Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism

Nature

Volumn 524, Issue 7565, 2015, Pages 361-365

  Perera, Rushika M ^a,b,c   Stoykova, Svetlana ^a,b   Nicolay, Brandon N ^a,c   Ross, Kenneth N ^a,b,c   Fitamant, Julien ^a,b,c   Boukhali, Myriam ^a   Lengrand, Justine ^a,b   Deshpande, Vikram ^a,c   Selig, Martin K ^a   Ferrone, Cristina R ^a,c   Settleman, Jeff ^a   Stephanopoulos, Gregory ^d   Dyson, Nicholas J ^a,c   Zoncu, Roberto ^e   Ramaswamy, Sridhar ^a,b,c   Haas, Wilhelm ^a,c   Bardeesy, Nabeel ^a,b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d Massachusetts Institute of Technology Cambridge   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CARBOHYDRATE; LAMIN; LIPID; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; NUCLEOTIDE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; MITF PROTEIN, HUMAN; TFE3 PROTEIN, HUMAN; TFEB PROTEIN, HUMAN;

AMINO ACID; APOPTOSIS; CANCER; CYTOPLASM; GENE EXPRESSION; GROWTH RATE; HOMEOSTASIS; METABOLISM; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CANCER GROWTH; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LYSOSOME; MOUSE; NONHUMAN; NUCLEAR IMPORT; PANCREAS ADENOCARCINOMA; PINOCYTOSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; ACTIVE TRANSPORT; ANIMAL; CANCER TRANSPLANTATION; ENERGY METABOLISM; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HOMEOSTASIS; METABOLISM; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY; TUMOR CELL LINE; XENOGRAFT;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACIDS; ANIMALS; AUTOPHAGY; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CARCINOMA, PANCREATIC DUCTAL; CELL LINE, TUMOR; ENERGY METABOLISM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HETEROGRAFTS; HOMEOSTASIS; HUMANS; LYSOSOMES; MICE; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; NEOPLASM TRANSPLANTATION; PANCREATIC NEOPLASMS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 84939787271     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14587     Document Type: Article

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