Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 42, 2016, Pages 11859-11864

  Tetteh, Paul W ^a,b,c   Kretzschmar, Kai ^a,b   Begthel, Harry ^a,b   Van Den Born, Maaike ^a,b   Korving, Jeroen ^a,b   Morsink, Folkert ^b   Farin, Henner ^a,b,d   Van Es, Johan H ^a,b   Offerhaus, G Johan A ^b   Clevers, Hans ^a,b  

^a HUBRECHT INSTITUTE   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

Author keywords

Car1; Colorectal cancer; Differentiated epithelial cells; Gastrointestinal tract; Mouse model

Indexed keywords

APC PROTEIN; CARBONATE DEHYDRATASE I; CRE RECOMBINASE; PROTEIN P53; SMAD4 PROTEIN; INTEGRASE; TUMOR MARKER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APC GENE; ARTICLE; ASCENDING COLON; CECUM; COLON ADENOMA; COLON CANCER; COLON CARCINOGENESIS; GENE DELETION; GENE MUTATION; GENE TARGETING; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MOUSE; MOUSE MODEL; NONHUMAN; ONCOGENE K RAS; P53 GENE; PRIORITY JOURNAL; SMAD4 GENE; ADENOMA; ANIMAL; ANTIBODY SPECIFICITY; CELL TRANSFORMATION; COLON TUMOR; DISEASE EXACERBATION; DISEASE MODEL; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENE KNOCK-IN; GENE LOCUS; GENETICS; IMMUNOHISTOCHEMISTRY; INTESTINE MUCOSA; KNOCKOUT MOUSE; METABOLISM; MUTATION; ONCOGENE RAS; PATHOLOGY; RESEARCH; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE;

ADENOMA; ANIMALS; BIOMARKERS, TUMOR; CARBONIC ANHYDRASE I; CELL TRANSFORMATION, NEOPLASTIC; COLONIC NEOPLASMS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENE KNOCK-IN TECHNIQUES; GENE TARGETING; GENES, APC; GENES, RAS; GENETIC LOCI; HUMANS; IMMUNOHISTOCHEMISTRY; INTEGRASES; INTESTINAL MUCOSA; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MUTATION; ORGAN SPECIFICITY; RESEARCH;

EID: 84991735271     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1614057113     Document Type: Article

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