Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 12, 2017, Pages E2357-E2364

  Fumagalli, Arianna ^a   Drost, Jarno ^a,c   Suijkerbuijk, Saskia J E ^a   Van Boxtel, Ruben ^a   De Ligt, Joep ^a   Offerhaus, G Johan ^a   Begthel, Harry ^a   Beerling, Evelyne ^a   Tan, Ee Hong ^b   Sansom, Owen J ^b   Cuppen, Edwin ^a   Clevers, Hans ^a,c   Van Rheenen, Jacco ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c University Medical Center Utrecht Princess Máxima Center for Pediatric Oncology   (Netherlands)

Author keywords

Adenoma carcinoma sequence; Colorectal cancer; Metastasis; Niche independence; Organoids

Indexed keywords

APC PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; K RAS PROTEIN; NOGGIN; PROTEIN P53; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN; EGFR PROTEIN, HUMAN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER STEM CELL; CANCER TRANSPLANTATION; CELL CYCLE PROGRESSION; CELL MIGRATION; COLORECTAL ADENOMA; COLORECTAL CARCINOMA; CONTROLLED STUDY; CRISPR CAS SYSTEM; CRISPR CAS9 SYSTEM; CYTOPLASM; DISTANT METASTASIS; FEMALE; GENE EDITING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTESTINAL STEM CELL; LIVER METASTASIS; LUNG METASTASIS; MALE; MIDDLE AGED; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STEM CELL NICHE; ANIMAL; CELL MOTION; COLORECTAL TUMOR; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETIC ENGINEERING; GENETICS; METABOLISM; METASTASIS; MUTATION; NONOBESE DIABETIC MOUSE; ONCOGENESIS AND MALIGNANT TRANSFORMATION; ORGANOID; PATHOLOGY; PATHOPHYSIOLOGY; TRANSPLANTATION;

ADULT; ANIMALS; CELL MOVEMENT; COLORECTAL NEOPLASMS; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC ENGINEERING; HUMANS; MALE; MICE; MICE, INBRED NOD; MIDDLE AGED; MUTATION; NEOPLASM METASTASIS; NEOPLASTIC PROCESSES; ORGANOIDS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 85016113409     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1701219114     Document Type: Article

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