-
1
-
-
0034644537
-
Ras and Rho GTPases: A family reunion
-
Bar-Sagi, D.; Hall, A. Ras and Rho GTPases: A family reunion. Cell 2000, 103, 227–238
-
(2000)
Cell
, vol.103
, pp. 227-238
-
-
Bar-Sagi, D.1
Hall, A.2
-
2
-
-
0037069690
-
Rho GTPases in cell biology
-
Etienne-Manneville, S.; Hall, A. Rho GTPases in cell biology. Nature 2002, 420, 629–635
-
(2002)
Nature
, vol.420
, pp. 629-635
-
-
Etienne-Manneville, S.1
Hall, A.2
-
3
-
-
16844387479
-
The ras superfamily at a glance
-
Wennerberg, K.; Rossman, K.L.; Der, C.J. The ras superfamily at a glance. J. Cell Sci. 2005, 118, 843–846
-
(2005)
J. Cell Sci
, vol.118
, pp. 843-846
-
-
Wennerberg, K.1
Rossman, K.L.2
Der, C.J.3
-
4
-
-
0026026818
-
The GTPase superfamily: Conserved structure and molecular mechanism
-
Bourne, H.R.; Sanders, D.A.; McCormick, F. The GTPase superfamily: Conserved structure and molecular mechanism. Nature 1991, 349, 117–127
-
(1991)
Nature
, vol.349
, pp. 117-127
-
-
Bourne, H.R.1
Sanders, D.A.2
McCormick, F.3
-
5
-
-
0032502733
-
Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA
-
Zhang, B.; Chernoff, J.; Zheng, Y. Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA. J. Biol. Chem. 1998, 273, 8776–8782
-
(1998)
J. Biol. Chem
, vol.273
, pp. 8776-8782
-
-
Zhang, B.1
Chernoff, J.2
Zheng, Y.3
-
6
-
-
0034213327
-
Rho GTPases and their effector proteins
-
Bishop, A.L.; Hall, A. Rho GTPases and their effector proteins. Biochem. J. 2000, 348, 241–255
-
(2000)
Biochem. J
, vol.348
, pp. 241-255
-
-
Bishop, A.L.1
Hall, A.2
-
7
-
-
10944244704
-
Rho signalling at a glance
-
Schwartz, M. Rho signalling at a glance. J. Cell Sci.2004, 117, 5457–5458
-
(2004)
J. Cell Sci
, vol.117
, pp. 5457-5458
-
-
Schwartz, M.1
-
8
-
-
54549104845
-
Crosstalk between small GTPases and polarity proteins in cell polarization
-
Iden, S.; Collard, J.G. Crosstalk between small GTPases and polarity proteins in cell polarization. Nat. Rev. Mol. Cell Biol. 2008, 9, 846–859
-
(2008)
Nat. Rev. Mol. Cell Biol
, vol.9
, pp. 846-859
-
-
Iden, S.1
Collard, J.G.2
-
9
-
-
0033604638
-
Signaling to Rho GTPases
-
Kjoller, L.; Hall, A. Signaling to Rho GTPases. Exp. Cell Res.1999, 253, 166–179
-
(1999)
Exp. Cell Res
, vol.253
, pp. 166-179
-
-
Kjoller, L.1
Hall, A.2
-
10
-
-
0030968580
-
Rho GTPases and signaling networks
-
Van Aelst, L.; D’Souza-Schorey, C. Rho GTPases and signaling networks. Genes Dev. 1997, 11, 2295–2322
-
(1997)
Genes Dev
, vol.11
, pp. 2295-2322
-
-
Van Aelst, L.1
D’souza-Schorey, C.2
-
11
-
-
0026640530
-
Post-translational modifications of p21Rho proteins
-
Adamson, P.; Marshall, C.J.; Hall, A.; Tilbrook, P.A. Post-translational modifications of p21Rho proteins. J. Biol. Chem. 1992, 267, 20033–20038
-
(1992)
J. Biol. Chem
, vol.267
, pp. 20033-20038
-
-
Adamson, P.1
Marshall, C.J.2
Hall, A.3
Tilbrook, P.A.4
-
12
-
-
0026612457
-
Intracellular localization of the p21Rho proteins
-
Adamson, P.; Paterson, H.F.; Hall, A. Intracellular localization of the p21Rho proteins. J. Cell Biol.1992, 119, 617–627
-
(1992)
J. Cell Biol
, vol.119
, pp. 617-627
-
-
Adamson, P.1
Paterson, H.F.2
Hall, A.3
-
13
-
-
0034603198
-
Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator Rhogdi
-
Hoffman, G.R.; Nassar, N.; Cerione, R.A. Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator Rhogdi. Cell 2000, 100, 345–356
-
(2000)
Cell
, vol.100
, pp. 345-356
-
-
Hoffman, G.R.1
Nassar, N.2
Cerione, R.A.3
-
14
-
-
0033058184
-
Rho guanine dissociation inhibitors: Pivotal molecules in cellular signalling
-
Olofsson, B. Rho guanine dissociation inhibitors: Pivotal molecules in cellular signalling. Cell Signal 1999, 11, 545–554
-
(1999)
Cell Signal
, vol.11
, pp. 545-554
-
-
Olofsson, B.1
-
15
-
-
0033787469
-
Microbial toxins and the glycosylation of Rho family GTPases
-
Busch, C.; Aktories, K. Microbial toxins and the glycosylation of Rho family GTPases. Curr. Opin. Struct. Biol. 2000, 10, 528–535
-
(2000)
Curr. Opin. Struct. Biol
, vol.10
, pp. 528-535
-
-
Busch, C.1
Aktories, K.2
-
16
-
-
0033924259
-
Rho GTPases as targets of bacterial protein toxins
-
Aktories, K.; Schmidt, G.; Just, I. Rho GTPases as targets of bacterial protein toxins. Biol. Chem. 2000, 381, 421–426
-
(2000)
Biol. Chem
, vol.381
, pp. 421-426
-
-
Aktories, K.1
Schmidt, G.2
Just, I.3
-
17
-
-
0032559362
-
Rho GTPases and the actin cytoskeleton
-
Hall, A. Rho GTPases and the actin cytoskeleton. Science 1998, 279, 509–514
-
(1998)
Science
, vol.279
, pp. 509-514
-
-
Hall, A.1
-
18
-
-
0027052132
-
Ras-related GTPases and the cytoskeleton
-
Hall, A. Ras-related GTPases and the cytoskeleton. Mol. Cell Biol.1992, 3, 475–479
-
(1992)
Mol. Cell Biol
, vol.3
, pp. 475-479
-
-
Hall, A.1
-
19
-
-
0029055812
-
The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
-
Coso, O.A.; Chiariello, M.; Yu, J.C.; Teramoto, H.; Crespo, P.; Xu, N.; Miki, T.; Gutkind, J.S. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 1995, 81, 1137–1146
-
(1995)
Cell
, vol.81
, pp. 1137-1146
-
-
Coso, O.A.1
Chiariello, M.2
Yu, J.C.3
Teramoto, H.4
Crespo, P.5
Xu, N.6
Miki, T.7
Gutkind, J.S.8
-
20
-
-
0029070887
-
Selective activation of the JNK signaling cascade and c-jun transcriptional activity by the small GTPases Rac and Cdc42hs
-
Minden, A.; Lin, A.; Claret, F.X.; Abo, A.; Karin, M. Selective activation of the JNK signaling cascade and c-jun transcriptional activity by the small GTPases Rac and Cdc42hs. Cell 1995, 81, 1147–1157
-
(1995)
Cell
, vol.81
, pp. 1147-1157
-
-
Minden, A.1
Lin, A.2
Claret, F.X.3
Abo, A.4
Karin, M.5
-
21
-
-
0030597239
-
Three paths to stress relief
-
Canman, C.E.; Kastan, M.B. Three paths to stress relief. Nature 1996, 384, 213–214
-
(1996)
Nature
, vol.384
, pp. 213-214
-
-
Canman, C.E.1
Kastan, M.B.2
-
22
-
-
0347537940
-
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
-
Verheij, M.; Bose, R.; Lin, X.H.; Yao, B.; Jarvis, W.D.; Grant, S.; Birrer, M.J.; Szabo, E.; Zon, L.I.; Kyriakis, J.M.; et al. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 1996, 380, 75–79
-
(1996)
Nature
, vol.380
, pp. 75-79
-
-
Verheij, M.1
Bose, R.2
Lin, X.H.3
Yao, B.4
Jarvis, W.D.5
Grant, S.6
Birrer, M.J.7
Szabo, E.8
Zon, L.I.9
Kyriakis, J.M.10
-
23
-
-
0028880006
-
Opposing effects of ERK and JNK-p38 map kinases on apoptosis
-
Xia, Z.; Dickens, M.; Raingeaud, J.; Davis, R.J.; Greenberg, M.E. Opposing effects of ERK and JNK-p38 map kinases on apoptosis. Science 1995, 270, 1326–1331
-
(1995)
Science
, vol.270
, pp. 1326-1331
-
-
Xia, Z.1
Dickens, M.2
Raingeaud, J.3
Davis, R.J.4
Greenberg, M.E.5
-
24
-
-
0038757747
-
The activation of c-jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair
-
Hayakawa, J.; Depatie, C.; Ohmichi, M.; Mercola, D. The activation of c-jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair. J. Biol. Chem. 2003, 278, 20582–20592
-
(2003)
J. Biol. Chem
, vol.278
, pp. 20582-20592
-
-
Hayakawa, J.1
Depatie, C.2
Ohmichi, M.3
Mercola, D.4
-
25
-
-
0031034469
-
Activation of the nuclear factor-κB by Rho, Cdc42, and Rac-1 proteins
-
Perona, R.; Montaner, S.; Saniger, L.; Sanchez-Perez, I.; Bravo, R.; Lacal, J.C. Activation of the nuclear factor-κB by Rho, Cdc42, and Rac-1 proteins. Genes Dev. 1997, 11, 463–475
-
(1997)
Genes Dev
, vol.11
, pp. 463-475
-
-
Perona, R.1
Montaner, S.2
Saniger, L.3
Sanchez-Perez, I.4
Bravo, R.5
Lacal, J.C.6
-
26
-
-
0034715895
-
Rho GTPases: Signaling, migration, and invasion
-
Schmitz, A.A.; Govek, E.E.; Bottner, B.; van Aelst, L. Rho GTPases: Signaling, migration, and invasion. Exp. Cell Res. 2000, 261, 1–12
-
(2000)
Exp. Cell Res
, vol.261
, pp. 1-12
-
-
Schmitz, A.A.1
Govek, E.E.2
Bottner, B.3
Van Aelst, L.4
-
27
-
-
0036191304
-
Rho GTPases in transformation and metastasis
-
Jaffe, A.B.; Hall, A. Rho GTPases in transformation and metastasis. Adv. Cancer Res.2002, 84, 57–80
-
(2002)
Adv. Cancer Res
, vol.84
, pp. 57-80
-
-
Jaffe, A.B.1
Hall, A.2
-
29
-
-
0030968177
-
The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts
-
Braga, V.M.; Machesky, L.M.; Hall, A.; Hotchin, N.A. The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J. Cell Biol. 1997, 137, 1421–1431
-
(1997)
J. Cell Biol
, vol.137
, pp. 1421-1431
-
-
Braga, V.M.1
Machesky, L.M.2
Hall, A.3
Hotchin, N.A.4
-
30
-
-
0026778133
-
The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
-
Ridley, A.J.; Hall, A. The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 1992, 70, 389–399
-
(1992)
Cell
, vol.70
, pp. 389-399
-
-
Ridley, A.J.1
Hall, A.2
-
31
-
-
0029101360
-
An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1
-
Olson, M.F.; Ashworth, A.; Hall, A. An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 1995, 269, 1270–1272
-
(1995)
Science
, vol.269
, pp. 1270-1272
-
-
Olson, M.F.1
Ashworth, A.2
Hall, A.3
-
32
-
-
0035836791
-
Rho signals to cell growth and apoptosis
-
Aznar, S.; Lacal, J.C. Rho signals to cell growth and apoptosis. Cancer Lett.2001, 165, 1–10
-
(2001)
Cancer Lett
, vol.165
, pp. 1-10
-
-
Aznar, S.1
Lacal, J.C.2
-
33
-
-
0029790979
-
Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents
-
Knebel, A.; Rahmsdorf, H.J.; Ullrich, A.; Herrlich, P. Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents. EMBO J. 1996, 15, 5314–5325
-
(1996)
EMBO J
, vol.15
, pp. 5314-5325
-
-
Knebel, A.1
Rahmsdorf, H.J.2
Ullrich, A.3
Herrlich, P.4
-
34
-
-
0027931641
-
Involvement of growth factor receptors in the mammalian uvc response
-
Sachsenmaier, C.; Radler-Pohl, A.; Zinck, R.; Nordheim, A.; Herrlich, P.; Rahmsdorf, H.J. Involvement of growth factor receptors in the mammalian uvc response. Cell 1994, 78, 963–972
-
(1994)
Cell
, vol.78
, pp. 963-972
-
-
Sachsenmaier, C.1
Radler-Pohl, A.2
Zinck, R.3
Nordheim, A.4
Herrlich, P.5
Rahmsdorf, H.J.6
-
35
-
-
38949158000
-
Supreme enlightenment: Damage recognition and signaling in the mammalian UV response
-
Herrlich, P.; Karin, M.; Weiss, C. Supreme enlightenment: Damage recognition and signaling in the mammalian UV response. Mol. Cell 2008, 29, 279–290
-
(2008)
Mol. Cell
, vol.29
, pp. 279-290
-
-
Herrlich, P.1
Karin, M.2
Weiss, C.3
-
36
-
-
0008805915
-
Inactivation of protein-tyrosine phosphatases as mechanism of UV-induced signal transduction
-
Gross, S.; Knebel, A.; Tenev, T.; Neininger, A.; Gaestel, M.; Herrlich, P.; Bohmer, F.D. Inactivation of protein-tyrosine phosphatases as mechanism of UV-induced signal transduction. J. Biol. Chem. 1999, 274, 26378–26386
-
(1999)
J. Biol. Chem
, vol.274
, pp. 26378-26386
-
-
Gross, S.1
Knebel, A.2
Tenev, T.3
Neininger, A.4
Gaestel, M.5
Herrlich, P.6
Bohmer, F.D.7
-
37
-
-
0033231020
-
From receptors to stress-activated map kinases
-
Ichijo, H. From receptors to stress-activated map kinases. Oncogene 1999, 18, 6087–6093
-
(1999)
Oncogene
, vol.18
, pp. 6087-6093
-
-
Ichijo, H.1
-
38
-
-
0029856557
-
Three distinct signalling responses by murine fibroblasts to genotoxic stress
-
Liu, Z.G.; Baskaran, R.; Lea-Chou, E.T.; Wood, L.D.; Chen, Y.; Karin, M.; Wang, J.Y. Three distinct signalling responses by murine fibroblasts to genotoxic stress. Nature 1996, 384, 273–276
-
(1996)
Nature
, vol.384
, pp. 273-276
-
-
Liu, Z.G.1
Baskaran, R.2
Lea-Chou, E.T.3
Wood, L.D.4
Chen, Y.5
Karin, M.6
Wang, J.Y.7
-
39
-
-
0034693878
-
Regulation of cell death by the Abl tyrosine kinase
-
Wang, J.Y. Regulation of cell death by the Abl tyrosine kinase. Oncogene 2000, 19, 5643–5650
-
(2000)
Oncogene
, vol.19
, pp. 5643-5650
-
-
Wang, J.Y.1
-
40
-
-
0029098225
-
Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents
-
Kharbanda, S.; Ren, R.; Pandey, P.; Shafman, T.D.; Feller, S.M.; Weichselbaum, R.R.; Kufe, D.W. Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents. Nature 1995, 376, 785–788
-
(1995)
Nature
, vol.376
, pp. 785-788
-
-
Kharbanda, S.1
Ren, R.2
Pandey, P.3
Shafman, T.D.4
Feller, S.M.5
Weichselbaum, R.R.6
Kufe, D.W.7
-
41
-
-
0030877559
-
Differential induction of c-Jun NH2-terminal kinase and c-Abl kinase in DNA mismatch repair-proficient and -deficient cells exposed to cisplatin
-
Nehme, A.; Baskaran, R.; Aebi, S.; Fink, D.; Nebel, S.; Cenni, B.; Wang, J.Y.; Howell, S.B.; Christen, R.D. Differential induction of c-Jun NH2-terminal kinase and c-Abl kinase in DNA mismatch repair-proficient and -deficient cells exposed to cisplatin. Cancer Res. 1997, 57, 3253–3257
-
(1997)
Cancer Res
, vol.57
, pp. 3253-3257
-
-
Nehme, A.1
Baskaran, R.2
Aebi, S.3
Fink, D.4
Nebel, S.5
Cenni, B.6
Wang, J.Y.7
Howell, S.B.8
Christen, R.D.9
-
42
-
-
0036098552
-
Ap-1 as a regulator of cell life and death
-
Shaulian, E.; Karin, M. Ap-1 as a regulator of cell life and death. Nat. Cell Biol.2002, 4, E131–E136
-
(2002)
Nat. Cell Biol
, vol.4
-
-
Shaulian, E.1
Karin, M.2
-
43
-
-
31944445312
-
Late activation of stress kinases (SAPK/JNK) by genotoxins requires the DNA repair proteins DNA-PKcs and CSB
-
Fritz, G.; Kaina, B. Late activation of stress kinases (SAPK/JNK) by genotoxins requires the DNA repair proteins DNA-PKcs and CSB. Mol. Biol. Cell 2006, 17, 851–861
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 851-861
-
-
Fritz, G.1
Kaina, B.2
-
44
-
-
0033016378
-
Induction of JNK and c-Abl signalling by cisplatin and oxaliplatin in mismatch repair-proficient and -deficient cells
-
Nehme, A.; Baskaran, R.; Nebel, S.; Fink, D.; Howell, S.B.; Wang, J.Y.; Christen, R.D. Induction of JNK and c-Abl signalling by cisplatin and oxaliplatin in mismatch repair-proficient and -deficient cells. Br. J. Cancer 1999, 79, 1104–1110
-
(1999)
Br. J. Cancer
, vol.79
, pp. 1104-1110
-
-
Nehme, A.1
Baskaran, R.2
Nebel, S.3
Fink, D.4
Howell, S.B.5
Wang, J.Y.6
Christen, R.D.7
-
45
-
-
58549109806
-
DNA replication arrest in response to genotoxic stress provokes early activation of stress-activated protein kinases (SAPK/JNK)
-
Damrot, J.; Helbig, L.; Roos, W.P.; Barrantes, S.Q.; Kaina, B.; Fritz, G. DNA replication arrest in response to genotoxic stress provokes early activation of stress-activated protein kinases (SAPK/JNK). J. Mol. Biol.2009, 385, 1409–1421
-
(2009)
J. Mol. Biol
, vol.385
, pp. 1409-1421
-
-
Damrot, J.1
Helbig, L.2
Roos, W.P.3
Barrantes, S.Q.4
Kaina, B.5
Fritz, G.6
-
46
-
-
36749022214
-
The DNA damage response: Ten years after
-
Harper, J.W.; Elledge, S.J. The DNA damage response: Ten years after. Mol. Cell 2007, 28, 739–745
-
(2007)
Mol. Cell
, vol.28
, pp. 739-745
-
-
Harper, J.W.1
Elledge, S.J.2
-
47
-
-
77951026398
-
A minority of foci or pan-nuclear apoptotic staining of γH2AX in the s phase after UV damage contain DNA doublestrand breaks
-
De Feraudy, S.; Revet, I.; Bezrookove, V.; Feeney, L.; Cleaver, J.E. A minority of foci or pan-nuclear apoptotic staining of γH2AX in the s phase after UV damage contain DNA doublestrand breaks. Proc. Natl. Acad. Sci. USA 2010, 107, 6870–6875
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 6870-6875
-
-
De Feraudy, S.1
Revet, I.2
Bezrookove, V.3
Feeney, L.4
Cleaver, J.E.5
-
48
-
-
33745487368
-
Cell apoptosis: Requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3
-
Lu, C.; Zhu, F.; Cho, Y.Y.; Tang, F.; Zykova, T.; Ma, W.Y.; Bode, A.M.; Dong, Z. Cell apoptosis: Requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3. Mol. Cell 2006, 23, 121–132
-
(2006)
Mol. Cell
, vol.23
, pp. 121-132
-
-
Lu, C.1
Zhu, F.2
Cho, Y.Y.3
Tang, F.4
Zykova, T.5
Ma, W.Y.6
Bode, A.M.7
Dong, Z.8
-
49
-
-
33745934311
-
H2AX is a target of the JNK signaling pathway that is required for apoptotic DNA fragmentation
-
Sluss, H.K.; Davis, R.J. H2AX is a target of the JNK signaling pathway that is required for apoptotic DNA fragmentation. Mol. Cell 2006, 23, 152–153
-
(2006)
Mol. Cell
, vol.23
, pp. 152-153
-
-
Sluss, H.K.1
Davis, R.J.2
-
50
-
-
57149136324
-
γH2AX and cancer
-
Bonner, W.M.; Redon, C.E.; Dickey, J.S.; Nakamura, A.J.; Sedelnikova, O.A.; Solier, S.; Pommier, Y. γH2AX and cancer. Nat. Rev. Cancer 2008, 8, 957–967
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 957-967
-
-
Bonner, W.M.1
Redon, C.E.2
Dickey, J.S.3
Nakamura, A.J.4
Sedelnikova, O.A.5
Solier, S.6
Pommier, Y.7
-
51
-
-
84885720011
-
Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity
-
Kopper, F.; Bierwirth, C.; Schon, M.; Kunze, M.; Elvers, I.; Kranz, D.; Saini, P.; Menon, M.B.; Walter, D.; Sorensen, C.S., et al. Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity. Proc. Natl. Acad. Sci. USA 2013, 110, 16856–16861
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 16856-16861
-
-
Kopper, F.1
Bierwirth, C.2
Schon, M.3
Kunze, M.4
Elvers, I.5
Kranz, D.6
Saini, P.7
Menon, M.B.8
Walter, D.9
Sorensen, C.S.10
-
52
-
-
77957361354
-
DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated rna stabilization
-
Reinhardt, H.C.; Hasskamp, P.; Schmedding, I.; Morandell, S.; van Vugt, M.A.; Wang, X.; Linding, R.; Ong, S.E.; Weaver, D.; Carr, S.A., et al. DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated rna stabilization. Mol. Cell 2010, 40, 34–49
-
(2010)
Mol. Cell
, vol.40
, pp. 34-49
-
-
Reinhardt, H.C.1
Hasskamp, P.2
Schmedding, I.3
Morandell, S.4
Van Vugt, M.A.5
Wang, X.6
Linding, R.7
Ong, S.E.8
Weaver, D.9
Carr, S.A.10
-
53
-
-
63749131243
-
Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2
-
Reinhardt, H.C.; Yaffe, M.B. Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr. Opin. Cell Biol. 2009, 21, 245–255
-
(2009)
Curr. Opin. Cell Biol
, vol.21
, pp. 245-255
-
-
Reinhardt, H.C.1
Yaffe, M.B.2
-
54
-
-
33846821915
-
P53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage
-
Reinhardt, H.C.; Aslanian, A.S.; Lees, J.A.; Yaffe, M.B. P53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell 2007, 11, 175–189
-
(2007)
Cancer Cell
, vol.11
, pp. 175-189
-
-
Reinhardt, H.C.1
Aslanian, A.S.2
Lees, J.A.3
Yaffe, M.B.4
-
55
-
-
0033675202
-
Inhibition of protein isoprenylation impairs Rho-regulated early cellular response to genotoxic stress
-
Gnad, R.; Aktories, K.; Kaina, B.; Fritz, G. Inhibition of protein isoprenylation impairs Rho-regulated early cellular response to genotoxic stress. Mol. Pharmacol.2000, 58, 1389–1397
-
(2000)
Mol. Pharmacol
, vol.58
, pp. 1389-1397
-
-
Gnad, R.1
Aktories, K.2
Kaina, B.3
Fritz, G.4
-
56
-
-
59449102167
-
Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-coA reductase inhibitors
-
Rashid, M.; Tawara, S.; Fukumoto, Y.; Seto, M.; Yano, K.; Shimokawa, H. Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-coA reductase inhibitors. Circ. J. 2009, 73, 361–370
-
(2009)
Circ. J
, vol.73
, pp. 361-370
-
-
Rashid, M.1
Tawara, S.2
Fukumoto, Y.3
Seto, M.4
Yano, K.5
Shimokawa, H.6
-
57
-
-
77951709095
-
Pleiotropic effects of statins—Basic research and clinical perspectives
-
Zhou, Q.; Liao, J.K. Pleiotropic effects of statins—Basic research and clinical perspectives. Circ. J. 2010, 74, 818–826
-
(2010)
Circ. J
, vol.74
, pp. 818-826
-
-
Zhou, Q.1
Liao, J.K.2
-
58
-
-
7644242146
-
Effects of statins on endothelium and signaling mechanisms
-
Endres, M.; Laufs, U. Effects of statins on endothelium and signaling mechanisms. Stroke 2004, 35, 2708–2711
-
(2004)
Stroke
, vol.35
, pp. 2708-2711
-
-
Endres, M.1
Laufs, U.2
-
59
-
-
33644854484
-
Rho GTPases: Promising cellular targets for novel anticancer drugs
-
Fritz, G.; Kaina, B. Rho GTPases: Promising cellular targets for novel anticancer drugs. Curr. Cancer Drug Targets 2006, 6, 1–14
-
(2006)
Curr. Cancer Drug Targets
, vol.6
, pp. 1-14
-
-
Fritz, G.1
Kaina, B.2
-
60
-
-
69249219178
-
Targeting the mevalonate pathway for improved anticancer therapy
-
Fritz, G. Targeting the mevalonate pathway for improved anticancer therapy. Curr. Cancer Drug Targets 2009, 9, 626–638
-
(2009)
Curr. Cancer Drug Targets
, vol.9
, pp. 626-638
-
-
Fritz, G.1
-
61
-
-
33845680365
-
Lovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposide
-
Damrot, J.; Nubel, T.; Epe, B.; Roos, W.P.; Kaina, B.; Fritz, G. Lovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposide. Br. J. Pharmacol.2006, 149, 988–997
-
(2006)
Br. J. Pharmacol
, vol.149
, pp. 988-997
-
-
Damrot, J.1
Nubel, T.2
Epe, B.3
Roos, W.P.4
Kaina, B.5
Fritz, G.6
-
62
-
-
79952246410
-
Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells
-
Nilsson, S.; Huelsenbeck, J.; Fritz, G. Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells. Cancer Lett.2011, 304, 60–69
-
(2011)
Cancer Lett
, vol.304
, pp. 60-69
-
-
Nilsson, S.1
Huelsenbeck, J.2
Fritz, G.3
-
63
-
-
79953836781
-
Late activation of stress-activated protein kinases/c-jun N-terminal kinases triggered by cisplatin-induced DNA damage in repair-defective cells
-
Helbig, L.; Damrot, J.; Hulsenbeck, J.; Koberle, B.; Brozovic, A.; Osmak, M.; Fiket, Z.; Kaina, B.; Fritz, G. Late activation of stress-activated protein kinases/c-jun N-terminal kinases triggered by cisplatin-induced DNA damage in repair-defective cells. J. Biol. Chem.2011, 286, 12991–13001
-
(2011)
J. Biol. Chem
, vol.286
, pp. 12991-13001
-
-
Helbig, L.1
Damrot, J.2
Hulsenbeck, J.3
Koberle, B.4
Brozovic, A.5
Osmak, M.6
Fiket, Z.7
Kaina, B.8
Fritz, G.9
-
64
-
-
0027049804
-
The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases
-
Devary, Y.; Gottlieb, R.A.; Smeal, T.; Karin, M. The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases. Cell 1992, 71, 1081–1091
-
(1992)
Cell
, vol.71
, pp. 1081-1091
-
-
Devary, Y.1
Gottlieb, R.A.2
Smeal, T.3
Karin, M.4
-
65
-
-
45549094636
-
Characterization of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases
-
Onesto, C.; Shutes, A.; Picard, V.; Schweighoffer, F.; Der, C.J. Characterization of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. Methods Enzymol. 2008, 439, 111–129
-
(2008)
Methods Enzymol
, vol.439
, pp. 111-129
-
-
Onesto, C.1
Shutes, A.2
Picard, V.3
Schweighoffer, F.4
Der, C.J.5
-
66
-
-
2442664118
-
Rational design and characterization of a Rac GTPase-specific small molecule inhibitor
-
Gao, Y.; Dickerson, J.B.; Guo, F.; Zheng, J.; Zheng, Y. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc. Natl. Acad. Sci. USA 2004, 101, 7618–7623
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 7618-7623
-
-
Gao, Y.1
Dickerson, J.B.2
Guo, F.3
Zheng, J.4
Zheng, Y.5
-
67
-
-
84869074814
-
Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons
-
Huelsenbeck, S.C.; Schorr, A.; Roos, W.P.; Huelsenbeck, J.; Henninger, C.; Kaina, B.; Fritz, G. Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons. J. Biol. Chem.2012, 287, 38590–38599
-
(2012)
J. Biol. Chem
, vol.287
, pp. 38590-38599
-
-
Huelsenbeck, S.C.1
Schorr, A.2
Roos, W.P.3
Huelsenbeck, J.4
Henninger, C.5
Kaina, B.6
Fritz, G.7
-
68
-
-
80052328841
-
Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
-
Huelsenbeck, J.; Henninger, C.; Schad, A.; Lackner, K.J.; Kaina, B.; Fritz, G. Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity. Cell Death Dis. 2011, doi:10.1038/cddis.2011.65
-
(2011)
Cell Death Dis
-
-
Huelsenbeck, J.1
Henninger, C.2
Schad, A.3
Lackner, K.J.4
Kaina, B.5
Fritz, G.6
-
69
-
-
84884375366
-
DNA damage response (DDR) induced by topoisomerase ii poisons requires nuclear function of the small GTPase Rac
-
Wartlick, F.; Bopp, A.; Henninger, C.; Fritz, G. DNA damage response (DDR) induced by topoisomerase ii poisons requires nuclear function of the small GTPase Rac. Biochim. Biophys. Acta 2013, 1833, 3093–3103
-
(2013)
Biochim. Biophys. Acta
, vol.1833
, pp. 3093-3103
-
-
Wartlick, F.1
Bopp, A.2
Henninger, C.3
Fritz, G.4
-
70
-
-
58349097915
-
Pretreatment with statin attenuates the cardiotoxicity of doxorubicin in mice
-
Riad, A.; Bien, S.; Westermann, D.; Becher, P.M.; Loya, K.; Landmesser, U.; Kroemer, H.K.; Schultheiss, H.P.; Tschope, C. Pretreatment with statin attenuates the cardiotoxicity of doxorubicin in mice. Cancer Res. 2009, 69, 695–699
-
(2009)
Cancer Res
, vol.69
, pp. 695-699
-
-
Riad, A.1
Bien, S.2
Westermann, D.3
Becher, P.M.4
Loya, K.5
Landmesser, U.6
Kroemer, H.K.7
Schultheiss, H.P.8
Tschope, C.9
-
71
-
-
70349734337
-
Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity
-
Yoshida, M.; Shiojima, I.; Ikeda, H.; Komuro, I. Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity. J. Mol. Cell Cardiol. 2009, 47, 698–705
-
(2009)
J. Mol. Cell Cardiol
, vol.47
, pp. 698-705
-
-
Yoshida, M.1
Shiojima, I.2
Ikeda, H.3
Komuro, I.4
-
72
-
-
84871729133
-
Rac1 signalling mediates doxorubicin-induced cardiotoxicity through both reactive oxygen species-dependent and -independent pathways
-
Ma, J.; Wang, Y.; Zheng, D.; Wei, M.; Xu, H.; Peng, T. Rac1 signalling mediates doxorubicin-induced cardiotoxicity through both reactive oxygen species-dependent and -independent pathways. Cardiovasc. Res.2013, 97, 77–87
-
(2013)
Cardiovasc. Res
, vol.97
, pp. 77-87
-
-
Ma, J.1
Wang, Y.2
Zheng, D.3
Wei, M.4
Xu, H.5
Peng, T.6
-
73
-
-
84915795118
-
Chronic heart damage following doxorubicin treatment is alleviated by lovastatin
-
Henninger, C.; Huelsenbeck, S.; Wenzel, P.; Brand, M.; Huelsenbeck, J.; Schad, A.; Fritz, G. Chronic heart damage following doxorubicin treatment is alleviated by lovastatin. Pharmacol. Res. 2015, 91, 47–56
-
(2015)
Pharmacol. Res
, vol.91
, pp. 47-56
-
-
Henninger, C.1
Huelsenbeck, S.2
Wenzel, P.3
Brand, M.4
Huelsenbeck, J.5
Schad, A.6
Fritz, G.7
-
74
-
-
77958498222
-
The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer
-
Smith, J.; Tho, L.M.; Xu, N.; Gillespie, D.A. The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. Adv. Cancer Res.2010, 108, 73–112
-
(2010)
Adv. Cancer Res
, vol.108
, pp. 73-112
-
-
Smith, J.1
Tho, L.M.2
Xu, N.3
Gillespie, D.A.4
-
75
-
-
84875906348
-
Rac1 modulates acute and subacute genotoxin-induced hepatic stress responses, fibrosis and liver aging
-
Bopp, A.; Wartlick, F.; Henninger, C.; Kaina, B.; Fritz, G. Rac1 modulates acute and subacute genotoxin-induced hepatic stress responses, fibrosis and liver aging. Cell Death Dis.2013, doi:10.1038/cddis.2013.57
-
(2013)
Cell Death Dis
-
-
Bopp, A.1
Wartlick, F.2
Henninger, C.3
Kaina, B.4
Fritz, G.5
-
76
-
-
84924430060
-
Rac1 promotes diethylnitrosamine (Den)-induced formation of liver tumors
-
Bopp, A.; Wartlick, F.; Henninger, C.; Schwarz, M.; Kaina, B.; Fritz, G. Rac1 promotes diethylnitrosamine (den)-induced formation of liver tumors. Carcinogenesis 2015, 36, 378–389
-
(2015)
Carcinogenesis
, vol.36
, pp. 378-389
-
-
Bopp, A.1
Wartlick, F.2
Henninger, C.3
Schwarz, M.4
Kaina, B.5
Fritz, G.6
-
77
-
-
14644424522
-
HMG-coA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage
-
Paajarvi, G.; Roudier, E.; Crisby, M.; Hogberg, J.; Stenius, U. HMG-coA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage. FASEB J. 2005, 19, 476–478
-
(2005)
FASEB J
, vol.19
, pp. 476-478
-
-
Paajarvi, G.1
Roudier, E.2
Crisby, M.3
Hogberg, J.4
Stenius, U.5
-
78
-
-
54449083115
-
Statins use a novel nijmegen breakage syndrome-1-dependent pathway to accelerate DNA repair in vascular smooth muscle cells
-
Mahmoudi, M.; Gorenne, I.; Mercer, J.; Figg, N.; Littlewood, T.; Bennett, M. Statins use a novel nijmegen breakage syndrome-1-dependent pathway to accelerate DNA repair in vascular smooth muscle cells. Circ. Res. 2008, 103, 717–725
-
(2008)
Circ. Res
, vol.103
, pp. 717-725
-
-
Mahmoudi, M.1
Gorenne, I.2
Mercer, J.3
Figg, N.4
Littlewood, T.5
Bennett, M.6
-
79
-
-
0030925565
-
Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation
-
Baskaran, R.; Wood, L.D.; Whitaker, L.L.; Canman, C.E.; Morgan, S.E.; Xu, Y.; Barlow, C.; Baltimore, D.; Wynshaw-Boris, A.; Kastan, M.B., et al. Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Nature 1997, 387, 516–519
-
(1997)
Nature
, vol.387
, pp. 516-519
-
-
Baskaran, R.1
Wood, L.D.2
Whitaker, L.L.3
Canman, C.E.4
Morgan, S.E.5
Xu, Y.6
Barlow, C.7
Baltimore, D.8
Wynshaw-Boris, A.9
Kastan, M.B.10
-
80
-
-
0033600234
-
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
-
Gong, J.G.; Costanzo, A.; Yang, H.Q.; Melino, G.; Kaelin, W.G., Jr.; Levrero, M.; Wang, J.Y. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 1999, 399, 806–809
-
(1999)
Nature
, vol.399
, pp. 806-809
-
-
Gong, J.G.1
Costanzo, A.2
Yang, H.Q.3
Melino, G.4
Kaelin, W.G.5
Levrero, M.6
Wang, J.Y.7
-
81
-
-
0031020908
-
Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase
-
Yuan, Z.M.; Huang, Y.; Ishiko, T.; Kharbanda, S.; Weichselbaum, R.; Kufe, D. Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase. Proc. Natl. Acad. Sci. USA 1997, 94, 1437–1440
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 1437-1440
-
-
Yuan, Z.M.1
Huang, Y.2
Ishiko, T.3
Kharbanda, S.4
Weichselbaum, R.5
Kufe, D.6
-
82
-
-
0037427194
-
Ionizing radiation-induced Rad51 nuclear focus formation is cell cycle-regulated and defective in both ATM−/− and c-Abl−/− cells
-
Yuan, S.S.; Chang, H.L.; Lee, E.Y. Ionizing radiation-induced Rad51 nuclear focus formation is cell cycle-regulated and defective in both ATM−/− and c-Abl−/− cells. Mutat. Res. 2003, 525, 85–92
-
(2003)
Mutat. Res
, vol.525
, pp. 85-92
-
-
Yuan, S.S.1
Chang, H.L.2
Lee, E.Y.3
-
83
-
-
0033617368
-
Arlinghaus, R.; et al. Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl
-
Chen, G.; Yuan Shyng Shiou, F.; Liu, W.; Xu, Y.; Trujillo, K.; Song, B.; Cong, F.; Goff Stephen, P.; Wu, Y.; Arlinghaus, R.; et al. Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl. J. Biol. Chem. 1999, 274, 12748–12752
-
(1999)
J. Biol. Chem
, vol.274
, pp. 12748-12752
-
-
Chen, G.1
Yuan Shyng Shiou, F.2
Liu, W.3
Xu, Y.4
Trujillo, K.5
Song, B.6
Cong, F.7
Goff Stephen, P.8
Wu, Y.9
-
84
-
-
0032443366
-
Determination of cell fate by c-Abl activation in the response to DNA damage
-
Kharbanda, S.; Yuan Zhi, M.; Weichselbaum, R.; Kufe, D. Determination of cell fate by c-Abl activation in the response to DNA damage. Oncogene 1998, 17, 3309–3318
-
(1998)
Oncogene
, vol.17
, pp. 3309-3318
-
-
Kharbanda, S.1
Yuan Zhi, M.2
Weichselbaum, R.3
Kufe, D.4
-
85
-
-
78650087114
-
He, G.; et al. A positive role for c-Abl in ATM and ATR activation in DNA damage response
-
Wang, X.; Zeng, L.; Wang, J.; Chau, J.F.; Lai, K.P.; Jia, D.; Poonepalli, A.; Hande, M.P.; Liu, H.; He, G.; et al. A positive role for c-Abl in ATM and ATR activation in DNA damage response. Cell Death Differ. 2011, 18, 5–15
-
(2011)
Cell Death Differ
, vol.18
, pp. 5-15
-
-
Wang, X.1
Zeng, L.2
Wang, J.3
Chau, J.F.4
Lai, K.P.5
Jia, D.6
Poonepalli, A.7
Hande, M.P.8
Liu, H.9
-
86
-
-
14744301343
-
JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage
-
Yoshida, K.; Yamaguchi, T.; Natsume, T.; Kufe, D.; Miki, Y. JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. Nat. Cell Biol.2005, 7, 278–285
-
(2005)
Nat. Cell Biol
, vol.7
, pp. 278-285
-
-
Yoshida, K.1
Yamaguchi, T.2
Natsume, T.3
Kufe, D.4
Miki, Y.5
-
87
-
-
36749011318
-
Abl tyrosine kinases regulate cell-cell adhesion through Rho GTPases
-
Zandy, N.L.; Playford, M.; Pendergast, A.M. Abl tyrosine kinases regulate cell-cell adhesion through Rho GTPases. Proc. Natl. Acad. Sci. USA 2007, 104, 17686–17691
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 17686-17691
-
-
Zandy, N.L.1
Playford, M.2
Pendergast, A.M.3
-
88
-
-
0037023762
-
Association of Bcr-Abl with the proto-oncogene vav is implicated in activation of the Rac-1 pathway
-
Bassermann, F.; Jahn, T.; Miething, C.; Seipel, P.; Bai, R.Y.; Coutinho, S.; Tybulewicz, V.L.; Peschel, C.; Duyster, J. Association of Bcr-Abl with the proto-oncogene vav is implicated in activation of the Rac-1 pathway. J. Biol. Chem.2002, 277, 12437–12445
-
(2002)
J. Biol. Chem
, vol.277
, pp. 12437-12445
-
-
Bassermann, F.1
Jahn, T.2
Miething, C.3
Seipel, P.4
Bai, R.Y.5
Coutinho, S.6
Tybulewicz, V.L.7
Peschel, C.8
Duyster, J.9
-
89
-
-
73549115097
-
The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin α2
-
Sandrock, K.; Bielek, H.; Schradi, K.; Schmidt, G.; Klugbauer, N. The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin α2. Traffic 2010, 11, 198–209
-
(2010)
Traffic
, vol.11
, pp. 198-209
-
-
Sandrock, K.1
Bielek, H.2
Schradi, K.3
Schmidt, G.4
Klugbauer, N.5
-
90
-
-
43149116339
-
Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division
-
Michaelson, D.; Abidi, W.; Guardavaccaro, D.; Zhou, M.; Ahearn, I.; Pagano, M.; Philips, M.R. Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division. J. Cell Biol. 2008, 181, 485–496
-
(2008)
J. Cell Biol
, vol.181
, pp. 485-496
-
-
Michaelson, D.1
Abidi, W.2
Guardavaccaro, D.3
Zhou, M.4
Ahearn, I.5
Pagano, M.6
Philips, M.R.7
-
91
-
-
84859513105
-
Rac1 GTPase plays an important role in γ-irradiation induced G2/M checkpoint activation
-
Yan, Y.; Greer, P.M.; Cao, P.T.; Kolb, R.H.; Cowan, K.H. Rac1 GTPase plays an important role in γ-irradiation induced G2/M checkpoint activation. Breast Cancer Res. 2012, doi:10.1186/bcr3164
-
(2012)
Breast Cancer Res
-
-
Yan, Y.1
Greer, P.M.2
Cao, P.T.3
Kolb, R.H.4
Cowan, K.H.5
-
92
-
-
77954766868
-
Actin-related proteins in the nucleus: Life beyond chromatin remodelers
-
Dion, V.; Shimada, K.; Gasser, S.M. Actin-related proteins in the nucleus: Life beyond chromatin remodelers. Curr. Opin. Cell Biol. 2010, 22, 383–391
-
(2010)
Curr. Opin. Cell Biol
, vol.22
, pp. 383-391
-
-
Dion, V.1
Shimada, K.2
Gasser, S.M.3
-
93
-
-
84922860464
-
Fluctuation-based imaging of nuclear Rac1 activation by protein oligomerisation
-
Hinde, E.; Yokomori, K.; Gaus, K.; Hahn, K.M.; Gratton, E. Fluctuation-based imaging of nuclear Rac1 activation by protein oligomerisation. Sci. Rep. 2014, doi:10.1038/srep04219
-
(2014)
Sci. Rep
-
-
Hinde, E.1
Yokomori, K.2
Gaus, K.3
Hahn, K.M.4
Gratton, E.5
-
94
-
-
84878009944
-
8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1
-
Hajas, G.; Bacsi, A.; Aguilera-Aguirre, L.; Hegde, M.L.; Tapas, K.H.; Sur, S.; Radak, Z.; Ba, X.; Boldogh, I. 8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1. Free Radic. Biol. Med. 2013, 61, 384–394
-
(2013)
Free Radic. Biol. Med
, vol.61
, pp. 384-394
-
-
Hajas, G.1
Bacsi, A.2
Aguilera-Aguirre, L.3
Hegde, M.L.4
Tapas, K.H.5
Sur, S.6
Radak, Z.7
Ba, X.8
Boldogh, I.9
-
95
-
-
84881519374
-
Identification of novel gene targets and functions of p21-activated kinase 1 during DNA damage by gene expression profiling
-
Motwani, M.; Li, D.Q.; Horvath, A.; Kumar, R. Identification of novel gene targets and functions of p21-activated kinase 1 during DNA damage by gene expression profiling. PLoS ONE 2013, doi:10.1371/journal.pone.0066585
-
(2013)
Plos ONE
-
-
Motwani, M.1
Li, D.Q.2
Horvath, A.3
Kumar, R.4
-
96
-
-
0034812916
-
Involvement of α-PAK-interacting exchange factor in the PAK1-c-jun NH2-terminal kinase 1 activation and apoptosis induced by benzo[a]pyrene
-
Yoshii, S.; Tanaka, M.; Otsuki, Y.; Fujiyama, T.; Kataoka, H.; Arai, H.; Hanai, H.; Sugimura, H. Involvement of α-PAK-interacting exchange factor in the PAK1-c-jun NH2-terminal kinase 1 activation and apoptosis induced by benzo[a]pyrene. Mol. Cell Biol 2001, 21, 6796–6807
-
(2001)
Mol. Cell Biol
, vol.21
, pp. 6796-6807
-
-
Yoshii, S.1
Tanaka, M.2
Otsuki, Y.3
Fujiyama, T.4
Kataoka, H.5
Arai, H.6
Hanai, H.7
Sugimura, H.8
-
97
-
-
48249149894
-
A bacterial cytotoxin identifies the RhoA exchange factor net1 as a key effector in the response to DNA damage
-
Guerra, L.; Carr, H.S.; Richter-Dahlfors, A.; Masucci, M.G.; Thelestam, M.; Frost, J.A.; Frisan, T. A bacterial cytotoxin identifies the RhoA exchange factor net1 as a key effector in the response to DNA damage. PLoS ONE 2008, doi:10.1371/journal.pone.0002254
-
(2008)
Plos ONE
-
-
Guerra, L.1
Carr, H.S.2
Richter-Dahlfors, A.3
Masucci, M.G.4
Thelestam, M.5
Frost, J.A.6
Frisan, T.7
-
98
-
-
79961160914
-
Sjogren, C.; et al. Bacterial genotoxin triggers fen1-dependent RhoA activation, cytoskeleton remodeling and cell survival
-
Guerra, L.; Guidi, R.; Slot, I.; Callegari, S.; Sompallae, R.; Pickett, C.L.; Astrom, S.; Eisele, F.; Wolf, D.; Sjogren, C.; et al. Bacterial genotoxin triggers fen1-dependent RhoA activation, cytoskeleton remodeling and cell survival. J. Cell Sci.2011, 124, 2735–2742
-
(2011)
J. Cell Sci
, vol.124
, pp. 2735-2742
-
-
Guerra, L.1
Guidi, R.2
Slot, I.3
Callegari, S.4
Sompallae, R.5
Pickett, C.L.6
Astrom, S.7
Eisele, F.8
Wolf, D.9
-
99
-
-
0033529620
-
Signaling from Rho to the actin cytoskeleton through protein kinases rock and lim-kinase
-
Maekawa, M.; Ishizaki, T.; Boku, S.; Watanabe, N.; Fujita, A.; Iwamatsu, A.; Obinata, T.; Ohashi, K.; Mizuno, K.; Narumiya, S. Signaling from Rho to the actin cytoskeleton through protein kinases rock and lim-kinase. Science 1999, 285, 895–898
-
(1999)
Science
, vol.285
, pp. 895-898
-
-
Maekawa, M.1
Ishizaki, T.2
Boku, S.3
Watanabe, N.4
Fujita, A.5
Iwamatsu, A.6
Obinata, T.7
Ohashi, K.8
Mizuno, K.9
Narumiya, S.10
-
100
-
-
84873030736
-
Rac1 controls the subcellular localization of the Rho guanine nucleotide exchange factor net1a to regulate focal adhesion formation and cell spreading
-
Carr, H.S.; Morris, C.A.; Menon, S.; Song, E.H.; Frost, J.A. Rac1 controls the subcellular localization of the Rho guanine nucleotide exchange factor net1a to regulate focal adhesion formation and cell spreading. Mol. Cell Biol. 2013, 33, 622–634
-
(2013)
Mol. Cell Biol
, vol.33
, pp. 622-634
-
-
Carr, H.S.1
Morris, C.A.2
Menon, S.3
Song, E.H.4
Frost, J.A.5
-
101
-
-
84928776401
-
Nuclear f-actin formation and reorganization upon cell spreading
-
Plessner, M.; Melak, M.; Chinchilla, P.; Baarlink, C.; Grosse, R. Nuclear f-actin formation and reorganization upon cell spreading. J. Biol. Chem. 2015, 290, 11209–11216
-
(2015)
J. Biol. Chem
, vol.290
, pp. 11209-11216
-
-
Plessner, M.1
Melak, M.2
Chinchilla, P.3
Baarlink, C.4
Grosse, R.5
-
102
-
-
84922795011
-
Rac1 nucleocytoplasmic shuttling drives nuclear shape changes and tumor invasion
-
Navarro-Lerida, I.; Pellinen, T.; Sanchez, S.A.; Guadamillas, M.C.; Wang, Y.; Mirtti, T.; Calvo, E.; del Pozo, M.A. Rac1 nucleocytoplasmic shuttling drives nuclear shape changes and tumor invasion. Dev. Cell 2015, 32, 318–334
-
(2015)
Dev. Cell
, vol.32
, pp. 318-334
-
-
Navarro-Lerida, I.1
Pellinen, T.2
Sanchez, S.A.3
Guadamillas, M.C.4
Wang, Y.5
Mirtti, T.6
Calvo, E.7
Del Pozo, M.A.8
-
103
-
-
1242339596
-
Recovery from DNA damage-induced G2 arrest requires actin-binding protein filamin-A/actin-binding protein 280
-
Meng, X.; Yuan, Y.; Maestas, A.; Shen, Z. Recovery from DNA damage-induced G2 arrest requires actin-binding protein filamin-A/actin-binding protein 280. J. Biol. Chem. 2004, 279, 6098–6105
-
(2004)
J. Biol. Chem
, vol.279
, pp. 6098-6105
-
-
Meng, X.1
Yuan, Y.2
Maestas, A.3
Shen, Z.4
-
104
-
-
84863853737
-
A requirement for polymerized actin in DNA double-strand break repair
-
Andrin, C.; McDonald, D.; Attwood, K.M.; Rodrigue, A.; Ghosh, S.; Mirzayans, R.; Masson, J.Y.; Dellaire, G.; Hendzel, M.J. A requirement for polymerized actin in DNA double-strand break repair. Nucleus 2012, 3, 384–395
-
(2012)
Nucleus
, vol.3
, pp. 384-395
-
-
Andrin, C.1
McDonald, D.2
Attwood, K.M.3
Rodrigue, A.4
Ghosh, S.5
Mirzayans, R.6
Masson, J.Y.7
Dellaire, G.8
Hendzel, M.J.9
-
105
-
-
84905385420
-
ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress
-
Kumar, A.; Mazzanti, M.; Mistrik, M.; Kosar, M.; Beznoussenko, G.V.; Mironov, A.A.; Garre, M.; Parazzoli, D.; Shivashankar, G.V.; Scita, G., et al. ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress. Cell 2014, 158, 633–646
-
(2014)
Cell
, vol.158
, pp. 633-646
-
-
Kumar, A.1
Mazzanti, M.2
Mistrik, M.3
Kosar, M.4
Beznoussenko, G.V.5
Mironov, A.A.6
Garre, M.7
Parazzoli, D.8
Shivashankar, G.V.9
Scita, G.10
-
106
-
-
0030883583
-
Rac1 is required for cell proliferation and G2/M progression
-
Moore, K.A.; Sethi, R.; Doanes, A.M.; Johnson, T.M.; Pracyk, J.B.; Kirby, M.; Irani, K.; Goldschmidt-Clermont, P.J.; Finkel, T. Rac1 is required for cell proliferation and G2/M progression. Biochem. J. 1997, 326, 17–20
-
(1997)
Biochem. J
, vol.326
, pp. 17-20
-
-
Moore, K.A.1
Sethi, R.2
Doanes, A.M.3
Johnson, T.M.4
Pracyk, J.B.5
Kirby, M.6
Irani, K.7
Goldschmidt-Clermont, P.J.8
Finkel, T.9
-
107
-
-
84924276464
-
Controlling the switches: Rho GTPase regulation during animal cell mitosis
-
Zuo, Y.; Oh, W.; Frost, J.A. Controlling the switches: Rho GTPase regulation during animal cell mitosis. Cell Signal 2014, 26, 2998–3006
-
(2014)
Cell Signal
, vol.26
, pp. 2998-3006
-
-
Zuo, Y.1
Oh, W.2
Frost, J.A.3
-
108
-
-
84922227318
-
Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells
-
Chircop, M. Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells. Small GTPases 2014, doi:10.4161/sgtp.29770
-
(2014)
Small Gtpases
-
-
Chircop, M.1
-
109
-
-
0042672950
-
Activity of Rho-family GTPases during cell division as visualized with fret-based probes
-
Yoshizaki, H.; Ohba, Y.; Kurokawa, K.; Itoh, R.E.; Nakamura, T.; Mochizuki, N.; Nagashima, K.; Matsuda, M. Activity of Rho-family GTPases during cell division as visualized with fret-based probes. J. Cell Biol. 2003, 162, 223–232
-
(2003)
J. Cell Biol
, vol.162
, pp. 223-232
-
-
Yoshizaki, H.1
Ohba, Y.2
Kurokawa, K.3
Itoh, R.E.4
Nakamura, T.5
Mochizuki, N.6
Nagashima, K.7
Matsuda, M.8
-
110
-
-
42449140710
-
Statin-induced inhibition of 3-hydroxy-3-methyl glutaryl coenzyme a reductase sensitizes human osteosarcoma cells to anticancer drugs
-
Fromigue, O.; Hamidouche, Z.; Marie, P.J. Statin-induced inhibition of 3-hydroxy-3-methyl glutaryl coenzyme a reductase sensitizes human osteosarcoma cells to anticancer drugs. J. Pharmacol. Exp. Ther. 2008, 325, 595–600
-
(2008)
J. Pharmacol. Exp. Ther
, vol.325
, pp. 595-600
-
-
Fromigue, O.1
Hamidouche, Z.2
Marie, P.J.3
-
111
-
-
0034124301
-
Lovastatin potentiates antitumor activity and attenuates cardiotoxicity of doxorubicin in three tumor models in mice
-
Feleszko, W.; Mlynarczuk, I.; Balkowiec-Iskra, E.Z.; Czajka, A.; Switaj, T.; Stoklosa, T.; Giermasz, A.; Jakobisiak, M. Lovastatin potentiates antitumor activity and attenuates cardiotoxicity of doxorubicin in three tumor models in mice. Clin. Cancer Res. 2000, 6, 2044–2052
-
(2000)
Clin. Cancer Res
, vol.6
, pp. 2044-2052
-
-
Feleszko, W.1
Mlynarczuk, I.2
Balkowiec-Iskra, E.Z.3
Czajka, A.4
Switaj, T.5
Stoklosa, T.6
Giermasz, A.7
Jakobisiak, M.8
-
112
-
-
14544278377
-
Inhibition of Rho kinase modulates radiation induced fibrogenic phenotype in intestinal smooth muscle cells through alteration of the cytoskeleton and connective tissue growth factor expression
-
Bourgier, C.; Haydont, V.; Milliat, F.; Francois, A.; Holler, V.; Lasser, P.; Bourhis, J.; Mathe, D.; Vozenin-Brotons, M.C. Inhibition of Rho kinase modulates radiation induced fibrogenic phenotype in intestinal smooth muscle cells through alteration of the cytoskeleton and connective tissue growth factor expression. Gut 2005, 54, 336–343
-
(2005)
Gut
, vol.54
, pp. 336-343
-
-
Bourgier, C.1
Haydont, V.2
Milliat, F.3
Francois, A.4
Holler, V.5
Lasser, P.6
Bourhis, J.7
Mathe, D.8
Vozenin-Brotons, M.C.9
-
113
-
-
34948907775
-
Rho/rock pathway as a molecular target for modulation of intestinal radiation-induced toxicity
-
Haydont, V.; Bourgier, C.; Vozenin-Brotons, M.C. Rho/rock pathway as a molecular target for modulation of intestinal radiation-induced toxicity. Br. J. Radiol.2007, 80, 32–40
-
(2007)
Br. J. Radiol
, vol.80
, pp. 32-40
-
-
Haydont, V.1
Bourgier, C.2
Vozenin-Brotons, M.C.3
-
114
-
-
33846220751
-
Simvastatin attenuates cisplatin-induced kidney and liver damage in rats
-
Iseri, S.; Ercan, F.; Gedik, N.; Yuksel, M.; Alican, I. Simvastatin attenuates cisplatin-induced kidney and liver damage in rats. Toxicology 2007, 230, 256–264
-
(2007)
Toxicology
, vol.230
, pp. 256-264
-
-
Iseri, S.1
Ercan, F.2
Gedik, N.3
Yuksel, M.4
Alican, I.5
-
115
-
-
79951677271
-
Amelioration of cisplatin-induced nephrotoxicity by pravastatin in mice
-
An, Y.; Xin, H.; Yan, W.; Zhou, X. Amelioration of cisplatin-induced nephrotoxicity by pravastatin in mice. Exp. Toxicol. Pathol. 2011, 63, 215–219
-
(2011)
Exp. Toxicol. Pathol
, vol.63
, pp. 215-219
-
-
An, Y.1
Xin, H.2
Yan, W.3
Zhou, X.4
-
116
-
-
84893113213
-
Association between statin use and colorectal cancer risk: A meta-analysis of 42 studies
-
Liu, Y.; Tang, W.; Wang, J.; Xie, L.; Li, T.; He, Y.; Deng, Y.; Peng, Q.; Li, S.; Qin, X. Association between statin use and colorectal cancer risk: A meta-analysis of 42 studies. Cancer Causes Control 2014, 25, 237–249
-
(2014)
Cancer Causes Control
, vol.25
, pp. 237-249
-
-
Liu, Y.1
Tang, W.2
Wang, J.3
Xie, L.4
Li, T.5
He, Y.6
Deng, Y.7
Peng, Q.8
Li, S.9
Qin, X.10
-
117
-
-
0027978838
-
Prevention of 1,2-dimethylhydrazine-induced colon tumorigenesis by HMG-coA reductase inhibitors, pravastatin and simvastatin, in icr mice
-
Narisawa, T.; Fukaura, Y.; Terada, K.; Umezawa, A.; Tanida, N.; Yazawa, K.; Ishikawa, C. Prevention of 1,2-dimethylhydrazine-induced colon tumorigenesis by HMG-coA reductase inhibitors, pravastatin and simvastatin, in icr mice. Carcinogenesis 1994, 15, 2045–2048
-
(1994)
Carcinogenesis
, vol.15
, pp. 2045-2048
-
-
Narisawa, T.1
Fukaura, Y.2
Terada, K.3
Umezawa, A.4
Tanida, N.5
Yazawa, K.6
Ishikawa, C.7
-
118
-
-
0242464926
-
Cd28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes
-
Tiede, I.; Fritz, G.; Strand, S.; Poppe, D.; Dvorsky, R.; Strand, D.; Lehr, H.A.; Wirtz, S.; Becker, C.; Atreya, R., et al. Cd28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes. J. Clin. Invest.2003, 111, 1133–1145
-
(2003)
J. Clin. Invest
, vol.111
, pp. 1133-1145
-
-
Tiede, I.1
Fritz, G.2
Strand, S.3
Poppe, D.4
Dvorsky, R.5
Strand, D.6
Lehr, H.A.7
Wirtz, S.8
Becker, C.9
Atreya, R.10
-
119
-
-
79953243528
-
The biology of the cytolethal distending toxins
-
Guerra, L.; Cortes-Bratti, X.; Guidi, R.; Frisan, T. The biology of the cytolethal distending toxins. Toxins 2011, 3, 172–190
-
(2011)
Toxins
, vol.3
, pp. 172-190
-
-
Guerra, L.1
Cortes-Bratti, X.2
Guidi, R.3
Frisan, T.4
-
120
-
-
13644262252
-
Cytolethal distending toxin: A bacterial bullet targeted to nucleus
-
Ohara, M.; Oswald, E.; Sugai, M. Cytolethal distending toxin: A bacterial bullet targeted to nucleus. J. Biochem. 2004, 136, 409–413
-
(2004)
J. Biochem
, vol.136
, pp. 409-413
-
-
Ohara, M.1
Oswald, E.2
Sugai, M.3
-
121
-
-
84922022031
-
The cytolethal distending toxin effects on mammalian cells: A DNA damage perspective
-
Bezine, E.; Vignard, J.; Mirey, G. The cytolethal distending toxin effects on mammalian cells: A DNA damage perspective. Cells 2014, 3, 592–615
-
(2014)
Cells
, vol.3
, pp. 592-615
-
-
Bezine, E.1
Vignard, J.2
Mirey, G.3
-
122
-
-
84900342577
-
Cytolethal distending toxin (CDT) is a radiomimetic agent and induces persistent levels of DNA double-strand breaks in human fibroblasts
-
Fahrer, J.; Huelsenbeck, J.; Jaurich, H.; Dorsam, B.; Frisan, T.; Eich, M.; Roos, W.P.; Kaina, B.; Fritz, G. Cytolethal distending toxin (CDT) is a radiomimetic agent and induces persistent levels of DNA double-strand breaks in human fibroblasts. DNA Repair 2014, 18, 31–43
-
(2014)
DNA Repair
, vol.18
, pp. 31-43
-
-
Fahrer, J.1
Huelsenbeck, J.2
Jaurich, H.3
Dorsam, B.4
Frisan, T.5
Eich, M.6
Roos, W.P.7
Kaina, B.8
Fritz, G.9
-
123
-
-
0036498707
-
Cytolethal distending toxin: Limited damage as a strategy to modulate cellular functions
-
Lara-Tejero, M.; Galan, J.E. Cytolethal distending toxin: Limited damage as a strategy to modulate cellular functions. Trends Microbiol. 2002, 10, 147–152
-
(2002)
Trends Microbiol
, vol.10
, pp. 147-152
-
-
Lara-Tejero, M.1
Galan, J.E.2
-
124
-
-
0032585635
-
Rac1 is required for the formation of three germ layers during gastrulation
-
Sugihara, K.; Nakatsuji, N.; Nakamura, K.; Nakao, K.; Hashimoto, R.; Otani, H.; Sakagami, H.; Kondo, H.; Nozawa, S.; Aiba, A., et al. Rac1 is required for the formation of three germ layers during gastrulation. Oncogene 1998, 17, 3427–3433.
-
(1998)
Oncogene
, vol.17
, pp. 3427-3433
-
-
Sugihara, K.1
Nakatsuji, N.2
Nakamura, K.3
Nakao, K.4
Hashimoto, R.5
Otani, H.6
Sakagami, H.7
Kondo, H.8
Nozawa, S.9
Aiba, A.10
|