Microbial toxins and the glycosylation of Rho family GTPases

Current Opinion in Structural Biology

Volumn 10, Issue 5, 2000, Pages 528-535

  Busch, Christian ^a   Aktories, Klaus ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; CLOSTRIDIUM TOXIN; CYTOTOXIN; GLYCOSYLTRANSFERASE; GUANOSINE TRIPHOSPHATASE; RHO FACTOR;

ENZYME ACTIVITY; ENZYME GLYCOSYLATION; ENZYME MODIFICATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; REVIEW; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; TOXIN STRUCTURE;

ANIMALIA; BACTERIA (MICROORGANISMS); CLOSTRIDIUM;

EID: 0033787469     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-440X(00)00126-3     Document Type: Review

References (72)

1. Neurotoxins affecting neuroexocytosis
2. Actin-ADP-ribosylating toxins: Cytotoxic mechanism of Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin
3. Rho proteins: Targets for bacterial toxins
4. Large clostridfal cytotoxins - A family of glycosyltransferases modifying small GTP-binding proteins
5. Clostridium difficile infection
6. Glucosylation of Rho proteins by Clostridium difficile toxin B
7. Inactivation of Ras by Clostridium sordellii lethal toxin-catalyzed glucosylation
8. Ras, Rap, and Rac small GTP-binding proteins are targets for Clostridium sordellii lethal toxin glucosylation
9. The enteretoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins
10. Clostridium novyi α-toxin-catalyzed incorporation of GIcNAc into Rho subfamily proteins
11. A novel cytotoxin from Clostridium difficile serogroup F is a functional hybrid between two other large clostridial cytotoxins
12. Genetic rearrangements in the pathogenicity locus of Clostridium difficile strain 8864: Implications for transcription, expression and enzymatic activity of toxins A and B
13. Clostridium difficile toxins A and B are cation-dependent UDP-glucose hydrolases with differing catalytic activities
14. Rho GTPases and signaling networks
15. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
16. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
17. The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts
18. Rho GTPases control polarity, protrusion, and adhesion during cell movement
19. Untying the gordian knot of cytokinesis: Role of small G proteins and their regulators
20. Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases
21. Inhibition of FcεRl-mediated activation of rat basophilic leukemia cells by Clostridium difficile toxin B (monoglucosyltransferase)
22. Activation of the NADPH oxidase involves the small GTP-binding protein p21 rac
23. The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF
24. 1
25. Rho GTPases and their effector proteins
26. Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells
27. Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue
28. Crystal structure of RhoA-GDP and its functional implications
29. Impact of amino acids 22-27 of Rho-subfamily GTPases on glucosylafion by the large clostridial cytotoxins TcsL-1522, TcdB-1470 and TcdB-8864
30. Functional consequences of monoglucosylation of H-Ras at effector domain amino acid threonine-35
31. Glucosylation and ADP-ribosylation of Rho proteins - Effects on nucleotide binding, GTPase activity, and effector-coupling
32. Monoglucosylation of RhoA at threonine-37 blocks cytosol-membrane cycling
33. Clostridium difficile toxin B induces reorganization of actin, vinculin, and talin in cultures cells
34. Inhibition of receptor signaling to phospholipase D by Clostridium difficile toxin B - Role of Rho proteins
35. Inhibition of calcium release-activated calcium current (ICRAC) by Rac/Cdc42-inactivating clostridial cytotoxins in RBL cells
36. A role for the small molecular weight GTPases, Rho and Cdc42, in muscarinic receptor signaling to focal adhesion kinase
37. Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas
38. 2+-dependent neurotransmitter exocytosis
39. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
40. The role of local actin instability in axon formation
41. Localization of the glucosyltransferase activity of Clostridium difficile toxin B to the N-terminal part of the holotoxin
42. Chimeric clostridial cytotoxins: Identification of the N-terminal region involved in protein substrate recognition
43. Evidence for a modular structure of the homologous repetitive C-terminal carbohydrate-binding sites of Clostridium difficile toxins and Streptcoccus mutans glucosyltransferases
44. The C-terminal ligand-binding domain of Clostridium difficile toxin A (TcdA) abrogates TcdA-specific binding to cells and prevents mouse lethality
45. Localization of two epitopes recognized by monoclonal antibody PCG-4 on Clostridium difficile toxin A
46. Toxin A of Clostridium difficile binds to the human carbohydrate antigens I, X, and Y
47. Rabbit sucrase-isomaltase contains a functional intestinal receptor for Clostridium difficile toxin A
48. Molecular mimicry in the recognition of glycosphingolipids by Galα3Galβ4GIcNAcβ-binding Clostridium difficile toxin A, human natural anti α-galactosyl IgG and the monoclonal antibody Gal-13: Characterization of a binding-active human glycosphingolipid, non-identical with the animal receptor
49. Cellular internalisation of Clostridium difficile toxin A
50. pH-induced conformational changes in Clostridium difficile toxin B
51. A common motif of eukaryotic glycosyltransferases is essential for the enzyme activity of large clostridial cytotoxins
52. Structure/function studies of glycosyltransferases
53. A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities
54. Characterization of the glycosyltransferase enzyme from the Escherichia coil K5 capsule gene cluster and identification and characterization of the glucuronyl active site
55. Characterization of chitin synthase 2 of Saccharomyces cerevisiae
56. Structure-function analysis of the UDP-N-acetyl-D-galactosamine: Polypeptide N-acetylgalactosaminyltransferase
57. Activity of the yeast MNN1 α-1,3-mannosyltransferase requires a motif conserved in many other families of glycosyltransferases
58. Identification that KfiA, a protein essential for the biosynthesis of the Escherichia coli K5 capsular polysaccharide, is an α-UDP-GIcNAc glycosyltransferase: The formation of a membrane associated K5 biosynthetic complex requires KfiA, KfiB and KfiC
59. Conserved structural regions involved in the catalytic mechanism of Escherichia coli K-12 WaaO (Rfal)
60. Involvement of a conserved tryptophan residue in the UDP-glucose binding of large clostridial cytotoxin glycosyltransferases
61. Structure of the nucleotide-diphosphosugar transferase, SpsA from Bacillus subtilis, in native and nucleotide-complexed forms
62. Crystal structures of the bovine β4 galactosyltransferase catalytic domain and its complex with uridine diphosphogalactose
63. Hydrophobic cluster analysis: An efficient new way to compare and analyse amino acid sequences
64. 3 synthase, the key enzyme in globo-series glycosphingolipid synthesis, predicts a family of α1,4 glycosyltransferases conserved in plants, insects and mammals
65. Expression cloning of a human α1,4-N-acetylglucosaminyl-transferase that forms GIcNAcα1→)4Galβ→)R, a glycan specifically expressed in the gastric gland mucous cell-type mucin
66. OCH1 encodes a novel membrane bound mannosyltransferase: Outer chain elongation of asparagine-linked oligosaccharides
67. Structural consequences of mono-glucosylation of H-Ras by Clostridium sordellii lethal toxin
68. Capsular polysaccharide synthesis in Streptococcus pneumoniae serotype 14: Molecular analysis of the complete cps locus and identification of genes encoding glycosyltransferases required for the biosynthesis of the tetrasaccharide subunit
69. Complete DNA sequence and structural analysis of the enteropathogenic Escherichia coli adherence factor plasmid
70. Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis
71. Clostridium difficile toxin A causes early damage to mitochondria in cultured cells
72. Characterization of the catalytic domain of Clostridium novyi α-toxin