메뉴 건너뛰기




Volumn 2, Issue , 2016, Pages

Pancreatic cancer

(11)  Kleeff, Jorg a,b   Korc, Murray c   Apte, Minoti d   La Vecchia, Carlo e   Johnson, Colin D f   Biankin, Andrew V g   Neale, Rachel E h   Tempero, Margaret i   Tuveson, David A j   Hruban, Ralph H k   Neoptolemos, John P a  


Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; BRCA1 PROTEIN; BRCA2 PROTEIN; CA 19-9 ANTIGEN; CAPECITABINE; CISPLATIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR ALPHA; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; GLYPICAN 1; IRINOTECAN; K RAS PROTEIN; OXALIPLATIN; PACLITAXEL; PROTEIN KINASE LKB1; PROTEIN MLH1; PROTEIN P53; SMAD4 PROTEIN; TENASCIN; TRANSFORMING GROWTH FACTOR BETA; CANCER BASIC PROTEIN, HUMAN; KRAS PROTEIN, HUMAN; PROTEIN P21; TUMOR MARKER; TUMOR PROTEIN;

EID: 85019538575     PISSN: None     EISSN: 2056676X     Source Type: Journal    
DOI: 10.1038/nrdp.2016.22     Document Type: Article
Times cited : (1424)

References (286)
  • 1
    • 84907850657 scopus 로고    scopus 로고
    • GLOBOCAN 2012: Cancer incidence and mortality worldwide: IARC CancerBase No. 11
    • [online]
    • Ferlay, J. et al. GLOBOCAN 2012: cancer incidence and mortality worldwide: IARC CancerBase No. 11. International Agency for Research on Cancer [online], http://globocan.iarc.fr (2013).
    • (2013) International Agency for Research on Cancer
    • Ferlay, J.1
  • 2
    • 84902147062 scopus 로고    scopus 로고
    • Projecting cancer incidence and deaths to 2030: The unexpected burden of thyroid, liver, and pancreas cancers in the United States
    • Rahib, L. et al. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 74, 2913-2921 (2014).
    • (2014) Cancer Res. , vol.74 , pp. 2913-2921
    • Rahib, L.1
  • 4
    • 84890546918 scopus 로고    scopus 로고
    • 2564 resected periampullary adenocarcinomas at a single institution: Trends over three decades
    • He, J. et al. 2564 resected periampullary adenocarcinomas at a single institution: trends over three decades. HPB (Oxford) 16, 83-90 (2014).
    • (2014) HPB (Oxford) , vol.16 , pp. 83-90
    • He, J.1
  • 5
    • 84925858899 scopus 로고    scopus 로고
    • Population attributable risk for pancreatic cancer in Northern Italy
    • Rosato, V. et al. Population attributable risk for pancreatic cancer in Northern Italy. Pancreas 44, 216-220 (2015).
    • (2015) Pancreas , vol.44 , pp. 216-220
    • Rosato, V.1
  • 8
    • 84926457179 scopus 로고    scopus 로고
    • European cancer mortality predictions for the year 2015: Does lung cancer have the highest death rate in EU women?
    • Malvezzi, M. et al. European cancer mortality predictions for the year 2015: does lung cancer have the highest death rate in EU women? Ann. Oncol. 26, 779-786 (2015).
    • (2015) Ann. Oncol. , vol.26 , pp. 779-786
    • Malvezzi, M.1
  • 10
    • 33846529846 scopus 로고    scopus 로고
    • (eds Schottenfeld, D. & Fraumeni, J.) Oxford Univ. Press
    • Anderson, K., Mack, T. & Silverman, D. in Cancer of the Pancreas (eds Schottenfeld, D. & Fraumeni, J.) 721-762 (Oxford Univ. Press, 2006).
    • (2006) Cancer of the Pancreas , pp. 721-762
    • Anderson, K.1    Mack, T.2    Silverman, D.3
  • 11
    • 84864299220 scopus 로고    scopus 로고
    • Cigarette smoking and pancreatic cancer: An analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4)
    • Bosetti, C. et al. Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4). Ann. Oncol. 23, 1880-1888 (2012).
    • (2012) Ann. Oncol. , vol.23 , pp. 1880-1888
    • Bosetti, C.1
  • 12
    • 83255175652 scopus 로고    scopus 로고
    • 2. Tobacco-attributable cancer burden in the UK in 2010
    • Parkin, D. M. 2. Tobacco-attributable cancer burden in the UK in 2010. Br. J. Cancer 105, S6-S13 (2011).
    • (2011) Br. J. Cancer , vol.105 , pp. S6-S13
    • Parkin, D.M.1
  • 13
    • 84943191635 scopus 로고    scopus 로고
    • Cancers in Australia in 2010 attributable to modifiable factors: Introduction and overview
    • Whiteman, D. C. et al. Cancers in Australia in 2010 attributable to modifiable factors: introduction and overview. Aust. N. Z. J. Public Health 39, 403-407 (2015).
    • (2015) Aust. N. Z. J. Public Health , vol.39 , pp. 403-407
    • Whiteman, D.C.1
  • 15
    • 84930516622 scopus 로고    scopus 로고
    • Physical activity and risk of pancreatic cancer: A systematic review and meta-analysis
    • Behrens, G. et al. Physical activity and risk of pancreatic cancer: a systematic review and meta-analysis. Eur. J. Epidemiol. 30, 279-298 (2015).
    • (2015) Eur. J. Epidemiol. , vol.30 , pp. 279-298
    • Behrens, G.1
  • 16
    • 84947747164 scopus 로고    scopus 로고
    • Central adiposity, obesity during early adulthood, and pancreatic cancer mortality in a pooled analysis of cohort studies
    • Genkinger, J. M. et al. Central adiposity, obesity during early adulthood, and pancreatic cancer mortality in a pooled analysis of cohort studies. Ann. Oncol. 26, 2257-2266 (2015).
    • (2015) Ann. Oncol. , vol.26 , pp. 2257-2266
    • Genkinger, J.M.1
  • 17
    • 84856497052 scopus 로고    scopus 로고
    • Red and processed meat consumption and risk of pancreatic cancer: Meta-analysis of prospective studies
    • Larsson, S. C. & Wolk, A. Red and processed meat consumption and risk of pancreatic cancer: meta-analysis of prospective studies. Br. J. Cancer 106, 603-607 (2012).
    • (2012) Br. J. Cancer , vol.106 , pp. 603-607
    • Larsson, S.C.1    Wolk, A.2
  • 18
    • 84870241775 scopus 로고    scopus 로고
    • Meat and fish consumption and risk of pancreatic cancer: Results from the European Prospective Investigation into Cancer and Nutrition
    • Rohrmann, S. et al. Meat and fish consumption and risk of pancreatic cancer: results from the European Prospective Investigation into Cancer and Nutrition. Int. J. Cancer 132, 617-624 (2013).
    • (2013) Int. J. Cancer , vol.132 , pp. 617-624
    • Rohrmann, S.1
  • 19
    • 84873433933 scopus 로고    scopus 로고
    • Nutrient-based dietary patterns and pancreatic cancer risk
    • Bosetti, C. et al. Nutrient-based dietary patterns and pancreatic cancer risk. Ann. Epidemiol. 23, 124-128 (2013).
    • (2013) Ann. Epidemiol. , vol.23 , pp. 124-128
    • Bosetti, C.1
  • 21
    • 74949137279 scopus 로고    scopus 로고
    • Alcohol drinking and pancreatic cancer risk: A meta-analysis of the dose-risk relation
    • Tramacere, I. et al. Alcohol drinking and pancreatic cancer risk: a meta-analysis of the dose-risk relation. Int. J. Cancer 126, 1474-1486 (2010).
    • (2010) Int. J. Cancer , vol.126 , pp. 1474-1486
    • Tramacere, I.1
  • 22
    • 84863064182 scopus 로고    scopus 로고
    • Alcohol consumption and pancreatic cancer: A pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4)
    • Lucenteforte, E. et al. Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4). Ann. Oncol. 23, 374-382 (2012).
    • (2012) Ann. Oncol. , vol.23 , pp. 374-382
    • Lucenteforte, E.1
  • 23
    • 84924610155 scopus 로고    scopus 로고
    • Diabetes, antidiabetic medications, and pancreatic cancer risk: An analysis from the International Pancreatic Cancer Case-Control Consortium
    • Bosetti, C. et al. Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium. Ann. Oncol. 25, 2065-2072 (2014).
    • (2014) Ann. Oncol. , vol.25 , pp. 2065-2072
    • Bosetti, C.1
  • 24
    • 37349014799 scopus 로고    scopus 로고
    • Pancreatic cancer-associated diabetes mellitus: Prevalence and temporal association with diagnosis of cancer
    • Chari, S. T. et al. Pancreatic cancer-associated diabetes mellitus: prevalence and temporal association with diagnosis of cancer. Gastroenterology 134, 95-101 (2008).
    • (2008) Gastroenterology , vol.134 , pp. 95-101
    • Chari, S.T.1
  • 25
    • 84887067227 scopus 로고    scopus 로고
    • Ulcer, gastric surgery and pancreatic cancer risk: An analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4)
    • Bosetti, C. et al. Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4). Ann. Oncol. 24, 2903-2910 (2013).
    • (2013) Ann. Oncol. , vol.24 , pp. 2903-2910
    • Bosetti, C.1
  • 26
    • 84884705554 scopus 로고    scopus 로고
    • Family history of cancer and the risk of cancer: A network of case-control studies
    • Turati, F. et al. Family history of cancer and the risk of cancer: a network of case-control studies. Ann. Oncol. 24, 2651-2656 (2013).
    • (2013) Ann. Oncol. , vol.24 , pp. 2651-2656
    • Turati, F.1
  • 27
    • 84874721663 scopus 로고    scopus 로고
    • ABO blood groups and pancreatic cancer risk and survival: Results from the PANcreatic Disease ReseArch (PANDoRA) consortium
    • Rizzato, C. et al. ABO blood groups and pancreatic cancer risk and survival: results from the PANcreatic Disease ReseArch (PANDoRA) consortium. Oncol. Rep. 29, 1637-1644 (2013).
    • (2013) Oncol. Rep. , vol.29 , pp. 1637-1644
    • Rizzato, C.1
  • 29
    • 84923125228 scopus 로고    scopus 로고
    • Thirty years of experience with intraductal papillary mucinous neoplasm of the pancreas: From discovery to international consensus
    • Tanaka, M. Thirty years of experience with intraductal papillary mucinous neoplasm of the pancreas: from discovery to international consensus. Digestion 90, 265-272 (2014).
    • (2014) Digestion , vol.90 , pp. 265-272
    • Tanaka, M.1
  • 30
    • 80755163679 scopus 로고    scopus 로고
    • Signaling pathways in pancreatic cancer
    • Preis, M. & Korc, M. Signaling pathways in pancreatic cancer. Crit. Rev. Eukaryot. Gene Expr. 21, 115-129 (2011).
    • (2011) Crit. Rev. Eukaryot. Gene Expr. , vol.21 , pp. 115-129
    • Preis, M.1    Korc, M.2
  • 31
    • 42649138943 scopus 로고    scopus 로고
    • Common activation of canonical Wnt signaling in pancreatic adenocarcinoma
    • Pasca di Magliano, M. et al. Common activation of canonical Wnt signaling in pancreatic adenocarcinoma. PLoS ONE 2, e1155 (2007).
    • (2007) PLoS ONE , vol.2
    • Pasca Di Magliano, M.1
  • 32
    • 80052443441 scopus 로고    scopus 로고
    • Differential roles of trans-phosphorylated EGFR, HER2, HER3, and RET as heterodimerisation partners of MET in lung cancer with MET amplification
    • Tanizaki, J., Okamoto, I., Sakai, K. & Nakagawa, K. Differential roles of trans-phosphorylated EGFR, HER2, HER3, and RET as heterodimerisation partners of MET in lung cancer with MET amplification. Br. J. Cancer 105, 807-813 (2011).
    • (2011) Br. J. Cancer , vol.105 , pp. 807-813
    • Tanizaki, J.1    Okamoto, I.2    Sakai, K.3    Nakagawa, K.4
  • 33
    • 84892912591 scopus 로고    scopus 로고
    • Pancreatic cancer-associated retinoblastoma 1 dysfunction enables TGF-β to promote proliferation
    • Gore, A. J., Deitz, S. L., Palam, L. R., Craven, K. E. & Korc, M. Pancreatic cancer-associated retinoblastoma 1 dysfunction enables TGF-β to promote proliferation. J. Clin. Invest. 124, 338-352 (2014).
    • (2014) J. Clin. Invest. , vol.124 , pp. 338-352
    • Gore, A.J.1    Deitz, S.L.2    Palam, L.R.3    Craven, K.E.4    Korc, M.5
  • 34
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones, S. et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321, 1801-1806 (2008).
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1
  • 35
    • 84863011464 scopus 로고    scopus 로고
    • Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency
    • Wang, L. et al. Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency. Genome Res. 22, 208-219 (2012).
    • (2012) Genome Res. , vol.22 , pp. 208-219
    • Wang, L.1
  • 36
    • 84869091997 scopus 로고    scopus 로고
    • Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
    • Biankin, A. V. et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 491, 399-405 (2012).
    • (2012) Nature , vol.491 , pp. 399-405
    • Biankin, A.V.1
  • 37
    • 84924056345 scopus 로고    scopus 로고
    • Whole genomes redefine the mutational landscape of pancreatic cancer
    • Waddell, N. et al. Whole genomes redefine the mutational landscape of pancreatic cancer. Nature 518, 495-501 (2015).
    • (2015) Nature , vol.518 , pp. 495-501
    • Waddell, N.1
  • 38
    • 84927144113 scopus 로고    scopus 로고
    • Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets
    • Witkiewicz, A. K. et al. Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets. Nat. Commun. 6, 6744 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 6744
    • Witkiewicz, A.K.1
  • 39
    • 84960194345 scopus 로고    scopus 로고
    • Genomic analyses identify molecular subtypes of pancreatic cancer
    • Bailey, P. et al. Genomic analyses identify molecular subtypes of pancreatic cancer. Nature 531, 47-52 (2016).
    • (2016) Nature , vol.531 , pp. 47-52
    • Bailey, P.1
  • 41
    • 84882837534 scopus 로고    scopus 로고
    • Signatures of mutational processes in human cancer
    • Alexandrov, L. B. et al. Signatures of mutational processes in human cancer. Nature 500, 415-421 (2013).
    • (2013) Nature , vol.500 , pp. 415-421
    • Alexandrov, L.B.1
  • 42
    • 65949122339 scopus 로고    scopus 로고
    • Genetic mutations associated with cigarette smoking in pancreatic cancer
    • Blackford, A. et al. Genetic mutations associated with cigarette smoking in pancreatic cancer. Cancer Res. 69, 3681-3688 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 3681-3688
    • Blackford, A.1
  • 43
    • 84902438252 scopus 로고    scopus 로고
    • Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling
    • Nones, K. et al. Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling. Int. J. Cancer 135, 1110-1118 (2014).
    • (2014) Int. J. Cancer , vol.135 , pp. 1110-1118
    • Nones, K.1
  • 44
    • 79953756460 scopus 로고    scopus 로고
    • Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy
    • Collisson, E. A. et al. Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy. Nat. Med. 17, 500-503 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 500-503
    • Collisson, E.A.1
  • 45
    • 84942885357 scopus 로고    scopus 로고
    • Virtual microdissection identifies distinct tumor-and stroma-specific subtypes of pancreatic ductal adenocarcinoma
    • Moffitt, R. A. et al. Virtual microdissection identifies distinct tumor-and stroma-specific subtypes of pancreatic ductal adenocarcinoma. Nat. Genet. 47, 1168-1178 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 1168-1178
    • Moffitt, R.A.1
  • 46
    • 84938940583 scopus 로고    scopus 로고
    • Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors
    • Daemen, A. et al. Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors. Proc. Natl Acad. Sci. USA 112, E4410-E4417 (2015).
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. E4410-E4417
    • Daemen, A.1
  • 47
    • 84902482580 scopus 로고    scopus 로고
    • Pancreatic cancer stroma: Friend or foe?
    • Gore, J. & Korc, M. Pancreatic cancer stroma: friend or foe? Cancer Cell 25, 711-712 (2014).
    • (2014) Cancer Cell , vol.25 , pp. 711-712
    • Gore, J.1    Korc, M.2
  • 48
    • 84944073483 scopus 로고    scopus 로고
    • Subtyping pancreatic cancer
    • Biankin, A. V. & Maitra, A. Subtyping pancreatic cancer. Cancer Cell 28, 411-413 (2015).
    • (2015) Cancer Cell , vol.28 , pp. 411-413
    • Biankin, A.V.1    Maitra, A.2
  • 49
    • 84942870377 scopus 로고    scopus 로고
    • Gene signatures from pancreatic cancer tumor and stromal cells predict disease outcome
    • Kottakis, F. & Bardeesy, N. Gene signatures from pancreatic cancer tumor and stromal cells predict disease outcome. Nat. Genet. 47, 1102-1103 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 1102-1103
    • Kottakis, F.1    Bardeesy, N.2
  • 50
    • 0028225322 scopus 로고
    • Allelotype of pancreatic adenocarcinoma
    • Seymour, A. B. et al. Allelotype of pancreatic adenocarcinoma. Cancer Res. 54, 2761-2764 (1994).
    • (1994) Cancer Res. , vol.54 , pp. 2761-2764
    • Seymour, A.B.1
  • 51
    • 35148814410 scopus 로고    scopus 로고
    • Dynamics of the immune reaction to pancreatic cancer from inception to invasion
    • Clark, C. E. et al. Dynamics of the immune reaction to pancreatic cancer from inception to invasion. Cancer Res. 67, 9518-9527 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 9518-9527
    • Clark, C.E.1
  • 52
    • 84921803174 scopus 로고    scopus 로고
    • Pancreatic cancer: Role of the immune system in cancer progression and vaccine-based immunotherapy
    • Amedei, A., Niccolai, E. & Prisco, D. Pancreatic cancer: role of the immune system in cancer progression and vaccine-based immunotherapy. Hum. Vaccin. Immunother. 10, 3354-3368 (2014).
    • (2014) Hum. Vaccin. Immunother. , vol.10 , pp. 3354-3368
    • Amedei, A.1    Niccolai, E.2    Prisco, D.3
  • 53
    • 84909606805 scopus 로고    scopus 로고
    • Complex role for the immune system in initiation and progression of pancreatic cancer
    • Inman, K. S., Francis, A. A. & Murray, N. R. Complex role for the immune system in initiation and progression of pancreatic cancer. World J. Gastroenterol. 20, 11160-11181 (2014).
    • (2014) World J. Gastroenterol. , vol.20 , pp. 11160-11181
    • Inman, K.S.1    Francis, A.A.2    Murray, N.R.3
  • 54
    • 84964314430 scopus 로고    scopus 로고
    • Immunotherapy converts nonimmunogenic pancreatic tumors into immunogenic foci of immune regulation
    • Lutz, E. R. et al. Immunotherapy converts nonimmunogenic pancreatic tumors into immunogenic foci of immune regulation. Cancer Immunol. Res. 2, 616-631 (2014).
    • (2014) Cancer Immunol. Res. , vol.2 , pp. 616-631
    • Lutz, E.R.1
  • 55
    • 52149094275 scopus 로고    scopus 로고
    • The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma
    • Erkan, M. et al. The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma. Clin. Gastroenterol. Hepatol. 6, 1155-1161 (2008).
    • (2008) Clin. Gastroenterol. Hepatol. , vol.6 , pp. 1155-1161
    • Erkan, M.1
  • 56
    • 84924311219 scopus 로고    scopus 로고
    • The prognostic value of stroma in pancreatic cancer in patients receiving adjuvant therapy
    • Bever, K. M. et al. The prognostic value of stroma in pancreatic cancer in patients receiving adjuvant therapy. HPB (Oxford) 17, 292-298 (2014).
    • (2014) HPB (Oxford) , vol.17 , pp. 292-298
    • Bever, K.M.1
  • 57
    • 84902469661 scopus 로고    scopus 로고
    • Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
    • Ozdemir, B. C. et al. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell 25, 719-734 (2014).
    • (2014) Cancer Cell , vol.25 , pp. 719-734
    • Ozdemir, B.C.1
  • 58
    • 84958025726 scopus 로고    scopus 로고
    • The prognostic role of desmoplastic stroma in pancreatic ductal adenocarcinoma
    • Wang, L. M. et al. The prognostic role of desmoplastic stroma in pancreatic ductal adenocarcinoma. Oncotarget 7, 4183-4194 (2016).
    • (2016) Oncotarget , vol.7 , pp. 4183-4194
    • Wang, L.M.1
  • 59
    • 84876786403 scopus 로고    scopus 로고
    • A starring role for stellate cells in the pancreatic cancer microenvironment
    • Apte, M. V., Wilson, J. S., Lugea, A. & Pandol, S. J. A starring role for stellate cells in the pancreatic cancer microenvironment. Gastroenterology 144, 1210-1219 (2013).
    • (2013) Gastroenterology , vol.144 , pp. 1210-1219
    • Apte, M.V.1    Wilson, J.S.2    Lugea, A.3    Pandol, S.J.4
  • 60
    • 84860431671 scopus 로고    scopus 로고
    • Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells
    • Hamada, S. et al. Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells. Biochem. Biophys. Res. Commun. 421, 349-354 (2012).
    • (2012) Biochem. Biophys. Res. Commun. , vol.421 , pp. 349-354
    • Hamada, S.1
  • 61
    • 78149315330 scopus 로고    scopus 로고
    • Role of pancreatic stellate cells in pancreatic cancer metastasis
    • Xu, Z. et al. Role of pancreatic stellate cells in pancreatic cancer metastasis. Am. J. Pathol. 177, 2585-2596 (2010).
    • (2010) Am. J. Pathol. , vol.177 , pp. 2585-2596
    • Xu, Z.1
  • 62
    • 84905675342 scopus 로고    scopus 로고
    • The role of the hepatocyte growth factor/c-MET pathway in pancreatic stellate cell-endothelial cell interactions: Antiangiogenic implications in pancreatic cancer
    • Patel, M. B. et al. The role of the hepatocyte growth factor/c-MET pathway in pancreatic stellate cell-endothelial cell interactions: antiangiogenic implications in pancreatic cancer. Carcinogenesis 35, 1891-1900 (2014).
    • (2014) Carcinogenesis , vol.35 , pp. 1891-1900
    • Patel, M.B.1
  • 63
    • 84886780808 scopus 로고    scopus 로고
    • Activated pancreatic stellate cells sequester CD8+ T-cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma
    • Ene-Obong, A. et al. Activated pancreatic stellate cells sequester CD8+ T-cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma. Gastroenterology 45, 1121-1132 (2013).
    • (2013) Gastroenterology , vol.45 , pp. 1121-1132
    • Ene-Obong, A.1
  • 64
    • 84856960944 scopus 로고    scopus 로고
    • High expression of galectin-1 in pancreatic stellate cells plays a role in the development and maintenance of an immunosuppressive microenvironment in pancreatic cancer
    • Tang, D. et al. High expression of galectin-1 in pancreatic stellate cells plays a role in the development and maintenance of an immunosuppressive microenvironment in pancreatic cancer. Int. J. Cancer 130, 2337-2348 (2012).
    • (2012) Int. J. Cancer , vol.130 , pp. 2337-2348
    • Tang, D.1
  • 65
    • 84886943841 scopus 로고    scopus 로고
    • Pancreatic cancer-associated stellate cells: A viable target for reducing immunosuppression in the tumor microenvironment
    • Mace, T. A., Bloomston, M. & Lesinski, G. B. Pancreatic cancer-associated stellate cells: a viable target for reducing immunosuppression in the tumor microenvironment. Oncoimmunology 2, e24891 (2013).
    • (2013) Oncoimmunology , vol.2
    • Mace, T.A.1    Bloomston, M.2    Lesinski, G.B.3
  • 66
    • 84880074843 scopus 로고    scopus 로고
    • Dynamic mast cell-stromal cell interactions promote growth of pancreatic cancer
    • Ma, Y., Hwang, R. F., Logsdon, C. D. & Ullrich, S. E. Dynamic mast cell-stromal cell interactions promote growth of pancreatic cancer. Cancer Res. 73, 3927-3937 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 3927-3937
    • Ma, Y.1    Hwang, R.F.2    Logsdon, C.D.3    Ullrich, S.E.4
  • 67
    • 84897403310 scopus 로고    scopus 로고
    • Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction
    • Shi, C. et al. Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction. Lab. Invest. 94, 409-421 (2014).
    • (2014) Lab. Invest. , vol.94 , pp. 409-421
    • Shi, C.1
  • 68
    • 84905992751 scopus 로고    scopus 로고
    • Sonic Hedgehog paracrine signaling activates stromal cells to promote perineural invasion in pancreatic cancer
    • Li, X. et al. Sonic Hedgehog paracrine signaling activates stromal cells to promote perineural invasion in pancreatic cancer. Clin. Cancer Res. 20, 4326-4338 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 4326-4338
    • Li, X.1
  • 69
    • 84876313494 scopus 로고    scopus 로고
    • Pancreatic stellate cells reduce insulin expression and induce apoptosis in pancreatic β-cells
    • Kikuta, K. et al. Pancreatic stellate cells reduce insulin expression and induce apoptosis in pancreatic β-cells. Biochem. Biophys. Res. Commun. 433, 292-297 (2013).
    • (2013) Biochem. Biophys. Res. Commun. , vol.433 , pp. 292-297
    • Kikuta, K.1
  • 70
    • 84904994417 scopus 로고    scopus 로고
    • Stromal response to Hedgehog signaling restrains pancreatic cancer progression
    • Lee, J. J. et al. Stromal response to Hedgehog signaling restrains pancreatic cancer progression. Proc. Natl Acad. Sci. USA 111, E3091-E3100 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. E3091-E3100
    • Lee, J.J.1
  • 71
    • 84902435628 scopus 로고    scopus 로고
    • Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
    • Rhim, A. D. et al. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell 25, 735-747 (2014).
    • (2014) Cancer Cell , vol.25 , pp. 735-747
    • Rhim, A.D.1
  • 72
    • 65949114866 scopus 로고    scopus 로고
    • Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma
    • Erkan, M. et al. Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma. Neoplasia 11, 497-508 (2009).
    • (2009) Neoplasia , vol.11 , pp. 497-508
    • Erkan, M.1
  • 73
    • 84945575382 scopus 로고    scopus 로고
    • Hypoxia-induced endoplasmic reticulum stress characterizes a necrotic phenotype of pancreatic cancer
    • Kong, B. et al. Hypoxia-induced endoplasmic reticulum stress characterizes a necrotic phenotype of pancreatic cancer. Oncotarget 6, 32154-32160 (2015).
    • (2015) Oncotarget , vol.6 , pp. 32154-32160
    • Kong, B.1
  • 74
    • 85006480808 scopus 로고    scopus 로고
    • Hypoxia signaling pathways: Modulators of oxygen-related organelles
    • Schonenberger, M. J. & Kovacs, W. J. Hypoxia signaling pathways: modulators of oxygen-related organelles. Front. Cell Dev. Biol. 3, 42 (2015).
    • (2015) Front. Cell Dev. Biol. , vol.3 , pp. 42
    • Schonenberger, M.J.1    Kovacs, W.J.2
  • 75
    • 84908237673 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1- expression and its clinical significance in pancreatic cancer: A meta-analysis
    • Ye, L. Y. et al. Hypoxia-inducible factor 1- expression and its clinical significance in pancreatic cancer: a meta-analysis. Pancreatology 14, 391-397 (2014).
    • (2014) Pancreatology , vol.14 , pp. 391-397
    • Ye, L.Y.1
  • 76
    • 79952229430 scopus 로고    scopus 로고
    • Pancreatic cancers require autophagy for tumor growth
    • Yang, S. et al. Pancreatic cancers require autophagy for tumor growth. Genes Dev. 25, 717-729 (2011).
    • (2011) Genes Dev. , vol.25 , pp. 717-729
    • Yang, S.1
  • 77
    • 84939787271 scopus 로고    scopus 로고
    • Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism
    • Perera, R. M. et al. Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature 524, 361-365 (2015).
    • (2015) Nature , vol.524 , pp. 361-365
    • Perera, R.M.1
  • 78
    • 84890432985 scopus 로고    scopus 로고
    • P53 status determines the role of autophagy in pancreatic tumour development
    • Rosenfeldt, M. T. et al. p53 status determines the role of autophagy in pancreatic tumour development. Nature 504, 296-300 (2013).
    • (2013) Nature , vol.504 , pp. 296-300
    • Rosenfeldt, M.T.1
  • 79
    • 84905499163 scopus 로고    scopus 로고
    • Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations
    • Yang, A. et al. Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations. Cancer Discov. 4, 905-913 (2014).
    • (2014) Cancer Discov. , vol.4 , pp. 905-913
    • Yang, A.1
  • 80
    • 84878396462 scopus 로고    scopus 로고
    • Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
    • Commisso, C. et al. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature 497, 633-637 (2013).
    • (2013) Nature , vol.497 , pp. 633-637
    • Commisso, C.1
  • 81
    • 84961288972 scopus 로고    scopus 로고
    • Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein
    • Kamphorst, J. J. et al. Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Res. 75, 544-553 (2015).
    • (2015) Cancer Res. , vol.75 , pp. 544-553
    • Kamphorst, J.J.1
  • 82
    • 84938267002 scopus 로고    scopus 로고
    • Targeting cancer cell metabolism in pancreatic adenocarcinoma
    • Cohen, R. et al. Targeting cancer cell metabolism in pancreatic adenocarcinoma. Oncotarget 6, 16832-16847 (2015).
    • (2015) Oncotarget , vol.6 , pp. 16832-16847
    • Cohen, R.1
  • 83
    • 0028059330 scopus 로고
    • Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
    • Caldas, C. et al. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat. Genet. 8, 27-32 (1994).
    • (1994) Nat. Genet. , vol.8 , pp. 27-32
    • Caldas, C.1
  • 84
    • 9144266295 scopus 로고    scopus 로고
    • Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
    • Hingorani, S. R. et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4, 437-450 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 437-450
    • Hingorani, S.R.1
  • 85
    • 33847419143 scopus 로고    scopus 로고
    • Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
    • Guerra, C. et al. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 11, 291-302 (2007).
    • (2007) Cancer Cell , vol.11 , pp. 291-302
    • Guerra, C.1
  • 86
    • 0346455774 scopus 로고    scopus 로고
    • Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
    • Aguirre, A. J. et al. Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev. 17, 3112-3126 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 3112-3126
    • Aguirre, A.J.1
  • 87
    • 84946215806 scopus 로고    scopus 로고
    • Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell-and patient-derived tumor organoids
    • Huang, L. et al. Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell-and patient-derived tumor organoids. Nat. Med. 21, 1364-1371 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 1364-1371
    • Huang, L.1
  • 88
    • 84920983131 scopus 로고    scopus 로고
    • Organoid models of human and mouse ductal pancreatic cancer
    • Boj, S. F. et al. Organoid models of human and mouse ductal pancreatic cancer. Cell 160, 324-338 (2015).
    • (2015) Cell , vol.160 , pp. 324-338
    • Boj, S.F.1
  • 89
    • 84885846800 scopus 로고    scopus 로고
    • Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/ R-spondin axis
    • Huch, M. et al. Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/ R-spondin axis. EMBO J. 32, 2708-2721 (2013).
    • (2013) EMBO J. , vol.32 , pp. 2708-2721
    • Huch, M.1
  • 90
    • 33751251034 scopus 로고    scopus 로고
    • Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer
    • Bardeesy, N. et al. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev. 20, 3130-3146 (2006).
    • (2006) Genes Dev. , vol.20 , pp. 3130-3146
    • Bardeesy, N.1
  • 91
    • 19344362405 scopus 로고    scopus 로고
    • Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
    • Hingorani, S. R. et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7, 469-483 (2005).
    • (2005) Cancer Cell , vol.7 , pp. 469-483
    • Hingorani, S.R.1
  • 92
    • 31544467540 scopus 로고    scopus 로고
    • Pathology of genetically engineered mouse models of pancreatic exocrine cancer: Consensus report and recommendations
    • Hruban, R. H. et al. Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations. Cancer Res. 66, 95-106 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 95-106
    • Hruban, R.H.1
  • 93
    • 33847387472 scopus 로고    scopus 로고
    • KrasG12D and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas
    • Izeradjene, K. et al. KrasG12D and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. Cancer Cell 11, 229-243 (2007).
    • (2007) Cancer Cell , vol.11 , pp. 229-243
    • Izeradjene, K.1
  • 94
    • 33751247898 scopus 로고    scopus 로고
    • Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-β signaling in cooperation with active Kras expression
    • Ijichi, H. et al. Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-β signaling in cooperation with active Kras expression. Genes Dev. 20, 3147-3160 (2006).
    • (2006) Genes Dev. , vol.20 , pp. 3147-3160
    • Ijichi, H.1
  • 95
    • 84859947197 scopus 로고    scopus 로고
    • Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma
    • Mann, K. M. et al. Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Proc. Natl Acad. Sci. USA 109, 5934-5941 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 5934-5941
    • Mann, K.M.1
  • 96
    • 84861990162 scopus 로고    scopus 로고
    • The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma
    • Perez-Mancera, P. A. et al. The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature 486, 266-270 (2012).
    • (2012) Nature , vol.486 , pp. 266-270
    • Perez-Mancera, P.A.1
  • 97
    • 84964312485 scopus 로고    scopus 로고
    • A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer
    • Rad, R. et al. A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer. Nat. Genet. 47, 47-56 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 47-56
    • Rad, R.1
  • 98
    • 84866035571 scopus 로고    scopus 로고
    • EGF receptor signaling is essential for K-ras oncogene-driven pancreatic ductal adenocarcinoma
    • Navas, C. et al. EGF receptor signaling is essential for K-ras oncogene-driven pancreatic ductal adenocarcinoma. Cancer Cell 22, 318-330 (2012).
    • (2012) Cancer Cell , vol.22 , pp. 318-330
    • Navas, C.1
  • 99
    • 79960060305 scopus 로고    scopus 로고
    • Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
    • DeNicola, G. M. et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 475, 106-109 (2011).
    • (2011) Nature , vol.475 , pp. 106-109
    • DeNicola, G.M.1
  • 100
    • 84860321700 scopus 로고    scopus 로고
    • Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
    • Ying, H. et al. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell 149, 656-670 (2012).
    • (2012) Cell , vol.149 , pp. 656-670
    • Ying, H.1
  • 101
    • 84863012865 scopus 로고    scopus 로고
    • Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
    • Collins, M. A. et al. Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. J. Clin. Invest. 122, 639-653 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 639-653
    • Collins, M.A.1
  • 102
    • 84891711129 scopus 로고    scopus 로고
    • A modular and flexible ESC-based mouse model of pancreatic cancer
    • Saborowski, M. et al. A modular and flexible ESC-based mouse model of pancreatic cancer. Genes Dev. 28, 85-97 (2014).
    • (2014) Genes Dev. , vol.28 , pp. 85-97
    • Saborowski, M.1
  • 103
    • 84875894714 scopus 로고    scopus 로고
    • Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
    • Son, J. et al. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature 496, 101-105 (2013).
    • (2013) Nature , vol.496 , pp. 101-105
    • Son, J.1
  • 104
    • 84870803922 scopus 로고    scopus 로고
    • Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma
    • Kopp, J. L. et al. Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell 22, 737-750 (2012).
    • (2012) Cancer Cell , vol.22 , pp. 737-750
    • Kopp, J.L.1
  • 105
    • 84895432066 scopus 로고    scopus 로고
    • The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma
    • von Figura, G. et al. The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma. Nat. Cell Biol. 16, 255-267 (2014).
    • (2014) Nat. Cell Biol. , vol.16 , pp. 255-267
    • Von Figura, G.1
  • 106
    • 70350513347 scopus 로고    scopus 로고
    • Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras
    • Gidekel Friedlander, S. Y. et al. Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras. Cancer Cell 16, 379-389 (2009).
    • (2009) Cancer Cell , vol.16 , pp. 379-389
    • Gidekel Friedlander, S.Y.1
  • 107
    • 57749113202 scopus 로고    scopus 로고
    • Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice
    • Habbe, N. et al. Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc. Natl Acad. Sci. USA 105, 18913-18918 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 18913-18918
    • Habbe, N.1
  • 108
    • 84982182050 scopus 로고    scopus 로고
    • P53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells
    • Bailey, J. M. et al. p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells. Oncogene http://dx.doi.org/ 10.1038/onc.2015.441 (2015).
    • (2015) Oncogene
    • Bailey, J.M.1
  • 109
    • 84862147254 scopus 로고    scopus 로고
    • Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia
    • Pylayeva-Gupta, Y., Lee, K. E., Hajdu, C. H., Miller, G. & Bar-Sagi, D. Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer Cell 21, 836-847 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 836-847
    • Pylayeva-Gupta, Y.1    Lee, K.E.2    Hajdu, C.H.3    Miller, G.4    Bar-Sagi, D.5
  • 110
    • 84862150896 scopus 로고    scopus 로고
    • Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer
    • Bayne, L. J. et al. Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer. Cancer Cell 21, 822-835 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 822-835
    • Bayne, L.J.1
  • 111
    • 84903462699 scopus 로고    scopus 로고
    • Pancreatic cancer-induced cachexia is Jak2-dependent in mice
    • Gilabert, M. et al. Pancreatic cancer-induced cachexia is Jak2-dependent in mice. J. Cell. Physiol. 229, 1437-1443 (2014).
    • (2014) J. Cell. Physiol. , vol.229 , pp. 1437-1443
    • Gilabert, M.1
  • 112
    • 84896496826 scopus 로고    scopus 로고
    • Neuroplastic changes occur early in the development of pancreatic ductal adenocarcinoma
    • Stopczynski, R. E. et al. Neuroplastic changes occur early in the development of pancreatic ductal adenocarcinoma. Cancer Res. 74, 1718-1727 (2014).
    • (2014) Cancer Res. , vol.74 , pp. 1718-1727
    • Stopczynski, R.E.1
  • 113
    • 84887898693 scopus 로고    scopus 로고
    • High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model
    • Dawson, D. W. et al. High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model. Cancer Prev. Res. (Phila.) 6, 1064-1073 (2013).
    • (2013) Cancer Prev. Res. (Phila.) , vol.6 , pp. 1064-1073
    • Dawson, D.W.1
  • 114
    • 84964391958 scopus 로고    scopus 로고
    • TLR9 ligation in pancreatic stellate cells promotes tumorigenesis
    • Zambirinis, C. P. et al. TLR9 ligation in pancreatic stellate cells promotes tumorigenesis. J. Exp. Med. 212, 2077-2094 (2015).
    • (2015) J. Exp. Med. , vol.212 , pp. 2077-2094
    • Zambirinis, C.P.1
  • 115
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • Olive, K. P. et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324, 1457-1461 (2009).
    • (2009) Science , vol.324 , pp. 1457-1461
    • Olive, K.P.1
  • 116
    • 84918811818 scopus 로고    scopus 로고
    • Pilot clinical trial of hedgehog pathway inhibitor GDC-0449 (vismodegib) in combination with gemcitabine in patients with metastatic pancreatic adenocarcinoma
    • Kim, E. J. et al. Pilot clinical trial of hedgehog pathway inhibitor GDC-0449 (vismodegib) in combination with gemcitabine in patients with metastatic pancreatic adenocarcinoma. Clin. Cancer Res. 20, 5937-5945 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 5937-5945
    • Kim, E.J.1
  • 117
    • 84957580046 scopus 로고    scopus 로고
    • Randomized Phase Ib/II study of gemcitabine plus placebo or vismodegib, a Hedgehog pathway inhibitor, in patients with metastatic pancreatic cancer
    • Catenacci, D. V. et al. Randomized Phase Ib/II study of gemcitabine plus placebo or vismodegib, a Hedgehog pathway inhibitor, in patients with metastatic pancreatic cancer. J. Clin. Oncol. 33, 4284-4292 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 4284-4292
    • Catenacci, D.V.1
  • 118
    • 84858602107 scopus 로고    scopus 로고
    • Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
    • Provenzano, P. P. et al. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 21, 418-429 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 418-429
    • Provenzano, P.P.1
  • 119
    • 84871157346 scopus 로고    scopus 로고
    • Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
    • Jacobetz, M. A. et al. Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut 62, 112-120 (2013).
    • (2013) Gut , vol.62 , pp. 112-120
    • Jacobetz, M.A.1
  • 120
    • 84907485104 scopus 로고    scopus 로고
    • Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy
    • Sherman, M. H. et al. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell 159, 80-93 (2014).
    • (2014) Cell , vol.159 , pp. 80-93
    • Sherman, M.H.1
  • 121
    • 84890281217 scopus 로고    scopus 로고
    • Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer
    • Feig, C. et al. Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. Proc. Natl Acad. Sci. USA 110, 20212-20217 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 20212-20217
    • Feig, C.1
  • 122
    • 79953154967 scopus 로고    scopus 로고
    • CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
    • Beatty, G. L. et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science 331, 1612-1616 (2011).
    • (2011) Science , vol.331 , pp. 1612-1616
    • Beatty, G.L.1
  • 123
    • 84931434511 scopus 로고    scopus 로고
    • Exclusion of T cells from pancreatic carcinomas in mice is regulated by Ly6Clow F4/80+ extratumoral macrophages
    • Beatty, G. L. et al. Exclusion of T cells from pancreatic carcinomas in mice is regulated by Ly6Clow F4/80+ extratumoral macrophages. Gastroenterology 149, 201-210 (2015).
    • (2015) Gastroenterology , vol.149 , pp. 201-210
    • Beatty, G.L.1
  • 124
    • 84901218374 scopus 로고    scopus 로고
    • A Listeria vaccine and depletion of T-regulatory cells activate immunity against early stage pancreatic intraepithelial neoplasms and prolong survival of mice
    • Keenan, B. P. et al. A Listeria vaccine and depletion of T-regulatory cells activate immunity against early stage pancreatic intraepithelial neoplasms and prolong survival of mice. Gastroenterology 146, 1784-1794 (2014).
    • (2014) Gastroenterology , vol.146 , pp. 1784-1794
    • Keenan, B.P.1
  • 125
    • 84921064807 scopus 로고    scopus 로고
    • Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer
    • Alagesan, B. et al. Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer. Clin. Cancer Res. 21, 396-404 (2015).
    • (2015) Clin. Cancer Res. , vol.21 , pp. 396-404
    • Alagesan, B.1
  • 126
    • 84860374357 scopus 로고    scopus 로고
    • Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma
    • Cook, N. et al. Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma. J. Exp. Med. 209, 437-444 (2012).
    • (2012) J. Exp. Med. , vol.209 , pp. 437-444
    • Cook, N.1
  • 127
    • 79251492724 scopus 로고    scopus 로고
    • Plectin-1 as a novel biomarker for pancreatic cancer
    • Bausch, D. et al. Plectin-1 as a novel biomarker for pancreatic cancer. Clin. Cancer Res. 17, 302-309 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 302-309
    • Bausch, D.1
  • 128
    • 84878749585 scopus 로고    scopus 로고
    • Claudin-4-targeted optical imaging detects pancreatic cancer and its precursor lesions
    • Neesse, A. et al. Claudin-4-targeted optical imaging detects pancreatic cancer and its precursor lesions. Gut 62, 1034-1043 (2013).
    • (2013) Gut , vol.62 , pp. 1034-1043
    • Neesse, A.1
  • 129
    • 46349104324 scopus 로고    scopus 로고
    • A mouse to human search for plasma proteome changes associated with pancreatic tumor development
    • Faca, V. M. et al. A mouse to human search for plasma proteome changes associated with pancreatic tumor development. PLoS Med. 5, e123 (2008).
    • (2008) PLoS Med. , vol.5 , pp. e123
    • Faca, V.M.1
  • 130
    • 84936980504 scopus 로고    scopus 로고
    • Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
    • Melo, S. A. et al. Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature 523, 177-182 (2015).
    • (2015) Nature , vol.523 , pp. 177-182
    • Melo, S.A.1
  • 131
    • 84938151244 scopus 로고    scopus 로고
    • Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/ Cas9-mediated somatic genome editing
    • Chiou, S. H. et al. Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/ Cas9-mediated somatic genome editing. Genes Dev. 29, 1576-1585 (2015).
    • (2015) Genes Dev. , vol.29 , pp. 1576-1585
    • Chiou, S.H.1
  • 132
    • 78049398107 scopus 로고    scopus 로고
    • Distant metastasis occurs late during the genetic evolution of pancreatic cancer
    • Yachida, S. et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 467, 1114-1117 (2010).
    • (2010) Nature , vol.467 , pp. 1114-1117
    • Yachida, S.1
  • 133
    • 84903955049 scopus 로고    scopus 로고
    • The early detection of pancreatic cancer: What will it take to diagnose and treat curable pancreatic neoplasia?
    • Lennon, A. M. et al. The early detection of pancreatic cancer: what will it take to diagnose and treat curable pancreatic neoplasia? Cancer Res. 74, 3381-3389 (2014).
    • (2014) Cancer Res , vol.74 , pp. 3381-3389
    • Lennon, A.M.1
  • 134
    • 84877746197 scopus 로고    scopus 로고
    • The clinical utility of CA 19-19 in pancreatic adenocarcinoma: Diagnostic and prognostic updates
    • Poruk, K. E. et al. The clinical utility of CA 19-19 in pancreatic adenocarcinoma: diagnostic and prognostic updates. Curr. Mol. Med. 13, 340-351 (2013).
    • (2013) Curr. Mol. Med. , vol.13 , pp. 340-351
    • Poruk, K.E.1
  • 135
    • 84987784586 scopus 로고    scopus 로고
    • Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients
    • Sausen, M. et al. Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients. Nat. Commun. 6, 7686 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 7686
    • Sausen, M.1
  • 136
    • 84896371874 scopus 로고    scopus 로고
    • Detection of circulating tumor DNA in early-and late-stage human malignancies
    • Bettegowda, C. et al. Detection of circulating tumor DNA in early-and late-stage human malignancies. Sci. Transl Med. 6, 224ra24 (2014).
    • (2014) Sci. Transl Med. , vol.6 , pp. 224ra24
    • Bettegowda, C.1
  • 137
    • 84921950738 scopus 로고    scopus 로고
    • Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development
    • Mayers, J. R. et al. Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development. Nat. Med. 20, 1193-1198 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 1193-1198
    • Mayers, J.R.1
  • 138
    • 84927590328 scopus 로고    scopus 로고
    • Cross-species antibody microarray interrogation identifies a 3-protein panel of plasma biomarkers for early diagnosis of pancreas cancer
    • Mirus, J. E. et al. Cross-species antibody microarray interrogation identifies a 3-protein panel of plasma biomarkers for early diagnosis of pancreas cancer. Clin. Cancer Res. 21, 1764-1771 (2015).
    • (2015) Clin. Cancer Res. , vol.21 , pp. 1764-1771
    • Mirus, J.E.1
  • 139
    • 84927637238 scopus 로고    scopus 로고
    • Pancreatic cancer-derived exosomes cause paraneoplastic β-cell dysfunction
    • Javeed, N. et al. Pancreatic cancer-derived exosomes cause paraneoplastic β-cell dysfunction. Clin. Cancer Res. 21, 1722-1733 (2015).
    • (2015) Clin. Cancer Res. , vol.21 , pp. 1722-1733
    • Javeed, N.1
  • 140
    • 84927177778 scopus 로고    scopus 로고
    • A pilot study to develop a diagnostic test for pancreatic ductal adenocarcinoma based on differential expression of select miRNA in plasma and bile
    • Cote, G. A. et al. A pilot study to develop a diagnostic test for pancreatic ductal adenocarcinoma based on differential expression of select miRNA in plasma and bile. Am. J. Gastroenterol. 109, 1942-1952 (2014).
    • (2014) Am. J. Gastroenterol. , vol.109 , pp. 1942-1952
    • Cote, G.A.1
  • 141
    • 70350714432 scopus 로고    scopus 로고
    • Circulating mesothelin protein and cellular antimesothelin immunity in patients with pancreatic cancer
    • Johnston, F. M. et al. Circulating mesothelin protein and cellular antimesothelin immunity in patients with pancreatic cancer. Clin. Cancer Res. 15, 6511-6518 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 6511-6518
    • Johnston, F.M.1
  • 142
    • 84879953494 scopus 로고    scopus 로고
    • Mesothelin virus-like particle immunization controls pancreatic cancer growth through CD8+ T cell induction and reduction in the frequency of CD4+ Foxp3+ ICOS-regulatory T cells
    • Zhang, S. et al. Mesothelin virus-like particle immunization controls pancreatic cancer growth through CD8+ T cell induction and reduction in the frequency of CD4+ Foxp3+ ICOS-regulatory T cells. PLoS ONE 8, e68303 (2013).
    • (2013) PLoS ONE , vol.8
    • Zhang, S.1
  • 143
    • 84883670305 scopus 로고    scopus 로고
    • Recent progress in pancreatic cancer
    • Wolfgang, C. L. et al. Recent progress in pancreatic cancer. CA Cancer J. Clin. 63, 318-348 (2013).
    • (2013) CA Cancer J. Clin. , vol.63 , pp. 318-348
    • Wolfgang, C.L.1
  • 144
    • 84903140829 scopus 로고    scopus 로고
    • Imaging diagnosis of pancreatic cancer: A state-of-the-art review
    • Lee, E. S. & Lee, J. M. Imaging diagnosis of pancreatic cancer: a state-of-the-art review. World J. Gastroenterol. 20, 7864-7877 (2014).
    • (2014) World J. Gastroenterol. , vol.20 , pp. 7864-7877
    • Lee, E.S.1    Lee, J.M.2
  • 145
    • 79960694072 scopus 로고    scopus 로고
    • Detection of pancreatic carcinoma and liver metastases with gadoxetic acid-enhanced MR imaging: Comparison with contrast-enhanced multi-detector row CT
    • Motosugi, U. et al. Detection of pancreatic carcinoma and liver metastases with gadoxetic acid-enhanced MR imaging: comparison with contrast-enhanced multi-detector row CT. Radiology 260, 446-453 (2011).
    • (2011) Radiology , vol.260 , pp. 446-453
    • Motosugi, U.1
  • 146
    • 84982791113 scopus 로고    scopus 로고
    • Current evidence for the diagnostic value of gadoxetic acid-enhanced magnetic resonance imaging for liver metastasis
    • Tsurusaki, M., Sofue, K. & Murakami, T. Current evidence for the diagnostic value of gadoxetic acid-enhanced magnetic resonance imaging for liver metastasis. Hepatol. Res. http://dx.doi.org/10.1111/ hepr.12646 (2016).
    • (2016) Hepatol. Res.
    • Tsurusaki, M.1    Sofue, K.2    Murakami, T.3
  • 147
    • 84985905020 scopus 로고    scopus 로고
    • A multicentre comparative prospective blinded analysis of EUS and MRI for screening of pancreatic cancer in high-risk individuals
    • Harinck, F. et al. A multicentre comparative prospective blinded analysis of EUS and MRI for screening of pancreatic cancer in high-risk individuals. Gut http://dx.doi.org/10.1136/gutjnl-2014-308008 (2015).
    • (2015) Gut
    • Harinck, F.1
  • 148
    • 84944341941 scopus 로고    scopus 로고
    • Linear-array EUS improves detection of pancreatic lesions in high-risk individuals: A randomized tandem study
    • Shin, E. J. et al. Linear-array EUS improves detection of pancreatic lesions in high-risk individuals: a randomized tandem study. Gastrointest. Endosc. 82, 812-818 (2015).
    • (2015) Gastrointest. Endosc. , vol.82 , pp. 812-818
    • Shin, E.J.1
  • 149
    • 84931957361 scopus 로고    scopus 로고
    • FDG PET/CT in pancreatic and hepatobiliary carcinomas: Value to patient management and patient outcomes
    • Parikh, U., Marcus, C., Sarangi, R., Taghipour, M. & Subramaniam, R. M. FDG PET/CT in pancreatic and hepatobiliary carcinomas: value to patient management and patient outcomes. PET Clin. 10, 327-343 (2015).
    • (2015) PET Clin. , vol.10 , pp. 327-343
    • Parikh, U.1    Marcus, C.2    Sarangi, R.3    Taghipour, M.4    Subramaniam, R.M.5
  • 152
    • 0033891752 scopus 로고    scopus 로고
    • Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas: A new marker of DPC4 inactivation
    • Wilentz, R. E. et al. Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas: a new marker of DPC4 inactivation. Am. J. Pathol. 156, 37-43 (2000).
    • (2000) Am. J. Pathol. , vol.156 , pp. 37-43
    • Wilentz, R.E.1
  • 153
    • 84948695938 scopus 로고    scopus 로고
    • A revised classification system and recommendations from the Baltimore consensus meeting for neoplastic precursor lesions in the pancreas
    • Basturk, O. et al. A revised classification system and recommendations from the Baltimore consensus meeting for neoplastic precursor lesions in the pancreas. Am. J. Surg. Pathol. 39, 1730-1741 (2015).
    • (2015) Am. J. Surg. Pathol. , vol.39 , pp. 1730-1741
    • Basturk, O.1
  • 154
    • 71049161648 scopus 로고    scopus 로고
    • Resected pancreatic adenosquamous carcinoma: Clinicopathologic review and evaluation of adjuvant chemotherapy and radiation in 38 patients
    • Voong, K. R. et al. Resected pancreatic adenosquamous carcinoma: clinicopathologic review and evaluation of adjuvant chemotherapy and radiation in 38 patients. Hum. Pathol. 41, 113-122 (2010).
    • (2010) Hum. Pathol. , vol.41 , pp. 113-122
    • Voong, K.R.1
  • 155
    • 84932628341 scopus 로고    scopus 로고
    • PD-1 blockade in tumors with mismatch-repair deficiency
    • Le, D. T. et al. PD-1 blockade in tumors with mismatch-repair deficiency. N. Engl. J. Med. 372, 2509-2520 (2015).
    • (2015) N. Engl. J. Med. , vol.372 , pp. 2509-2520
    • Le, D.T.1
  • 156
    • 41149135288 scopus 로고    scopus 로고
    • Mucinous cystic neoplasm of the pancreas is not an aggressive entity: Lessons from 163 resected patients
    • Crippa, S. et al. Mucinous cystic neoplasm of the pancreas is not an aggressive entity: lessons from 163 resected patients. Ann. Surg. 247, 571-579 (2008).
    • (2008) Ann. Surg. , vol.247 , pp. 571-579
    • Crippa, S.1
  • 157
    • 79960847682 scopus 로고    scopus 로고
    • Survival after resection for invasive intraductal papillary mucinous neoplasm and for pancreatic adenocarcinoma: A multi-institutional comparison according to American Joint Committee on Cancer Stage
    • Waters, J. A. et al. Survival after resection for invasive intraductal papillary mucinous neoplasm and for pancreatic adenocarcinoma: a multi-institutional comparison according to American Joint Committee on Cancer Stage. J. Am. Coll. Surg. 213, 275-283 (2011).
    • (2011) J. Am. Coll. Surg. , vol.213 , pp. 275-283
    • Waters, J.A.1
  • 158
    • 84355162899 scopus 로고    scopus 로고
    • Management of patients with pancreatic adenocarcinoma: National trends in patient selection, operative management, and use of adjuvant therapy
    • Mayo, S. C. et al. Management of patients with pancreatic adenocarcinoma: national trends in patient selection, operative management, and use of adjuvant therapy. J. Am. Coll. Surg. 214, 33-45 (2012).
    • (2012) J. Am. Coll. Surg. , vol.214 , pp. 33-45
    • Mayo, S.C.1
  • 159
    • 84932617756 scopus 로고    scopus 로고
    • Early detection of sporadic pancreatic cancer: Summative review
    • Chari, S. T. et al. Early detection of sporadic pancreatic cancer: summative review. Pancreas 44, 693-712 (2015).
    • (2015) Pancreas , vol.44 , pp. 693-712
    • Chari, S.T.1
  • 160
    • 84884164667 scopus 로고    scopus 로고
    • An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population
    • Klein, A. P. et al. An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population. PLoS ONE 8, e72311 (2013).
    • (2013) PLoS ONE , vol.8
    • Klein, A.P.1
  • 161
    • 84936791882 scopus 로고    scopus 로고
    • Detectable symptomatology preceding the diagnosis of pancreatic cancer and absolute risk of pancreatic cancer diagnosis
    • Risch, H. A., Yu, H., Lu, L. & Kidd, M. S. Detectable symptomatology preceding the diagnosis of pancreatic cancer and absolute risk of pancreatic cancer diagnosis. Am. J. Epidemiol. 182, 26-34 (2015).
    • (2015) Am. J. Epidemiol. , vol.182 , pp. 26-34
    • Risch, H.A.1    Yu, H.2    Lu, L.3    Kidd, M.S.4
  • 162
    • 11144353646 scopus 로고    scopus 로고
    • Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds
    • Klein, A. P. et al. Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds. Cancer Res. 64, 2634-2638 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 2634-2638
    • Klein, A.P.1
  • 163
    • 84858704828 scopus 로고    scopus 로고
    • Screening for pancreatic cancer in a high-risk cohort: An eight-year experience
    • Al-Sukhni, W. et al. Screening for pancreatic cancer in a high-risk cohort: an eight-year experience. J. Gastrointest. Surg. 16, 771-783 (2012).
    • (2012) J. Gastrointest. Surg. , vol.16 , pp. 771-783
    • Al-Sukhni, W.1
  • 164
    • 84873412474 scopus 로고    scopus 로고
    • International Cancer of the Pancreas Screening (CAPS) consortium summit on the management of patients with increased risk for familial pancreatic cancer
    • Canto, M. I. et al. International Cancer of the Pancreas Screening (CAPS) consortium summit on the management of patients with increased risk for familial pancreatic cancer. Gut 62, 339-347 (2013).
    • (2013) Gut , vol.62 , pp. 339-347
    • Canto, M.I.1
  • 165
    • 84862168016 scopus 로고    scopus 로고
    • International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas
    • Tanaka, M. et al. International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology 12, 183-197 (2012).
    • (2012) Pancreatology , vol.12 , pp. 183-197
    • Tanaka, M.1
  • 166
    • 84926451694 scopus 로고    scopus 로고
    • Targeted screening of individuals at high risk for pancreatic cancer: Results of a simulation model
    • Pandharipande, P. V. et al. Targeted screening of individuals at high risk for pancreatic cancer: results of a simulation model. Radiology 275, 177-187 (2015).
    • (2015) Radiology , vol.275 , pp. 177-187
    • Pandharipande, P.V.1
  • 167
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
    • Burris, H. A. et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J. Clin. Oncol. 15, 2403-2413 (1997).
    • (1997) J. Clin. Oncol. , vol.15 , pp. 2403-2413
    • Burris, H.A.1
  • 168
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A Phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore, M. J. et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a Phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol. 25, 1960-1966 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , pp. 1960-1966
    • Moore, M.J.1
  • 169
    • 79955921754 scopus 로고    scopus 로고
    • FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
    • Conroy, T. et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N. Engl. J. Med. 364, 1817-1825 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , pp. 1817-1825
    • Conroy, T.1
  • 170
    • 84886741654 scopus 로고    scopus 로고
    • Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine
    • Von Hoff, D. D. et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N. Engl. J. Med. 369, 1691-1703 (2013).
    • (2013) N. Engl. J. Med. , vol.369 , pp. 1691-1703
    • Von Hoff, D.D.1
  • 171
    • 0142121290 scopus 로고    scopus 로고
    • Randomized Phase II comparison of dose-intense gemcitabine: Thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma
    • Tempero, M. et al. Randomized Phase II comparison of dose-intense gemcitabine: thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma. J. Clin. Oncol. 21, 3402-3408 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , pp. 3402-3408
    • Tempero, M.1
  • 172
    • 84908365902 scopus 로고    scopus 로고
    • Overall survival and clinical characteristics of pancreatic cancer in BRCA mutation carriers
    • Golan, T. et al. Overall survival and clinical characteristics of pancreatic cancer in BRCA mutation carriers. Br. J. Cancer 111, 1132-1138 (2014).
    • (2014) Br. J. Cancer , vol.111 , pp. 1132-1138
    • Golan, T.1
  • 173
    • 73949135518 scopus 로고    scopus 로고
    • Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer
    • Cunningham, D. et al. Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer. J. Clin. Oncol. 27, 5513-5518 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 5513-5518
    • Cunningham, D.1
  • 174
    • 34848896905 scopus 로고    scopus 로고
    • The gemcitabine, docetaxel, and capecitabine (GTX) regimen for metastatic pancreatic cancer: A retrospective analysis
    • Fine, R. L. et al. The gemcitabine, docetaxel, and capecitabine (GTX) regimen for metastatic pancreatic cancer: a retrospective analysis. Cancer Chemother. Pharmacol. 61, 167-175 (2008).
    • (2008) Cancer Chemother. Pharmacol. , vol.61 , pp. 167-175
    • Fine, R.L.1
  • 175
    • 84959459386 scopus 로고    scopus 로고
    • Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): A global, randomised, open-label, Phase 3 trial
    • Wang-Gillam, A. et al. Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, Phase 3 trial. Lancet 387, 545-557 (2016).
    • (2016) Lancet , vol.387 , pp. 545-557
    • Wang-Gillam, A.1
  • 176
    • 84884556143 scopus 로고    scopus 로고
    • Comparison of chemoradiotherapy (CRT) and chemotherapy (CT) in patients with a locally advanced pancreatic cancer (LAPC) controlled after 4 months of gemcitabine with or without erlotinib: Final results of the international Phase III LAP 07 study
    • Hammel, P. et al. Comparison of chemoradiotherapy (CRT) and chemotherapy (CT) in patients with a locally advanced pancreatic cancer (LAPC) controlled after 4 months of gemcitabine with or without erlotinib: final results of the international Phase III LAP 07 study. J. Clin. Oncol. Abstr. 31, LBA4003 (2013).
    • (2013) J. Clin. Oncol. Abstr. , vol.31 , pp. LBA4003
    • Hammel, P.1
  • 177
    • 0028985078 scopus 로고
    • Treatment and survival in 13,560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: An epidemiological study
    • Bramhall, S. R. et al. Treatment and survival in 13,560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: an epidemiological study. Br. J. Surg. 82, 111-115 (1995).
    • (1995) Br. J. Surg. , vol.82 , pp. 111-115
    • Bramhall, S.R.1
  • 178
    • 28244489494 scopus 로고    scopus 로고
    • Hospital volume and mortality after pancreatic resection: A systematic review and an evaluation of intervention in the Netherlands
    • discussion 788-790
    • van Heek, N. T. et al. Hospital volume and mortality after pancreatic resection: a systematic review and an evaluation of intervention in the Netherlands. Ann. Surg. 242, 781-788; discussion 788-790 (2005).
    • (2005) Ann. Surg. , vol.242 , pp. 781-788
    • Van Heek, N.T.1
  • 179
    • 14544270277 scopus 로고    scopus 로고
    • Does anyone survive pancreatic ductal adenocarcinoma? A nationwide study re-evaluating the data of the Finnish Cancer Registry
    • Carpelan-Holmstrom, M. et al. Does anyone survive pancreatic ductal adenocarcinoma? A nationwide study re-evaluating the data of the Finnish Cancer Registry. Gut 54, 385-387 (2005).
    • (2005) Gut , vol.54 , pp. 385-387
    • Carpelan-Holmstrom, M.1
  • 180
    • 0028849463 scopus 로고
    • Carcinoma of the pancreas: Critical analysis of costs, results of resections, and the need for standardized reporting
    • Gudjonsson, B. Carcinoma of the pancreas: critical analysis of costs, results of resections, and the need for standardized reporting. J. Am. Coll. Surg. 181, 483-503 (1995).
    • (1995) J. Am. Coll. Surg. , vol.181 , pp. 483-503
    • Gudjonsson, B.1
  • 181
    • 34547568957 scopus 로고    scopus 로고
    • National failure to operate on early stage pancreatic cancer
    • Bilimoria, K. Y. et al. National failure to operate on early stage pancreatic cancer. Ann. Surg. 246, 173-180 (2007).
    • (2007) Ann. Surg. , vol.246 , pp. 173-180
    • Bilimoria, K.Y.1
  • 182
    • 84939465520 scopus 로고    scopus 로고
    • Trends in hospital volume and failure to rescue for pancreatic surgery
    • Amini, N., Spolverato, G., Kim, Y. & Pawlik, T. M. Trends in hospital volume and failure to rescue for pancreatic surgery. J. Gastrointest. Surg. 19, 1581-1592 (2015).
    • (2015) J. Gastrointest. Surg. , vol.19 , pp. 1581-1592
    • Amini, N.1    Spolverato, G.2    Kim, Y.3    Pawlik, T.M.4
  • 183
    • 84856443426 scopus 로고    scopus 로고
    • Impact of nationwide centralization of pancreaticoduodenectomy on hospital mortality
    • de Wilde, R. F. et al. Impact of nationwide centralization of pancreaticoduodenectomy on hospital mortality. Br. J. Surg. 99, 404-410 (2012).
    • (2012) Br. J. Surg. , vol.99 , pp. 404-410
    • De Wilde, R.F.1
  • 184
    • 79961021004 scopus 로고    scopus 로고
    • Pancreatic cancer surgery in the new millennium: Better prediction of outcome
    • Hartwig, W. et al. Pancreatic cancer surgery in the new millennium: better prediction of outcome. Ann. Surg. 254, 311-319 (2011).
    • (2011) Ann. Surg. , vol.254 , pp. 311-319
    • Hartwig, W.1
  • 185
    • 77956416112 scopus 로고    scopus 로고
    • Adjuvant chemotherapy with fluorouracil plus folinic acid versus gemcitabine following pancreatic cancer resection: A randomized controlled trial
    • Neoptolemos, J. P. et al. Adjuvant chemotherapy with fluorouracil plus folinic acid versus gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA 304, 1073-1081 (2010).
    • (2010) JAMA , vol.304 , pp. 1073-1081
    • Neoptolemos, J.P.1
  • 186
    • 12144287320 scopus 로고    scopus 로고
    • A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer
    • Neoptolemos, J. P. et al. A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N. Engl. J. Med. 350, 1200-1210 (2004).
    • (2004) N. Engl. J. Med. , vol.350 , pp. 1200-1210
    • Neoptolemos, J.P.1
  • 187
    • 84885462618 scopus 로고    scopus 로고
    • Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: The CONKO-001 randomized trial
    • Oettle, H. et al. Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO-001 randomized trial. JAMA 310, 1473-1481 (2013).
    • (2013) JAMA , vol.310 , pp. 1473-1481
    • Oettle, H.1
  • 188
    • 33747507299 scopus 로고    scopus 로고
    • One thousand consecutive pancreaticoduodenectomies
    • Cameron, J. L., Riall, T. S., Coleman, J. & Belcher, K. A. One thousand consecutive pancreaticoduodenectomies. Ann. Surg. 244, 10-15 (2006).
    • (2006) Ann. Surg. , vol.244 , pp. 10-15
    • Cameron, J.L.1    Riall, T.S.2    Coleman, J.3    Belcher, K.A.4
  • 189
    • 84994070681 scopus 로고    scopus 로고
    • Pylorus-preserving pancreaticoduodenectomy (pp Whipple) versus pancreaticoduodenectomy (classic Whipple) for surgical treatment of periampullary and pancreatic carcinoma
    • Diener, M. K. et al. Pylorus-preserving pancreaticoduodenectomy (pp Whipple) versus pancreaticoduodenectomy (classic Whipple) for surgical treatment of periampullary and pancreatic carcinoma. Cochrane Database Syst. Rev. 11, CD006053 (2014).
    • (2014) Cochrane Database Syst. Rev. , vol.11 , pp. CD006053
    • Diener, M.K.1
  • 190
    • 84927116633 scopus 로고    scopus 로고
    • Total pancreatectomy for primary pancreatic neoplasms: Renaissance of an unpopular operation
    • Hartwig, W. et al. Total pancreatectomy for primary pancreatic neoplasms: renaissance of an unpopular operation. Ann. Surg. 261, 537-546 (2015).
    • (2015) Ann. Surg. , vol.261 , pp. 537-546
    • Hartwig, W.1
  • 191
    • 84919458867 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of laparoscopic versus open distal pancreatectomy for benign and malignant lesions of the pancreas: It's time to randomize
    • Mehrabi, A. et al. A systematic review and meta-analysis of laparoscopic versus open distal pancreatectomy for benign and malignant lesions of the pancreas: it's time to randomize. Surgery 157, 45-55 (2015).
    • (2015) Surgery , vol.157 , pp. 45-55
    • Mehrabi, A.1
  • 192
    • 84890805005 scopus 로고    scopus 로고
    • Minimally-invasive versus open pancreaticoduodenectomy: Systematic review and meta-analysis
    • Correa-Gallego, C. et al. Minimally-invasive versus open pancreaticoduodenectomy: systematic review and meta-analysis. J. Am. Coll. Surg. 218, 129-139 (2014).
    • (2014) J. Am. Coll. Surg. , vol.218 , pp. 129-139
    • Correa-Gallego, C.1
  • 193
    • 84938263418 scopus 로고    scopus 로고
    • Minimally invasive versus open pancreaticoduodenectomy for cancer: Practice patterns and short-term outcomes among 7061 patients
    • Abdelgadir Adam, M. et al. Minimally invasive versus open pancreaticoduodenectomy for cancer: practice patterns and short-term outcomes among 7061 patients. Ann. Surg. 262, 372-377 (2015).
    • (2015) Ann. Surg. , vol.262 , pp. 372-377
    • Abdelgadir Adam, M.1
  • 194
    • 84889649924 scopus 로고    scopus 로고
    • A systematic review on robotic pancreaticoduodenectomy
    • Cirocchi, R. et al. A systematic review on robotic pancreaticoduodenectomy. Surg. Oncol. 22, 238-246 (2013).
    • (2013) Surg. Oncol. , vol.22 , pp. 238-246
    • Cirocchi, R.1
  • 195
    • 84884501120 scopus 로고    scopus 로고
    • 250 robotic pancreatic resections: Safety and feasibility
    • discussion 559-562
    • Zureikat, A. H. et al. 250 robotic pancreatic resections: safety and feasibility. Ann. Surg. 258, 554-559; discussion 559-562 (2013).
    • (2013) Ann. Surg. , vol.258 , pp. 554-559
    • Zureikat, A.H.1
  • 196
    • 84901455120 scopus 로고    scopus 로고
    • Borderline resectable pancreatic cancer: A consensus statement by the International Study Group of Pancreatic Surgery (ISGPS)
    • Bockhorn, M. et al. Borderline resectable pancreatic cancer: a consensus statement by the International Study Group of Pancreatic Surgery (ISGPS). Surgery 155, 977-988 (2014).
    • (2014) Surgery , vol.155 , pp. 977-988
    • Bockhorn, M.1
  • 197
    • 84906258991 scopus 로고    scopus 로고
    • Pancreatic adenocarcinoma, version 2.2014: Featured updates to the NCCN guidelines
    • Tempero, M. A. et al. Pancreatic adenocarcinoma, version 2.2014: featured updates to the NCCN guidelines. J. Natl Compr. Canc. Netw. 12, 1083-1093 (2014).
    • (2014) J. Natl Compr. Canc. Netw. , vol.12 , pp. 1083-1093
    • Tempero, M.A.1
  • 198
    • 84896775403 scopus 로고    scopus 로고
    • Benefit from synchronous portal-superior mesenteric vein resection during pancreaticoduodenectomy for cancer: A meta-analysis
    • Yu, X. Z. et al. Benefit from synchronous portal-superior mesenteric vein resection during pancreaticoduodenectomy for cancer: a meta-analysis. Eur. J. Surg. Oncol. 40, 371-378 (2014).
    • (2014) Eur. J. Surg. Oncol. , vol.40 , pp. 371-378
    • Yu, X.Z.1
  • 199
    • 84863724498 scopus 로고    scopus 로고
    • Pancreatectomy combined with superior mesenteric vein-portal vein resection for pancreatic cancer: A meta-analysis
    • Zhou, Y., Zhang, Z., Liu, Y., Li, B. & Xu, D. Pancreatectomy combined with superior mesenteric vein-portal vein resection for pancreatic cancer: a meta-analysis. World J. Surg. 36, 884-891 (2012).
    • (2012) World J. Surg. , vol.36 , pp. 884-891
    • Zhou, Y.1    Zhang, Z.2    Liu, Y.3    Li, B.4    Xu, D.5
  • 200
    • 84955409965 scopus 로고    scopus 로고
    • Meta-analysis of benefits of portal-superior mesenteric vein resection in pancreatic resection for ductal adenocarcinoma
    • Giovinazzo, F., Turri, G., Katz, M. H., Heaton, N. & Ahmed, I. Meta-analysis of benefits of portal-superior mesenteric vein resection in pancreatic resection for ductal adenocarcinoma. Br. J. Surg. 103, 179-191 (2016).
    • (2016) Br. J. Surg. , vol.103 , pp. 179-191
    • Giovinazzo, F.1    Turri, G.2    Katz, M.H.3    Heaton, N.4    Ahmed, I.5
  • 201
    • 81855198904 scopus 로고    scopus 로고
    • Arterial resection during pancreatectomy for pancreatic cancer: A systematic review and meta-analysis
    • Mollberg, N. et al. Arterial resection during pancreatectomy for pancreatic cancer: a systematic review and meta-analysis. Ann. Surg. 254, 882-893 (2011).
    • (2011) Ann. Surg. , vol.254 , pp. 882-893
    • Mollberg, N.1
  • 202
    • 84939472470 scopus 로고    scopus 로고
    • Distal pancreatectomy with celiac axis resection: What are the added risks?
    • Beane, J. D. et al. Distal pancreatectomy with celiac axis resection: what are the added risks? HPB (Oxford) 17, 777-784 (2015).
    • (2015) HPB (Oxford) , vol.17 , pp. 777-784
    • Beane, J.D.1
  • 203
    • 84869102923 scopus 로고    scopus 로고
    • Modified Appleby procedure for resection of tumors of the pancreatic body and tail with celiac axis involvement
    • Smoot, R. L. & Donohue, J. H. Modified Appleby procedure for resection of tumors of the pancreatic body and tail with celiac axis involvement. J. Gastrointest. Surg. 16, 2167-2169 (2012).
    • (2012) J. Gastrointest. Surg. , vol.16 , pp. 2167-2169
    • Smoot, R.L.1    Donohue, J.H.2
  • 204
    • 34347350243 scopus 로고    scopus 로고
    • Distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic body cancer: Long-term results
    • Hirano, S. et al. Distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic body cancer: long-term results. Ann. Surg. 246, 46-51 (2007).
    • (2007) Ann. Surg. , vol.246 , pp. 46-51
    • Hirano, S.1
  • 205
    • 68249098299 scopus 로고    scopus 로고
    • Multivisceral resection for pancreatic malignancies: Risk-analysis and long-term outcome
    • Hartwig, W. et al. Multivisceral resection for pancreatic malignancies: risk-analysis and long-term outcome. Ann. Surg. 250, 81-87 (2009).
    • (2009) Ann. Surg. , vol.250 , pp. 81-87
    • Hartwig, W.1
  • 206
    • 84907598225 scopus 로고    scopus 로고
    • Definition of a standard lymphadenectomy in surgery for pancreatic ductal adenocarcinoma: A consensus statement by the International Study Group on Pancreatic Surgery (ISGPS)
    • Tol, J. A. et al. Definition of a standard lymphadenectomy in surgery for pancreatic ductal adenocarcinoma: a consensus statement by the International Study Group on Pancreatic Surgery (ISGPS). Surgery 156, 591-600 (2014).
    • (2014) Surgery , vol.156 , pp. 591-600
    • Tol, J.A.1
  • 207
    • 84939469227 scopus 로고    scopus 로고
    • Extended versus standard lymphadenectomy for pancreatic head cancer: Meta-analysis of randomized controlled trials
    • Dasari, B. V. et al. Extended versus standard lymphadenectomy for pancreatic head cancer: meta-analysis of randomized controlled trials. J. Gastrointest. Surg. 19, 1725-1732 (2015).
    • (2015) J. Gastrointest. Surg. , vol.19 , pp. 1725-1732
    • Dasari, B.V.1
  • 208
    • 33947196024 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of standard and extended lymphadenectomy in pancreaticoduodenectomy for pancreatic cancer
    • Michalski, C. W. et al. Systematic review and meta-analysis of standard and extended lymphadenectomy in pancreaticoduodenectomy for pancreatic cancer. Br. J. Surg. 94, 265-273 (2007).
    • (2007) Br. J. Surg. , vol.94 , pp. 265-273
    • Michalski, C.W.1
  • 209
    • 36448987851 scopus 로고    scopus 로고
    • Is resection of periampullary or pancreatic adenocarcinoma with synchronous hepatic metastasis justified?
    • Gleisner, A. L. et al. Is resection of periampullary or pancreatic adenocarcinoma with synchronous hepatic metastasis justified? Cancer 110, 2484-2492 (2007).
    • (2007) Cancer , vol.110 , pp. 2484-2492
    • Gleisner, A.L.1
  • 210
    • 60149108795 scopus 로고    scopus 로고
    • Resection of primary pancreatic cancer and liver metastasis: A systematic review
    • Michalski, C. W. et al. Resection of primary pancreatic cancer and liver metastasis: a systematic review. Dig. Surg. 25, 473-480 (2008).
    • (2008) Dig. Surg. , vol.25 , pp. 473-480
    • Michalski, C.W.1
  • 211
    • 80051928519 scopus 로고    scopus 로고
    • Pulmonary resection for isolated pancreatic adenocarcinoma metastasis: An analysis of outcomes and survival
    • Arnaoutakis, G. J. et al. Pulmonary resection for isolated pancreatic adenocarcinoma metastasis: an analysis of outcomes and survival. J. Gastrointest. Surg. 15, 1611-1617 (2011).
    • (2011) J. Gastrointest. Surg. , vol.15 , pp. 1611-1617
    • Arnaoutakis, G.J.1
  • 212
    • 84859104258 scopus 로고    scopus 로고
    • Palliative resections versus palliative bypass procedures in pancreatic cancer - A systematic review
    • Gillen, S., Schuster, T., Friess, H. & Kleeff, J. Palliative resections versus palliative bypass procedures in pancreatic cancer - a systematic review. Am. J. Surg. 203, 496-502 (2012).
    • (2012) Am. J. Surg. , vol.203 , pp. 496-502
    • Gillen, S.1    Schuster, T.2    Friess, H.3    Kleeff, J.4
  • 213
    • 84944097183 scopus 로고    scopus 로고
    • Meta-analysis of radical resection rates and margin assessment in pancreatic cancer
    • Chandrasegaram, M. D. et al. Meta-analysis of radical resection rates and margin assessment in pancreatic cancer. Br. J. Surg. 102, 1459-1472 (2015).
    • (2015) Br. J. Surg. , vol.102 , pp. 1459-1472
    • Chandrasegaram, M.D.1
  • 214
    • 43449107352 scopus 로고    scopus 로고
    • Most pancreatic cancer resections are R1 resections
    • Esposito, I. et al. Most pancreatic cancer resections are R1 resections. Ann. Surg. Oncol. 15, 1651-1660 (2008).
    • (2008) Ann. Surg. Oncol. , vol.15 , pp. 1651-1660
    • Esposito, I.1
  • 215
    • 79952303917 scopus 로고    scopus 로고
    • Definition of microscopic tumor clearance (r0) in pancreatic cancer resections
    • Schlitter, A. M. & Esposito, I. Definition of microscopic tumor clearance (r0) in pancreatic cancer resections. Cancers (Basel) 2, 2001-2010 (2010).
    • (2010) Cancers (Basel) , vol.2 , pp. 2001-2010
    • Schlitter, A.M.1    Esposito, I.2
  • 216
    • 69549108342 scopus 로고    scopus 로고
    • Classification of R1 resections for pancreatic cancer: The prognostic relevance of tumour involvement within 1 mm of a resection margin
    • Campbell, F. et al. Classification of R1 resections for pancreatic cancer: the prognostic relevance of tumour involvement within 1 mm of a resection margin. Histopathology 55, 277-283 (2009).
    • (2009) Histopathology , vol.55 , pp. 277-283
    • Campbell, F.1
  • 217
    • 33645456587 scopus 로고    scopus 로고
    • Pancreatic cancer: Surgery alone is not sufficient
    • Traverso, L. W. Pancreatic cancer: surgery alone is not sufficient. Surg. Endosc. 20, S446-S449 (2006).
    • (2006) Surg. Endosc. , vol.20 , pp. S446-S449
    • Traverso, L.W.1
  • 218
    • 79955841030 scopus 로고    scopus 로고
    • Fluorouracil-based chemoradiation with either gemcitabine or fluorouracil chemotherapy after resection of pancreatic adenocarcinoma: 5-year analysis of the U. S. Intergroup/RTOG 9704 Phase III trial
    • Regine, W. F. et al. Fluorouracil-based chemoradiation with either gemcitabine or fluorouracil chemotherapy after resection of pancreatic adenocarcinoma: 5-year analysis of the U. S. Intergroup/RTOG 9704 Phase III trial. Ann. Surg. Oncol. 18, 1319-1326 (2011).
    • (2011) Ann. Surg. Oncol. , vol.18 , pp. 1319-1326
    • Regine, W.F.1
  • 219
    • 77951709577 scopus 로고    scopus 로고
    • Preoperative/neoadjuvant therapy in pancreatic cancer: A systematic review and meta-analysis of response and resection percentages
    • Gillen, S., Schuster, T., Meyer Zum Buschenfelde, C., Friess, H. & Kleeff, J. Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages. PLoS Med. 7, e1000267 (2010).
    • (2010) PLoS Med. , vol.7
    • Gillen, S.1    Schuster, T.2    Meyer Zum Buschenfelde, C.3    Friess, H.4    Kleeff, J.5
  • 220
    • 81155158875 scopus 로고    scopus 로고
    • Adjuvant gemcitabine versus NEOadjuvant gemcitabine/oxaliplatin plus adjuvant gemcitabine in resectable pancreatic cancer: A randomized multicenter Phase III study (NEOPAC study)
    • Heinrich, S. et al. Adjuvant gemcitabine versus NEOadjuvant gemcitabine/oxaliplatin plus adjuvant gemcitabine in resectable pancreatic cancer: a randomized multicenter Phase III study (NEOPAC study). BMC Cancer 11, 346 (2011).
    • (2011) BMC Cancer , vol.11 , pp. 346
    • Heinrich, S.1
  • 221
    • 84902547857 scopus 로고    scopus 로고
    • Sequential neoadjuvant chemoradiotherapy (CRT) followed by curative surgery versus primary surgery alone for resectable, non-metastasized pancreatic adenocarcinoma: NEOPA - A randomized multicenter Phase III study (NCT01900327, DRKS00003893, ISRCTN82191749)
    • Tachezy, M. et al. Sequential neoadjuvant chemoradiotherapy (CRT) followed by curative surgery versus primary surgery alone for resectable, non-metastasized pancreatic adenocarcinoma: NEOPA - a randomized multicenter Phase III study (NCT01900327, DRKS00003893, ISRCTN82191749). BMC Cancer 14, 411 (2014).
    • (2014) BMC Cancer , vol.14 , pp. 411
    • Tachezy, M.1
  • 222
    • 84928471389 scopus 로고    scopus 로고
    • Radiological and surgical implications of neoadjuvant treatment with FOLFIRINOX for locally advanced and borderline resectable pancreatic cancer
    • Ferrone, C. R. et al. Radiological and surgical implications of neoadjuvant treatment with FOLFIRINOX for locally advanced and borderline resectable pancreatic cancer. Ann. Surg. 261, 12-17 (2015).
    • (2015) Ann. Surg. , vol.261 , pp. 12-17
    • Ferrone, C.R.1
  • 223
    • 84952872152 scopus 로고    scopus 로고
    • Resectability after first-line FOLFIRINOX in initially unresectable locally advanced pancreatic cancer: A single-center experience
    • Nitsche, U. et al. Resectability after first-line FOLFIRINOX in initially unresectable locally advanced pancreatic cancer: a single-center experience. Ann. Surg. Oncol. 22 (Suppl. 3), 1212-1220 (2015).
    • (2015) Ann. Surg. Oncol. , vol.22 , pp. 1212-1220
    • Nitsche, U.1
  • 224
    • 84964684411 scopus 로고    scopus 로고
    • Preoperative modified FOLFIRINOX (mFOLFIRINOX) followed by chemoradiation (CRT) for borderline resectable (BLR) pancreatic cancer (PDAC): Initial results from Alliance Trial A021101
    • Katz, M. H. G. et al. Preoperative modified FOLFIRINOX (mFOLFIRINOX) followed by chemoradiation (CRT) for borderline resectable (BLR) pancreatic cancer (PDAC): initial results from Alliance Trial A021101. J. Clin. Oncol. Abstr. 33 (Suppl.), 4008 (2015).
    • (2015) J. Clin. Oncol. Abstr. , vol.33 , pp. 4008
    • Katz, M.H.G.1
  • 225
    • 85020146207 scopus 로고    scopus 로고
    • ESPAC-5F: European study group for pancreatic cancer - trial 5F
    • [online]
    • Cancer Research UK. ESPAC-5F: European study group for pancreatic cancer - trial 5F. Cancer Research UK [online], www.isrctn.com/ ISRCTN89500674 (2014).
    • (2014) Cancer Research UK
    • Cancer Research UK1
  • 226
    • 48149112300 scopus 로고    scopus 로고
    • Evaluating the impact of a single-day multidisciplinary clinic on the management of pancreatic cancer
    • Pawlik, T. M. et al. Evaluating the impact of a single-day multidisciplinary clinic on the management of pancreatic cancer. Ann. Surg. Oncol. 15, 2081-2088 (2008).
    • (2008) Ann. Surg. Oncol. , vol.15 , pp. 2081-2088
    • Pawlik, T.M.1
  • 228
    • 0027417437 scopus 로고
    • The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology
    • Aaronson, N. K. et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J. Natl Cancer Inst. 85, 365-376 (1993).
    • (1993) J. Natl Cancer Inst. , vol.85 , pp. 365-376
    • Aaronson, N.K.1
  • 229
    • 0027407786 scopus 로고
    • The Functional Assessment of Cancer Therapy scale: Development and validation of the general measure
    • Cella, D. F. et al. The Functional Assessment of Cancer Therapy scale: development and validation of the general measure. J. Clin. Oncol. 11, 570-579 (1993).
    • (1993) J. Clin. Oncol. , vol.11 , pp. 570-579
    • Cella, D.F.1
  • 230
    • 0033152173 scopus 로고    scopus 로고
    • Development of a disease specific quality of life (QoL) questionnaire module to supplement the EORTC core cancer QoL questionnaire, the QLQ-C30 in patients with pancreatic cancer. EORTC Study Group on Quality of Life
    • Fitzsimmons, D. et al. Development of a disease specific quality of life (QoL) questionnaire module to supplement the EORTC core cancer QoL questionnaire, the QLQ-C30 in patients with pancreatic cancer. EORTC Study Group on Quality of Life. Eur. J. Cancer 35, 939-941 (1999).
    • (1999) Eur. J. Cancer , vol.35 , pp. 939-941
    • Fitzsimmons, D.1
  • 231
    • 84878691423 scopus 로고    scopus 로고
    • Validity of the FACT Hepatobiliary (FACT-Hep) questionnaire for assessing disease-related symptoms and health-related quality of life in patients with metastatic pancreatic cancer
    • Cella, D. et al. Validity of the FACT Hepatobiliary (FACT-Hep) questionnaire for assessing disease-related symptoms and health-related quality of life in patients with metastatic pancreatic cancer. Qual. Life Res. 22, 1105-1112 (2013).
    • (2013) Qual. Life Res. , vol.22 , pp. 1105-1112
    • Cella, D.1
  • 232
    • 84908260165 scopus 로고    scopus 로고
    • Quality of life in a prospective, multicenter Phase 2 trial of neoadjuvant full-dose gemcitabine, oxaliplatin, and radiation in patients with resectable or borderline resectable pancreatic adenocarcinoma
    • Serrano, P. E. et al. Quality of life in a prospective, multicenter Phase 2 trial of neoadjuvant full-dose gemcitabine, oxaliplatin, and radiation in patients with resectable or borderline resectable pancreatic adenocarcinoma. Int. J. Radiat. Oncol. Biol. Phys. 90, 270-277 (2014).
    • (2014) Int. J. Radiat. Oncol. Biol. Phys. , vol.90 , pp. 270-277
    • Serrano, P.E.1
  • 233
    • 84871391116 scopus 로고    scopus 로고
    • Impact of gemcitabine chemotherapy and 3-dimensional conformal radiation therapy/5-fluorouracil on quality of life of patients managed for pancreatic cancer
    • Short, M. et al. Impact of gemcitabine chemotherapy and 3-dimensional conformal radiation therapy/5-fluorouracil on quality of life of patients managed for pancreatic cancer. Int. J. Radiat. Oncol. Biol. Phys. 85, 157-162 (2013).
    • (2013) Int. J. Radiat. Oncol. Biol. Phys. , vol.85 , pp. 157-162
    • Short, M.1
  • 234
    • 0034043540 scopus 로고    scopus 로고
    • Quality of life and outcomes after pancreaticoduodenectomy
    • Huang, J. J. et al. Quality of life and outcomes after pancreaticoduodenectomy. Ann. Surg. 231, 890-898 (2000).
    • (2000) Ann. Surg. , vol.231 , pp. 890-898
    • Huang, J.J.1
  • 235
    • 33750293070 scopus 로고    scopus 로고
    • Quality of life assessment in advanced pancreatic adenocarcinoma: Results from a Phase III randomized trial
    • Reni, M. et al. Quality of life assessment in advanced pancreatic adenocarcinoma: results from a Phase III randomized trial. Pancreatology 6, 454-463 (2006).
    • (2006) Pancreatology , vol.6 , pp. 454-463
    • Reni, M.1
  • 236
    • 84948421502 scopus 로고    scopus 로고
    • Health-related quality of life in SCALOP, a randomized Phase 2 trial comparing chemoradiation therapy regimens in locally advanced pancreatic cancer
    • Hurt, C. N. et al. Health-related quality of life in SCALOP, a randomized Phase 2 trial comparing chemoradiation therapy regimens in locally advanced pancreatic cancer. Int. J. Radiat. Oncol. Biol. Phys. 93, 810-818 (2015).
    • (2015) Int. J. Radiat. Oncol. Biol. Phys. , vol.93 , pp. 810-818
    • Hurt, C.N.1
  • 237
    • 84943338881 scopus 로고    scopus 로고
    • The role of end-of-life issues in the design and reporting of cancer clinical trials: A structured literature review
    • Gaertner, J. et al. The role of end-of-life issues in the design and reporting of cancer clinical trials: a structured literature review. PLoS ONE 10, e0136640 (2015).
    • (2015) PLoS ONE , vol.10
    • Gaertner, J.1
  • 238
    • 84944316022 scopus 로고    scopus 로고
    • Patient-centric trials for therapeutic development in precision oncology
    • Biankin, A. V., Piantadosi, S. & Hollingsworth, S. J. Patient-centric trials for therapeutic development in precision oncology. Nature 526, 361-370 (2015).
    • (2015) Nature , vol.526 , pp. 361-370
    • Biankin, A.V.1    Piantadosi, S.2    Hollingsworth, S.J.3
  • 240
    • 85020142819 scopus 로고    scopus 로고
    • Personal genome test will sell at new low price of $250
    • [online]
    • Steenhuysen, J. Personal genome test will sell at new low price of $250. Scientific American [online], http://www.scientificamerican.com/article/craig-venter-s-company-in-deal-for-whole-exome-tests-at-new-low-cost/ (2015).
    • (2015) Scientific American
    • Steenhuysen, J.1
  • 241
    • 85020144524 scopus 로고    scopus 로고
    • Pancreatic cancer white paper 2015. Deadly 'silent' cancer needs a voice in EU research and investment
    • [online]
    • European Alliance for Personalised Medicine. Pancreatic cancer white paper 2015. Deadly 'silent' cancer needs a voice in EU research and investment. European Alliance for Personalised Medicine [online], http://www.euapm.eu/pdf/EAPM-Eapancreatic- cancer-white-paper-2015.pdf (2015).
    • (2015) European Alliance for Personalised Medicine
    • European Alliance for Personalised Medicine1
  • 242
    • 84938562889 scopus 로고    scopus 로고
    • High response rate and PFS with PEGPH20 added to nab-paclitaxel/gemcitabine in stage IV previously untreated pancreatic cancer patients with high-HA tumors: Interim results of a randomized Phase II study
    • Hingorani, S. R. et al. High response rate and PFS with PEGPH20 added to nab-paclitaxel/gemcitabine in stage IV previously untreated pancreatic cancer patients with high-HA tumors: interim results of a randomized Phase II study. J. Clin. Oncol. Abstr. 33 (Suppl.), 4006 (2015).
    • (2015) J. Clin. Oncol. Abstr. , vol.33 , pp. 4006
    • Hingorani, S.R.1
  • 243
    • 84951828799 scopus 로고    scopus 로고
    • Randomized, double-blind, Phase II study of ruxolitinib or placebo in combination with capecitabine in patients with metastatic pancreatic cancer for whom therapy with gemcitabine has failed
    • Hurwitz, H. I. et al. Randomized, double-blind, Phase II study of ruxolitinib or placebo in combination with capecitabine in patients with metastatic pancreatic cancer for whom therapy with gemcitabine has failed. J. Clin. Oncol. 33, 4039-4047 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 4039-4047
    • Hurwitz, H.I.1
  • 244
    • 84938612287 scopus 로고    scopus 로고
    • Ibrutinib exerts potent antifibrotic and antitumor activities in mouse models of pancreatic adenocarcinoma
    • Masso-Valles, D. et al. Ibrutinib exerts potent antifibrotic and antitumor activities in mouse models of pancreatic adenocarcinoma. Cancer Res. 75, 1675-1681 (2015).
    • (2015) Cancer Res. , vol.75 , pp. 1675-1681
    • Masso-Valles, D.1
  • 245
    • 34547095748 scopus 로고    scopus 로고
    • Pancreatic cancer microenvironment
    • Kleeff, J. et al. Pancreatic cancer microenvironment. Int. J. Cancer 121, 699-705 (2007).
    • (2007) Int. J. Cancer , vol.121 , pp. 699-705
    • Kleeff, J.1
  • 246
    • 84917722205 scopus 로고    scopus 로고
    • PD-1/PD-L1 blockade together with vaccine therapy facilitates effector T-cell infiltration into pancreatic tumors
    • Soares, K. C. et al. PD-1/PD-L1 blockade together with vaccine therapy facilitates effector T-cell infiltration into pancreatic tumors. J. Immunother. 38, 1-11 (2015).
    • (2015) J. Immunother. , vol.38 , pp. 1-11
    • Soares, K.C.1
  • 247
    • 3242713145 scopus 로고    scopus 로고
    • Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey
    • Dindo, D., Demartines, N. & Clavien, P. A. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann. Surg. 240, 205-213 (2004).
    • (2004) Ann. Surg. , vol.240 , pp. 205-213
    • Dindo, D.1    Demartines, N.2    Clavien, P.A.3
  • 248
    • 21644446129 scopus 로고    scopus 로고
    • Postoperative pancreatic fistula: An international study group (ISGPF) definition
    • Bassi, C. et al. Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery 138, 8-13 (2005).
    • (2005) Surgery , vol.138 , pp. 8-13
    • Bassi, C.1
  • 249
    • 35549000914 scopus 로고    scopus 로고
    • Delayed gastric emptying (DGE) after pancreatic surgery: A suggested definition by the International Study Group of Pancreatic Surgery (ISGPS)
    • Wente, M. N. et al. Delayed gastric emptying (DGE) after pancreatic surgery: a suggested definition by the International Study Group of Pancreatic Surgery (ISGPS). Surgery 142, 761-768 (2007).
    • (2007) Surgery , vol.142 , pp. 761-768
    • Wente, M.N.1
  • 250
    • 34447273097 scopus 로고    scopus 로고
    • Postpancreatectomy hemorrhage (PPH): An International Study Group of Pancreatic Surgery (ISGPS) definition
    • Wente, M. N. et al. Postpancreatectomy hemorrhage (PPH): an International Study Group of Pancreatic Surgery (ISGPS) definition. Surgery 142, 20-25 (2007).
    • (2007) Surgery , vol.142 , pp. 20-25
    • Wente, M.N.1
  • 251
    • 85020154675 scopus 로고    scopus 로고
    • Common terminology criteria for adverse events (CTCAE), version 4.03
    • [online]
    • US National Cancer Institute. Common terminology criteria for adverse events (CTCAE), version 4.03. NCI [online], http://evs.nci.nih.gov/ftp1/CTCAE/ CTCAE-4.03-2010-06-14-QuickReference-5x7.pdf (2010).
    • (2010) NCI
    • US National Cancer Institute1
  • 252
    • 85021366967 scopus 로고    scopus 로고
    • WHO's cancer pain ladder for adults
    • [online]
    • World Health Organization.WHO's cancer pain ladder for adults. WHO [online], http://www.who.int/cancer/ palliative/painladder/en/ (2016).
    • (2016) WHO
    • World Health Organization1
  • 253
    • 80052997944 scopus 로고    scopus 로고
    • Randomized, double-blind, controlled trial of early endoscopic ultrasound-guided celiac plexus neurolysis to prevent pain progression in patients with newly diagnosed, painful, inoperable pancreatic cancer
    • Wyse, J. M., Carone, M., Paquin, S. C., Usatii, M. & Sahai, A. V. Randomized, double-blind, controlled trial of early endoscopic ultrasound-guided celiac plexus neurolysis to prevent pain progression in patients with newly diagnosed, painful, inoperable pancreatic cancer. J. Clin. Oncol. 29, 3541-3546 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 3541-3546
    • Wyse, J.M.1    Carone, M.2    Paquin, S.C.3    Usatii, M.4    Sahai, A.V.5
  • 254
    • 84995810313 scopus 로고    scopus 로고
    • Pain management of pancreatic head adenocarcinomas that are unresectable: Celiac plexus neurolysis and splanchnicectomy
    • Jones, W. B., Jordan, P. & Pudi, M. Pain management of pancreatic head adenocarcinomas that are unresectable: celiac plexus neurolysis and splanchnicectomy. J. Gastrointest. Oncol. 6, 445-451 (2015).
    • (2015) J. Gastrointest. Oncol. , vol.6 , pp. 445-451
    • Jones, W.B.1    Jordan, P.2    Pudi, M.3
  • 255
    • 84887258785 scopus 로고    scopus 로고
    • Covered self-expandable metal stents with an anti-migration system improve patency duration without increased complications compared with uncovered stents for distal biliary obstruction caused by pancreatic carcinoma: A randomized multicenter trial
    • Kitano, M. et al. Covered self-expandable metal stents with an anti-migration system improve patency duration without increased complications compared with uncovered stents for distal biliary obstruction caused by pancreatic carcinoma: a randomized multicenter trial. Am. J. Gastroenterol. 108, 1713-1722 (2013).
    • (2013) Am. J. Gastroenterol. , vol.108 , pp. 1713-1722
    • Kitano, M.1
  • 256
    • 84931317401 scopus 로고    scopus 로고
    • Cost efficacy of metal stents for palliation of extrahepatic bile duct obstruction in a randomized controlled trial
    • Walter, D. et al. Cost efficacy of metal stents for palliation of extrahepatic bile duct obstruction in a randomized controlled trial. Gastroenterology 149, 130-138 (2015).
    • (2015) Gastroenterology , vol.149 , pp. 130-138
    • Walter, D.1
  • 257
    • 79957598142 scopus 로고    scopus 로고
    • Predictors of survival in patients with malignant gastric outlet obstruction: A patient-oriented decision approach for palliative treatment
    • Jeurnink, S. M. et al. Predictors of survival in patients with malignant gastric outlet obstruction: a patient-oriented decision approach for palliative treatment. Dig. Liver Dis. 43, 548-552 (2011).
    • (2011) Dig. Liver Dis. , vol.43 , pp. 548-552
    • Jeurnink, S.M.1
  • 258
    • 84871622862 scopus 로고    scopus 로고
    • Stent treatment of malignant gastric outlet obstruction: The effect on rate of gastric emptying, symptoms, and survival
    • Larssen, L., Hauge, T. & Medhus, A. W. Stent treatment of malignant gastric outlet obstruction: the effect on rate of gastric emptying, symptoms, and survival. Surg. Endosc. 26, 2955-2960 (2012).
    • (2012) Surg. Endosc. , vol.26 , pp. 2955-2960
    • Larssen, L.1    Hauge, T.2    Medhus, A.W.3
  • 259
    • 85020148112 scopus 로고    scopus 로고
    • Distress management clinical practice guidelines in oncology, version 3.2015
    • [online]
    • National Comprehensive Cancer Network. Distress management clinical practice guidelines in oncology, version 3.2015. NCCN [online], http://www.nccn.org/ professionals/physician-gls/f-guidelines.asp# supportive (2015).
    • (2015) NCCN
    • National Comprehensive Cancer Network1
  • 260
    • 84875901426 scopus 로고    scopus 로고
    • Supportive care of the patient with advanced pancreatic cancer
    • Torgerson, S. & Wiebe, L. A. Supportive care of the patient with advanced pancreatic cancer. Oncology (Williston Park) 27, 183-190 (2013).
    • (2013) Oncology (Williston Park) , vol.27 , pp. 183-190
    • Torgerson, S.1    Wiebe, L.A.2
  • 261
    • 84965188936 scopus 로고    scopus 로고
    • Current and future care of patients with the cancer anorexia-cachexia syndrome
    • Del Fabbro, E. Current and future care of patients with the cancer anorexia-cachexia syndrome. Am. Soc. Clin. Oncol. Educ. Book 35, e229-e237 (2015).
    • (2015) Am. Soc. Clin. Oncol. Educ. Book , vol.35 , pp. e229-e237
    • Del Fabbro, E.1
  • 262
    • 84929431322 scopus 로고    scopus 로고
    • Safety and survival with GVAX pancreas prime and Listeria monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer
    • Le, D. T. et al. Safety and survival with GVAX pancreas prime and Listeria monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer. J. Clin. Oncol. 33, 1325-1333 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 1325-1333
    • Le, D.T.1
  • 263
    • 84922367332 scopus 로고    scopus 로고
    • The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapy
    • Xiao, Y. & Freeman, G. J. The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapy. Cancer Discov. 5, 16-18 (2015).
    • (2015) Cancer Discov. , vol.5 , pp. 16-18
    • Xiao, Y.1    Freeman, G.J.2
  • 264
    • 84990238295 scopus 로고    scopus 로고
    • Anti-cancer effects of oncolytic viral therapy combined with photodynamic therapy in human pancreatic cancer cell lines
    • Khaled, Y. S., Wright, K., Melcher, A. & Jayne, D. Anti-cancer effects of oncolytic viral therapy combined with photodynamic therapy in human pancreatic cancer cell lines. Lancet 385, S56 (2015).
    • (2015) Lancet , vol.385 , pp. S56
    • Khaled, Y.S.1    Wright, K.2    Melcher, A.3    Jayne, D.4
  • 265
    • 33847718214 scopus 로고    scopus 로고
    • The EGF receptor family: Spearheading a merger of signaling and therapeutics
    • Bublil, E. M. & Yarden, Y. The EGF receptor family: spearheading a merger of signaling and therapeutics. Curr. Opin. Cell Biol. 19, 124-134 (2007).
    • (2007) Curr. Opin. Cell Biol. , vol.19 , pp. 124-134
    • Bublil, E.M.1    Yarden, Y.2
  • 266
    • 35948964766 scopus 로고    scopus 로고
    • Hepatocyte growth factor-mediated cell invasion in pancreatic cancer cells is dependent on neuropilin-1
    • Matsushita, A., Gotze, T. & Korc, M. Hepatocyte growth factor-mediated cell invasion in pancreatic cancer cells is dependent on neuropilin-1. Cancer Res. 67, 10309-10316 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 10309-10316
    • Matsushita, A.1    Gotze, T.2    Korc, M.3
  • 267
    • 80053320001 scopus 로고    scopus 로고
    • β1 integrin controls EGFR signaling and tumorigenic properties of lung cancer cells
    • Morello, V. et al. β1 integrin controls EGFR signaling and tumorigenic properties of lung cancer cells. Oncogene 30, 4087-4096 (2011).
    • (2011) Oncogene , vol.30 , pp. 4087-4096
    • Morello, V.1
  • 268
    • 0032213027 scopus 로고    scopus 로고
    • The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer
    • Kleeff, J. et al. The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer. J. Clin. Invest. 102, 1662-1673 (1998).
    • (1998) J. Clin. Invest. , vol.102 , pp. 1662-1673
    • Kleeff, J.1
  • 269
    • 0032814008 scopus 로고    scopus 로고
    • Molecular genetics and related developments in pancreatic cancer
    • Hruban, R. H., Goggins, M. & Kern, S. E. Molecular genetics and related developments in pancreatic cancer. Curr. Opin. Gastroenterol. 15, 404-409 (1999).
    • (1999) Curr. Opin. Gastroenterol. , vol.15 , pp. 404-409
    • Hruban, R.H.1    Goggins, M.2    Kern, S.E.3
  • 270
    • 84883514161 scopus 로고    scopus 로고
    • Targeting lactate metabolism for cancer therapeutics
    • Doherty, J. R. & Cleveland, J. L. Targeting lactate metabolism for cancer therapeutics. J. Clin. Invest. 123, 3685-3692 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 3685-3692
    • Doherty, J.R.1    Cleveland, J.L.2
  • 271
    • 84878225772 scopus 로고    scopus 로고
    • Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cells
    • Ma, Z., Vocadlo, D. J. & Vosseller, K. Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cells. J. Biol. Chem. 288, 15121-15130 (2013).
    • (2013) J. Biol. Chem. , vol.288 , pp. 15121-15130
    • Ma, Z.1    Vocadlo, D.J.2    Vosseller, K.3
  • 272
    • 84856014884 scopus 로고    scopus 로고
    • Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
    • Metallo, C. M. et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 481, 380-384 (2012).
    • (2012) Nature , vol.481 , pp. 380-384
    • Metallo, C.M.1
  • 273
    • 83755178091 scopus 로고    scopus 로고
    • Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of -ketoglutarate to citrate to support cell growth and viability
    • Wise, D. R. et al. Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of -ketoglutarate to citrate to support cell growth and viability. Proc. Natl Acad. Sci. USA 108, 19611-19616 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 19611-19616
    • Wise, D.R.1
  • 274
    • 70349318549 scopus 로고    scopus 로고
    • Serum fatty acid synthase as a marker of pancreatic neoplasia
    • Walter, K. et al. Serum fatty acid synthase as a marker of pancreatic neoplasia. Cancer Epidemiol. Biomarkers Prev. 18, 2380-2385 (2009).
    • (2009) Cancer Epidemiol. Biomarkers Prev. , vol.18 , pp. 2380-2385
    • Walter, K.1
  • 275
    • 0034464147 scopus 로고    scopus 로고
    • Very high risk of cancer in familial Peutz-Jeghers syndrome
    • Giardiello, F. M. et al. Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology 119, 1447-1453 (2000).
    • (2000) Gastroenterology , vol.119 , pp. 1447-1453
    • Giardiello, F.M.1
  • 276
    • 0030975440 scopus 로고    scopus 로고
    • Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group
    • Lowenfels, A. B. et al. Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group. J. Natl Cancer Inst. 89, 442-446 (1997).
    • (1997) J. Natl Cancer Inst. , vol.89 , pp. 442-446
    • Lowenfels, A.B.1
  • 277
    • 10744233747 scopus 로고    scopus 로고
    • Clinical and genetic characteristics of hereditary pancreatitis in Europe
    • Howes, N. et al. Clinical and genetic characteristics of hereditary pancreatitis in Europe. Clin. Gastroenterol. Hepatol. 2, 252-261 (2004).
    • (2004) Clin. Gastroenterol. Hepatol. , vol.2 , pp. 252-261
    • Howes, N.1
  • 278
    • 0029129816 scopus 로고
    • Increased risk of pancreatic cancer in melanoma-prone kindreds with p16INK4 mutations
    • Goldstein, A. M. et al. Increased risk of pancreatic cancer in melanoma-prone kindreds with p16INK4 mutations. N. Engl. J. Med. 333, 970-974 (1995).
    • (1995) N. Engl. J. Med. , vol.333 , pp. 970-974
    • Goldstein, A.M.1
  • 279
    • 0034596343 scopus 로고    scopus 로고
    • High frequency of multiple melanomas and breast and pancreas carcinomas in CDKN2A mutation-positive melanoma families
    • Borg, A. et al. High frequency of multiple melanomas and breast and pancreas carcinomas in CDKN2A mutation-positive melanoma families. J. Natl Cancer Inst. 92, 1260-1266 (2000).
    • (2000) J. Natl Cancer Inst. , vol.92 , pp. 1260-1266
    • Borg, A.1
  • 280
    • 70350733425 scopus 로고    scopus 로고
    • Risk of pancreatic cancer in families with Lynch syndrome
    • Kastrinos, F. et al. Risk of pancreatic cancer in families with Lynch syndrome. JAMA 302, 1790-1795 (2009).
    • (2009) JAMA , vol.302 , pp. 1790-1795
    • Kastrinos, F.1
  • 281
    • 34548128021 scopus 로고    scopus 로고
    • Risk of pancreatic cancer in patients with cystic fibrosis
    • Maisonneuve, P., Marshall, B. C. & Lowenfels, A. B. Risk of pancreatic cancer in patients with cystic fibrosis. Gut 56, 1327-1328 (2007).
    • (2007) Gut , vol.56 , pp. 1327-1328
    • Maisonneuve, P.1    Marshall, B.C.2    Lowenfels, A.B.3
  • 282
    • 84870802792 scopus 로고    scopus 로고
    • The incidence of pancreatic cancer in BRCA1 and BRCA2 mutation carriers
    • Iqbal, J. et al. The incidence of pancreatic cancer in BRCA1 and BRCA2 mutation carriers. Br. J. Cancer 107, 2005-2009 (2012).
    • (2012) Br. J. Cancer , vol.107 , pp. 2005-2009
    • Iqbal, J.1
  • 284
    • 0035879874 scopus 로고    scopus 로고
    • Cancer risk in heterozygotes for ataxia-telangiectasia
    • Geoffroy-Perez, B. et al. Cancer risk in heterozygotes for ataxia-telangiectasia. Int. J. Cancer 93, 288-293 (2001).
    • (2001) Int. J. Cancer , vol.93 , pp. 288-293
    • Geoffroy-Perez, B.1
  • 285
    • 77953718900 scopus 로고    scopus 로고
    • TP53 germline mutation testing in 180 families suspected of Li-Fraumeni syndrome: Mutation detection rate and relative frequency of cancers in different familial phenotypes
    • Ruijs, M. W. et al. TP53 germline mutation testing in 180 families suspected of Li-Fraumeni syndrome: mutation detection rate and relative frequency of cancers in different familial phenotypes. J. Med. Genet. 47, 421-428 (2010).
    • (2010) J. Med. Genet. , vol.47 , pp. 421-428
    • Ruijs, M.W.1
  • 286
    • 0027429364 scopus 로고
    • Increased risk of thyroid and pancreatic carcinoma in familial adenomatous polyposis
    • Giardiello, F. M. et al. Increased risk of thyroid and pancreatic carcinoma in familial adenomatous polyposis. Gut 34, 1394-1396 (1993).
    • (1993) Gut , vol.34 , pp. 1394-1396
    • Giardiello, F.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.