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Volumn 3, Issue 3, 2011, Pages 172-190

The biology of the cytolethal distending toxins

Author keywords

Bacterial genotoxin; Chancroid; Colitis hepatitis; Cytolethal distending toxin; DNA damage; DNA damage response; Periodontitis; Survival signals; Toxin internalization; Virulence factor

Indexed keywords

CYTOLETHAL DISTENDING TOXIN;

EID: 79953243528     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins3030172     Document Type: Review
Times cited : (108)

References (83)
  • 2
    • 0034868506 scopus 로고    scopus 로고
    • The cytolethal distending toxins induce DNA damage and cell cycle arrest
    • Cortes-Bratti, X.; Frisan, T.; Thelestam, M. The cytolethal distending toxins induce DNA damage and cell cycle arrest. Toxicon 2001, 39, 1729-1736.
    • (2001) Toxicon , vol.39 , pp. 1729-1736
    • Cortes-Bratti, X.1    Frisan, T.2    Thelestam, M.3
  • 4
    • 2642550772 scopus 로고    scopus 로고
    • Assembly and function of a bacterial genotoxin
    • Nesic, D.; Hsu, Y.; Stebbins, C.E. Assembly and function of a bacterial genotoxin. Nature 2004, 429, 429-433.
    • (2004) Nature , vol.429 , pp. 429-433
    • Nesic, D.1    Hsu, Y.2    Stebbins, C.E.3
  • 5
    • 0033854239 scopus 로고    scopus 로고
    • DNAase I homologous residues in CdtB are critical for cytolethal distending toxin-mediated cell cycle arrest
    • Elwell, C.A.; Dreyfus, L.A. DNAase I homologous residues in CdtB are critical for cytolethal distending toxin-mediated cell cycle arrest. Mol. Microbiol. 2000, 37, 952-963.
    • (2000) Mol. Microbiol , vol.37 , pp. 952-963
    • Elwell, C.A.1    Dreyfus, L.A.2
  • 6
    • 0034644631 scopus 로고    scopus 로고
    • A bacterial toxin that controls cell cycle progression as a deoxyribonuclease I-like protein
    • Lara-Tejero, M.; Galan, J.E. A bacterial toxin that controls cell cycle progression as a deoxyribonuclease I-like protein. Science 2000, 290, 354-357.
    • (2000) Science , vol.290 , pp. 354-357
    • Lara-Tejero, M.1    Galan, J.E.2
  • 7
    • 0034876258 scopus 로고    scopus 로고
    • Cytolethal distending toxin demonstrates genotoxic activity in a yeast model
    • Hassane, D.C.; Lee, R.B.; Mendenhall, M.D.; Pickett, C.L. Cytolethal distending toxin demonstrates genotoxic activity in a yeast model. Infect. Immun. 2001, 69, 5752-5759.
    • (2001) Infect. Immun , vol.69 , pp. 5752-5759
    • Hassane, D.C.1    Lee, R.B.2    Mendenhall, M.D.3    Pickett, C.L.4
  • 9
    • 30144440665 scopus 로고    scopus 로고
    • Comparative structure-function analysis of cytolethal distending toxins
    • Hu, X.; Nesic, D.; Stebbins, C.E. Comparative structure-function analysis of cytolethal distending toxins. Proteins 2006, 62, 421-434.
    • (2006) Proteins , vol.62 , pp. 421-434
    • Hu, X.1    Nesic, D.2    Stebbins, C.E.3
  • 10
    • 33646918281 scopus 로고    scopus 로고
    • Biogenesis of the Actinobacillus actinomycetemcomitans cytolethal distending toxin holotoxin
    • Ueno, Y.; Ohara, M.; Kawamoto, T.; Fujiwara, T.; Komatsuzawa, H.; Oswald, E.; Sugai, M. Biogenesis of the Actinobacillus actinomycetemcomitans cytolethal distending toxin holotoxin. Infect. Immun. 2006, 74, 3480-3487.
    • (2006) Infect. Immun , vol.74 , pp. 3480-3487
    • Ueno, Y.1    Ohara, M.2    Kawamoto, T.3    Fujiwara, T.4    Komatsuzawa, H.5    Oswald, E.6    Sugai, M.7
  • 11
    • 0041322857 scopus 로고    scopus 로고
    • Interactions of Campylobacter jejuni cytolethal distending toxin subunits CdtA and CdtC with HeLa cells
    • Lee, R.B.; Hassane, D.C.; Cottle, D.L.; Pickett, C.L. Interactions of Campylobacter jejuni cytolethal distending toxin subunits CdtA and CdtC with HeLa cells. Infect. Immun. 2003, 71, 4883-4890.
    • (2003) Infect. Immun , vol.71 , pp. 4883-4890
    • Lee, R.B.1    Hassane, D.C.2    Cottle, D.L.3    Pickett, C.L.4
  • 12
    • 16244386487 scopus 로고    scopus 로고
    • Carbohydrate-binding specificity of the Escherichia coli cytolethal distending toxin CdtA-II and CdtC-II subunits
    • McSweeney, L.A.; Dreyfus, L.A. Carbohydrate-binding specificity of the Escherichia coli cytolethal distending toxin CdtA-II and CdtC-II subunits. Infect. Immun. 2005, 73, 2051-2060.
    • (2005) Infect. Immun , vol.73 , pp. 2051-2060
    • McSweeney, L.A.1    Dreyfus, L.A.2
  • 13
    • 23344447887 scopus 로고    scopus 로고
    • Involvement of ganglioside GM3 in G(2)/M cell cycle arrest of human monocytic cells induced by Actinobacillus actinomycetemcomitans cytolethal distending toxin
    • Mise, K.; Akifusa, S.; Watarai, S.; Ansai, T.; Nishihara, T.; Takehara, T. Involvement of ganglioside GM3 in G(2)/M cell cycle arrest of human monocytic cells induced by Actinobacillus actinomycetemcomitans cytolethal distending toxin. Infect. Immun. 2005, 73, 4846-4852.
    • (2005) Infect. Immun , vol.73 , pp. 4846-4852
    • Mise, K.1    Akifusa, S.2    Watarai, S.3    Ansai, T.4    Nishihara, T.5    Takehara, T.6
  • 14
    • 0036231176 scopus 로고    scopus 로고
    • Functional studies of the recombinant subunits of a cytolethal distending holotoxin
    • Mao, X.; DiRienzo, J.M. Functional studies of the recombinant subunits of a cytolethal distending holotoxin. Cell. Microbiol. 2002, 4, 245-255.
    • (2002) Cell. Microbiol , vol.4 , pp. 245-255
    • Mao, X.1    Dirienzo, J.M.2
  • 15
    • 19044380605 scopus 로고    scopus 로고
    • Mechanism of internalization of the cytolethal distending toxin of Actinobacillus actinomycetemcomitans
    • Akifusa, S.; Heywood, W.; Nair, S.P.; Stenbeck, G.; Henderson, B. Mechanism of internalization of the cytolethal distending toxin of Actinobacillus actinomycetemcomitans. Microbiology 2005, 151, 1395-1402.
    • (2005) Microbiology , vol.151 , pp. 1395-1402
    • Akifusa, S.1    Heywood, W.2    Nair, S.P.3    Stenbeck, G.4    Henderson, B.5
  • 16
    • 79953251636 scopus 로고    scopus 로고
    • Karolinska Institute, Sweden. Unpublished work
    • Frisan, T. Karolinska Institute, Sweden. Unpublished work, 2011.
    • (2011)
    • Frisan, T.1
  • 17
    • 33645539767 scopus 로고    scopus 로고
    • Cholesterol-rich membrane microdomains mediate cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal-distending toxin
    • Boesze-Battaglia, K.; Besack, D.; McKay, T.; Zekavat, A.; Otis, L.; Jordan-Sciutto, K.; Shenker, B.J. Cholesterol-rich membrane microdomains mediate cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal-distending toxin. Cell. Microbiol. 2006, 8, 823-836.
    • (2006) Cell. Microbiol , vol.8 , pp. 823-836
    • Boesze-Battaglia, K.1    Besack, D.2    McKay, T.3    Zekavat, A.4    Otis, L.5    Jordan-Sciutto, K.6    Shenker, B.J.7
  • 19
    • 77953299606 scopus 로고    scopus 로고
    • Cytolethal distending toxin family members are differentially affected by alterations in host glycans and membrane cholesterol
    • Eshraghi, A.; Maldonado-Arocho, F.J.; Gargi, A.; Cardwell, M.M.; Prouty, M.G.; Blanke, S.R.; Bradley, K.A. Cytolethal distending toxin family members are differentially affected by alterations in host glycans and membrane cholesterol. J. Biol. Chem. 2010, 285, 18199-18207.
    • (2010) J. Biol. Chem , vol.285 , pp. 18199-18207
    • Eshraghi, A.1    Maldonado-Arocho, F.J.2    Gargi, A.3    Cardwell, M.M.4    Prouty, M.G.5    Blanke, S.R.6    Bradley, K.A.7
  • 21
    • 1842585488 scopus 로고    scopus 로고
    • Salmonella typhi encodes a functional cytolethal distending toxin that is delivered into host cells by a bacterial-internalization pathway
    • Haghjoo, E.; Galan, J.E. Salmonella typhi encodes a functional cytolethal distending toxin that is delivered into host cells by a bacterial-internalization pathway. Proc. Natl. Acad. Sci. USA 2004, 101, 4614-4619.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 4614-4619
    • Haghjoo, E.1    Galan, J.E.2
  • 22
    • 38049046618 scopus 로고    scopus 로고
    • Delivery of a Salmonella typhi exotoxin from a host intracellular compartment
    • Spano, S.; Ugalde, J.E.; Galan, J.E. Delivery of a Salmonella typhi exotoxin from a host intracellular compartment. Cell Host Microbe 2008, 3, 30-38.
    • (2008) Cell Host Microbe , vol.3 , pp. 30-38
    • Spano, S.1    Ugalde, J.E.2    Galan, J.E.3
  • 23
    • 0034441256 scopus 로고    scopus 로고
    • Cellular internalization of cytolethal distending toxin from Haemophilus ducreyi
    • Cortes-Bratti, X.; Chaves-Olarte, E.; Lagergård, T.; Thelestam, M. Cellular internalization of cytolethal distending toxin from Haemophilus ducreyi. Infect. Immun. 2000, 68, 6903-6911.
    • (2000) Infect. Immun , vol.68 , pp. 6903-6911
    • Cortes-Bratti, X.1    Chaves-Olarte, E.2    Lagergård, T.3    Thelestam, M.4
  • 25
    • 0346118865 scopus 로고    scopus 로고
    • An N-terminal segment of the active component of the bacterial genotoxin cytolethal distending toxin B (CDTB) directs CDTB into the nucleus
    • Nishikubo, S.; Ohara, M.; Ueno, Y.; Ikura, M.; Kurihara, H.; Komatsuzawa, H.; Oswald, E.; Sugai, M. An N-terminal segment of the active component of the bacterial genotoxin cytolethal distending toxin B (CDTB) directs CDTB into the nucleus. J. Biol. Chem. 2003, 278, 50671-50681.
    • (2003) J. Biol. Chem , vol.278 , pp. 50671-50681
    • Nishikubo, S.1    Ohara, M.2    Ueno, Y.3    Ikura, M.4    Kurihara, H.5    Komatsuzawa, H.6    Oswald, E.7    Sugai, M.8
  • 26
    • 1842840103 scopus 로고    scopus 로고
    • Nuclear localization of the Escherichia coli cytolethal distending toxin CdtB subunit
    • McSweeney, L.A.; Dreyfus, L.A. Nuclear localization of the Escherichia coli cytolethal distending toxin CdtB subunit. Cell. Microbiol. 2004, 6, 447-458.
    • (2004) Cell. Microbiol , vol.6 , pp. 447-458
    • McSweeney, L.A.1    Dreyfus, L.A.2
  • 27
    • 0345490781 scopus 로고    scopus 로고
    • The intracellular voyage of cholera toxin: Going retro
    • Lencer, W.I.; Tsai, B. The intracellular voyage of cholera toxin: going retro. Trends Biochem. Sci. 2003, 28, 639-645.
    • (2003) Trends Biochem. Sci , vol.28 , pp. 639-645
    • Lencer, W.I.1    Tsai, B.2
  • 28
    • 0033167976 scopus 로고    scopus 로고
    • The cytolethal distending toxin family
    • Pickett, C.L.; Whitehouse, C.A. The cytolethal distending toxin family. Trends Microbiol. 1999, 7, 292-297.
    • (1999) Trends Microbiol , vol.7 , pp. 292-297
    • Pickett, C.L.1    Whitehouse, C.A.2
  • 31
    • 0141725786 scopus 로고    scopus 로고
    • The Haemophilus ducreyi cytolethal distending toxin induces DNA double strand breaks and promotes ATM-dependent activation of RhoA
    • Frisan, T.; Cortes-Bratti, X.; Chaves-Olarte, E.; Stenerlöw, B.; Thelestam, M. The Haemophilus ducreyi cytolethal distending toxin induces DNA double strand breaks and promotes ATM-dependent activation of RhoA. Cell. Microbiol. 2003, 5, 695-707.
    • (2003) Cell. Microbiol , vol.5 , pp. 695-707
    • Frisan, T.1    Cortes-Bratti, X.2    Chaves-Olarte, E.3    Stenerlöw, B.4    Thelestam, M.5
  • 32
    • 0035058434 scopus 로고    scopus 로고
    • Escherichia coli CdtB mediates cytolethal distending toxin cell cycle arrest
    • Elwell, C.; Chao, K.; Patel, K.; Dreyfus, L. Escherichia coli CdtB mediates cytolethal distending toxin cell cycle arrest. Infect. Immun. 2001, 69, 3418-3422.
    • (2001) Infect. Immun , vol.69 , pp. 3418-3422
    • Elwell, C.1    Chao, K.2    Patel, K.3    Dreyfus, L.4
  • 33
    • 0036123023 scopus 로고    scopus 로고
    • The Haemophilus ducreyi cytolethal distending toxin activates sensors of DNA damage and repair complexes in proliferating and non-proliferating cells
    • Li, L.; Sharipo, A.; Chaves-Olarte, E.; Masucci, M.G.; Levitsky, V.; Thelestam, M.; Frisan, T. The Haemophilus ducreyi cytolethal distending toxin activates sensors of DNA damage and repair complexes in proliferating and non-proliferating cells. Cell. Microbiol. 2002, 4, 87-99.
    • (2002) Cell. Microbiol , vol.4 , pp. 87-99
    • Li, L.1    Sharipo, A.2    Chaves-Olarte, E.3    Masucci, M.G.4    Levitsky, V.5    Thelestam, M.6    Frisan, T.7
  • 34
    • 77958498222 scopus 로고    scopus 로고
    • The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer
    • Smith, J.; Tho, L.M.; Xu, N.; Gillespie, D.A. The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. Adv. Cancer Res. 2010, 108, 73-112.
    • (2010) Adv. Cancer Res , vol.108 , pp. 73-112
    • Smith, J.1    Tho, L.M.2    Xu, N.3    Gillespie, D.A.4
  • 35
    • 40449120350 scopus 로고    scopus 로고
    • An oncogene-induced DNA damage model for cancer development
    • Halazonetis, T.D.; Gorgoulis, V.G.; Bartek, J. An oncogene-induced DNA damage model for cancer development. Science 2008, 319, 1352-1355.
    • (2008) Science , vol.319 , pp. 1352-1355
    • Halazonetis, T.D.1    Gorgoulis, V.G.2    Bartek, J.3
  • 36
    • 0030775355 scopus 로고    scopus 로고
    • Escherichia coli cytolethal distending toxin blocks the HeLa cell cycle at the G2/M transition by preventing cdc2 protein kinase dephosphorylation and activation
    • Comayras, C.; Tasca, C.; Peres, S.Y.; Ducommun, B.; Oswald, E.; de Rycke, J. Escherichia coli cytolethal distending toxin blocks the HeLa cell cycle at the G2/M transition by preventing cdc2 protein kinase dephosphorylation and activation. Infect. Immun. 1997, 65, 5088-5095.
    • (1997) Infect. Immun , vol.65 , pp. 5088-5095
    • Comayras, C.1    Tasca, C.2    Peres, S.Y.3    Ducommun, B.4    Oswald, E.5    de Rycke, J.6
  • 37
    • 0033561543 scopus 로고    scopus 로고
    • Actinobacillus actinomycetemcomitans immunosuppressive protein is a member of the family of cytolethal distending toxins capable of causing a G2 arrest in human T cells
    • 4773-4680
    • Shenker, B.J.; McKay, T.; Datar, S.; Miller, M.; Chowhan, R.; Demuth, D. Actinobacillus actinomycetemcomitans immunosuppressive protein is a member of the family of cytolethal distending toxins capable of causing a G2 arrest in human T cells. J. Immunol. 1999, 162, 4773-4680.
    • (1999) J. Immunol , vol.162
    • Shenker, B.J.1    McKay, T.2    Datar, S.3    Miller, M.4    Chowhan, R.5    Demuth, D.6
  • 38
    • 0033523948 scopus 로고    scopus 로고
    • The bacterial cytolethal distending toxin (CDT) triggers a G2 cell cycle checkpoint in mammalian cells without preliminary induction of DNA strand breaks
    • Sert, V.; Cans, C.; Tasca, C.; Bret-Bennis, L.; Oswald, E.; Ducommun, B.; de Rycke, J. The bacterial cytolethal distending toxin (CDT) triggers a G2 cell cycle checkpoint in mammalian cells without preliminary induction of DNA strand breaks. Oncogene 1999, 18, 6296-6304.
    • (1999) Oncogene , vol.18 , pp. 6296-6304
    • Sert, V.1    Cans, C.2    Tasca, C.3    Bret-Bennis, L.4    Oswald, E.5    Ducommun, B.6    de Rycke, J.7
  • 39
    • 0035895984 scopus 로고    scopus 로고
    • The Haemophilus ducreyi cytolethal distending toxin induces cell cycle arrest and apoptosis via the DNA damage checkpoint pathways
    • Cortes-Bratti, X.; Karlsson, C.; Lagergard, T.; Thelestam, M.; Frisan, T. The Haemophilus ducreyi cytolethal distending toxin induces cell cycle arrest and apoptosis via the DNA damage checkpoint pathways. J. Biol. Chem. 2001, 276, 5296-5302.
    • (2001) J. Biol. Chem , vol.276 , pp. 5296-5302
    • Cortes-Bratti, X.1    Karlsson, C.2    Lagergard, T.3    Thelestam, M.4    Frisan, T.5
  • 40
    • 0037219984 scopus 로고    scopus 로고
    • Campylobacter jejuni cytolethal distending toxin promotes DNA repair responses in normal human cells
    • Hassane, D.C.; Lee, R.B.; Pickett, C.L. Campylobacter jejuni cytolethal distending toxin promotes DNA repair responses in normal human cells. Infect. Immun. 2003, 71, 541-545.
    • (2003) Infect. Immun , vol.71 , pp. 541-545
    • Hassane, D.C.1    Lee, R.B.2    Pickett, C.L.3
  • 41
    • 7644229244 scopus 로고    scopus 로고
    • Delivery of cytolethal distending toxin B induces cell cycle arrest and apoptosis in gingival squamous cell carcinoma in vitro
    • Yamamoto, K.; Tominaga, K.; Sukedai, M.; Okinaga, T.; Iwanaga, K.; Nishihara, T.; Fukuda, J. Delivery of cytolethal distending toxin B induces cell cycle arrest and apoptosis in gingival squamous cell carcinoma in vitro. Eur. J. Oral. Sci. 2004, 112, 445-451.
    • (2004) Eur. J. Oral. Sci , vol.112 , pp. 445-451
    • Yamamoto, K.1    Tominaga, K.2    Sukedai, M.3    Okinaga, T.4    Iwanaga, K.5    Nishihara, T.6    Fukuda, J.7
  • 42
    • 0036153510 scopus 로고    scopus 로고
    • P53-independent expression of p21(CIP1/WAF1) in plasmacytic cells during G(2) cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal distending toxin
    • Sato, T.; Koseki, T.; Yamato, K.; Saiki, K.; Konishi, K.; Yoshikawa, M.; Ishikawa, I.; Nishihara, T. p53-independent expression of p21(CIP1/WAF1) in plasmacytic cells during G(2) cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal distending toxin. Infect. Immun. 2002, 70, 528-534.
    • (2002) Infect. Immun , vol.70 , pp. 528-534
    • Sato, T.1    Koseki, T.2    Yamato, K.3    Saiki, K.4    Konishi, K.5    Yoshikawa, M.6    Ishikawa, I.7    Nishihara, T.8
  • 44
    • 77951958808 scopus 로고    scopus 로고
    • Bacterial Intoxication Evokes Cellular Senescence with Persistent DNA Damage and Cytokine Signaling
    • Blazkova, H.; Krejcikova, K.; Moudry, P.; Frisan, T.; Hodny, Z.; Bartek, J. Bacterial Intoxication Evokes Cellular Senescence with Persistent DNA Damage and Cytokine Signaling. J. Cell. Mol. Med. 2010, 14, 357-367.
    • (2010) J. Cell. Mol. Med , vol.14 , pp. 357-367
    • Blazkova, H.1    Krejcikova, K.2    Moudry, P.3    Frisan, T.4    Hodny, Z.5    Bartek, J.6
  • 45
    • 33847747460 scopus 로고    scopus 로고
    • Genome-wide analysis of cellular response to bacterial genotoxin CdtB in yeast
    • Kitagawa, T.; Hoshida, H.; Akada, R. Genome-wide analysis of cellular response to bacterial genotoxin CdtB in yeast. Infect. Immun. 2007, 75, 1393-1402.
    • (2007) Infect. Immun , vol.75 , pp. 1393-1402
    • Kitagawa, T.1    Hoshida, H.2    Akada, R.3
  • 46
    • 9244251125 scopus 로고    scopus 로고
    • Cell-cycle checkpoints and cancer
    • Kastan, M.B.; Bartek, J. Cell-cycle checkpoints and cancer. Nature 2004, 432, 316-323.
    • (2004) Nature , vol.432 , pp. 316-323
    • Kastan, M.B.1    Bartek, J.2
  • 47
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: Safeguarding genome integrity
    • Shiloh, Y. ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer 2003, 3, 155-168.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 48
    • 0032722556 scopus 로고    scopus 로고
    • Cytolethal distending toxin of Haemophilus ducreyi induces apoptotic death of Jurkat T cells
    • Gelfanova, V.; Hansen, E.J.; Spinola, S.M. Cytolethal distending toxin of Haemophilus ducreyi induces apoptotic death of Jurkat T cells. Infect. Immun. 1999, 67, 6394-6402.
    • (1999) Infect. Immun , vol.67 , pp. 6394-6402
    • Gelfanova, V.1    Hansen, E.J.2    Spinola, S.M.3
  • 49
    • 0032893106 scopus 로고    scopus 로고
    • The cytolethal distending toxin from the chancroid bacterium Haemophilus ducreyi induces cell-cycle arrest in the G2 phase
    • Cortes-Bratti, X.; Chaves-Olarte, E.; Lagergård, T.; Thelestam, M. The cytolethal distending toxin from the chancroid bacterium Haemophilus ducreyi induces cell-cycle arrest in the G2 phase. J. Clin. Invest. 1999, 103, 107-115.
    • (1999) J. Clin. Invest , vol.103 , pp. 107-115
    • Cortes-Bratti, X.1    Chaves-Olarte, E.2    Lagergård, T.3    Thelestam, M.4
  • 50
    • 48249149894 scopus 로고    scopus 로고
    • A bacterial cytotoxin identifies the RhoA exchange factor Net1 as a key effector in the response to DNA damage
    • Guerra, L.; Carr, H.S.; Richter-Dahlfors, A.; Masucci, M.G.; Thelestam, M.; Frost, J.A.; Frisan, T. A bacterial cytotoxin identifies the RhoA exchange factor Net1 as a key effector in the response to DNA damage. PLoS One 2008, 3, e2254.
    • (2008) PLoS One , vol.3
    • Guerra, L.1    Carr, H.S.2    Richter-Dahlfors, A.3    Masucci, M.G.4    Thelestam, M.5    Frost, J.A.6    Frisan, T.7
  • 52
    • 0035399760 scopus 로고    scopus 로고
    • Induction of apoptosis in human T cells by Actinobacillus actinomycetemcomitans cytolethal distending toxin is a consequence of G2 arrest of the cell cycle
    • Shenker, B.J.; Hoffmaster, R.H.; Zekavat, A.; Yamaguchi, N.; Lally, E.T.; Demuth, D.R. Induction of apoptosis in human T cells by Actinobacillus actinomycetemcomitans cytolethal distending toxin is a consequence of G2 arrest of the cell cycle. J. Immun. 2001, 167, 435-441.
    • (2001) J. Immun , vol.167 , pp. 435-441
    • Shenker, B.J.1    Hoffmaster, R.H.2    Zekavat, A.3    Yamaguchi, N.4    Lally, E.T.5    Demuth, D.R.6
  • 53
    • 0842327139 scopus 로고    scopus 로고
    • Caspase-2 and caspase-7 are involved in cytolethal distending toxin-induced apoptosis in Jurkat and MOLT-4 T-cell lines
    • Ohara, M.; Hayashi, T.; Kusunoki, Y.; Miyauchi, M.; Takata, T.; Sugai, M. Caspase-2 and caspase-7 are involved in cytolethal distending toxin-induced apoptosis in Jurkat and MOLT-4 T-cell lines. Infect. Immun. 2004, 72, 871-879.
    • (2004) Infect. Immun , vol.72 , pp. 871-879
    • Ohara, M.1    Hayashi, T.2    Kusunoki, Y.3    Miyauchi, M.4    Takata, T.5    Sugai, M.6
  • 54
    • 53649093971 scopus 로고    scopus 로고
    • Cytolethal distending toxin induces caspase-dependent and -independent cell death in MOLT-4 cells
    • Ohara, M.; Hayashi, T.; Kusunoki, Y.; Nakachi, K.; Fujiwara, T.; Komatsuzawa, H.; Sugai, M. Cytolethal distending toxin induces caspase-dependent and -independent cell death in MOLT-4 cells. Infect. Immun. 2008, 76, 4783-4791.
    • (2008) Infect. Immun , vol.76 , pp. 4783-4791
    • Ohara, M.1    Hayashi, T.2    Kusunoki, Y.3    Nakachi, K.4    Fujiwara, T.5    Komatsuzawa, H.6    Sugai, M.7
  • 55
    • 67651229415 scopus 로고    scopus 로고
    • Aggregatibacter actinomycetemcomitans cytolethal distending toxin induces apoptosis in nonproliferating macrophages by a phosphatase-independent mechanism
    • Rabin, S.D.; Flitton, J.G.; Demuth, D.R. Aggregatibacter actinomycetemcomitans cytolethal distending toxin induces apoptosis in nonproliferating macrophages by a phosphatase-independent mechanism. Infect. Immun. 2009, 77, 3161-3169.
    • (2009) Infect. Immun , vol.77 , pp. 3161-3169
    • Rabin, S.D.1    Flitton, J.G.2    Demuth, D.R.3
  • 56
    • 34247148624 scopus 로고    scopus 로고
    • A novel mode of action for a microbial-derived immunotoxin: The cytolethal distending toxin subunit B exhibits phosphatidylinositol 3,4,5-triphosphate phosphatase activity
    • Shenker, B.J.; Dlakic, M.; Walker, L.P.; Besack, D.; Jaffe, E.; LaBelle, E.; Boesze-Battaglia, K. A novel mode of action for a microbial-derived immunotoxin: the cytolethal distending toxin subunit B exhibits phosphatidylinositol 3,4,5-triphosphate phosphatase activity. J. Immunol. 2007, 178, 5099-5108.
    • (2007) J. Immunol , vol.178 , pp. 5099-5108
    • Shenker, B.J.1    Dlakic, M.2    Walker, L.P.3    Besack, D.4    Jaffe, E.5    Labelle, E.6    Boesze-Battaglia, K.7
  • 57
    • 76749131183 scopus 로고    scopus 로고
    • Cytolethal distending toxin from Aggregatibacter actinomycetemcomitans induces DNA damage, S/G2 cell cycle arrest, and caspase- independent death in a Saccharomyces cerevisiae model
    • Matangkasombut, O.; Wattanawaraporn, R.; Tsuruda, K.; Ohara, M.; Sugai, M.; Mongkolsuk, S. Cytolethal distending toxin from Aggregatibacter actinomycetemcomitans induces DNA damage, S/G2 cell cycle arrest, and caspase- independent death in a Saccharomyces cerevisiae model. Infect. Immun. 2010, 78, 783-792.
    • (2010) Infect. Immun , vol.78 , pp. 783-792
    • Matangkasombut, O.1    Wattanawaraporn, R.2    Tsuruda, K.3    Ohara, M.4    Sugai, M.5    Mongkolsuk, S.6
  • 58
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov, S.I.; Greten, F.R.; Karin, M. Immunity, inflammation, and cancer. Cell 2010, 140, 883-899.
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 59
    • 32944474237 scopus 로고    scopus 로고
    • Innate immunity gone awry: Linking microbial infections to chronic inflammation and cancer
    • Karin, M.; Lawrence, T.; Nizet, V. Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell 2006, 124, 823-835.
    • (2006) Cell , vol.124 , pp. 823-835
    • Karin, M.1    Lawrence, T.2    Nizet, V.3
  • 60
    • 0000784774 scopus 로고
    • Schistosomes
    • IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, World Health Organization: Lyon, France
    • IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Schistosomes, Liver Flukes and Helicobacter Pylori; World Health Organization: Lyon, France, 1994; Volume 61, pp. 177-240.
    • (1994) Liver Flukes and Helicobacter Pylori , vol.61 , pp. 177-240
  • 61
    • 0034307022 scopus 로고    scopus 로고
    • Detection of Helicobacter species in the liver of patients with and without primary liver carcinoma
    • Avenaud, P.; Marais, A.; Monteiro, L.; Le Bail, B.; Bioulac Sage, P.; Balabaud, C.; Megraud, F. Detection of Helicobacter species in the liver of patients with and without primary liver carcinoma. Cancer 2000, 89, 1431-1439.
    • (2000) Cancer , vol.89 , pp. 1431-1439
    • Avenaud, P.1    Marais, A.2    Monteiro, L.3    le Bail, B.4    Bioulac Sage, P.5    Balabaud, C.6    Megraud, F.7
  • 62
    • 0035170630 scopus 로고    scopus 로고
    • Helicobacter species identified in liver from patients with cholangiocarcinoma and hepatocellular carcinoma
    • Nilsson, H.O.; Mulchandani, R.; Tranberg, K.G.; Stenram, U.; Wadstrom, T. Helicobacter species identified in liver from patients with cholangiocarcinoma and hepatocellular carcinoma. Gastroenterology 2001, 120, 323-324.
    • (2001) Gastroenterology , vol.120 , pp. 323-324
    • Nilsson, H.O.1    Mulchandani, R.2    Tranberg, K.G.3    Stenram, U.4    Wadstrom, T.5
  • 65
    • 0842283045 scopus 로고    scopus 로고
    • Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains
    • Fox, J.G.; Rogers, A.B.; Whary, M.T.; Ge, Z.; Taylor, N.S.; Xu, S.; Horwitz, B.H.; Erdman, S.E. Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains. Infect. Immun. 2004, 72, 1116-1125.
    • (2004) Infect. Immun , vol.72 , pp. 1116-1125
    • Fox, J.G.1    Rogers, A.B.2    Whary, M.T.3    Ge, Z.4    Taylor, N.S.5    Xu, S.6    Horwitz, B.H.7    Erdman, S.E.8
  • 67
    • 0034081113 scopus 로고    scopus 로고
    • Identification of cdtB homologues and cytolethal distending toxin activity in enterohepatic Helicobacter spp
    • Chien, C.C.; Taylor, N.S.; Ge, Z.; Schauer, D.B.; Young, V.B.; Fox, J.G. Identification of cdtB homologues and cytolethal distending toxin activity in enterohepatic Helicobacter spp. J. Med. Microbiol. 2000, 49, 525-534.
    • (2000) J. Med. Microbiol , vol.49 , pp. 525-534
    • Chien, C.C.1    Taylor, N.S.2    Ge, Z.3    Schauer, D.B.4    Young, V.B.5    Fox, J.G.6
  • 68
    • 19744378055 scopus 로고    scopus 로고
    • Cytolethal distending toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster mice
    • Ge, Z.; Feng, Y.; Whary, M.T.; Nambiar, P.R.; Xu, S.; Ng, V.; Taylor, N.S.; Fox, J.G. Cytolethal distending toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster mice. Infect. Immun. 2005, 73, 3559-3567.
    • (2005) Infect. Immun , vol.73 , pp. 3559-3567
    • Ge, Z.1    Feng, Y.2    Whary, M.T.3    Nambiar, P.R.4    Xu, S.5    Ng, V.6    Taylor, N.S.7    Fox, J.G.8
  • 70
    • 34447621233 scopus 로고    scopus 로고
    • Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis
    • Ge, Z.; Rogers, A.B.; Feng, Y.; Lee, A.; Xu, S.; Taylor, N.S.; Fox, J.G. Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis. Cell. Microbiol. 2007, 9, 2070-2080.
    • (2007) Cell. Microbiol , vol.9 , pp. 2070-2080
    • Ge, Z.1    Rogers, A.B.2    Feng, Y.3    Lee, A.4    Xu, S.5    Taylor, N.S.6    Fox, J.G.7
  • 71
    • 0028981507 scopus 로고
    • Chancroid and Haemophilus ducreyi: An update
    • Trees, D.L.; Morse, S.A. Chancroid and Haemophilus ducreyi: An update. Clin. Microbiol. Rev. 1995, 8, 357-375.
    • (1995) Clin. Microbiol. Rev , vol.8 , pp. 357-375
    • Trees, D.L.1    Morse, S.A.2
  • 72
    • 0030934532 scopus 로고    scopus 로고
    • Wound healing-aiming for perfect skin regeneration
    • Martin, P. Wound healing-aiming for perfect skin regeneration. Science 1997, 276, 75-81.
    • (1997) Science , vol.276 , pp. 75-81
    • Martin, P.1
  • 73
    • 2442595111 scopus 로고    scopus 로고
    • Understanding the role of immune regulation in wound healing
    • Park, J.E.; Barbul, A. Understanding the role of immune regulation in wound healing. Am. J. Surg. 2004,187, 11S-16S.
    • (2004) Am. J. Surg , vol.187
    • Park, J.E.1    Barbul, A.2
  • 74
    • 20444469533 scopus 로고    scopus 로고
    • The cytolethal distending toxin of Haemophilus ducreyi aggravates dermal lesions in a rabbit model of chancroid
    • Wising, C.; Molne, L.; Jonsson, I.M.; Ahlman, K.; Lagergard, T. The cytolethal distending toxin of Haemophilus ducreyi aggravates dermal lesions in a rabbit model of chancroid. Microb. Infect. 2005,7, 867-874.
    • (2005) Microb. Infect , vol.7 , pp. 867-874
    • Wising, C.1    Molne, L.2    Jonsson, I.M.3    Ahlman, K.4    Lagergard, T.5
  • 75
    • 11944254634 scopus 로고    scopus 로고
    • Cell cycle arrest of human gingival fibroblasts and periodontal ligament cells by Actinobacillus ctinomycetemcomitans: Involvement of the cytolethal distending toxin
    • Belibasakis, G.N.; Mattsson, A.; Wang, Y.; Chen, C.; Johansson, A. Cell cycle arrest of human gingival fibroblasts and periodontal ligament cells by Actinobacillus ctinomycetemcomitans: Involvement of the cytolethal distending toxin. APMIS 2004, 112, 674-685.
    • (2004) APMIS , vol.112 , pp. 674-685
    • Belibasakis, G.N.1    Mattsson, A.2    Wang, Y.3    Chen, C.4    Johansson, A.5
  • 76
    • 0036122043 scopus 로고    scopus 로고
    • The cytolethal distending toxin of Haemophilus ducreyi inhibits endothelial cell proliferation
    • Svensson, L.A.; Henning, P.; Lagergard, T. The cytolethal distending toxin of Haemophilus ducreyi inhibits endothelial cell proliferation. Infect. Immun. 2002, 70, 2665-2669.
    • (2002) Infect. Immun , vol.70 , pp. 2665-2669
    • Svensson, L.A.1    Henning, P.2    Lagergard, T.3
  • 77
    • 0034987923 scopus 로고    scopus 로고
    • The impact of Haemophilus ducreyi cytolethal distending toxin on cells involved in immune response
    • Svensson, L.; Tarkowski, A.; Thelestam, M.; Lagergård, T. The impact of Haemophilus ducreyi cytolethal distending toxin on cells involved in immune response. Microb. Pathog. 2001, 30, 157-166.
    • (2001) Microb. Pathog , vol.30 , pp. 157-166
    • Svensson, L.1    Tarkowski, A.2    Thelestam, M.3    Lagergård, T.4
  • 79
    • 77955745849 scopus 로고    scopus 로고
    • Aggregatibacter (Actinobacillus) actinomycetemcomitans: A triple A* periodontopathogen?
    • Henderson, B.; Ward, J.M.; Ready, D. Aggregatibacter (Actinobacillus) actinomycetemcomitans: A triple A* periodontopathogen? Periodontol 2000 2010, 54, 78-105.
    • (2010) Periodontol 2000 , vol.54 , pp. 78-105
    • Henderson, B.1    Ward, J.M.2    Ready, D.3
  • 80
    • 0037673945 scopus 로고    scopus 로고
    • Osteoclast differentiation and activation
    • Boyle, W.J.; Simonet, W.S.; Lacey, D.L. Osteoclast differentiation and activation. Nature 2003, 423, 337-342.
    • (2003) Nature , vol.423 , pp. 337-342
    • Boyle, W.J.1    Simonet, W.S.2    Lacey, D.L.3
  • 81
    • 11144339339 scopus 로고    scopus 로고
    • The cytolethal distending toxin induces receptor activator of NF-kB ligand expression in human gingival fibroblasts and periodontal ligament cells
    • Belibasakis, G.; Johansson, A.; Wang, Y.; Chen, C.; Kalfas, S.; Lerner, U.H. The cytolethal distending toxin induces receptor activator of NF-kB ligand expression in human gingival fibroblasts and periodontal ligament cells. Infect. Immun. 2005, 73, 342-351.
    • (2005) Infect. Immun , vol.73 , pp. 342-351
    • Belibasakis, G.1    Johansson, A.2    Wang, Y.3    Chen, C.4    Kalfas, S.5    Lerner, U.H.6
  • 82
    • 49649127399 scopus 로고    scopus 로고
    • Cytolethal distending toxin upregulates RANKL expression in Jurkat T-cells
    • Belibasakis, G.N.; Brage, M.; Lagergard, T.; Johansson, A. Cytolethal distending toxin upregulates RANKL expression in Jurkat T-cells. APMIS 2008, 116, 499-506.
    • (2008) APMIS , vol.116 , pp. 499-506
    • Belibasakis, G.N.1    Brage, M.2    Lagergard, T.3    Johansson, A.4
  • 83
    • 0034861059 scopus 로고    scopus 로고
    • Recombinant Actinobacillus actinomycetemcomitans cytolethal distending toxin proteins are required to interact to inhibit human cell cycle progression and to stimulate human leukocyte cytokine synthesis
    • Akifusa, S.; Poole, S.; Lewthwaite, J.; Henderson, B.; Nair, S.P. Recombinant Actinobacillus actinomycetemcomitans cytolethal distending toxin proteins are required to interact to inhibit human cell cycle progression and to stimulate human leukocyte cytokine synthesis. Infect. Immun. 2001, 69, 5925-5930.
    • (2001) Infect. Immun , vol.69 , pp. 5925-5930
    • Akifusa, S.1    Poole, S.2    Lewthwaite, J.3    Henderson, B.4    Nair, S.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.