메뉴 건너뛰기




Volumn 33, Issue 3, 2013, Pages 622-634

Rac1 controls the subcellular localization of the Rho guanine nucleotide exchange factor net1A to regulate focal adhesion formation and cell spreading

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; MYOSIN LIGHT CHAIN; NET1A PROTEIN; PLECKSTRIN; PROTEASOME; RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

EID: 84873030736     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00980-12     Document Type: Article
Times cited : (27)

References (49)
  • 2
  • 6
    • 0029995797 scopus 로고    scopus 로고
    • Rho-stimulated contractility drives the formation of stress fibers and focal adhesions
    • Chrzanowska-Wodnicka M, Burridge K. 1996. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J. Cell Biol. 133:1403-1415.
    • (1996) J. Cell Biol. , vol.133 , pp. 1403-1415
    • Chrzanowska-Wodnicka, M.1    Burridge, K.2
  • 8
    • 33646197411 scopus 로고    scopus 로고
    • Spatiotemporal dynamics of RhoA activity in migrating cells
    • Pertz O, Hodgson L, Klemke RL, Hahn KM. 2006. Spatiotemporal dynamics of RhoA activity in migrating cells. Nature 440:1069-1072.
    • (2006) Nature , vol.440 , pp. 1069-1072
    • Pertz, O.1    Hodgson, L.2    Klemke, R.L.3    Hahn, K.M.4
  • 9
    • 79959677602 scopus 로고    scopus 로고
    • Life at the leading edge
    • Ridley AJ. 2011. Life at the leading edge. Cell 145:1012-1022.
    • (2011) Cell , vol.145 , pp. 1012-1022
    • Ridley, A.J.1
  • 12
    • 0037048326 scopus 로고    scopus 로고
    • Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters
    • Fritz G, Brachetti C, Bahlmann F, Schmidt M, Kaina B. 2002. Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters. Br. J. Cancer 87:635-644.
    • (2002) Br. J. Cancer , vol.87 , pp. 635-644
    • Fritz, G.1    Brachetti, C.2    Bahlmann, F.3    Schmidt, M.4    Kaina, B.5
  • 13
    • 0032939619 scopus 로고    scopus 로고
    • Rho GTPases are over-expressed in human tumors
    • Fritz G, Just I, Kaina B. 1999. Rho GTPases are over-expressed in human tumors. Int. J. Cancer 81:682-687.
    • (1999) Int. J. Cancer , vol.81 , pp. 682-687
    • Fritz, G.1    Just, I.2    Kaina, B.3
  • 14
    • 0038679226 scopus 로고    scopus 로고
    • Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma
    • Horiuchi A, Imai T, Wang C, Ohira S, Feng Y, Nikaido T, Konishi I. 2003. Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma. Lab. Invest. 83:861-870.
    • (2003) Lab. Invest. , vol.83 , pp. 861-870
    • Horiuchi, A.1    Imai, T.2    Wang, C.3    Ohira, S.4    Feng, Y.5    Nikaido, T.6    Konishi, I.7
  • 16
    • 13444252631 scopus 로고    scopus 로고
    • GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
    • Rossman KL, Der CJ, Sondek J. 2005. GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat. Rev. Mol. Cell Biol. 6:167-180.
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 167-180
    • Rossman, K.L.1    Der, C.J.2    Sondek, J.3
  • 17
    • 33846969965 scopus 로고    scopus 로고
    • Current knowledge of the large RhoGAP family of proteins
    • Tcherkezian J, Lamarche-Vane N. 2007. Current knowledge of the large RhoGAP family of proteins. Biol. Cell 99:67-86.
    • (2007) Biol. Cell , vol.99 , pp. 67-86
    • Tcherkezian, J.1    Lamarche-Vane, N.2
  • 19
    • 58149263842 scopus 로고    scopus 로고
    • Expression and clinical significance of NET-1 and PCNA in hepatocellular carcinoma
    • Shen SQ, Li K, Zhu N, Nakao A. 2008. Expression and clinical significance of NET-1 and PCNA in hepatocellular carcinoma. Med. Oncol. 25:341-345.
    • (2008) Med. Oncol. , vol.25 , pp. 341-345
    • Shen, S.Q.1    Li, K.2    Zhu, N.3    Nakao, A.4
  • 20
    • 77952576092 scopus 로고    scopus 로고
    • Over-expression of neuroepithelial-transforming protein 1 confers poor prognosis of patients with gliomas
    • Tu Y, Lu J, Fu J, Cao Y, Fu G, Kang R, Tian X, Wang B. 2010. Over-expression of neuroepithelial-transforming protein 1 confers poor prognosis of patients with gliomas. Jpn. J. Clin. Oncol. 40:388-394.
    • (2010) Jpn. J. Clin. Oncol. , vol.40 , pp. 388-394
    • Tu, Y.1    Lu, J.2    Fu, J.3    Cao, Y.4    Fu, G.5    Kang, R.6    Tian, X.7    Wang, B.8
  • 23
    • 14844284583 scopus 로고    scopus 로고
    • Characterization of the biochemical and transforming properties of the neuroepithelial transforming protein 1
    • Qin H, Carr HS, Wu X, Muallem D, Tran NH, Frost JA. 2005. Characterization of the biochemical and transforming properties of the neuroepithelial transforming protein 1. J. Biol. Chem. 280:7603-7613.
    • (2005) J. Biol. Chem. , vol.280 , pp. 7603-7613
    • Qin, H.1    Carr, H.S.2    Wu, X.3    Muallem, D.4    Tran, N.H.5    Frost, J.A.6
  • 24
  • 25
    • 53849086471 scopus 로고    scopus 로고
    • NET1-mediated RhoA activation facilitates lysophosphatidic acid-induced cell migration and invasion in gastric cancer
    • Murray D, Horgan G, MacMathuna P, Doran P. 2008. NET1-mediated RhoA activation facilitates lysophosphatidic acid-induced cell migration and invasion in gastric cancer. Br. J. Cancer 99:1322-1329.
    • (2008) Br. J. Cancer , vol.99 , pp. 1322-1329
    • Murray, D.1    Horgan, G.2    MacMathuna, P.3    Doran, P.4
  • 26
    • 77956199210 scopus 로고    scopus 로고
    • Smad3 regulates Rho signaling via NET1 in the transforming growth factor-beta-induced epithelialmesenchymal transition of human retinal pigment epithelial cells
    • Lee J, Moon HJ, Lee JM, Joo CK. 2010. Smad3 regulates Rho signaling via NET1 in the transforming growth factor-beta-induced epithelialmesenchymal transition of human retinal pigment epithelial cells. J. Biol. Chem. 285:26618-26627.
    • (2010) J. Biol. Chem. , vol.285 , pp. 26618-26627
    • Lee, J.1    Moon, H.J.2    Lee, J.M.3    Joo, C.K.4
  • 27
    • 84861990869 scopus 로고    scopus 로고
    • Differential regulation of the two RhoA-specific GEF isoforms Net1/Net1A by TGF-beta and miR-24: role in epithelial-to-mesenchymal transition
    • Papadimitriou E, Vasilaki E, Vorvis C, Iliopoulos D, Moustakas A, Kardassis D, Stournaras C. 2012. Differential regulation of the two RhoA-specific GEF isoforms Net1/Net1A by TGF-beta and miR-24: role in epithelial-to-mesenchymal transition. Oncogene 31:2862-2875.
    • (2012) Oncogene , vol.31 , pp. 2862-2875
    • Papadimitriou, E.1    Vasilaki, E.2    Vorvis, C.3    Iliopoulos, D.4    Moustakas, A.5    Kardassis, D.6    Stournaras, C.7
  • 28
    • 0035805595 scopus 로고    scopus 로고
    • The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation
    • Shen X, Li J, Hu PP, Waddell D, Zhang J, Wang XF. 2001. The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation. J. Biol. Chem. 276:15362-15368.
    • (2001) J. Biol. Chem. , vol.276 , pp. 15362-15368
    • Shen, X.1    Li, J.2    Hu, P.P.3    Waddell, D.4    Zhang, J.5    Wang, X.F.6
  • 29
    • 0037177885 scopus 로고    scopus 로고
    • The Rho exchange factor Net1 is regulated by nuclear sequestration
    • Schmidt A, Hall A. 2002. The Rho exchange factor Net1 is regulated by nuclear sequestration. J. Biol. Chem. 277:14581-14588.
    • (2002) J. Biol. Chem. , vol.277 , pp. 14581-14588
    • Schmidt, A.1    Hall, A.2
  • 31
    • 16844379381 scopus 로고    scopus 로고
    • PAK1 negatively regulates the activity of the Rho exchange factor NET1
    • Alberts AS, Qin H, Carr HS, Frost JA. 2005. PAK1 negatively regulates the activity of the Rho exchange factor NET1. J. Biol. Chem. 280:12152-12161.
    • (2005) J. Biol. Chem. , vol.280 , pp. 12152-12161
    • Alberts, A.S.1    Qin, H.2    Carr, H.S.3    Frost, J.A.4
  • 34
    • 0033615966 scopus 로고    scopus 로고
    • Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior
    • Sander EE, ten Klooster JP, van Delft S, van der Kammen RA, Collard JG. 1999. Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior. J. Cell Biol. 147:1009-1022.
    • (1999) J. Cell Biol. , vol.147 , pp. 1009-1022
    • Sander, E.E.1    ten Klooster, J.P.2    van Delft, S.3    van der Kammen, R.A.4    Collard, J.G.5
  • 35
    • 37249071435 scopus 로고    scopus 로고
    • A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin
    • Dubash AD, Wennerberg K, Garcia-Mata R, Menold MM, Arthur WT, Burridge K. 2007. A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin. J. Cell Sci. 120:3989-3998.
    • (2007) J. Cell Sci. , vol.120 , pp. 3989-3998
    • Dubash, A.D.1    Wennerberg, K.2    Garcia-Mata, R.3    Menold, M.M.4    Arthur, W.T.5    Burridge, K.6
  • 36
    • 0032527805 scopus 로고    scopus 로고
    • Activation of RhoA and SAPK/JNK signalling pathways by the RhoA-specific exchange factor mNET1
    • Alberts AS, Treisman R. 1998. Activation of RhoA and SAPK/JNK signalling pathways by the RhoA-specific exchange factor mNET1. EMBO J. 17:4075-4085.
    • (1998) EMBO J. , vol.17 , pp. 4075-4085
    • Alberts, A.S.1    Treisman, R.2
  • 37
    • 0034213327 scopus 로고    scopus 로고
    • Rho GTPases and their effector proteins
    • Bishop AL, Hall A. 2000. Rho GTPases and their effector proteins. Biochem. J. 348:241-255.
    • (2000) Biochem. J. , vol.348 , pp. 241-255
    • Bishop, A.L.1    Hall, A.2
  • 38
    • 0034704120 scopus 로고    scopus 로고
    • Targeting of Rac1 to the phagocyte membrane is sufficient for the induction of NADPH oxidase assembly
    • Gorzalczany Y, Sigal N, Itan M, Lotan O, Pick E. 2000. Targeting of Rac1 to the phagocyte membrane is sufficient for the induction of NADPH oxidase assembly. J. Biol. Chem. 275:40073-40081.
    • (2000) J. Biol. Chem. , vol.275 , pp. 40073-40081
    • Gorzalczany, Y.1    Sigal, N.2    Itan, M.3    Lotan, O.4    Pick, E.5
  • 39
    • 0025874249 scopus 로고
    • Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA
    • Kinsella BT, Erdman RA, Maltese WA. 1991. Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA. J. Biol. Chem. 266:9786-9794.
    • (1991) J. Biol. Chem. , vol.266 , pp. 9786-9794
    • Kinsella, B.T.1    Erdman, R.A.2    Maltese, W.A.3
  • 40
    • 0026775475 scopus 로고
    • Regulation of the superoxidegenerating NADPH oxidase by a small GTP-binding protein and its stimulatory and inhibitory GDP/GTP exchange proteins
    • Mizuno T, Kaibuchi K, Ando S, Musha T, Hiraoka K, Takaishi K, Asada M, Nunoi H, Matsuda I, Takai Y. 1992. Regulation of the superoxidegenerating NADPH oxidase by a small GTP-binding protein and its stimulatory and inhibitory GDP/GTP exchange proteins. J. Biol. Chem. 267: 10215-10218.
    • (1992) J. Biol. Chem. , vol.267 , pp. 10215-10218
    • Mizuno, T.1    Kaibuchi, K.2    Ando, S.3    Musha, T.4    Hiraoka, K.5    Takaishi, K.6    Asada, M.7    Nunoi, H.8    Matsuda, I.9    Takai, Y.10
  • 41
    • 0032561355 scopus 로고    scopus 로고
    • Differential effects of PAK1-activating mutations reveal activitydependent and-independent effects on cytoskeletal regulation
    • Frost JA, Khokhlatchev A, Stippec S, White MA, Cobb MH. 1998. Differential effects of PAK1-activating mutations reveal activitydependent and-independent effects on cytoskeletal regulation. J. Biol. Chem. 273:28191-28198.
    • (1998) J. Biol. Chem. , vol.273 , pp. 28191-28198
    • Frost, J.A.1    Khokhlatchev, A.2    Stippec, S.3    White, M.A.4    Cobb, M.H.5
  • 42
    • 69949155967 scopus 로고    scopus 로고
    • Interaction of the RhoA exchange factor Net1 with discs large homolog 1 protects it from protea-some mediated degradation and potentiates Net1 activity
    • Carr HS, Cai C, Keinanen K, Frost JA. 2009. Interaction of the RhoA exchange factor Net1 with discs large homolog 1 protects it from protea-some mediated degradation and potentiates Net1 activity. J. Biol. Chem. 284:24269-24280.
    • (2009) J. Biol. Chem. , vol.284 , pp. 24269-24280
    • Carr, H.S.1    Cai, C.2    Keinanen, K.3    Frost, J.A.4
  • 43
    • 0037113091 scopus 로고    scopus 로고
    • The integrin beta tail is required and sufficient to regulate adhesion signaling to Rac1
    • Berrier AL, Martinez R, Bokoch GM, LaFlamme SE. 2002. The integrin beta tail is required and sufficient to regulate adhesion signaling to Rac1. J. Cell Sci. 115:4285-4291.
    • (2002) J. Cell Sci. , vol.115 , pp. 4285-4291
    • Berrier, A.L.1    Martinez, R.2    Bokoch, G.M.3    LaFlamme, S.E.4
  • 44
    • 0031844821 scopus 로고    scopus 로고
    • Activation of Rac and Cdc42 by integrins mediates cell spreading
    • Price LS, Leng J, Schwartz MA, Bokoch GM. 1998. Activation of Rac and Cdc42 by integrins mediates cell spreading. Mol. Biol. Cell 9:1863-1871.
    • (1998) Mol. Biol. Cell , vol.9 , pp. 1863-1871
    • Price, L.S.1    Leng, J.2    Schwartz, M.A.3    Bokoch, G.M.4
  • 45
    • 0842281652 scopus 로고    scopus 로고
    • Rho and Rac take center stage
    • Burridge K, Wennerberg K. 2004. Rho and Rac take center stage. Cell 116:167-179.
    • (2004) Cell , vol.116 , pp. 167-179
    • Burridge, K.1    Wennerberg, K.2
  • 48
    • 0038554077 scopus 로고    scopus 로고
    • Biology of the p21-activated kinases
    • Bokoch GM. 2003. Biology of the p21-activated kinases. Annu. Rev. Biochem. 72:743-781.
    • (2003) Annu. Rev. Biochem. , vol.72 , pp. 743-781
    • Bokoch, G.M.1
  • 49
    • 62449294770 scopus 로고    scopus 로고
    • The actin cytoskeleton in cancer cell motility
    • Olson MF, Sahai E. 2009. The actin cytoskeleton in cancer cell motility. Clin. Exp. Metastasis 26:273-287.
    • (2009) Clin. Exp. Metastasis , vol.26 , pp. 273-287
    • Olson, M.F.1    Sahai, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.