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Volumn 100, Issue 3, 2000, Pages 345-356

Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; RHO FACTOR;

EID: 0034603198     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80670-4     Document Type: Article
Times cited : (428)

References (40)
  • 1
    • 0033609388 scopus 로고    scopus 로고
    • Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein
    • Abdul-Manan, N., Aghazadeh, B., Liu, G.A., Majumadar, A., Ouerfelli, O., Siminovitch, K.A., and Rosen, M.K. (1999). Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein. Nature 399, 379-383.
    • (1999) Nature , vol.399 , pp. 379-383
    • Abdul-Manan, N.1    Aghazadeh, B.2    Liu, G.A.3    Majumadar, A.4    Ouerfelli, O.5    Siminovitch, K.A.6    Rosen, M.K.7
  • 2
    • 0026612457 scopus 로고
    • Intracellular localization of p21rho proteins
    • Adamson, P., Paterson, H.F., and Hall, A. (1992). Intracellular localization of p21rho proteins. J. Cell Biol. 119, 617-627.
    • (1992) J. Cell Biol. , vol.119 , pp. 617-627
    • Adamson, P.1    Paterson, H.F.2    Hall, A.3
  • 3
    • 0027412196 scopus 로고
    • ALSCRIPT: A tool to format multiple sequence alignments
    • Barton, G.J. (1993). ALSCRIPT: A tool to format multiple sequence alignments. Protein Eng. 6, 37-40.
    • (1993) Protein Eng. , vol.6 , pp. 37-40
    • Barton, G.J.1
  • 4
  • 6
    • 0029966304 scopus 로고    scopus 로고
    • Protein prenyltransferases
    • Casey, P.J., and Seabra, M.C. (1996). Protein prenyltransferases. J. Biol. Chem. 271, 5289-5292.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5289-5292
    • Casey, P.J.1    Seabra, M.C.2
  • 7
    • 0028103275 scopus 로고
    • The CCP4 suite: Programs for protein crystallography
    • CCP4 (Collaborative Computational Project, No. 4)
    • CCP4 (Collaborative Computational Project, No. 4). (1994). The CCP4 suite: Programs for protein crystallography. Acta Crystallogr. D 50, 760-763.
    • (1994) Acta Crystallogr. D , vol.50 , pp. 760-763
  • 9
    • 79952608525 scopus 로고
    • Accurate bond and angle parameters for X-ray protein-structure refinement
    • Engh, R.A., and Huber, R. (1991). Accurate bond and angle parameters for X-ray protein-structure refinement. Acta Crystallogr. A 47, 392-400.
    • (1991) Acta Crystallogr. A , vol.47 , pp. 392-400
    • Engh, R.A.1    Huber, R.2
  • 10
    • 0025073547 scopus 로고
    • Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins
    • Fukumoto, Y., Kaibuchi, K., Hori, Y., Fujioka, H., Araki, S., Ueda, T., Kikuchi, A., and Takai, Y. (1990). Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins. Oncogene 5, 1321-1328.
    • (1990) Oncogene , vol.5 , pp. 1321-1328
    • Fukumoto, Y.1    Kaibuchi, K.2    Hori, Y.3    Fujioka, H.4    Araki, S.5    Ueda, T.6    Kikuchi, A.7    Takai, Y.8
  • 11
    • 0031452275 scopus 로고    scopus 로고
    • GEFs, GAPs, GDIs and effectors: Taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins
    • Geyer, M., and Wittinghofer, A. (1997). GEFs, GAPs, GDIs and effectors: Taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins. Curr. Opin. Struct. Biol. 7, 786-792.
    • (1997) Curr. Opin. Struct. Biol. , vol.7 , pp. 786-792
    • Geyer, M.1    Wittinghofer, A.2
  • 12
    • 0029297389 scopus 로고
    • Visualization, virtual reality, and animation within the data flow model of computing
    • Gillilan, R.E., and Wood, F. (1995). Visualization, virtual reality, and animation within the data flow model of computing. Computer Graphics 29, 55.
    • (1995) Computer Graphics , vol.29 , pp. 55
    • Gillilan, R.E.1    Wood, F.2
  • 13
    • 0032538317 scopus 로고    scopus 로고
    • Structural basis for activation of Arf GTPases: Mechanism of guanine nucleotide exchange and GTP-myristoyl switching
    • Goldberg, J. (1998). Structural basis for activation of Arf GTPases: Mechanism of guanine nucleotide exchange and GTP-myristoyl switching. Cell 95, 237-248.
    • (1998) Cell , vol.95 , pp. 237-248
    • Goldberg, J.1
  • 14
    • 0030992879 scopus 로고    scopus 로고
    • C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases
    • Gosser, Y.Q., Nomanbhoy, T., Aghazadeh, B., Manor, D., Combs, C., Cerione, R., and Rosen, M. (1997). C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases. Nature 387, 814-819.
    • (1997) Nature , vol.387 , pp. 814-819
    • Gosser, Y.Q.1    Nomanbhoy, T.2    Aghazadeh, B.3    Manor, D.4    Combs, C.5    Cerione, R.6    Rosen, M.7
  • 15
    • 0032559362 scopus 로고    scopus 로고
    • Rho GTPases and the actin cytoskeleton
    • Hall, A. (1998). Rho GTPases and the actin cytoskeleton. Science 279, 509-514.
    • (1998) Science , vol.279 , pp. 509-514
    • Hall, A.1
  • 16
    • 0026496258 scopus 로고
    • A GDP dissociation inhibitor that serves as a GTPase inhibitor of the Ras-like protein CDC42Hs
    • Hart, M.J., Maru, Y., Leonard, D., Witte, O.N., Evans, T., and Cerione, R.A. (1992). A GDP dissociation inhibitor that serves as a GTPase inhibitor of the Ras-like protein CDC42Hs. Science 258, 812-815.
    • (1992) Science , vol.258 , pp. 812-815
    • Hart, M.J.1    Maru, Y.2    Leonard, D.3    Witte, O.N.4    Evans, T.5    Cerione, R.A.6
  • 17
    • 0031034136 scopus 로고    scopus 로고
    • The crystal structure of human Rac1, a member of the Rho-family, complexed with a GTP analogue
    • Hirshberg, M., Stockley, R.W., Dodson, G., and Webb, M.R. (1997). The crystal structure of human Rac1, a member of the Rho-family, complexed with a GTP analogue. Nat. Struct. Biol. 4, 147-151.
    • (1997) Nat. Struct. Biol. , vol.4 , pp. 147-151
    • Hirshberg, M.1    Stockley, R.W.2    Dodson, G.3    Webb, M.R.4
  • 18
    • 0025906597 scopus 로고
    • Post translational modification of the C-terminal region of the rho protein are important for its interaction with the membranes and inhibitory GDP/GTP exchange proteins
    • Hori, Y., Kikuchi, A., Isomura, M., Katayama, M., Miura, Y., Fujioka, H., Kaibuchi, K., and Takai, Y. (1991). Post translational modification of the C-terminal region of the rho protein are important for its interaction with the membranes and inhibitory GDP/GTP exchange proteins. Oncogene 6, 515-522.
    • (1991) Oncogene , vol.6 , pp. 515-522
    • Hori, Y.1    Kikuchi, A.2    Isomura, M.3    Katayama, M.4    Miura, Y.5    Fujioka, H.6    Kaibuchi, K.7    Takai, Y.8
  • 20
    • 0033007293 scopus 로고    scopus 로고
    • Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity
    • Johnson, D.I. (1999). Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity. Microbiol. Mol. Biol. Rev. 63, 54-105.
    • (1999) Microbiol. Mol. Biol. Rev. , vol.63 , pp. 54-105
    • Johnson, D.I.1
  • 21
    • 84889120137 scopus 로고
    • Improved methods for building protein models in electron density maps and the location of errors in these models
    • Jones, T.A., Zou, J.Y., Cowan, S.W., and Kjeldgaard, M. (1991). Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110-119.
    • (1991) Acta Crystallogr. A , vol.47 , pp. 110-119
    • Jones, T.A.1    Zou, J.Y.2    Cowan, S.W.3    Kjeldgaard, M.4
  • 22
    • 0031570337 scopus 로고    scopus 로고
    • A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm
    • Keep, N.H., Barnes, M., Barsukov, I., Badii, R., Lian, L.Y., Segal, A. W., Moody, P.C., and Roberts, G.C. (1997). A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm. Structure 5, 623-633.
    • (1997) Structure , vol.5 , pp. 623-633
    • Keep, N.H.1    Barnes, M.2    Barsukov, I.3    Badii, R.4    Lian, L.Y.5    Segal, A.W.6    Moody, P.C.7    Roberts, G.C.8
  • 23
    • 0026244229 scopus 로고
    • MolScript: A program to produce both detailed and schematic plots of protein structures
    • Kraulis, P.J. (1991). MolScript: A program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallogr. 24, 946-950.
    • (1991) J. Appl. Crystallogr. , vol.24 , pp. 946-950
    • Kraulis, P.J.1
  • 24
    • 0026475383 scopus 로고
    • The identification and characterization of a GDP-dissociation inhibitor (GDI) for the Cdc42Hs protein
    • Leonard, D., Hart, M.J., Platko, J.V., Eva, A., Henzel, W., Evans, T., and Cerione, R.A. (1992). The identification and characterization of a GDP-dissociation inhibitor (GDI) for the Cdc42Hs protein. J. Biol. Chem. 267, 22860-22868.
    • (1992) J. Biol. Chem. , vol.267 , pp. 22860-22868
    • Leonard, D.1    Hart, M.J.2    Platko, J.V.3    Eva, A.4    Henzel, W.5    Evans, T.A.6    Cerione, R.A.7
  • 25
    • 0031040253 scopus 로고    scopus 로고
    • Residues of the Rho family GTPases that specify sensitivity to Dbl-like guanine nucleotide exchange factors
    • Li, R., and Zheng, Y. (1997). Residues of the Rho family GTPases that specify sensitivity to Dbl-like guanine nucleotide exchange factors. J. Biol. Chem. 272, 4671-4679.
    • (1997) J. Biol. Chem. , vol.272 , pp. 4671-4679
    • Li, R.1    Zheng, Y.2
  • 27
    • 0028057108 scopus 로고
    • Raster3D version 2.0, a program for photorealistic molecular graphics
    • Merritt, E.A., and Murphy, M.E.P. (1994). Raster3D version 2.0, a program for photorealistic molecular graphics. Acta Crystallogr. D 50, 869-873.
    • (1994) Acta Crystallogr. D , vol.50 , pp. 869-873
    • Merritt, E.A.1    Murphy, M.E.P.2
  • 28
    • 0033609335 scopus 로고    scopus 로고
    • Structure of the small G protein Cdc42 bound to the GTPase binding domain of ACK
    • Mott, H.R., Owen, D., Nietlispach, D., Lowe, P.N., Manser, E., Lim, L., and Laue, E.D. (1999). Structure of the small G protein Cdc42 bound to the GTPase binding domain of ACK. Nature 399, 384-388.
    • (1999) Nature , vol.399 , pp. 384-388
    • Mott, H.R.1    Owen, D.2    Nietlispach, D.3    Lowe, P.N.4    Manser, E.5    Lim, L.6    Laue, E.D.7
  • 29
    • 0031762533 scopus 로고    scopus 로고
    • Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP
    • Nassar, N., Hoffman, G.R., Manor, D., Clardy, J.C., and Cerione, R.A. (1998). Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP. Nature Struct. Biol. 5, 1047-1052.
    • (1998) Nature Struct. Biol. , vol.5 , pp. 1047-1052
    • Nassar, N.1    Hoffman, G.R.2    Manor, D.3    Clardy, J.C.4    Cerione, R.A.5
  • 30
    • 0031053055 scopus 로고    scopus 로고
    • AMoRe: An automated molecular replacement program package
    • Navaza, J., and Saludjian, P. (1997). AMoRe: An automated molecular replacement program package. Methods Enzymol. 276, 581-594.
    • (1997) Methods Enzymol. , vol.276 , pp. 581-594
    • Navaza, J.1    Saludjian, P.2
  • 31
    • 0030001665 scopus 로고    scopus 로고
    • Characterization of the interaction between RhoGDI and Cdc42Hs using fluorescence spectroscopy
    • Nomanbhoy, T.K., and Cerione, R.A. (1996). Characterization of the interaction between RhoGDI and Cdc42Hs using fluorescence spectroscopy. J. Biol. Chem. 271, 10004-10009.
    • (1996) J. Biol. Chem. , vol.271 , pp. 10004-10009
    • Nomanbhoy, T.K.1    Cerione, R.A.2
  • 32
    • 0033049740 scopus 로고    scopus 로고
    • Kinetic analysis of the interaction between RhoGDI and membrane-associated Cdc42
    • Nomanbhoy, T.K., Erickson, J.W., and Cerione, R.A. (1999). Kinetic analysis of the interaction between RhoGDI and membrane-associated Cdc42. Biochemistry 38, 1744-1750.
    • (1999) Biochemistry , vol.38 , pp. 1744-1750
    • Nomanbhoy, T.K.1    Erickson, J.W.2    Cerione, R.A.3
  • 33
    • 0028956369 scopus 로고
    • A single residue can modify target-binding affinity and activity of the functional domain of the Rho-subfamily GDP dissociation inhibitors
    • Platko, J.V., Leonard, D.A., Adra, C.N., Shaw, R.J., Cerione, R.A., and Lim, B. (1995). A single residue can modify target-binding affinity and activity of the functional domain of the Rho-subfamily GDP dissociation inhibitors. Proc. Natl. Acad. Sci. USA 92, 2974-2978.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 2974-2978
    • Platko, J.V.1    Leonard, D.A.2    Adra, C.N.3    Shaw, R.J.4    Cerione, R.A.5    Lim, B.6
  • 34
    • 84944812409 scopus 로고
    • Improved Fourier coefficients for maps using phases from partial structures with errors
    • Read, R.J. (1986). Improved Fourier coefficients for maps using phases from partial structures with errors. Acta. Crystallogr. A 42, 140-149.
    • (1986) Acta. Crystallogr. A , vol.42 , pp. 140-149
    • Read, R.J.1
  • 35
    • 0026713293 scopus 로고
    • The small GTP-binding proteins in the cytosol of insulin-secreting cells are complexed to GDP dissociation inhibitor proteins
    • Regazzi, R., Kikuchi, A., Takai, Y., and Wollheim, C.B. (1992). The small GTP-binding proteins in the cytosol of insulin-secreting cells are complexed to GDP dissociation inhibitor proteins. J. Biol. Chem. 267, 17512-17519.
    • (1992) J. Biol. Chem. , vol.267 , pp. 17512-17519
    • Regazzi, R.1    Kikuchi, A.2    Takai, Y.3    Wollheim, C.B.4
  • 37
    • 0029968827 scopus 로고    scopus 로고
    • Rho family GTPases: The cytoskeleton and beyond
    • Symons, M. (1996). Rho family GTPases: The cytoskeleton and beyond. Trends Biochem. Sci. 21, 178-181.
    • (1996) Trends Biochem. Sci. , vol.21 , pp. 178-181
    • Symons, M.1
  • 38
    • 0028922586 scopus 로고
    • A program to generate schematic diagrams of protein-ligand interactions
    • Wallace, A.C., Laskowski, R.A., and Thornton, J.M. (1995). A program to generate schematic diagrams of protein-ligand interactions. Prot. Eng. 8, 127-134.
    • (1995) Prot. Eng. , vol.8 , pp. 127-134
    • Wallace, A.C.1    Laskowski, R.A.2    Thornton, J.M.3
  • 40
    • 0030711709 scopus 로고    scopus 로고
    • Interaction between Cdc42Hs and Rho-GDI is mediated through the Rho-insert region
    • Wu, W.J., Leonard, D.A., Cerione, R.A., and Manor, D. (1997). Interaction between Cdc42Hs and Rho-GDI is mediated through the Rho-insert region. J. Biol. Chem. 272, 26153-26158.
    • (1997) J. Biol. Chem. , vol.272 , pp. 26153-26158
    • Wu, W.J.1    Leonard, D.A.2    Cerione, R.A.3    Manor, D.4


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