Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons

Journal of Biological Chemistry

Volumn 287, Issue 46, 2012, Pages 38590-38599

  Huelsenbeck, Stefanie C ^b   Schorr, Anne ^a   Roos, Wynand P ^b   Huelsenbeck, Johannes ^b   Henninger, Christian ^a   Kaina, Bernd ^b   Fritz, Gerhard ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINES; ATAXIA-TELANGIECTASIA MUTATED; ATM AND RAD3-RELATED; COMPLEX FORMATIONS; DNA DAMAGE RESPONSE; DNA DAMAGES; DNA STRAND BREAK; DOSE-DEPENDENT; DOXORUBICIN; ETOPOSIDE; HIGH DOSE; IMMUNOHISTOCHEMICAL ANALYSIS; LOVASTATIN; LOW DOSE; PHARMACOLOGICAL INHIBITION; PROTEIN SIGNALING; SPECIFIC INHIBITORS; TOPO; TOPOISOMERASE I POISONS; TOPOISOMERASE II; TOPOTECAN; WESTERN BLOTTING;

INTERNET PROTOCOLS; PHOSPHORYLATION;

DNA;

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; ATM PROTEIN; ATR PROTEIN; CHECKPOINT KINASE 2; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; ETOPOSIDE; HISTONE H2AX; MEVINOLIN; P21 ACTIVATED KINASE 1; RAC1 PROTEIN; SERINE; TOPOTECAN;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CELL VIABILITY; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CLEAVAGE; DNA PROTEIN COMPLEX; DNA STRAND BREAKAGE; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EXPOSURE; ENZYME INHIBITION; HEART CELL CULTURE; HISTONE PHOSPHORYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL LINE; DNA DAMAGE; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; HISTONES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMUNOHISTOCHEMISTRY; NEOPLASMS; POISONS; RAC1 GTP-BINDING PROTEIN; RATS; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; TOPOISOMERASE II INHIBITORS;

ATAXIA TELANGIECTASIA; RATTUS;

EID: 84869074814     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.377903     Document Type: Article

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