Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 48, 2008, Pages 18913-18918

  Habbe, Nils ^a,e   Shi, Guanglu ^c   Meguid, Robert A ^a   Fendrich, Volker ^a,e   Esni, Farzad ^b   Chen, Huiping ^b   Feldmann, Georg ^a   Stoffers, Doris A ^d   Konieczny, Stephen F ^c   Leach, Steven D ^a   Maitra, Anirban ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c PURDUE UNIVERSITY   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Lineage tracing; Pancreatic cancer; Precursor lesions; Transdifferentiation

Indexed keywords

TAMOXIFEN;

ACINAR CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INVASION; CARCINOGENESIS; CELL LINE; CELL STRUCTURE; GENE ACTIVATION; GENE EXPRESSION; GENETIC MODEL; HISTOPATHOLOGY; NONHUMAN; ONCOGENE K RAS; PANCREAS CANCER; PANCREATIC DUCTAL ADENOCARCINOMA; PANCREATIC INTRAEPITHELIAL NEOPLASIA; PHENOTYPE; PRIORITY JOURNAL; TUMOR CELL;

ANIMALS; CARCINOMA, PANCREATIC DUCTAL; HUMANS; MICE; MICE, TRANSGENIC; PANCREAS, EXOCRINE; PANCREATIC NEOPLASMS; PRECANCEROUS CONDITIONS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS P21(RAS); RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

MURINAE; MUS;

EID: 57749113202     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0810097105     Document Type: Article

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