A listeria vaccine and depletion of t-regulatory cells activate immunity against early stage pancreatic intraepithelial neoplasms and prolong survival of mice

Gastroenterology

Volumn 146, Issue 7, 2014, Pages

  Keenan, Bridget P ^a,b   Saenger, Yvonne ^c   Kafrouni, Michel I ^a   Leubner, Ashley ^a   Lauer, Peter ^d   Maitra, Anirban ^e   Rucki, Agnieszka A ^a   Gunderson, Andrew J ^f   Coussens, Lisa M ^f   Brockstedt, Dirk G ^d   Dubensky Jr , Thomas W ^d   Hassan, Raffit ^g   Armstrong, Todd D ^a   Jaffee, Elizabeth M ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d Aduro BioTech Inc   (United States)

^e UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^f OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^g NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Immunity; Listeria Vaccine; Pancreatic Cancer; Tumor Microenvironment

Indexed keywords

ANTIBODY; BACTERIAL VACCINE; CD11B ANTIGEN; CHROMIUM; CRS 207; CYCLOPHOSPHAMIDE; GAMMA INTERFERON; INTERLEUKIN 17; K RAS PROTEIN; PC 61; PROTEIN P53; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CANCER IMMUNOTHERAPY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; FLOW CYTOMETRY; HELPER CELL; HISTOPATHOLOGY; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; LISTERIA MONOCYTOGENES; LOW DRUG DOSE; LYMPH NODE; LYMPHOCYTE DEPLETION; MOUSE; NONHUMAN; PANCREAS; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PANCREATIC INTRAEPITHELIAL NEOPLASM; PHASE 1 CLINICAL TRIAL; PHENOTYPE; PRIMARY PREVENTION; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SPLEEN; SURVIVAL TIME; VACCINATION;

IMMUNITY; LISTERIA VACCINE; PANCREATIC CANCER; TUMOR MICROENVIRONMENT;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD11B; CANCER VACCINES; CARCINOMA IN SITU; CARCINOMA, PANCREATIC DUCTAL; CYCLOPHOSPHAMIDE; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FORKHEAD TRANSCRIPTION FACTORS; HOMEODOMAIN PROTEINS; HUMANS; INFLAMMATION MEDIATORS; INTEGRASES; INTERFERON-GAMMA; INTERLEUKIN-17; LISTERIA MONOCYTOGENES; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS P21(RAS); RECEPTORS, CHEMOKINE; T-LYMPHOCYTES, REGULATORY; TIME FACTORS; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84901218374     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.02.055     Document Type: Article

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