Ascl2 acts as an R-spondin/wnt-responsive switch to control stemness in intestinal crypts

Cell Stem Cell

Volumn 16, Issue 2, 2015, Pages 158-170

  Schuijers, Jurian ^a   Junker, Jan Philipp ^a   Mokry, Michal ^b   Hatzis, Pantelis ^c   Koo, Bon Kyoung ^a,d   Sasselli, Valentina ^a   Van Der Flier, Laurens G ^a,e   Cuppen, Edwin ^a   Van Oudenaarden, Alexander ^a   Clevers, Hans ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING   (Greece)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e SomantiX BV Utrecht   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ASCL2 TRANSCRIPTION FACTOR; BETA CATENIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ASCL2 PROTEIN, MOUSE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; RSPO1 PROTEIN, MOUSE; THROMBOSPONDIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL DIFFERENTIATION; CELL SPECIFICITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA BINDING; FEEDBACK SYSTEM; FLUORESCENCE IN SITU HYBRIDIZATION; FLUORESCENCE MICROSCOPY; GENE ACTIVATION; GENE DELETION; GENE SWITCHING; GENOMIC FRAGMENT; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INTESTINAL STEM CELL; INTESTINE CRYPT; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PANETH CELL; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL; UPREGULATION; WNT SIGNALING PATHWAY; ANIMAL; CYTOLOGY; GENETICS; INTESTINE MUCOSA; METABOLISM; STEM CELL;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; INTESTINAL MUCOSA; MICE; STEM CELLS; THROMBOSPONDINS; WNT SIGNALING PATHWAY;

EID: 84924910660     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2014.12.006     Document Type: Article

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