Ras and Rho GTPases: A family reunion

Cell

Volumn 103, Issue 2, 2000, Pages 227-238

  Bar Sagi, Dafna ^a   Hall, Alan ^b  

^a STONY BROOK UNIVERSITY   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; RAS PROTEIN; RHO FACTOR;

CATALYSIS; CELL ACTIVITY; CELL INTERACTION; CELL PROLIFERATION; CONFORMATION; ENZYME ACTIVITY; EUKARYOTIC CELL; MOLECULAR BIOLOGY; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

EUKARYOTA;

EID: 0034644537     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)00115-X     Document Type: Review

References (120)

1. The small GTP-binding protein, p21rac1, is involved in the activation of the phagocyte NADPH oxidase
2. Activation of SRF-regulated chromosomal templates by Rho-family GTPases requires a signal that also induces H4 hyperacetylation
3. A role for Cdc42 in macrophage chemotaxis
4. Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase
5. Activate NF-kappa B or die?
6. Motility and invasion are differentially modulated by Rho family Rho GTPases
7. Rho GTPases and their effector proteins
8. Inhibition of Rap1A binding to cytochrome b558 of NADPH oxidase by phosphorylation of Rap1A
9. Increasing complexity of Ras signaling
10. Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases
11. The small GTPase Rap1 controls functional activation of the macrophage integrin αMβ2 by LPS and other inflammatory mediators
12. Cooperative interaction of S. pombe proteins required for mating and morphogenesis
13. Phosphatidylinositol 3-kinase regulates raf1 through pak phosphorylation of serine 338
14. Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)
15. Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells
16. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions
17. Integrin-mediated signals regulated by members of the rho family of GTPases
18. Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes
19. Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits
20. Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK
21. PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation
22. Regulation of phospholipsae D
23. The excahnge factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen activated protein kinase pathways
24. Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation
25. The regulation of endothelial cell motility by p21 Ras
26. Ral and Rho-dependent activation of phospholipase D in v-Raf transformed cells
27. Rac 'insert region' is a novel effector region that is implicated in the activation of NADPH oxidase, but not PAK65
28. Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members
29. Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins
30. Function of wild-type or mutant Rac2 and Rap1a GTPases in differentiated HL60 cell NADPH oxidase activation
31. Integrin signaling
32. Multiple ras effector pathways contribute to G(1) cell cycle progression
33. DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila
34. Role of substrates and products of Pl 3-kinase inregulating activation of Rac-related guanosine triphosphatases by Vav
35. Direct stimulation of the guanine nucleotide exchange activity of p115RhoGEF by Ga13
36. GTPases in antigen receptor signalling
37. The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF
38. Defects in actin-cap formation in vav-deficient mice implicate an actin requirement for lymphocyte signal transduction
39. Integrin signaling and cell growth control
40. RhoA stimulates p27(Kip) degradation through its regulation of cyclin E/CDK2 activity
41. Suppression of integrin activation: A novel function of a Ras/Raf-initiated MAP kinase pathway
42. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts
43. p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions
44. An essential part for Rho-kinase in the transcellular invasion of tumour cells
45. Possible involvement of the inactivation of the Rho-Rho kinase pathway in oncogenicRas-induced transformation
46. Involvement of Ral GTPase in v-Src induced phospholipase D activation
47. Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS
48. A Rac1 effector site controlling mitogenesis through superoxide production
49. 'Peptide walking' is a novel method for mapping functional domains in proteins. Its application to the Rac1-dependent activation of NADPH oxidase
50. Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway
51. Cdc42 and Rac induce integrin-mediated cell motility and invasiveness through Pl (3)K
52. Cell cycle targets of Ras/Raf signalling
53. Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation
54. The protein kinase pak3 positively regulates Raf-1 activity through phosphorylation of serine 338
55. Activation of Rac1 by a Crk SH3 bidning protein, DOCK180
56. CAS/Crk coupling serves as a molecular switch for induction of cell migration
57. The activation of phosphatidylinositol 3-kinase by Ras
58. Role of p120RasGAP in directed cell movement
59. RasGAP controls Rho-mediated cytoskeletal reorganization through its SH3 domain
60. Potentiation of cell migration by adhesion-dependent cooperative signals from the GTPase Rac and Raf kinase
61. The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in reorganization of the cytoskeleton
62. Integrin-mediated activation of MAP kinase is independent of FAK: Evidence for dual integrin signaling pathways in fibroblasts
63. Cell anchorage permits efficient signal transduction between ras and its downstream kinases
64. RalA interacts directly with the Arf-responsive PIP2-dependent phospholipase D1
65. Role of c-Src tyrosine kinase in G protein coupled receptor and G beta gamma-mediated activation of mitogen activated protein kinases
66. The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion
67. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain
68. Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras
69. Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein
70. Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1
71. Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPases
72. Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells
73. Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos
74. Rho, Rac and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia and filopodia
75. Rho GTPases control polarity, protrusion and adhesion during cell movement
76. Activation of small GTP-binding proteins rho and rac by grooth factor receptors
77. Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element
78. Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1
79. Characterization of a Racl signaling pathway to cyclin D (1) expression in airway smooth muscle cells
80. Two active states of the Ras-related Bud1/Rsr1 protein bind to different effectors to determine yeast cell polarity
81. Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein
82. The actin cytoskeleton and lymphocyte activation
83. Activation of the nuclear factor-kB by Rho, CDC42, and Rac-1 proteins
84. Activation of Rac and Cdc42 by integrins mediates cell spreading
85. An essential role for Rac in Ras transformation
86. A role for Rho in Ras transformation
87. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
88. Growth factor activation of MAP kinase requires cell adhesion
89. Focal adhesion kinase mediates the integrin signaling requirement for grwoth factor activation of MAP kinase
90. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
91. Regulation of scatter factor/HGF response by Ras, Rac and Rho in MDCK cells
92. RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation
93. Transformation mediated by RhoA requires activity of ROCK kinases
94. ZAP-70 is essential for the T cell antigen receptor-induced plasma membrane targetting of Sos and Vav in T cells
95. Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase
96. Rac downregulates Rho activity: Reciprocal balance between both GTPases determines cellular morphology and migratory behavior
97. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
98. Bidirectional signaling between the cytoskeleton and integrins
99. Transformation by Rho exchange factor oncogenes is mediated by activation of an integrin-dependent pathway
100. EPS8 and E3B1 transduce signals from Ras to Rac
101. High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1
102. The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter
103. Cancer cell cycles
104. Signal-regulated activation of serum response factor is mediated by changes in actin dynamics
105. rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation
106. The Akt proto-oncogene links Ras to Pak and cell survival signals
107. Na-H exchange acts downstream of RhoA to regulate integrin-induced cell adhesion and spreading
108. Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling
109. EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor
110. Rac1 regulates NFAT nuclear translocation in response to Fcepsilon receptor stimulation in mast cells
111. Rho GTPases and signaling networks
112. The adaptor protein Shc couples a class of integrins to the control of cell cycle progression
113. Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27
114. Rac regulation of transformation, gene expression, and actin organization by multiple PAK-independent pathways
115. Ras caught in another affair: The exchange factors for Ral
116. Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1
117. Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85
118. Interactions among proteins involved in bud-site selection and bud-site assembly in S. cerevisiae
119. Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells
120. Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial mesenchymal transition