Cytolethal distending toxin (CDT) is a radiomimetic agent and induces persistent levels of DNA double-strand breaks in human fibroblasts

DNA Repair

Volumn 18, Issue 1, 2014, Pages 31-43

  Fahrer, Jörg ^a   Huelsenbeck, Johannes ^a   Jaurich, Henriette ^a   Dörsam, Bastian ^a   Frisan, Teresa ^b   Eich, Marcus ^a   Roos, Wynand P ^a   Kaina, Bernd ^a   Fritz, Gerhard ^a,c  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b KAROLINSKA INSTITUTE   (Sweden)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Cytolethal distending toxin; DNA damage response; DNA double strand breaks; DNA repair; Gamma irradiation

Indexed keywords

CASPASE 3; CYTOLETHAL DISTENDING TOXIN; HISTONE H2AX; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PLASMID DNA; ATM PROTEIN; ATM PROTEIN, HUMAN; ATR PROTEIN, HUMAN; BACTERIAL TOXIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CHEK2 PROTEIN, HUMAN; H2AFX PROTEIN, HUMAN; HISTONE; PROTEIN KINASE; RECOMBINANT PROTEIN;

ARTICLE; CELL DEATH; COMET ASSAY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISEASE MARKER; DNA DAMAGE; DNA DAMAGE RESPONSE; DNA END JOINING REPAIR; DOUBLE STRANDED DNA BREAK; DYNAMICS; FIBROBLAST; HAEMOPHILUS DUCREYI; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IONIZING RADIATION; IRRADIATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; CELL LINE; COMPARATIVE STUDY; DRUG EFFECTS; GENETIC RECOMBINATION; GENETICS; METABOLISM; RADIATION RESPONSE; TIME;

MAMMALIA;

ATAXIA TELANGIECTASIA MUTATED PROTEINS; BACTERIAL TOXINS; CELL LINE; CHECKPOINT KINASE 2; DNA BREAKS, DOUBLE-STRANDED; DNA END-JOINING REPAIR; FIBROBLASTS; HISTONES; HUMANS; MICROSCOPY, CONFOCAL; PROTEIN KINASES; RADIATION, IONIZING; RECOMBINANT PROTEINS; RECOMBINATION, GENETIC; TIME;

EID: 84900342577     PISSN: 15687864     EISSN: 15687856     Source Type: Journal    
DOI: 10.1016/j.dnarep.2014.03.002     Document Type: Article

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