Genetics 179: 1357-1371.