-
1
-
-
84925880097
-
2015 Alzheimer’s disease facts and figures
-
2015 Alzheimer’s disease facts and figures. Alzheimers Dement, 2015, 11, (3), 332-384.
-
(2015)
Alzheimers Dement
, vol.11
, Issue.3
, pp. 332-384
-
-
-
2
-
-
84872466223
-
Clinical impact of updated diagnostic and research criteria for Alzheimer’s disease
-
Reiman, E.M.; McKhann, G.M.; Albert, M.S.; Sperling, R.A.; Petersen, R.C.; Blacker, D., Clinical impact of updated diagnostic and research criteria for Alzheimer’s disease. J Clin Psychiatry, 2011, 72, (12), e37.
-
(2011)
J Clin Psychiatry
, vol.72
, Issue.12
-
-
Reiman, E.M.1
McKhann, G.M.2
Albert, M.S.3
Sperling, R.A.4
Petersen, R.C.5
Blacker, D.6
-
3
-
-
77949439549
-
Lethality of Alzheimer disease and its impact on nursing home placement
-
Arrighi, H.M.; Neumann, P.J.; Lieberburg, I.M.; Townsend, R.J., Lethality of Alzheimer disease and its impact on nursing home placement. Alzheimer Dis Assoc Disord, 2010, 24, (1), 90-95.
-
(2010)
Alzheimer Dis Assoc Disord
, vol.24
, Issue.1
, pp. 90-95
-
-
Arrighi, H.M.1
Neumann, P.J.2
Lieberburg, I.M.3
Townsend, R.J.4
-
4
-
-
84894482159
-
Mortality from Alzheimer’s disease in the United States: Data for 2000 and 2010
-
Tejada-Vera, B., Mortality from Alzheimer’s disease in the United States: data for 2000 and 2010. NCHS Data Brief, 2013, (116), 1-8.
-
(2013)
NCHS Data Brief
, Issue.116
, pp. 1-8
-
-
Tejada-Vera, B.1
-
5
-
-
18544384554
-
Alzheimer disease and mortality: A 15-year epidemiological study
-
Ganguli, M.; Dodge, H.H.; Shen, C.; Pandav, R.S.; DeKosky, S.T., Alzheimer disease and mortality: a 15-year epidemiological study. Arch Neurol, 2005, 62, (5), 779-784.
-
(2005)
Arch Neurol
, vol.62
, Issue.5
, pp. 779-784
-
-
Ganguli, M.1
Dodge, H.H.2
Shen, C.3
Pandav, R.S.4
Dekosky, S.T.5
-
6
-
-
33644979452
-
Survival among patients with dementia from a large multi-ethnic population
-
Waring, S.C.; Doody, R.S.; Pavlik, V.N.; Massman, P.J.; Chan, W., Survival among patients with dementia from a large multi-ethnic population. Alzheimer Dis Assoc Disord, 2005, 19, (4), 178-183.
-
(2005)
Alzheimer Dis Assoc Disord
, vol.19
, Issue.4
, pp. 178-183
-
-
Waring, S.C.1
Doody, R.S.2
Pavlik, V.N.3
Massman, P.J.4
Chan, W.5
-
7
-
-
0036847626
-
Survival following a diagnosis of Alzheimer disease
-
Brookmeyer, R.; Corrada, M.M.; Curriero, F.C.; Kawas, C., Survival following a diagnosis of Alzheimer disease. Arch Neurol, 2002, 59, (11), 1764-1767.
-
(2002)
Arch Neurol
, vol.59
, Issue.11
, pp. 1764-1767
-
-
Brookmeyer, R.1
Corrada, M.M.2
Curriero, F.C.3
Kawas, C.4
-
8
-
-
84960940008
-
Long-term Course of Alzheimer Disease in Patients Treated According to the Dutch Dementia Guideline at a Memory Clinic: A “Real-Life” Study
-
Droogsma, E.; van Asselt, D.; van Steijn, J.; Diekhuis, M.; Veeger, N.; De Deyn, P.P., Long-term Course of Alzheimer Disease in Patients Treated According to the Dutch Dementia Guideline at a Memory Clinic: A “Real-Life” Study. Alzheimer Dis Assoc Disord, 2015.
-
(2015)
Alzheimer Dis Assoc Disord
-
-
Droogsma, E.1
Van Asselt, D.2
Van Steijn, J.3
Diekhuis, M.4
Veeger, N.5
De Deyn, P.P.6
-
9
-
-
80755156409
-
Long-term progression of Alzheimer’s disease in patients under antidementia drugs
-
Gillette-Guyonnet, S.; Andrieu, S.; Nourhashemi, F.; Gardette, V.; Coley, N.; Cantet, C.; Gauthier, S.; Ousset, P.J.; Vellas, B.; Group, R.F.S., Long-term progression of Alzheimer’s disease in patients under antidementia drugs. Alzheimers Dement, 2011, 7, (6), 579-592.
-
(2011)
Alzheimers Dement
, vol.7
, Issue.6
, pp. 579-592
-
-
Gillette-Guyonnet, S.1
Andrieu, S.2
Nourhashemi, F.3
Gardette, V.4
Coley, N.5
Cantet, C.6
Gauthier, S.7
Ousset, P.J.8
Vellas, B.9
-
10
-
-
70350741346
-
Predictors of entering 24-h care for people with Alzheimer’s disease: Results from the LASER-AD study
-
Habermann, S.; Cooper, C.; Katona, C.; Livingston, G., Predictors of entering 24-h care for people with Alzheimer’s disease: results from the LASER-AD study. Int J Geriatr Psychiatry, 2009, 24, (11), 1291-1298.
-
(2009)
Int J Geriatr Psychiatry
, vol.24
, Issue.11
, pp. 1291-1298
-
-
Habermann, S.1
Cooper, C.2
Katona, C.3
Livingston, G.4
-
11
-
-
67651180986
-
The amyloid hypothesis for Alzheimer’s disease: A critical reappraisal
-
Hardy, J., The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal. J Neurochem, 2009, 110, (4), 1129-1134.
-
(2009)
J Neurochem
, vol.110
, Issue.4
, pp. 1129-1134
-
-
Hardy, J.1
-
12
-
-
77956057086
-
Murine models of Alzheimer’s disease and their use in developing immunotherapies
-
Wisniewski, T.; Sigurdsson, E.M., Murine models of Alzheimer’s disease and their use in developing immunotherapies. Biochim Biophys Acta, 2010, 1802, (10), 847-859.
-
(2010)
Biochim Biophys Acta
, vol.1802
, Issue.10
, pp. 847-859
-
-
Wisniewski, T.1
Sigurdsson, E.M.2
-
13
-
-
78649664226
-
Apolipoprotein E and central nervous system disorders: Reviews of clinical findings
-
Takeda, M.; Martinez, R.; Kudo, T.; Tanaka, T.; Okochi, M.; Tagami, S.; Morihara, T.; Hashimoto, R.; Cacabelos, R., Apolipoprotein E and central nervous system disorders: reviews of clinical findings. Psychiatry Clin Neurosci, 2010, 64, (6), 592-607.
-
(2010)
Psychiatry Clin Neurosci
, vol.64
, Issue.6
, pp. 592-607
-
-
Takeda, M.1
Martinez, R.2
Kudo, T.3
Tanaka, T.4
Okochi, M.5
Tagami, S.6
Morihara, T.7
Hashimoto, R.8
Cacabelos, R.9
-
14
-
-
84939773933
-
A genetic cause of Alzheimer disease: Mechanistic insights from Down syndrome
-
Wiseman, F.K.; Al-Janabi, T.; Hardy, J.; Karmiloff-Smith, A.; Nizetic, D.; Tybulewicz, V.L.; Fisher, E.M.; Strydom, A., A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome. Nat Rev Neurosci, 2015, 16, (9), 564-574.
-
(2015)
Nat Rev Neurosci
, vol.16
, Issue.9
, pp. 564-574
-
-
Wiseman, F.K.1
Al-Janabi, T.2
Hardy, J.3
Karmiloff-Smith, A.4
Nizetic, D.5
Tybulewicz, V.L.6
Fisher, E.M.7
Strydom, A.8
-
15
-
-
84889649093
-
A prospective 14-year longitudinal follow-up of dementia in persons with Down syndrome
-
McCarron, M.; McCallion, P.; Reilly, E.; Mulryan, N., A prospective 14-year longitudinal follow-up of dementia in persons with Down syndrome. J Intellect Disabil Res, 2014, 58, (1), 61-70.
-
(2014)
J Intellect Disabil Res
, vol.58
, Issue.1
, pp. 61-70
-
-
McCarron, M.1
McCallion, P.2
Reilly, E.3
Mulryan, N.4
-
16
-
-
18344371352
-
Incidence and temporal patterns of adaptive behavior change in adults with mental retardation
-
Zigman, W.B.; Schupf, N.; Urv, T.; Zigman, A.; Silverman, W., Incidence and temporal patterns of adaptive behavior change in adults with mental retardation. Am J Ment Retard, 2002, 107, (3), 161-174.
-
(2002)
Am J Ment Retard
, vol.107
, Issue.3
, pp. 161-174
-
-
Zigman, W.B.1
Schupf, N.2
Urv, T.3
Zigman, A.4
Silverman, W.5
-
17
-
-
34249293987
-
Abeta42 neurotoxicity in primary co-cultures: Effect of apoE isoform and Abeta conformation
-
Manelli, A.M.; Bulfinch, L.C.; Sullivan, P.M.; LaDu, M.J., Abeta42 neurotoxicity in primary co-cultures: effect of apoE isoform and Abeta conformation. Neurobiol Aging, 2007, 28, (8), 1139-1147.
-
(2007)
Neurobiol Aging
, vol.28
, Issue.8
, pp. 1139-1147
-
-
Manelli, A.M.1
Bulfinch, L.C.2
Sullivan, P.M.3
Ladu, M.J.4
-
18
-
-
84927606405
-
A novel brain-derived neurotrophic factor-modulating peptide attenuates Abeta1-42-induced neurotoxicity in vitro
-
Shin, M.K.; Kim, H.G.; Kim, K.L., A novel brain-derived neurotrophic factor-modulating peptide attenuates Abeta1-42-induced neurotoxicity in vitro. Neurosci Lett, 2015, 595, 63-68.
-
(2015)
Neurosci Lett
, vol.595
, pp. 63-68
-
-
Shin, M.K.1
Kim, H.G.2
Kim, K.L.3
-
19
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
-
Lambert, M.P.; Barlow, A.K.; Chromy, B.A.; Edwards, C.; Freed, R.; Liosatos, M.; Morgan, T.E.; Rozovsky, I.; Trommer, B.; Viola, K.L.; Wals, P.; Zhang, C.; Finch, C.E.; Krafft, G.A.; Klein, W.L., Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci U S A, 1998, 95, (11), 6448-6453.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, Issue.11
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
Edwards, C.4
Freed, R.5
Liosatos, M.6
Morgan, T.E.7
Rozovsky, I.8
Trommer, B.9
Viola, K.L.10
Wals, P.11
Zhang, C.12
Finch, C.E.13
Krafft, G.A.14
Klein, W.L.15
-
20
-
-
0035297712
-
Targeting small Abeta oligomers: The solution to an Alzheimer’s disease conundrum?
-
Klein, W.L.; Krafft, G.A.; Finch, C.E., Targeting small Abeta oligomers: the solution to an Alzheimer’s disease conundrum? Trends Neurosci, 2001, 24, (4), 219-224.
-
(2001)
Trends Neurosci
, vol.24
, Issue.4
, pp. 219-224
-
-
Klein, W.L.1
Krafft, G.A.2
Finch, C.E.3
-
21
-
-
0037135111
-
The amyloid hypothesis of Alzheimer’s disease: Progress and problems on the road to therapeutics
-
Hardy, J.; Selkoe, D.J., The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics. Science, 2002, 297, (5580), 353-356.
-
(2002)
Science
, vol.297
, Issue.5580
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
22
-
-
0036855661
-
Deciphering the genesis and fate of amyloid betaprotein yields novel therapies for Alzheimer disease
-
Selkoe, D.J., Deciphering the genesis and fate of amyloid betaprotein yields novel therapies for Alzheimer disease. J Clin Invest, 2002, 110, (10), 1375-1381.
-
(2002)
J Clin Invest
, vol.110
, Issue.10
, pp. 1375-1381
-
-
Selkoe, D.J.1
-
23
-
-
84912143249
-
The evolution of preclinical Alzheimer’s disease: Implications for prevention trials
-
Sperling, R.; Mormino, E.; Johnson, K., The evolution of preclinical Alzheimer’s disease: implications for prevention trials. Neuron, 2014, 84, (3), 608-622.
-
(2014)
Neuron
, vol.84
, Issue.3
, pp. 608-622
-
-
Sperling, R.1
Mormino, E.2
Johnson, K.3
-
24
-
-
84938349981
-
Anti-dementia medications: Current prescriptions in clinical practice and new agents in progress
-
Stella, F.; Radanovic, M.; Canineu, P.R.; de Paula, V.J.; Forlenza, O.V., Anti-dementia medications: current prescriptions in clinical practice and new agents in progress. Ther Adv Drug Saf, 2015, 6, (4), 151-165.
-
(2015)
Ther Adv Drug Saf
, vol.6
, Issue.4
, pp. 151-165
-
-
Stella, F.1
Radanovic, M.2
Canineu, P.R.3
De Paula, V.J.4
Forlenza, O.V.5
-
25
-
-
80051957021
-
Clinical practice with anti-dementia drugs: A revised (second) consensus statement from the British Association for Psychopharmacology
-
O’Brien, J.T.; Burns, A.; Group, B.A.P.D.C., Clinical practice with anti-dementia drugs: a revised (second) consensus statement from the British Association for Psychopharmacology. J Psychopharmacol, 2011, 25, (8), 997-1019.
-
(2011)
J Psychopharmacol
, vol.25
, Issue.8
, pp. 997-1019
-
-
O’Brien, J.T.1
Burns, A.2
-
26
-
-
84903947419
-
Alzheimer’s disease drug-development pipeline: Few candidates, frequent failures
-
Cummings, J.L.; Morstorf, T.; Zhong, K., Alzheimer’s disease drug-development pipeline: few candidates, frequent failures. Alzheimers Res Ther, 2014, 6, (4), 37.
-
(2014)
Alzheimers Res Ther
, vol.6
, Issue.4
, pp. 37
-
-
Cummings, J.L.1
Morstorf, T.2
Zhong, K.3
-
27
-
-
79951713725
-
Apolipoprotein E in Alzheimer’s disease and other neurological disorders
-
Verghese, P.B.; Castellano, J.M.; Holtzman, D.M., Apolipoprotein E in Alzheimer’s disease and other neurological disorders. Lancet Neurol, 2011, 10, (3), 241-252.
-
(2011)
Lancet Neurol
, vol.10
, Issue.3
, pp. 241-252
-
-
Verghese, P.B.1
Castellano, J.M.2
Holtzman, D.M.3
-
28
-
-
75149145165
-
Use of genetic variation as biomarkers for mild cognitive impairment and progression of mild cognitive impairment to dementia
-
Reitz, C.; Mayeux, R., Use of genetic variation as biomarkers for mild cognitive impairment and progression of mild cognitive impairment to dementia. J Alzheimers Dis, 2010, 19, (1), 229-251.
-
(2010)
J Alzheimers Dis
, vol.19
, Issue.1
, pp. 229-251
-
-
Reitz, C.1
Mayeux, R.2
-
29
-
-
79952812955
-
The effect of apolipoprotein E (ApoE) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in Alzheimer’s disease
-
Leoni, V., The effect of apolipoprotein E (ApoE) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in Alzheimer’s disease. Clin Chem Lab Med, 2011, 49, (3), 375-383.
-
(2011)
Clin Chem Lab Med
, vol.49
, Issue.3
, pp. 375-383
-
-
Leoni, V.1
-
30
-
-
0027194791
-
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families
-
Corder, E.H.; Saunders, A.M.; Strittmatter, W.J.; Schmechel, D.E.; Gaskell, P.C.; Small, G.W.; Roses, A.D.; Haines, J.L.; Pericak-Vance, M.A., Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science, 1993, 261, (5123), 921-923.
-
(1993)
Science
, vol.261
, Issue.5123
, pp. 921-923
-
-
Corder, E.H.1
Saunders, A.M.2
Strittmatter, W.J.3
Schmechel, D.E.4
Gaskell, P.C.5
Small, G.W.6
Roses, A.D.7
Haines, J.L.8
Pericak-Vance, M.A.9
-
31
-
-
2442419100
-
Apolipoprotein E epsilon4 count affects age at onset of Alzheimer disease, but not lifetime susceptibility: The Cache County Study
-
Khachaturian, A.S.; Corcoran, C.D.; Mayer, L.S.; Zandi, P.P.; Breitner, J.C., Apolipoprotein E epsilon4 count affects age at onset of Alzheimer disease, but not lifetime susceptibility: The Cache County Study. Arch Gen Psychiatry, 2004, 61, (5), 518-524.
-
(2004)
Arch Gen Psychiatry
, vol.61
, Issue.5
, pp. 518-524
-
-
Khachaturian, A.S.1
Corcoran, C.D.2
Mayer, L.S.3
Zandi, P.P.4
Breitner, J.C.5
-
32
-
-
0027327267
-
Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer’s disease
-
Saunders, A.M.; Strittmatter, W.J.; Schmechel, D.; George-Hyslop, P.H.; Pericak-Vance, M.A.; Joo, S.H.; Rosi, B.L.; Gusella, J.F.; Crapper-MacLachlan, D.R.; Alberts, M.J.; et al., Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer’s disease. Neurology, 1993, 43, (8), 1467-1472.
-
(1993)
Neurology
, vol.43
, Issue.8
, pp. 1467-1472
-
-
Saunders, A.M.1
Strittmatter, W.J.2
Schmechel, D.3
George-Hyslop, P.H.4
Pericak-Vance, M.A.5
Joo, S.H.6
Rosi, B.L.7
Gusella, J.F.8
Crapper-Maclachlan, D.R.9
Erts, M.J.10
-
33
-
-
0032450315
-
Risk of Alzheimer disease with the epsilon4 allele for apolipoprotein E in a population-based study of men aged 62-73 years
-
Breitner, J.C.; Jarvik, G.P.; Plassman, B.L.; Saunders, A.M.; Welsh, K.A., Risk of Alzheimer disease with the epsilon4 allele for apolipoprotein E in a population-based study of men aged 62-73 years. Alzheimer Dis Assoc Disord, 1998, 12, (1), 40-44.
-
(1998)
Alzheimer Dis Assoc Disord
, vol.12
, Issue.1
, pp. 40-44
-
-
Breitner, J.C.1
Jarvik, G.P.2
Plassman, B.L.3
Saunders, A.M.4
Welsh, K.A.5
-
34
-
-
0030823158
-
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium
-
Farrer, L.A.; Cupples, L.A.; Haines, J.L.; Hyman, B.; Kukull, W.A.; Mayeux, R.; Myers, R.H.; Pericak-Vance, M.A.; Risch, N.; van Duijn, C.M., Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA, 1997, 278, (16), 1349-1356.
-
(1997)
JAMA
, vol.278
, Issue.16
, pp. 1349-1356
-
-
Farrer, L.A.1
Cupples, L.A.2
Haines, J.L.3
Hyman, B.4
Kukull, W.A.5
Mayeux, R.6
Myers, R.H.7
Pericak-Vance, M.A.8
Risch, N.9
Van Duijn, C.M.10
-
35
-
-
43249124446
-
APOE epsilon 4 allele predicts faster cognitive decline in mild Alzheimer disease
-
Cosentino, S.; Scarmeas, N.; Helzner, E.; Glymour, M.M.; Brandt, J.; Albert, M.; Blacker, D.; Stern, Y., APOE epsilon 4 allele predicts faster cognitive decline in mild Alzheimer disease. Neurology, 2008, 70, (19 Pt 2), 1842-1849.
-
(2008)
Neurology
, vol.70
, Issue.19
, pp. 1842-1849
-
-
Cosentino, S.1
Scarmeas, N.2
Helzner, E.3
Glymour, M.M.4
Brandt, J.5
Albert, M.6
Blacker, D.7
Stern, Y.8
-
36
-
-
85027912655
-
Late-onset Alzheimer’s risk variants in memory decline, incident mild cognitive impairment, and Alzheimer’s disease
-
Carrasquillo, M.M.; Crook, J.E.; Pedraza, O.; Thomas, C.S.; Pankratz, V.S.; Allen, M.; Nguyen, T.; Malphrus, K.G.; Ma, L.; Bisceglio, G.D.; Roberts, R.O.; Lucas, J.A.; Smith, G.E.; Ivnik, R.J.; Machulda, M.M.; Graff-Radford, N.R.; Petersen, R.C.; Younkin, S.G.; Ertekin-Taner, N., Late-onset Alzheimer’s risk variants in memory decline, incident mild cognitive impairment, and Alzheimer’s disease. Neurobiol Aging, 2014.
-
(2014)
Neurobiol Aging
-
-
Carrasquillo, M.M.1
Crook, J.E.2
Pedraza, O.3
Thomas, C.S.4
Pankratz, V.S.5
Allen, M.6
Nguyen, T.7
Malphrus, K.G.8
Ma, L.9
Bisceglio, G.D.10
Roberts, R.O.11
Lucas, J.A.12
Smith, G.E.13
Ivnik, R.J.14
Machulda, M.M.15
Graff-Radford, N.R.16
Petersen, R.C.17
Younkin, S.G.18
Ertekin-Taner, N.19
-
37
-
-
0034575124
-
Apolipoprotein E: Far more than a lipid transport protein
-
Mahley, R.W.; Rall, S.C., Jr., Apolipoprotein E: far more than a lipid transport protein. Annu Rev Genomics Hum Genet, 2000, 1, 507-537.
-
(2000)
Annu Rev Genomics Hum Genet
, vol.1
, pp. 507-537
-
-
Mahley, R.W.1
Rall, S.C.2
-
38
-
-
0031970198
-
Nascent astrocyte particles differ from lipoproteins in CSF
-
LaDu, M.J.; Gilligan, S.M.; Lukens, J.R.; Cabana, V.G.; Reardon, C.A.; Van Eldik, L.J.; Holtzman, D.M., Nascent astrocyte particles differ from lipoproteins in CSF. J Neurochem, 1998, 70, (5), 2070-2081.
-
(1998)
J Neurochem
, vol.70
, Issue.5
, pp. 2070-2081
-
-
Ladu, M.J.1
Gilligan, S.M.2
Lukens, J.R.3
Cabana, V.G.4
Reardon, C.A.5
Van Eldik, L.J.6
Holtzman, D.M.7
-
39
-
-
0033968648
-
Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture
-
Michikawa, M.; Fan, Q.W.; Isobe, I.; Yanagisawa, K., Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture. J Neurochem, 2000, 74, (3), 1008-1016.
-
(2000)
J Neurochem
, vol.74
, Issue.3
, pp. 1008-1016
-
-
Michikawa, M.1
Fan, Q.W.2
Isobe, I.3
Yanagisawa, K.4
-
40
-
-
77953248905
-
Formation and function of apolipoprotein E-containing lipoproteins in the nervous system
-
Vance, J.E.; Hayashi, H., Formation and function of apolipoprotein E-containing lipoproteins in the nervous system. Biochim Biophys Acta, 2010, 1801, (8), 806-818.
-
(2010)
Biochim Biophys Acta
, vol.1801
, Issue.8
, pp. 806-818
-
-
Vance, J.E.1
Hayashi, H.2
-
41
-
-
0034017316
-
Lipoproteins in the central nervous system
-
LaDu, M.J.; Reardon, C.; Van Eldik, L.; Fagan, A.M.; Bu, G.; Holtzman, D.; Getz, G.S., Lipoproteins in the central nervous system. Ann N Y Acad Sci, 2000, 903, 167-175.
-
(2000)
Ann N Y Acad Sci
, vol.903
, pp. 167-175
-
-
Ladu, M.J.1
Reardon, C.2
Van Eldik, L.3
Fagan, A.M.4
Bu, G.5
Holtzman, D.6
Getz, G.S.7
-
42
-
-
84863029161
-
APOE genotype alters glial activation and loss of synaptic markers in mice
-
Zhu, Y.; Nwabuisi-Heath, E.; Dumanis, S.B.; Tai, L.M.; Yu, C.; Rebeck, G.W.; LaDu, M.J., APOE genotype alters glial activation and loss of synaptic markers in mice. Glia, 2012, 60, (4), 559-569.
-
(2012)
Glia
, vol.60
, Issue.4
, pp. 559-569
-
-
Zhu, Y.1
Nwabuisi-Heath, E.2
Dumanis, S.B.3
Tai, L.M.4
Yu, C.5
Rebeck, G.W.6
Ladu, M.J.7
-
43
-
-
84903743112
-
APOepsilon4 is associated with enhanced in vivo innate immune responses in human subjects
-
Gale, S.C.; Gao, L.; Mikacenic, C.; Coyle, S.M.; Rafaels, N.; Murray Dudenkov, T.; Madenspacher, J.H.; Draper, D.W.; Ge, W.; Aloor, J.J.; Azzam, K.M.; Lai, L.; Blackshear, P.J.; Calvano, S.E.; Barnes, K.C.; Lowry, S.F.; Corbett, S.; Wurfel, M.M.; Fessler, M.B., APOepsilon4 is associated with enhanced in vivo innate immune responses in human subjects. J Allergy Clin Immunol, 2014, 134, (1), 127-134.
-
(2014)
J Allergy Clin Immunol
, vol.134
, Issue.1
, pp. 127-134
-
-
Gale, S.C.1
Gao, L.2
Mikacenic, C.3
Coyle, S.M.4
Rafaels, N.5
Murray Dudenkov, T.6
Madenspacher, J.H.7
Draper, D.W.8
Ge, W.9
Aloor, J.J.10
Azzam, K.M.11
Lai, L.12
Blackshear, P.J.13
Calvano, S.E.14
Barnes, K.C.15
Lowry, S.F.16
Corbett, S.17
Wurfel, M.M.18
Fessler, M.B.19
-
44
-
-
84927594690
-
APOE-modulated Abeta-induced neuroinflammation in Alzheimer’s disease: Current landscape, novel data and future perspective
-
Tai, L.M.; Ghura, S.; Koster, K.P.; Liakaite, V.; Maienschein-Cline, M.; Kanabar, P.; Collins, N.; Ben-Aissa, M.; Lei, A.Z.; Bahroos, N.; Green, S.; Hendrickson, B.; Eldik, L.J.; LaDu, M.J., APOE-modulated Abeta-induced neuroinflammation in Alzheimer’s disease: current landscape, novel data and future perspective. J Neurochem, 2015.
-
(2015)
J Neurochem
-
-
Tai, L.M.1
Ghura, S.2
Koster, K.P.3
Liakaite, V.4
Maienschein-Cline, M.5
Kanabar, P.6
Collins, N.7
Ben-Aissa, M.8
Lei, A.Z.9
Bahroos, N.10
Green, S.11
Hendrickson, B.12
Eldik, L.J.13
Ladu, M.J.14
-
45
-
-
84855512984
-
Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer’s disease
-
Keene, C.D.; Cudaback, E.; Li, X.; Montine, K.S.; Montine, T.J., Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer’s disease. Curr Opin Neurobiol, 2011, 21, (6), 920-928.
-
(2011)
Curr Opin Neurobiol
, vol.21
, Issue.6
, pp. 920-928
-
-
Keene, C.D.1
Cudaback, E.2
Li, X.3
Montine, K.S.4
Montine, T.J.5
-
46
-
-
84930655847
-
Apolipoprotein E inhibits cerebrovascular pericyte mobility through a RhoA-mediated pathway
-
Casey, C.S.; Atagi, Y.; Yamazaki, Y.; Shinohara, M.; Tachibana, M.; Fu, Y.; Bu, G.; Kanekiyo, T., Apolipoprotein E inhibits cerebrovascular pericyte mobility through a RhoA-mediated pathway. J Biol Chem, 2015.
-
(2015)
J Biol Chem
-
-
Casey, C.S.1
Atagi, Y.2
Yamazaki, Y.3
Shinohara, M.4
Tachibana, M.5
Fu, Y.6
Bu, G.7
Kanekiyo, T.8
-
47
-
-
84920686030
-
Human apolipoprotein E varepsilon4 expression impairs cerebral vascularization and blood-brain barrier function in mice
-
Alata, W.; Ye, Y.; St-Amour, I.; Vandal, M.; Calon, F., Human apolipoprotein E varepsilon4 expression impairs cerebral vascularization and blood-brain barrier function in mice. J Cereb Blood Flow Metab, 2015, 35, (1), 86-94.
-
(2015)
J Cereb Blood Flow Metab
, vol.35
, Issue.1
, pp. 86-94
-
-
Alata, W.1
Ye, Y.2
St-Amour, I.3
Vandal, M.4
Calon, F.5
-
48
-
-
84929940501
-
ApoE-deficient promotes blood-brain barrier disruption in experimental autoimmune encephalomyelitis via alteration of MMP-9
-
Zheng, M.; Wei, J.; Tang, Y.; Yang, C.; Wei, Y.; Yin, X.; Liu, Q., ApoE-deficient promotes blood-brain barrier disruption in experimental autoimmune encephalomyelitis via alteration of MMP-9. J Mol Neurosci, 2014, 54, (2), 282-290.
-
(2014)
J Mol Neurosci
, vol.54
, Issue.2
, pp. 282-290
-
-
Zheng, M.1
Wei, J.2
Tang, Y.3
Yang, C.4
Wei, Y.5
Yin, X.6
Liu, Q.7
-
49
-
-
85010696724
-
Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease
-
Halliday, M.R.; Rege, S.V.; Ma, Q.; Zhao, Z.; Miller, C.A.; Winkler, E.A.; Zlokovic, B.V., Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease. J Cereb Blood Flow Metab, 2015.
-
(2015)
J Cereb Blood Flow Metab
-
-
Halliday, M.R.1
Rege, S.V.2
Ma, Q.3
Zhao, Z.4
Miller, C.A.5
Winkler, E.A.6
Zlokovic, B.V.7
-
50
-
-
84883796045
-
Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown
-
Halliday, M.R.; Pomara, N.; Sagare, A.P.; Mack, W.J.; Frangione, B.; Zlokovic, B.V., Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown. JAMA Neurol, 2013, 70, (9), 1198-1200.
-
(2013)
JAMA Neurol
, vol.70
, Issue.9
, pp. 1198-1200
-
-
Halliday, M.R.1
Pomara, N.2
Sagare, A.P.3
Mack, W.J.4
Frangione, B.5
Zlokovic, B.V.6
-
51
-
-
84883803181
-
Angiotensin converting enzyme inhibitors and the reduced risk of Alzheimer’s disease in the absence of apolipoprotein E4 allele
-
Qiu, W.Q.; Mwamburi, M.; Besser, L.M.; Zhu, H.; Li, H.; Wallack, M.; Phillips, L.; Qiao, L.; Budson, A.E.; Stern, R.; Kowall, N., Angiotensin converting enzyme inhibitors and the reduced risk of Alzheimer’s disease in the absence of apolipoprotein E4 allele. J Alzheimers Dis, 2013, 37, (2), 421-428.
-
(2013)
J Alzheimers Dis
, vol.37
, Issue.2
, pp. 421-428
-
-
Qiu, W.Q.1
Mwamburi, M.2
Besser, L.M.3
Zhu, H.4
Li, H.5
Wallack, M.6
Phillips, L.7
Qiao, L.8
Budson, A.E.9
Stern, R.10
Kowall, N.11
-
52
-
-
84862777153
-
Amyloid-related imaging abnormalities in patients with Alzheimer’s disease treated with bapineuzumab: A retrospective analysis
-
Sperling, R.; Salloway, S.; Brooks, D.J.; Tampieri, D.; Barakos, J.; Fox, N.C.; Raskind, M.; Sabbagh, M.; Honig, L.S.; Porsteinsson, A.P.; Lieberburg, I.; Arrighi, H.M.; Morris, K.A.; Lu, Y.; Liu, E.; Gregg, K.M.; Brashear, H.R.; Kinney, G.G.; Black, R.; Grundman, M., Amyloid-related imaging abnormalities in patients with Alzheimer’s disease treated with bapineuzumab: a retrospective analysis. Lancet Neurol, 2012, 11, (3), 241-249.
-
(2012)
Lancet Neurol
, vol.11
, Issue.3
, pp. 241-249
-
-
Sperling, R.1
Salloway, S.2
Brooks, D.J.3
Tampieri, D.4
Barakos, J.5
Fox, N.C.6
Raskind, M.7
Sabbagh, M.8
Honig, L.S.9
Porsteinsson, A.P.10
Lieberburg, I.11
Arrighi, H.M.12
Morris, K.A.13
Lu, Y.14
Liu, E.15
Gregg, K.M.16
Brashear, H.R.17
Kinney, G.G.18
Black, R.19
Grundman, M.20
more..
-
53
-
-
0031943549
-
Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer’s disease
-
Farlow, M.R.; Lahiri, D.K.; Poirier, J.; Davignon, J.; Schneider, L.; Hui, S.L., Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer’s disease. Neurology, 1998, 50, (3), 669-677.
-
(1998)
Neurology
, vol.50
, Issue.3
, pp. 669-677
-
-
Farlow, M.R.1
Lahiri, D.K.2
Poirier, J.3
Davignon, J.4
Schneider, L.5
Hui, S.L.6
-
54
-
-
33745266146
-
Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer’s disease
-
Risner, M.E.; Saunders, A.M.; Altman, J.F.; Ormandy, G.C.; Craft, S.; Foley, I.M.; Zvartau-Hind, M.E.; Hosford, D.A.; Roses, A.D., Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer’s disease. The pharmacogenomics journal, 2006, 6, (4), 246-254.
-
(2006)
The Pharmacogenomics Journal
, vol.6
, Issue.4
, pp. 246-254
-
-
Risner, M.E.1
Saunders, A.M.2
Altman, J.F.3
Ormandy, G.C.4
Craft, S.5
Foley, I.M.6
Zvartau-Hind, M.E.7
Hosford, D.A.8
Roses, A.D.9
-
55
-
-
84907970354
-
Effects of the Absence of Apolipoprotein E on Lipoproteins, Neurocognitive Function, and Retinal Function
-
Mak, A.C.; Pullinger, C.R.; Tang, L.F.; Wong, J.S.; Deo, R.C.; Schwarz, J.M.; Gugliucci, A.; Movsesyan, I.; Ishida, B.Y.; Chu, C.; Poon, A.; Kim, P.; Stock, E.O.; Schaefer, E.J.; Asztalos, B.F.; Castellano, J.M.; Wyss-Coray, T.; Duncan, J.L.; Miller, B.L.; Kane, J.P.; Kwok, P.Y.; Malloy, M.J., Effects of the Absence of Apolipoprotein E on Lipoproteins, Neurocognitive Function, and Retinal Function. JAMA Neurol, 2014.
-
(2014)
JAMA Neurol
-
-
Mak, A.C.1
Pullinger, C.R.2
Tang, L.F.3
Wong, J.S.4
Deo, R.C.5
Schwarz, J.M.6
Gugliucci, A.7
Movsesyan, I.8
Ishida, B.Y.9
Chu, C.10
Poon, A.11
Kim, P.12
Stock, E.O.13
Schaefer, E.J.14
Asztalos, B.F.15
Castellano, J.M.16
Wyss-Coray, T.17
Duncan, J.L.18
Miller, B.L.19
Kane, J.P.20
Kwok, P.Y.21
Malloy, M.J.22
more..
-
56
-
-
84928140855
-
Apolipoprotein E and neurocognitive function
-
Cullum, C.M.; Weiner, M.F., Apolipoprotein E and neurocognitive function. JAMA Neurol, 2015, 72, (4), 478.
-
(2015)
JAMA Neurol
, vol.72
, Issue.4
, pp. 478
-
-
Cullum, C.M.1
Weiner, M.F.2
-
57
-
-
84918589796
-
Congenital absence of apolipoprotein E and neurological function
-
Laskowitz, D.T.; Kernagis, D.N., Congenital absence of apolipoprotein E and neurological function. JAMA Neurol, 2014, 71, (12), 1578-1579.
-
(2014)
JAMA Neurol
, vol.71
, Issue.12
, pp. 1578-1579
-
-
Laskowitz, D.T.1
Kernagis, D.N.2
-
58
-
-
84907996982
-
Is apolipoprotein e required for cognitive function in humans?: Implications for Alzheimer drug development
-
Lane-Donovan, C.; Herz, J., Is apolipoprotein e required for cognitive function in humans?: implications for Alzheimer drug development. JAMA Neurol, 2014, 71, (10), 1213-1215.
-
(2014)
JAMA Neurol
, vol.71
, Issue.10
, pp. 1213-1215
-
-
Lane-Donovan, C.1
Herz, J.2
-
59
-
-
0026592806
-
Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
-
Zhang, S.H.; Reddick, R.L.; Piedrahita, J.A.; Maeda, N., Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science (New York, N.Y, 1992, 258, (5081), 468-471.
-
(1992)
Science (New York, N.Y
, vol.258
, Issue.5081
, pp. 468-471
-
-
Zhang, S.H.1
Reddick, R.L.2
Piedrahita, J.A.3
Maeda, N.4
-
60
-
-
79953291282
-
ApoE4-Driven Accumulation of Intraneuronal Oligomerized Abeta42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function
-
Zepa, L.; Frenkel, M.; Belinson, H.; Kariv-Inbal, Z.; Kayed, R.; Masliah, E.; Michaelson, D.M., ApoE4-Driven Accumulation of Intraneuronal Oligomerized Abeta42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function. Int J Alzheimers Dis, 2011, 2011, 792070.
-
(2011)
Int J Alzheimers Dis, 2011
-
-
Zepa, L.1
Frenkel, M.2
Belinson, H.3
Kariv-Inbal, Z.4
Kayed, R.5
Masliah, E.6
Michaelson, D.M.7
-
61
-
-
19944429503
-
ApoE isoform-specific effects on LTP: Blockade by oligomeric amyloid-beta1-42
-
Trommer, B.L.; Shah, C.; Yun, S.H.; Gamkrelidze, G.; Pasternak, E.S.; Stine, W.B.; Manelli, A.; Sullivan, P.; Pasternak, J.F.; LaDu, M.J., ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-beta1-42. Neurobiology of disease, 2005, 18, (1), 75-82.
-
(2005)
Neurobiology of Disease
, vol.18
, Issue.1
, pp. 75-82
-
-
Trommer, B.L.1
Shah, C.2
Yun, S.H.3
Gamkrelidze, G.4
Pasternak, E.S.5
Stine, W.B.6
Manelli, A.7
Sullivan, P.8
Pasternak, J.F.9
Ladu, M.J.10
-
62
-
-
77958023983
-
Apolipoprotein E4 causes age-and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice
-
Andrews-Zwilling, Y.; Bien-Ly, N.; Xu, Q.; Li, G.; Bernardo, A.; Yoon, S.Y.; Zwilling, D.; Yan, T.X.; Chen, L.; Huang, Y., Apolipoprotein E4 causes age-and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. J Neurosci, 2010, 30, (41), 13707-13717.
-
(2010)
J Neurosci
, vol.30
, Issue.41
, pp. 13707-13717
-
-
Andrews-Zwilling, Y.1
Bien-Ly, N.2
Xu, Q.3
Li, G.4
Bernardo, A.5
Yoon, S.Y.6
Zwilling, D.7
Yan, T.X.8
Chen, L.9
Huang, Y.10
-
63
-
-
79952760270
-
C-terminal-truncated apolipoprotein (Apo) E4 inefficiently clears amyloid-{beta} (A{beta}) and acts in concert with A{beta} to elicit neuronal and behavioral deficits in mice
-
Bien-Ly, N.; Andrews-Zwilling, Y.; Xu, Q.; Bernardo, A.; Wang, C.; Huang, Y., C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-{beta} (A{beta}) and acts in concert with A{beta} to elicit neuronal and behavioral deficits in mice. Proc Natl Acad Sci U S A, 2011, 108, (10), 4236-4241.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.10
, pp. 4236-4241
-
-
Bien-Ly, N.1
Andrews-Zwilling, Y.2
Xu, Q.3
Bernardo, A.4
Wang, C.5
Huang, Y.6
-
64
-
-
0037154858
-
Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein
-
Nathan, B.P.; Jiang, Y.; Wong, G.K.; Shen, F.; Brewer, G.J.; Struble, R.G., Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein. Brain Res, 2002, 928, (1-2), 96-105.
-
(2002)
Brain Res
, vol.928
, Issue.1-2
, pp. 96-105
-
-
Nathan, B.P.1
Jiang, Y.2
Wong, G.K.3
Shen, F.4
Brewer, G.J.5
Struble, R.G.6
-
65
-
-
48949099311
-
Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks
-
Bour, A.; Grootendorst, J.; Vogel, E.; Kelche, C.; Dodart, J.C.; Bales, K.; Moreau, P.H.; Sullivan, P.M.; Mathis, C., Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks. Behav Brain Res, 2008, 193, (2), 174-182.
-
(2008)
Behav Brain Res
, vol.193
, Issue.2
, pp. 174-182
-
-
Bour, A.1
Grootendorst, J.2
Vogel, E.3
Kelche, C.4
Dodart, J.C.5
Bales, K.6
Moreau, P.H.7
Sullivan, P.M.8
Mathis, C.9
-
66
-
-
15744378392
-
Human apoE targeted replacement mouse lines: H-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior
-
Grootendorst, J.; Bour, A.; Vogel, E.; Kelche, C.; Sullivan, P.M.; Dodart, J.C.; Bales, K.; Mathis, C., Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior. Behavioural Brain Research, 2005, 159, (1), 1-14.
-
(2005)
Behavioural Brain Research
, vol.159
, Issue.1
, pp. 1-14
-
-
Grootendorst, J.1
Bour, A.2
Vogel, E.3
Kelche, C.4
Sullivan, P.M.5
Dodart, J.C.6
Bales, K.7
Mathis, C.8
-
67
-
-
19944426892
-
In human targeted replacement mice
-
Trommer, B.L.; Shah, C.; Yun, S.H.; Gamkrelidze, G.; Pasternak, E.S.; Ye, G.L.; Sotak, M.; Sullivan, P.M.; Pasternak, J.F.; LaDu, M.J., ApoE isoform affects LTP in human targeted replacement mice. Neuroreport, 2004, 15, (17), 2655-2658.
-
(2004)
Neuroreport
, vol.15
, Issue.17
, pp. 2655-2658
-
-
Trommer, B.L.1
Shah, C.2
Yun, S.H.3
Gamkrelidze, G.4
Pasternak, E.S.5
Ye, G.L.6
Sotak, M.7
Sullivan, P.M.8
Pasternak, J.F.9
Ladu, M.J.10
Apoe Isoform Affects, L.11
-
68
-
-
0033593027
-
Is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer’s disease
-
Bales, K.R.; Verina, T.; Cummins, D.J.; Du, Y.; Dodel, R.C.; Saura, J.; Fishman, C.E.; DeLong, C.A.; Piccardo, P.; Petegnief, V.; Ghetti, B.; Paul, S.M., Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer’s disease. Proc Natl Acad Sci U S A, 1999, 96, (26), 15233-15238.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, Issue.26
, pp. 15233-15238
-
-
Bales, K.R.1
Verina, T.2
Cummins, D.J.3
Du, Y.4
Dodel, R.C.5
Saura, J.6
Fishman, C.E.7
Delong, C.A.8
Piccardo, P.9
Petegnief, V.10
Ghetti, B.11
Paul, S.M.12
Apolipoprotein, E.13
-
69
-
-
84871268485
-
APOE4-specific Changes in Abeta Accumulation in a New Transgenic Mouse Model of Alzheimer Disease
-
Youmans, K.L.; Tai, L.M.; Nwabuisi-Heath, E.; Jungbauer, L.; Kanekiyo, T.; Gan, M.; Kim, J.; Eimer, W.A.; Estus, S.; Rebeck, G.W.; Weeber, E.J.; Bu, G.; Yu, C.; Ladu, M.J., APOE4-specific Changes in Abeta Accumulation in a New Transgenic Mouse Model of Alzheimer Disease. J Biol Chem, 2012, 287, (50), 41774-41786.
-
(2012)
J Biol Chem
, vol.287
, Issue.50
, pp. 41774-41786
-
-
Youmans, K.L.1
Tai, L.M.2
Nwabuisi-Heath, E.3
Jungbauer, L.4
Kanekiyo, T.5
Gan, M.6
Kim, J.7
Eimer, W.A.8
Estus, S.9
Rebeck, G.W.10
Weeber, E.J.11
Bu, G.12
Yu, C.13
Ladu, M.J.14
-
70
-
-
84855263811
-
Introducing Human APOE into Abeta Transgenic Mouse Models
-
Tai, L.M.; Youmans, K.L.; Jungbauer, L.; Yu, C.; Ladu, M.J., Introducing Human APOE into Abeta Transgenic Mouse Models. Int J Alzheimers Dis, 2011, 2011, 810981.
-
(2011)
Int J Alzheimers Dis, 2011
-
-
Tai, L.M.1
Youmans, K.L.2
Jungbauer, L.3
Yu, C.4
Ladu, M.J.5
-
71
-
-
84861418194
-
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
-
Bell, R.D.; Winkler, E.A.; Singh, I.; Sagare, A.P.; Deane, R.; Wu, Z.; Holtzman, D.M.; Betsholtz, C.; Armulik, A.; Sallstrom, J.; Berk, B.C.; Zlokovic, B.V., Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature, 2012, 485, (7399), 512-516.
-
(2012)
Nature
, vol.485
, Issue.7399
, pp. 512-516
-
-
Bell, R.D.1
Winkler, E.A.2
Singh, I.3
Sagare, A.P.4
Deane, R.5
Wu, Z.6
Holtzman, D.M.7
Betsholtz, C.8
Armulik, A.9
Sallstrom, J.10
Berk, B.C.11
Zlokovic, B.V.12
-
72
-
-
84866415195
-
A multifaceted role for apoE in the clearance of beta-amyloid across the blood-brain barrier
-
Bachmeier, C.; Paris, D.; Beaulieu-Abdelahad, D.; Mouzon, B.; Mullan, M.; Crawford, F., A multifaceted role for apoE in the clearance of beta-amyloid across the blood-brain barrier. Neurodegener Dis, 2013, 11, (1), 13-21.
-
(2013)
Neurodegener Dis
, vol.11
, Issue.1
, pp. 13-21
-
-
Bachmeier, C.1
Paris, D.2
Beaulieu-Abdelahad, D.3
Mouzon, B.4
Mullan, M.5
Crawford, F.6
-
73
-
-
84910090956
-
Amyloid-beta Pathology and APOE Genotype Modulate Retinoid X Receptor Agonist Activity in Vivo
-
Tai, L.M.; Koster, K.P.; Luo, J.; Lee, S.H.; Wang, Y.T.; Collins, N.C.; Ben Aissa, M.; Thatcher, G.R.; LaDu, M.J., Amyloid-beta Pathology and APOE Genotype Modulate Retinoid X Receptor Agonist Activity in Vivo. J Biol Chem, 2014, 289, (44), 30538-30555.
-
(2014)
J Biol Chem
, vol.289
, Issue.44
, pp. 30538-30555
-
-
Tai, L.M.1
Koster, K.P.2
Luo, J.3
Lee, S.H.4
Wang, Y.T.5
Collins, N.C.6
Ben Aissa, M.7
Thatcher, G.R.8
Ladu, M.J.9
-
74
-
-
66149181776
-
Human APOE isoformdependent effects on brain beta-amyloid levels in PDAPP transgenic mice
-
Bales, K.R.; Liu, F.; Wu, S.; Lin, S.; Koger, D.; DeLong, C.; Hansen, J.C.; Sullivan, P.M.; Paul, S.M., Human APOE isoformdependent effects on brain beta-amyloid levels in PDAPP transgenic mice. The Journal of neuroscience, 2009, 29, (21), 6771-6779.
-
(2009)
The Journal of Neuroscience
, vol.29
, Issue.21
, pp. 6771-6779
-
-
Bales, K.R.1
Liu, F.2
Wu, S.3
Lin, S.4
Koger, D.5
Delong, C.6
Hansen, J.C.7
Sullivan, P.M.8
Paul, S.M.9
-
75
-
-
84927516421
-
APOE4 enhances agedependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice
-
Liu, D.S.; Pan, X.D.; Zhang, J.; Shen, H.; Collins, N.C.; Cole, A.M.; Koster, K.P.; Ben Aissa, M.; Dai, X.M.; Zhou, M.; Tai, L.M.; Zhu, Y.G.; LaDu, M.; Chen, X.C., APOE4 enhances agedependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice. Mol Neurodegener, 2015, 10, (1), 7.
-
(2015)
Mol Neurodegener
, vol.10
, Issue.1
, pp. 7
-
-
Liu, D.S.1
Pan, X.D.2
Zhang, J.3
Shen, H.4
Collins, N.C.5
Cole, A.M.6
Koster, K.P.7
Ben Aissa, M.8
Dai, X.M.9
Zhou, M.10
Tai, L.M.11
Zhu, Y.G.12
Ladu, M.13
Chen, X.C.14
-
76
-
-
84927175748
-
APOE epsilon4: The most prevalent yet understudied risk factor for Alzheimer’s disease
-
Michaelson, D.M., APOE epsilon4: The most prevalent yet understudied risk factor for Alzheimer’s disease. Alzheimers Dement, 2014, 10, (6), 861-868.
-
(2014)
Alzheimers Dement
, vol.10
, Issue.6
, pp. 861-868
-
-
Michaelson, D.M.1
-
77
-
-
0028092997
-
Human apolipoprotein E: Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms
-
Dong, L.M.; Wilson, C.; Wardell, M.R.; Simmons, T.; Mahley, R.W.; Weisgraber, K.H.; Agard, D.A., Human apolipoprotein E: Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms. J. Biol. Chem., 1994, 269, (35), 22358-22365.
-
(1994)
J. Biol. Chem.
, vol.269
, Issue.35
, pp. 22358-22365
-
-
Dong, L.M.1
Wilson, C.2
Wardell, M.R.3
Simmons, T.4
Mahley, R.W.5
Weisgraber, K.H.6
Agard, D.A.7
-
78
-
-
0029766916
-
Human apolipoprotein E4 domain interaction: Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins
-
Dong, L.M.; Weisgraber, K.H., Human apolipoprotein E4 domain interaction: Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins. J. Biol. Chem., 1996, 271, (32), 19053-19057.
-
(1996)
J. Biol. Chem.
, vol.271
, Issue.32
, pp. 19053-19057
-
-
Dong, L.M.1
Weisgraber, K.H.2
-
79
-
-
0025171570
-
Apolipoprotein E distribution among human plasma lipoproteins: Role of the cysteine-arginine interchange at residue 112
-
Weisgraber, K.H., Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112. J Lipid Res, 1990, 31, (8), 1503-1511.
-
(1990)
J Lipid Res
, vol.31
, Issue.8
, pp. 1503-1511
-
-
Weisgraber, K.H.1
-
80
-
-
77953280431
-
Proposed mechanism for lipoprotein remodelling in the brain
-
Yu, C.; Youmans, K.L.; LaDu, M.J., Proposed mechanism for lipoprotein remodelling in the brain. Biochim Biophys Acta, 2010, 1801, (8), 819-823.
-
(2010)
Biochim Biophys Acta
, vol.1801
, Issue.8
, pp. 819-823
-
-
Yu, C.1
Youmans, K.L.2
Ladu, M.J.3
-
81
-
-
84876297937
-
In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis
-
Ulrich, J.D.; Burchett, J.M.; Restivo, J.L.; Schuler, D.R.; Verghese, P.B.; Mahan, T.E.; Landreth, G.E.; Castellano, J.M.; Jiang, H.; Cirrito, J.R.; Holtzman, D.M., In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis. Mol Neurodegener, 2013, 8, 13.
-
(2013)
Mol Neurodegener
, vol.8
, pp. 13
-
-
Ulrich, J.D.1
Burchett, J.M.2
Restivo, J.L.3
Schuler, D.R.4
Verghese, P.B.5
Mahan, T.E.6
Landreth, G.E.7
Castellano, J.M.8
Jiang, H.9
Cirrito, J.R.10
Holtzman, D.M.11
-
82
-
-
84901022738
-
Reversal of apoE4-Driven Brain Pathology and Behavioral Deficits by Bexarotene
-
Boehm-Cagan, A.; Michaelson, D.M., Reversal of apoE4-Driven Brain Pathology and Behavioral Deficits by Bexarotene. J Neurosci, 2014, 34, (21), 7293-7301.
-
(2014)
J Neurosci
, vol.34
, Issue.21
, pp. 7293-7301
-
-
Boehm-Cagan, A.1
Michaelson, D.M.2
-
83
-
-
84891502796
-
Soluble apoE/Abeta complex: Mechanism and therapeutic target for APOE4-induced AD risk
-
Tai, L.M.; Mehra, S.; Shete, V.; Estus, S.; Rebeck, G.W.; Bu, G.; Ladu, M.J., Soluble apoE/Abeta complex: mechanism and therapeutic target for APOE4-induced AD risk. Mol Neurodegener, 2014, 9, (1), 2.
-
(2014)
Mol Neurodegener
, vol.9
, Issue.1
, pp. 2
-
-
Tai, L.M.1
Mehra, S.2
Shete, V.3
Estus, S.4
Rebeck, G.W.5
Bu, G.6
Ladu, M.J.7
-
84
-
-
84863115245
-
Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons
-
Chen, H.K.; Liu, Z.; Meyer-Franke, A.; Brodbeck, J.; Miranda, R.D.; McGuire, J.G.; Pleiss, M.A.; Ji, Z.S.; Balestra, M.E.; Walker, D.W.; Xu, Q.; Jeong, D.E.; Budamagunta, M.S.; Voss, J.C.; Freedman, S.B.; Weisgraber, K.H.; Huang, Y.; Mahley, R.W., Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons. J Biol Chem, 2012, 287, (8), 5253-5266.
-
(2012)
J Biol Chem
, vol.287
, Issue.8
, pp. 5253-5266
-
-
Chen, H.K.1
Liu, Z.2
Meyer-Franke, A.3
Brodbeck, J.4
Miranda, R.D.5
McGuire, J.G.6
Pleiss, M.A.7
Ji, Z.S.8
Balestra, M.E.9
Walker, D.W.10
Xu, Q.11
Jeong, D.E.12
Budamagunta, M.S.13
Voss, J.C.14
Freedman, S.B.15
Weisgraber, K.H.16
Huang, Y.17
Mahley, R.W.18
-
85
-
-
79955754372
-
Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by smallmolecule structure correctors
-
Brodbeck, J.; McGuire, J.; Liu, Z.; Meyer-Franke, A.; Balestra, M.E.; Jeong, D.E.; Pleiss, M.; McComas, C.; Hess, F.; Witter, D.; Peterson, S.; Childers, M.; Goulet, M.; Liverton, N.; Hargreaves, R.; Freedman, S.; Weisgraber, K.H.; Mahley, R.W.; Huang, Y., Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by smallmolecule structure correctors. J Biol Chem, 2011, 286, (19), 17217-17226.
-
(2011)
J Biol Chem
, vol.286
, Issue.19
, pp. 17217-17226
-
-
Brodbeck, J.1
McGuire, J.2
Liu, Z.3
Meyer-Franke, A.4
Balestra, M.E.5
Jeong, D.E.6
Pleiss, M.7
McComas, C.8
Hess, F.9
Witter, D.10
Peterson, S.11
Childers, M.12
Goulet, M.13
Liverton, N.14
Hargreaves, R.15
Freedman, S.16
Weisgraber, K.H.17
Mahley, R.W.18
Huang, Y.19
-
86
-
-
84871887566
-
Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Abeta amyloidosis
-
Kim, J.; Eltorai, A.E.; Jiang, H.; Liao, F.; Verghese, P.B.; Kim, J.; Stewart, F.R.; Basak, J.M.; Holtzman, D.M., Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Abeta amyloidosis. J Exp Med, 2012, 209, (12), 2149-2156.
-
(2012)
J Exp Med
, vol.209
, Issue.12
, pp. 2149-2156
-
-
Kim, J.1
Eltorai, A.E.2
Jiang, H.3
Liao, F.4
Verghese, P.B.5
Kim, J.6
Stewart, F.R.7
Basak, J.M.8
Holtzman, D.M.9
-
87
-
-
84901008874
-
Anti-ApoE antibody given after plaque onset decreases Abeta accumulation and improves brain function in a mouse model of Abeta amyloidosis
-
Liao, F.; Hori, Y.; Hudry, E.; Bauer, A.Q.; Jiang, H.; Mahan, T.E.; Lefton, K.B.; Zhang, T.J.; Dearborn, J.T.; Kim, J.; Culver, J.P.; Betensky, R.; Wozniak, D.F.; Hyman, B.T.; Holtzman, D.M., Anti-ApoE antibody given after plaque onset decreases Abeta accumulation and improves brain function in a mouse model of Abeta amyloidosis. J Neurosci, 2014, 34, (21), 7281-7292.
-
(2014)
J Neurosci
, vol.34
, Issue.21
, pp. 7281-7292
-
-
Liao, F.1
Hori, Y.2
Hudry, E.3
Bauer, A.Q.4
Jiang, H.5
Mahan, T.E.6
Lefton, K.B.7
Zhang, T.J.8
Dearborn, J.T.9
Kim, J.10
Culver, J.P.11
Betensky, R.12
Wozniak, D.F.13
Hyman, B.T.14
Holtzman, D.M.15
-
88
-
-
0019258988
-
Genetics of the apolipoprotein
-
Utermann, G.; Langenbeck, U.; Beisiegel, U.; Weber, W., Genetics of the apolipoprotein E system in man. Am J Hum Genet, 1980, 32, (3), 339-347.
-
(1980)
E System in Man. am J Hum Genet
, vol.32
, Issue.3
, pp. 339-347
-
-
Utermann, G.1
Langenbeck, U.2
Beisiegel, U.3
Weber, W.4
-
89
-
-
38049115446
-
Represents a potent gene-based therapeutic target for the treatment of sporadic Alzheimer’s disease
-
Poirier, J., Apolipoprotein E represents a potent gene-based therapeutic target for the treatment of sporadic Alzheimer’s disease. Alzheimers Dement, 2008, 4, (1 Suppl 1), S91-97.
-
(2008)
Alzheimers Dement
, vol.4
, Issue.1
, pp. S91-S97
-
-
Poirier, J.1
Apolipoprotein, E.2
-
90
-
-
84860217416
-
APOE-mimetic peptides reduce behavioral deficits, plaques and tangles in Alzheimer’s disease transgenics
-
Vitek, M.P.; Christensen, D.J.; Wilcock, D.; Davis, J.; Van Nostrand, W.E.; Li, F.Q.; Colton, C.A., APOE-mimetic peptides reduce behavioral deficits, plaques and tangles in Alzheimer’s disease transgenics. Neurodegener Dis, 2012, 10, (1-4), 122-126.
-
(2012)
Neurodegener Dis
, vol.10
, Issue.1-4
, pp. 122-126
-
-
Vitek, M.P.1
Christensen, D.J.2
Wilcock, D.3
Davis, J.4
Van Nostrand, W.E.5
Li, F.Q.6
Colton, C.A.7
-
91
-
-
78649338449
-
Traumatic brain injury exacerbates neurodegenerative pathology: Improvement with an apolipoprotein E-based therapeutic
-
Laskowitz, D.T.; Song, P.; Wang, H.; Mace, B.; Sullivan, P.M.; Vitek, M.P.; Dawson, H.N., Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic. J Neurotrauma, 2010, 27, (11), 1983-1995.
-
(2010)
J Neurotrauma
, vol.27
, Issue.11
, pp. 1983-1995
-
-
Laskowitz, D.T.1
Song, P.2
Wang, H.3
Mace, B.4
Sullivan, P.M.5
Vitek, M.P.6
Dawson, H.N.7
-
92
-
-
84862777666
-
ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models
-
Cramer, P.E.; Cirrito, J.R.; Wesson, D.W.; Lee, C.Y.; Karlo, J.C.; Zinn, A.E.; Casali, B.T.; Restivo, J.L.; Goebel, W.D.; James, M.J.; Brunden, K.R.; Wilson, D.A.; Landreth, G.E., ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models. Science, 2012, 335, (6075), 1503-1506.
-
(2012)
Science
, vol.335
, Issue.6075
, pp. 1503-1506
-
-
Cramer, P.E.1
Cirrito, J.R.2
Wesson, D.W.3
Lee, C.Y.4
Karlo, J.C.5
Zinn, A.E.6
Casali, B.T.7
Restivo, J.L.8
Goebel, W.D.9
James, M.J.10
Brunden, K.R.11
Wilson, D.A.12
Landreth, G.E.13
-
93
-
-
84928740328
-
Opposing effects of viral mediated brain expression of apolipoprotein E2 (ApoE2) and apoE4 on apoE lipidation and Abeta metabolism in apoE4-targeted replacement mice
-
Hu, J.; Liu, C.C.; Chen, X.F.; Zhang, Y.W.; Xu, H.; Bu, G., Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Abeta metabolism in apoE4-targeted replacement mice. Mol Neurodegener, 2015, 10, (1), 6.
-
(2015)
Mol Neurodegener
, vol.10
, Issue.1
, pp. 6
-
-
Hu, J.1
Liu, C.C.2
Chen, X.F.3
Zhang, Y.W.4
Xu, H.5
Bu, G.6
-
94
-
-
0037073670
-
Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels
-
Fukumoto, H.; Deng, A.; Irizarry, M.C.; Fitzgerald, M.L.; Rebeck, G.W., Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels. J Biol Chem, 2002, 277, (50), 48508-48513.
-
(2002)
J Biol Chem
, vol.277
, Issue.50
, pp. 48508-48513
-
-
Fukumoto, H.1
Deng, A.2
Irizarry, M.C.3
Fitzgerald, M.L.4
Rebeck, G.W.5
-
95
-
-
12244255799
-
ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer’s disease
-
Wollmer, M.A.; Streffer, J.R.; Lutjohann, D.; Tsolaki, M.; Iakovidou, V.; Hegi, T.; Pasch, T.; Jung, H.H.; Bergmann, K.; Nitsch, R.M.; Hock, C.; Papassotiropoulos, A., ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer’s disease. Neurobiol Aging, 2003, 24, (3), 421-426.
-
(2003)
Neurobiol Aging
, vol.24
, Issue.3
, pp. 421-426
-
-
Wollmer, M.A.1
Streffer, J.R.2
Lutjohann, D.3
Tsolaki, M.4
Iakovidou, V.5
Hegi, T.6
Pasch, T.7
Jung, H.H.8
Bergmann, K.9
Nitsch, R.M.10
Hock, C.11
Papassotiropoulos, A.12
-
96
-
-
0042346382
-
Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion
-
Sun, Y.; Yao, J.; Kim, T.W.; Tall, A.R., Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion. J Biol Chem, 2003, 278, (30), 27688-27694.
-
(2003)
J Biol Chem
, vol.278
, Issue.30
, pp. 27688-27694
-
-
Sun, Y.1
Yao, J.2
Kim, T.W.3
Tall, A.R.4
-
97
-
-
0037969631
-
22Rhydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion
-
Koldamova, R.P.; Lefterov, I.M.; Ikonomovic, M.D.; Skoko, J.; Lefterov, P.I.; Isanski, B.A.; DeKosky, S.T.; Lazo, J.S., 22Rhydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion. J Biol Chem, 2003, 278, (15), 13244-13256.
-
(2003)
J Biol Chem
, vol.278
, Issue.15
, pp. 13244-13256
-
-
Koldamova, R.P.1
Lefterov, I.M.2
Ikonomovic, M.D.3
Skoko, J.4
Lefterov, P.I.5
Isanski, B.A.6
Dekosky, S.T.7
Lazo, J.S.8
-
98
-
-
63849221643
-
Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function
-
Karasinska, J.M.; Rinninger, F.; Lutjohann, D.; Ruddle, P.; Franciosi, S.; Kruit, J.K.; Singaraja, R.R.; Hirsch-Reinshagen, V.; Fan, J.; Brunham, L.R.; Bissada, N.; Ramakrishnan, R.; Wellington, C.L.; Parks, J.S.; Hayden, M.R., Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function. J Neurosci, 2009, 29, (11), 3579-3589.
-
(2009)
J Neurosci
, vol.29
, Issue.11
, pp. 3579-3589
-
-
Karasinska, J.M.1
Rinninger, F.2
Lutjohann, D.3
Ruddle, P.4
Franciosi, S.5
Kruit, J.K.6
Singaraja, R.R.7
Hirsch-Reinshagen, V.8
Fan, J.9
Brunham, L.R.10
Bissada, N.11
Ramakrishnan, R.12
Wellington, C.L.13
Parks, J.S.14
Hayden, M.R.15
-
99
-
-
84909633153
-
ATP-binding cassette transporter A1: From metabolism to neurodegeneration
-
Koldamova, R.; Fitz, N.F.; Lefterov, I., ATP-binding cassette transporter A1: from metabolism to neurodegeneration. Neurobiol Dis, 2014, 72 Pt A, 13-21.
-
(2014)
Neurobiol Dis
, vol.72
, pp. 13-21
-
-
Koldamova, R.1
Fitz, N.F.2
Lefterov, I.3
-
100
-
-
30044438463
-
Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice
-
Koldamova, R.; Staufenbiel, M.; Lefterov, I., Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice. J Biol Chem, 2005, 280, (52), 43224-43235.
-
(2005)
J Biol Chem
, vol.280
, Issue.52
, pp. 43224-43235
-
-
Koldamova, R.1
Staufenbiel, M.2
Lefterov, I.3
-
101
-
-
70450125444
-
Memory deficits in APP23/Abca1+/-mice correlate with the level of Abeta oligomers
-
Lefterov, I.; Fitz, N.F.; Cronican, A.; Lefterov, P.; Staufenbiel, M.; Koldamova, R., Memory deficits in APP23/Abca1+/-mice correlate with the level of Abeta oligomers. ASN Neuro, 2009, 1, (2).
-
(2009)
ASN Neuro
, vol.1
, Issue.2
-
-
Lefterov, I.1
Fitz, N.F.2
Cronican, A.3
Lefterov, P.4
Staufenbiel, M.5
Koldamova, R.6
-
102
-
-
84866385962
-
Abca1 deficiency affects Alzheimer’s disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice
-
Fitz, N.F.; Cronican, A.A.; Saleem, M.; Fauq, A.H.; Chapman, R.; Lefterov, I.; Koldamova, R., Abca1 deficiency affects Alzheimer’s disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice. J Neurosci, 2012, 32, (38), 13125-13136.
-
(2012)
J Neurosci
, vol.32
, Issue.38
, pp. 13125-13136
-
-
Fitz, N.F.1
Cronican, A.A.2
Saleem, M.3
Fauq, A.H.4
Chapman, R.5
Lefterov, I.6
Koldamova, R.7
-
103
-
-
38849086036
-
Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease
-
Wahrle, S.E.; Jiang, H.; Parsadanian, M.; Kim, J.; Li, A.; Knoten, A.; Jain, S.; Hirsch-Reinshagen, V.; Wellington, C.L.; Bales, K.R.; Paul, S.M.; Holtzman, D.M., Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. J Clin Invest, 2008, 118, (2), 671-682.
-
(2008)
J Clin Invest
, vol.118
, Issue.2
, pp. 671-682
-
-
Wahrle, S.E.1
Jiang, H.2
Parsadanian, M.3
Kim, J.4
Li, A.5
Knoten, A.6
Jain, S.7
Hirsch-Reinshagen, V.8
Wellington, C.L.9
Bales, K.R.10
Paul, S.M.11
Holtzman, D.M.12
-
104
-
-
80051774038
-
Nuclear receptors as therapeutic targets for Alzheimer’s disease
-
Mandrekar-Colucci, S.; Landreth, G.E., Nuclear receptors as therapeutic targets for Alzheimer’s disease. Expert Opin Ther Targets, 2011, 15, (9), 1085-1097.
-
(2011)
Expert Opin Ther Targets
, vol.15
, Issue.9
, pp. 1085-1097
-
-
Mandrekar-Colucci, S.1
Landreth, G.E.2
-
105
-
-
0034623288
-
Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor
-
Costet, P.; Luo, Y.; Wang, N.; Tall, A.R., Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J Biol Chem, 2000, 275, (36), 28240-28245.
-
(2000)
J Biol Chem
, vol.275
, Issue.36
, pp. 28240-28245
-
-
Costet, P.1
Luo, Y.2
Wang, N.3
Tall, A.R.4
-
106
-
-
33645968692
-
Tangier disease four decades of research: A reflection of the importance of HDL
-
Kolovou, G.D.; Mikhailidis, D.P.; Anagnostopoulou, K.K.; Daskalopoulou, S.S.; Cokkinos, D.V., Tangier disease four decades of research: a reflection of the importance of HDL. Curr Med Chem, 2006, 13, (7), 771-782.
-
(2006)
Curr Med Chem
, vol.13
, Issue.7
, pp. 771-782
-
-
Kolovou, G.D.1
Mikhailidis, D.P.2
Anagnostopoulou, K.K.3
Daskalopoulou, S.S.4
Cokkinos, D.V.5
-
107
-
-
85010635376
-
ATP-binding cassette transporter A1 mediates the beneficial effects of the liver-X-receptor agonist GW3965 on object recognition memory and amyloid burden in APP/PS1 mice
-
Donkin, J.J.; Stukas, S.; Hirsch-Reinshagen, V.; Namjoshi, D.; Wilkinson, A.; May, S.; Chan, J.; Fan, J.; Collins, J.; Wellington, C.L., ATP-binding cassette transporter A1 mediates the beneficial effects of the liver-X-receptor agonist GW3965 on object recognition memory and amyloid burden in APP/PS1 mice. The Journal of biological chemistry.
-
The Journal of Biological Chemistry
-
-
Donkin, J.J.1
Stukas, S.2
Hirsch-Reinshagen, V.3
Namjoshi, D.4
Wilkinson, A.5
May, S.6
Chan, J.7
Fan, J.8
Collins, J.9
Wellington, C.L.10
-
108
-
-
14244255485
-
The Liver X Receptor Ligand T0901317 Decreases Amyloid {beta} Production in Vitro and in a Mouse Model of Alzheimer’s Disease
-
Koldamova, R.P.; Lefterov, I.M.; Staufenbiel, M.; Wolfe, D.; Huang, S.; Glorioso, J.C.; Walter, M.; Roth, M.G.; Lazo, J.S., The Liver X Receptor Ligand T0901317 Decreases Amyloid {beta} Production in Vitro and in a Mouse Model of Alzheimer’s Disease. J Biol Chem, 2005, 280, (6), 4079-4088.
-
(2005)
J Biol Chem
, vol.280
, Issue.6
, pp. 4079-4088
-
-
Koldamova, R.P.1
Lefterov, I.M.2
Staufenbiel, M.3
Wolfe, D.4
Huang, S.5
Glorioso, J.C.6
Walter, M.7
Roth, M.G.8
Lazo, J.S.9
-
109
-
-
34547531201
-
Attenuation of neuroinflammation and Alzheimer’s disease pathology by liver x receptors
-
Zelcer, N.; Khanlou, N.; Clare, R.; Jiang, Q.; Reed-Geaghan, E.G.; Landreth, G.E.; Vinters, H.V.; Tontonoz, P., Attenuation of neuroinflammation and Alzheimer’s disease pathology by liver x receptors. Proc Natl Acad Sci U S A, 2007, 104, (25), 10601-10606.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, Issue.25
, pp. 10601-10606
-
-
Zelcer, N.1
Khanlou, N.2
Clare, R.3
Jiang, Q.4
Reed-Geaghan, E.G.5
Landreth, G.E.6
Vinters, H.V.7
Tontonoz, P.8
-
110
-
-
84909635949
-
Nuclear receptors in neurodegenerative diseases
-
Skerrett, R.; Malm, T.; Landreth, G., Nuclear receptors in neurodegenerative diseases. Neurobiol Dis, 2014, 72PA, 104-116.
-
(2014)
Neurobiol Dis
, vol.72PA
, pp. 104-116
-
-
Skerrett, R.1
Malm, T.2
Landreth, G.3
-
111
-
-
0034651101
-
Inflammatory mechanisms in Alzheimer’s disease: Inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists
-
Combs, C.K.; Johnson, D.E.; Karlo, J.C.; Cannady, S.B.; Landreth, G.E., Inflammatory mechanisms in Alzheimer’s disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists. J Neurosci, 2000, 20, (2), 558-567.
-
(2000)
J Neurosci
, vol.20
, Issue.2
, pp. 558-567
-
-
Combs, C.K.1
Johnson, D.E.2
Karlo, J.C.3
Cannady, S.B.4
Landreth, G.E.5
-
112
-
-
0034813586
-
Regulation of beta-amyloid stimulated proinflammatory responses by peroxisome proliferator-activated receptor alpha
-
Combs, C.K.; Bates, P.; Karlo, J.C.; Landreth, G.E., Regulation of beta-amyloid stimulated proinflammatory responses by peroxisome proliferator-activated receptor alpha. Neurochem Int, 2001, 39, (5-6), 449-457.
-
(2001)
Neurochem Int
, vol.39
, Issue.5-6
, pp. 449-457
-
-
Combs, C.K.1
Bates, P.2
Karlo, J.C.3
Landreth, G.E.4
-
113
-
-
31044445398
-
Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma
-
Sastre, M.; Dewachter, I.; Rossner, S.; Bogdanovic, N.; Rosen, E.; Borghgraef, P.; Evert, B.O.; Dumitrescu-Ozimek, L.; Thal, D.R.; Landreth, G.; Walter, J.; Klockgether, T.; van Leuven, F.; Heneka, M.T., Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. Proc Natl Acad Sci U S A, 2006, 103, (2), 443-448.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.2
, pp. 443-448
-
-
Sastre, M.1
Dewachter, I.2
Rossner, S.3
Bogdanovic, N.4
Rosen, E.5
Borghgraef, P.6
Evert, B.O.7
Dumitrescu-Ozimek, L.8
Thal, D.R.9
Landreth, G.10
Walter, J.11
Klockgether, T.12
Van Leuven, F.13
Heneka, M.T.14
-
114
-
-
20444499367
-
Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice
-
Heneka, M.T.; Sastre, M.; Dumitrescu-Ozimek, L.; Hanke, A.; Dewachter, I.; Kuiperi, C.; O’Banion, K.; Klockgether, T.; Van Leuven, F.; Landreth, G.E., Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. Brain, 2005, 128, (Pt 6), 1442-1453.
-
(2005)
Brain
, vol.128
, pp. 1442-1453
-
-
Heneka, M.T.1
Sastre, M.2
Dumitrescu-Ozimek, L.3
Hanke, A.4
Dewachter, I.5
Kuiperi, C.6
O’Banion, K.7
Klockgether, T.8
Van Leuven, F.9
Landreth, G.E.10
-
115
-
-
33748755428
-
Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: Relevance to Alzheimer’s disease
-
de la Monte, S.M.; Tong, M.; Lester-Coll, N.; Plater, M., Jr.; Wands, J.R., Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer’s disease. J Alzheimers Dis, 2006, 10, (1), 89-109.
-
(2006)
J Alzheimers Dis
, vol.10
, Issue.1
, pp. 89-109
-
-
De La Monte, S.M.1
Tong, M.2
Lester-Coll, N.3
Plater, M.4
Wands, J.R.5
-
116
-
-
70249113348
-
A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer’s disease
-
Kalinin, S.; Richardson, J.C.; Feinstein, D.L., A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer’s disease. Curr Alzheimer Res, 2009, 6, (5), 431-437.
-
(2009)
Curr Alzheimer Res
, vol.6
, Issue.5
, pp. 431-437
-
-
Kalinin, S.1
Richardson, J.C.2
Feinstein, D.L.3
-
117
-
-
84877946097
-
Comment on “ApoE-Directed Therapeutics Rapidly Clear beta-Amyloid and Reverse Deficits in AD Mouse Models”
-
Veeraraghavalu, K.; Zhang, C.; Miller, S.; Hefendehl, J.K.; Rajapaksha, T.W.; Ulrich, J.; Jucker, M.; Holtzman, D.M.; Tanzi, R.E.; Vassar, R.; Sisodia, S.S., Comment on “ApoE-Directed Therapeutics Rapidly Clear beta-Amyloid and Reverse Deficits in AD Mouse Models”. Science, 2013, 340, (6135), 924.
-
(2013)
Science
, vol.340
, Issue.6135
, pp. 924
-
-
Veeraraghavalu, K.1
Zhang, C.2
Miller, S.3
Hefendehl, J.K.4
Rajapaksha, T.W.5
Ulrich, J.6
Jucker, M.7
Holtzman, D.M.8
Tanzi, R.E.9
Vassar, R.10
Sisodia, S.S.11
-
118
-
-
84877946097
-
Comment on “ApoE-Directed Therapeutics Rapidly Clear beta-Amyloid and Reverse Deficits in AD Mouse Models”
-
Tesseur, I.; Lo, A.C.; Roberfroid, A.; Dietvorst, S.; Van Broeck, B.; Borgers, M.; Gijsen, H.; Moechars, D.; Mercken, M.; Kemp, J.; D’Hooge, R.; De Strooper, B., Comment on “ApoE-Directed Therapeutics Rapidly Clear beta-Amyloid and Reverse Deficits in AD Mouse Models”. Science, 2013, 340, (6135), 924.
-
(2013)
Science
, vol.340
, Issue.6135
, pp. 924
-
-
Tesseur, I.1
Lo, A.C.2
Roberfroid, A.3
Dietvorst, S.4
Van Broeck, B.5
Borgers, M.6
Gijsen, H.7
Moechars, D.8
Mercken, M.9
Kemp, J.10
D’Hooge, R.11
De Strooper, B.12
-
119
-
-
84877946097
-
Comment on “ApoEDirected Therapeutics Rapidly Clear beta-Amyloid and Reverse Deficits in AD Mouse Models”
-
Price, A.R.; Xu, G.; Siemienski, Z.B.; Smithson, L.A.; Borchelt, D.R.; Golde, T.E.; Felsenstein, K.M., Comment on “ApoEDirected Therapeutics Rapidly Clear beta-Amyloid and Reverse Deficits in AD Mouse Models”. Science, 2013, 340, (6135), 924.
-
(2013)
Science
, vol.340
, Issue.6135
, pp. 924
-
-
Price, A.R.1
Xu, G.2
Siemienski, Z.B.3
Smithson, L.A.4
Borchelt, D.R.5
Golde, T.E.6
Felsenstein, K.M.7
-
120
-
-
84877946097
-
Comment on “ApoE-Directed Therapeutics Rapidly Clear beta-Amyloid and Reverse Deficits in AD Mouse Models”
-
Fitz, N.F.; Cronican, A.A.; Lefterov, I.; Koldamova, R., Comment on “ApoE-Directed Therapeutics Rapidly Clear beta-Amyloid and Reverse Deficits in AD Mouse Models”. Science, 2013, 340, (6135), 924.
-
(2013)
Science
, vol.340
, Issue.6135
, pp. 924
-
-
Fitz, N.F.1
Cronican, A.A.2
Lefterov, I.3
Koldamova, R.4
-
121
-
-
84929326823
-
Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer’s disease
-
Savage, J.C.; Jay, T.; Goduni, E.; Quigley, C.; Mariani, M.M.; Malm, T.; Ransohoff, R.M.; Lamb, B.T.; Landreth, G.E., Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer’s disease. J Neurosci, 2015, 35, (16), 6532-6543.
-
(2015)
J Neurosci
, vol.35
, Issue.16
, pp. 6532-6543
-
-
Savage, J.C.1
Jay, T.2
Goduni, E.3
Quigley, C.4
Mariani, M.M.5
Malm, T.6
Ransohoff, R.M.7
Lamb, B.T.8
Landreth, G.E.9
-
122
-
-
84878816554
-
Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice
-
LaClair, K.D.; Manaye, K.F.; Lee, D.L.; Allard, J.S.; Savonenko, A.V.; Troncoso, J.C.; Wong, P.C., Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice. Mol Neurodegener, 2013, 8, 18.
-
(2013)
Mol Neurodegener
, vol.8
, pp. 18
-
-
Laclair, K.D.1
Manaye, K.F.2
Lee, D.L.3
Allard, J.S.4
Savonenko, A.V.5
Troncoso, J.C.6
Wong, P.C.7
-
123
-
-
84951137466
-
Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1
-
Tachibana, M.; Shinohara, M.; Yamazaki, Y.; Liu, C.C.; Rogers, J.; Bu, G.; Kanekiyo, T., Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1. Exp Neurol, 2015, 277, 1-9.
-
(2015)
Exp Neurol
, vol.277
, pp. 1-9
-
-
Tachibana, M.1
Shinohara, M.2
Yamazaki, Y.3
Liu, C.C.4
Rogers, J.5
Bu, G.6
Kanekiyo, T.7
-
124
-
-
84940403770
-
Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity
-
Mounier, A.; Georgiev, D.; Nam, K.N.; Fitz, N.F.; Castranio, E.L.; Wolfe, C.M.; Cronican, A.A.; Schug, J.; Lefterov, I.; Koldamova, R., Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity. J Neurosci, 2015, 35, (34), 11862-11876.
-
(2015)
J Neurosci
, vol.35
, Issue.34
, pp. 11862-11876
-
-
Mounier, A.1
Georgiev, D.2
Nam, K.N.3
Fitz, N.F.4
Castranio, E.L.5
Wolfe, C.M.6
Cronican, A.A.7
Schug, J.8
Lefterov, I.9
Koldamova, R.10
-
125
-
-
84956952788
-
Double-blind, placebo-controlled, proof-of-concept trial of bexarotene Xin moderate Alzheimer’s disease
-
Cummings, J.L.; Zhong, K.; Kinney, J.W.; Heaney, C.; Moll-Tudla, J.; Joshi, A.; Pontecorvo, M.; Devous, M.; Tang, A.; Bena, J., Double-blind, placebo-controlled, proof-of-concept trial of bexarotene Xin moderate Alzheimer’s disease. Alzheimers Res Ther, 2016, 8, (1), 4.
-
(2016)
Alzheimers Res Ther
, vol.8
, Issue.1
, pp. 4
-
-
Cummings, J.L.1
Zhong, K.2
Kinney, J.W.3
Heaney, C.4
Moll-Tudla, J.5
Joshi, A.6
Pontecorvo, M.7
Devous, M.8
Tang, A.9
Bena, J.10
-
126
-
-
84901587804
-
Bexarotene nanocrystal-Oral and parenteral formulation development, characterization and pharmacokinetic evaluation
-
Chen, L.; Wang, Y.; Zhang, J.; Hao, L.; Guo, H.; Lou, H.; Zhang, D., Bexarotene nanocrystal-Oral and parenteral formulation development, characterization and pharmacokinetic evaluation. Eur J Pharm Biopharm, 2014, 87, (1), 160-169.
-
(2014)
Eur J Pharm Biopharm
, vol.87
, Issue.1
, pp. 160-169
-
-
Chen, L.1
Wang, Y.2
Zhang, J.3
Hao, L.4
Guo, H.5
Lou, H.6
Zhang, D.7
-
127
-
-
84877946097
-
Response to comments on “ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models”
-
Landreth, G.E.; Cramer, P.E.; Lakner, M.M.; Cirrito, J.R.; Wesson, D.W.; Brunden, K.R.; Wilson, D.A., Response to comments on “ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models”. Science, 2013, 340, (6135), 924-g.
-
(2013)
Science
, vol.340
, Issue.6135
, pp. 924
-
-
Landreth, G.E.1
Cramer, P.E.2
Lakner, M.M.3
Cirrito, J.R.4
Wesson, D.W.5
Brunden, K.R.6
Wilson, D.A.7
-
128
-
-
0034999546
-
Worldwide Bexarotene Study, G., Phase 2 and 3 clinical trial of oral bexarotene (Targretin capsules) for the treatment of refractory or persistent early-stage cutaneous T-cell lymphoma
-
Duvic, M.; Martin, A.G.; Kim, Y.; Olsen, E.; Wood, G.S.; Crowley, C.A.; Yocum, R.C.; Worldwide Bexarotene Study, G., Phase 2 and 3 clinical trial of oral bexarotene (Targretin capsules) for the treatment of refractory or persistent early-stage cutaneous T-cell lymphoma. Arch Dermatol, 2001, 137, (5), 581-593.
-
(2001)
Arch Dermatol
, vol.137
, Issue.5
, pp. 581-593
-
-
Duvic, M.1
Martin, A.G.2
Kim, Y.3
Olsen, E.4
Wood, G.S.5
Crowley, C.A.6
Yocum, R.C.7
-
129
-
-
0031024325
-
Initial clinical trial of a selective retinoid X receptor ligand, LGD1069
-
Miller, V.A.; Benedetti, F.M.; Rigas, J.R.; Verret, A.L.; Pfister, D.G.; Straus, D.; Kris, M.G.; Crisp, M.; Heyman, R.; Loewen, G.R.; Truglia, J.A.; Warrell, R.P., Jr., Initial clinical trial of a selective retinoid X receptor ligand, LGD1069. J Clin Oncol, 1997, 15, (2), 790-795.
-
(1997)
J Clin Oncol
, vol.15
, Issue.2
, pp. 790-795
-
-
Miller, V.A.1
Benedetti, F.M.2
Rigas, J.R.3
Verret, A.L.4
Pfister, D.G.5
Straus, D.6
Kris, M.G.7
Crisp, M.8
Heyman, R.9
Loewen, G.R.10
Truglia, J.A.11
Warrell, R.P.12
-
130
-
-
0034231629
-
Bexarotene
-
discussion 251-242
-
Lowe, M.N.; Plosker, G.L., Bexarotene. Am J Clin Dermatol, 2000, 1, (4), 245-250; discussion 251-242.
-
(2000)
Am J Clin Dermatol
, vol.1
, Issue.4
, pp. 245-250
-
-
Lowe, M.N.1
Plosker, G.L.2
-
131
-
-
33749151707
-
Treatment of cutaneous T-cell lymphoma with retinoids
-
Zhang, C.; Duvic, M., Treatment of cutaneous T-cell lymphoma with retinoids. Dermatol Ther, 2006, 19, (5), 264-271.
-
(2006)
Dermatol Ther
, vol.19
, Issue.5
, pp. 264-271
-
-
Zhang, C.1
Duvic, M.2
-
132
-
-
83255176681
-
The retinoid X receptors and their ligands
-
Dawson, M.I.; Xia, Z., The retinoid X receptors and their ligands. Biochim Biophys Acta, 2012, 1821, (1), 21-56.
-
(2012)
Biochim Biophys Acta
, vol.1821
, Issue.1
, pp. 21-56
-
-
Dawson, M.I.1
Xia, Z.2
-
133
-
-
84887444110
-
Thyroid dysfunction as an unintended side effect of anticancer drugs
-
Torino, F.; Barnabei, A.; Paragliola, R.; Baldelli, R.; Appetecchia, M.; Corsello, S.M., Thyroid dysfunction as an unintended side effect of anticancer drugs. Thyroid, 2013, 23, (11), 1345-1366.
-
(2013)
Thyroid
, vol.23
, Issue.11
, pp. 1345-1366
-
-
Torino, F.1
Barnabei, A.2
Paragliola, R.3
Baldelli, R.4
Appetecchia, M.5
Corsello, S.M.6
-
134
-
-
0035340844
-
Bexarotene Worldwide Study, G., Bexarotene is effective and safe for treatment of refractory advanced-stage cutaneous T-cell lymphoma: Multinational phase II-III trial results
-
Duvic, M.; Hymes, K.; Heald, P.; Breneman, D.; Martin, A.G.; Myskowski, P.; Crowley, C.; Yocum, R.C.; Bexarotene Worldwide Study, G., Bexarotene is effective and safe for treatment of refractory advanced-stage cutaneous T-cell lymphoma: multinational phase II-III trial results. J Clin Oncol, 2001, 19, (9), 2456-2471.
-
(2001)
J Clin Oncol
, vol.19
, Issue.9
, pp. 2456-2471
-
-
Duvic, M.1
Hymes, K.2
Heald, P.3
Breneman, D.4
Martin, A.G.5
Myskowski, P.6
Crowley, C.7
Yocum, R.C.8
-
135
-
-
84897147399
-
Nuclear Receptors, RXR, and the Big Bang
-
Evans, R.M.; Mangelsdorf, D.J., Nuclear Receptors, RXR, and the Big Bang. Cell, 2014, 157, (1), 255-266.
-
(2014)
Cell
, vol.157
, Issue.1
, pp. 255-266
-
-
Evans, R.M.1
Mangelsdorf, D.J.2
-
136
-
-
84896717143
-
Relationships between diabetes and cognitive impairment
-
de la Monte, S.M., Relationships between diabetes and cognitive impairment. Endocrinol Metab Clin North Am, 2014, 43, (1), 245-267.
-
(2014)
Endocrinol Metab Clin North Am
, vol.43
, Issue.1
, pp. 245-267
-
-
De La Monte, S.M.1
-
137
-
-
27944445780
-
Neurological and neuropsychiatric syndromes associated with liver disease
-
Weissenborn, K.; Bokemeyer, M.; Krause, J.; Ennen, J.; Ahl, B., Neurological and neuropsychiatric syndromes associated with liver disease. AIDS, 2005, 19 Suppl 3, S93-98.
-
(2005)
AIDS
, vol.19
, pp. S93-S98
-
-
Weissenborn, K.1
Bokemeyer, M.2
Krause, J.3
Ennen, J.4
Ahl, B.5
-
138
-
-
0041876276
-
The neurology of liver failure
-
Lewis, M.; Howdle, P.D., The neurology of liver failure. QJM, 2003, 96, (9), 623-633.
-
(2003)
QJM
, vol.96
, Issue.9
, pp. 623-633
-
-
Lewis, M.1
Howdle, P.D.2
-
139
-
-
84946473585
-
Circulating Biomarker Panels in Alzheimer’s Disease
-
Zafari, S.; Backes, C.; Meese, E.; Keller, A., Circulating Biomarker Panels in Alzheimer’s Disease. Gerontology, 2015, 61, (6), 497-503.
-
(2015)
Gerontology
, vol.61
, Issue.6
, pp. 497-503
-
-
Zafari, S.1
Backes, C.2
Meese, E.3
Keller, A.4
-
140
-
-
77949423619
-
Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
-
Blennow, K.; Hampel, H.; Weiner, M.; Zetterberg, H., Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nat Rev Neurol, 2010, 6, (3), 131-144.
-
(2010)
Nat Rev Neurol
, vol.6
, Issue.3
, pp. 131-144
-
-
Blennow, K.1
Hampel, H.2
Weiner, M.3
Zetterberg, H.4
-
141
-
-
84936929218
-
MicroRNA-Based Biomarkers and the Diagnosis of Alzheimer’s Disease
-
Zhao, Y.; Bhattacharjee, S.; Dua, P.; Alexandrov, P.N.; Lukiw, W.J., MicroRNA-Based Biomarkers and the Diagnosis of Alzheimer’s Disease. Front Neurol, 2015, 6, 162.
-
(2015)
Front Neurol
, vol.6
, pp. 162
-
-
Zhao, Y.1
Bhattacharjee, S.2
Dua, P.3
Alexandrov, P.N.4
Lukiw, W.J.5
-
142
-
-
84940703438
-
Combined Liver X Receptor/Peroxisome Proliferator-activated Receptor gamma Agonist Treatment Reduces Amyloid beta Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 Mice
-
Skerrett, R.; Pellegrino, M.P.; Casali, B.T.; Taraboanta, L.; Landreth, G.E., Combined Liver X Receptor/Peroxisome Proliferator-activated Receptor gamma Agonist Treatment Reduces Amyloid beta Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 Mice. J Biol Chem, 2015, 290, (35), 21591-21602.
-
(2015)
J Biol Chem
, vol.290
, Issue.35
, pp. 21591-21602
-
-
Skerrett, R.1
Pellegrino, M.P.2
Casali, B.T.3
Taraboanta, L.4
Landreth, G.E.5
-
143
-
-
84931316307
-
Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer’s Disease
-
Casali, B.T.; Corona, A.W.; Mariani, M.M.; Karlo, J.C.; Ghosal, K.; Landreth, G.E., Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer’s Disease. J Neurosci, 2015, 35, (24), 9173-9181.
-
(2015)
J Neurosci
, vol.35
, Issue.24
, pp. 9173-9181
-
-
Casali, B.T.1
Corona, A.W.2
Mariani, M.M.3
Karlo, J.C.4
Ghosal, K.5
Landreth, G.E.6
-
144
-
-
35148833056
-
Panning for SNuRMs: Using cofactor profiling for the rational discovery of selective nuclear receptor modulators
-
Kremoser, C.; Albers, M.; Burris, T.P.; Deuschle, U.; Koegl, M., Panning for SNuRMs: using cofactor profiling for the rational discovery of selective nuclear receptor modulators. Drug Discov Today, 2007, 12, (19-20), 860-869.
-
(2007)
Drug Discov Today
, vol.12
, Issue.19-20
, pp. 860-869
-
-
Kremoser, C.1
Albers, M.2
Burris, T.P.3
Deuschle, U.4
Koegl, M.5
-
145
-
-
84991365057
-
Analysis of differential secondary effects of novel rexinoids: Select rexinoid X receptor ligands demonstrate differentiated side effect profiles
-
Marshall, P.A.; Jurutka, P.W.; Wagner, C.E.; van der Vaart, A.; Kaneko, I.; Chavez, P.I.; Ma, N.; Bhogal, J.S.; Shahani, P.; Swierski, J.C.; MacNeill, M., Analysis of differential secondary effects of novel rexinoids: select rexinoid X receptor ligands demonstrate differentiated side effect profiles. Pharmacol Res Perspect, 2015, 3, (2), e00122.
-
(2015)
Pharmacol Res Perspect
, vol.3
, Issue.2
, pp. e00122
-
-
Marshall, P.A.1
Jurutka, P.W.2
Wagner, C.E.3
Van Der Vaart, A.4
Kaneko, I.5
Chavez, P.I.6
Ma, N.7
Bhogal, J.S.8
Shahani, P.9
Swierski, J.C.10
Macneill, M.11
-
146
-
-
83255192155
-
Modulation of RXR function through ligand design
-
Perez, E.; Bourguet, W.; Gronemeyer, H.; de Lera, A.R., Modulation of RXR function through ligand design. Biochim Biophys Acta, 2012, 1821, (1), 57-69.
-
(2012)
Biochim Biophys Acta
, vol.1821
, Issue.1
, pp. 57-69
-
-
Perez, E.1
Bourguet, W.2
Gronemeyer, H.3
De Lera, A.R.4
-
147
-
-
84867928062
-
Advances in drug design with RXR modulators
-
Vaz, B.; de Lera, A.R., Advances in drug design with RXR modulators. Expert Opin Drug Discov, 2012, 7, (11), 1003-1016.
-
(2012)
Expert Opin Drug Discov
, vol.7
, Issue.11
, pp. 1003-1016
-
-
Vaz, B.1
De Lera, A.R.2
-
148
-
-
84941985441
-
Novel Apo E-Derived ABCA1 Agonist Peptide (CS-6253) Promotes Reverse Cholesterol Transport and Induces Formation of prebeta-1 HDL In Vitro
-
Hafiane, A.; Bielicki, J.K.; Johansson, J.O.; Genest, J., Novel Apo E-Derived ABCA1 Agonist Peptide (CS-6253) Promotes Reverse Cholesterol Transport and Induces Formation of prebeta-1 HDL In Vitro. PLoS One, 2015, 10, (7), e0131997.
-
(2015)
Plos One
, vol.10
, Issue.7
-
-
Hafiane, A.1
Bielicki, J.K.2
Johansson, J.O.3
Genest, J.4
-
149
-
-
33745751979
-
Apolipoprotein E-derived peptides reduce CNS inflammation: Implications for therapy of neurological disease
-
Laskowitz, D.T.; Fillit, H.; Yeung, N.; Toku, K.; Vitek, M.P., Apolipoprotein E-derived peptides reduce CNS inflammation: implications for therapy of neurological disease. Acta Neurol Scand Suppl, 2006, 185, 15-20.
-
(2006)
Acta Neurol Scand Suppl
, vol.185
, pp. 15-20
-
-
Laskowitz, D.T.1
Fillit, H.2
Yeung, N.3
Toku, K.4
Vitek, M.P.5
-
150
-
-
33644592598
-
Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: A preliminary study
-
Watson, G.S.; Cholerton, B.A.; Reger, M.A.; Baker, L.D.; Plymate, S.R.; Asthana, S.; Fishel, M.A.; Kulstad, J.J.; Green, P.S.; Cook, D.G.; Kahn, S.E.; Keeling, M.L.; Craft, S., Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study. The American journal of geriatric psychiatry, 2005, 13, (11), 950-958.
-
(2005)
The American Journal of Geriatric Psychiatry
, vol.13
, Issue.11
, pp. 950-958
-
-
Watson, G.S.1
Cholerton, B.A.2
Reger, M.A.3
Baker, L.D.4
Plymate, S.R.5
Asthana, S.6
Fishel, M.A.7
Kulstad, J.J.8
Green, P.S.9
Cook, D.G.10
Kahn, S.E.11
Keeling, M.L.12
Craft, S.13
-
151
-
-
79959479102
-
Efficacy of PPAR-gamma agonist pioglitazone in mild Alzheimer disease
-
Sato, T.; Hanyu, H.; Hirao, K.; Kanetaka, H.; Sakurai, H.; Iwamoto, T., Efficacy of PPAR-gamma agonist pioglitazone in mild Alzheimer disease. Neurobiol Aging, 2011, 32, (9), 1626-1633.
-
(2011)
Neurobiol Aging
, vol.32
, Issue.9
, pp. 1626-1633
-
-
Sato, T.1
Hanyu, H.2
Hirao, K.3
Kanetaka, H.4
Sakurai, H.5
Iwamoto, T.6
-
152
-
-
84878791042
-
Concurrent activation of liver X receptor and peroxisome proliferator-activated receptor alpha exacerbates hepatic steatosis in high fat diet-induced obese mice
-
Gao, M.; Bu, L.; Ma, Y.; Liu, D., Concurrent activation of liver X receptor and peroxisome proliferator-activated receptor alpha exacerbates hepatic steatosis in high fat diet-induced obese mice. PLoS One, 2013, 8, (6), e65641.
-
(2013)
Plos One
, vol.8
, Issue.6
-
-
Gao, M.1
Bu, L.2
Ma, Y.3
Liu, D.4
-
153
-
-
84901937811
-
Liver X receptors in lipid metabolism: Opportunities for drug discovery
-
Hong, C.; Tontonoz, P., Liver X receptors in lipid metabolism: opportunities for drug discovery. Nat Rev Drug Discov, 2014, 13, (6), 433-444.
-
(2014)
Nat Rev Drug Discov
, vol.13
, Issue.6
, pp. 433-444
-
-
Hong, C.1
Tontonoz, P.2
-
154
-
-
0036790994
-
The hypocholesterolemic agent LY295427 upregulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP
-
Janowski, B.A., The hypocholesterolemic agent LY295427 upregulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP. Proc Natl Acad Sci U S A, 2002, 99, (20), 12675-12680.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, Issue.20
, pp. 12675-12680
-
-
Janowski, B.A.1
-
155
-
-
84951083191
-
ABCA1 is Necessary for Bexarotene-Mediated Clearance of Soluble Amyloid Beta from the Hippocampus of APP/PS1 Mice
-
Corona, A.W.; Kodoma, N.; Casali, B.T.; Landreth, G.E., ABCA1 is Necessary for Bexarotene-Mediated Clearance of Soluble Amyloid Beta from the Hippocampus of APP/PS1 Mice. J Neuroimmune Pharmacol, 2015.
-
(2015)
J Neuroimmune Pharmacol
-
-
Corona, A.W.1
Kodoma, N.2
Casali, B.T.3
Landreth, G.E.4
-
156
-
-
84942366578
-
Lack of support for bexarotene as a treatment for Alzheimer’s disease
-
O’Hare, E.; Jeggo, R.; Kim, E.M.; Barbour, B.; Walczak, J.S.; Palmer, P.; Lyons, T.; Page, D.; Hanna, D.; Meara, J.R.; Spanswick, D.; Guo, J.P.; McGeer, E.G.; McGeer, P.L.; Hobson, P., Lack of support for bexarotene as a treatment for Alzheimer’s disease. Neuropharmacology, 2016, 100, 124-130.
-
(2016)
Neuropharmacology
, vol.100
, pp. 124-130
-
-
O’Hare, E.1
Jeggo, R.2
Kim, E.M.3
Barbour, B.4
Walczak, J.S.5
Palmer, P.6
Lyons, T.7
Page, D.8
Hanna, D.9
Meara, J.R.10
Spanswick, D.11
Guo, J.P.12
McGeer, E.G.13
McGeer, P.L.14
Hobson, P.15
-
157
-
-
83555164835
-
Meta-analysis: Pioglitazone improves liver histology and fibrosis in patients with non-alcoholic steatohepatitis
-
Boettcher, E.; Csako, G.; Pucino, F.; Wesley, R.; Loomba, R., Meta-analysis: pioglitazone improves liver histology and fibrosis in patients with non-alcoholic steatohepatitis. Aliment Pharmacol Ther, 2012, 35, (1), 66-75.
-
(2012)
Aliment Pharmacol Ther
, vol.35
, Issue.1
, pp. 66-75
-
-
Boettcher, E.1
Csako, G.2
Pucino, F.3
Wesley, R.4
Loomba, R.5
-
158
-
-
84868132548
-
Peroxisome proliferator-activated receptor delta agonist attenuates hepatic steatosis by anti-inflammatory mechanism
-
Lee, M.Y.; Choi, R.; Kim, H.M.; Cho, E.J.; Kim, B.H.; Choi, Y.S.; Naowaboot, J.; Lee, E.Y.; Yang, Y.C.; Shin, J.Y.; Shin, Y.G.; Chung, C.H., Peroxisome proliferator-activated receptor delta agonist attenuates hepatic steatosis by anti-inflammatory mechanism. Exp Mol Med, 2012, 44, (10), 578-585.
-
(2012)
Exp Mol Med
, vol.44
, Issue.10
, pp. 578-585
-
-
Lee, M.Y.1
Choi, R.2
Kim, H.M.3
Cho, E.J.4
Kim, B.H.5
Choi, Y.S.6
Naowaboot, J.7
Lee, E.Y.8
Yang, Y.C.9
Shin, J.Y.10
Shin, Y.G.11
Chung, C.H.12
-
159
-
-
79952032653
-
Activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats
-
Yang, S.J.; Choi, J.M.; Chae, S.W.; Kim, W.J.; Park, S.E.; Rhee, E.J.; Lee, W.Y.; Oh, K.W.; Park, S.W.; Kim, S.W.; Park, C.Y., Activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats. PLoS One, 2011, 6, (2), e17057.
-
(2011)
Plos One
, vol.6
, Issue.2
, pp. e17057
-
-
Yang, S.J.1
Choi, J.M.2
Chae, S.W.3
Kim, W.J.4
Park, S.E.5
Rhee, E.J.6
Lee, W.Y.7
Oh, K.W.8
Park, S.W.9
Kim, S.W.10
Park, C.Y.11
-
160
-
-
61649105063
-
Rosiglitazone prevents nutritional fibrosis and steatohepatitis in mice
-
Nan, Y.M.; Fu, N.; Wu, W.J.; Liang, B.L.; Wang, R.Q.; Zhao, S.X.; Zhao, J.M.; Yu, J., Rosiglitazone prevents nutritional fibrosis and steatohepatitis in mice. Scand J Gastroenterol, 2009, 44, (3), 358-365.
-
(2009)
Scand J Gastroenterol
, vol.44
, Issue.3
, pp. 358-365
-
-
Nan, Y.M.1
Fu, N.2
Wu, W.J.3
Liang, B.L.4
Wang, R.Q.5
Zhao, S.X.6
Zhao, J.M.7
Yu, J.8
-
161
-
-
84864249514
-
Mechanisms underlying the rapid peroxisome proliferator-activated receptorgamma-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer’s disease
-
Mandrekar-Colucci, S.; Karlo, J.C.; Landreth, G.E., Mechanisms underlying the rapid peroxisome proliferator-activated receptorgamma-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer’s disease. J Neurosci, 2012, 32, (30), 10117-10128.
-
(2012)
J Neurosci
, vol.32
, Issue.30
, pp. 10117-10128
-
-
Mandrekar-Colucci, S.1
Karlo, J.C.2
Landreth, G.E.3
-
162
-
-
0037072732
-
Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles
-
Grefhorst, A.; Elzinga, B.M.; Voshol, P.J.; Plosch, T.; Kok, T.; Bloks, V.W.; van der Sluijs, F.H.; Havekes, L.M.; Romijn, J.A.; Verkade, H.J.; Kuipers, F., Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles. J Biol Chem, 2002, 277, (37), 34182-34190.
-
(2002)
J Biol Chem
, vol.277
, Issue.37
, pp. 34182-34190
-
-
Grefhorst, A.1
Elzinga, B.M.2
Voshol, P.J.3
Plosch, T.4
Kok, T.5
Bloks, V.W.6
Van Der Sluijs, F.H.7
Havekes, L.M.8
Romijn, J.A.9
Verkade, H.J.10
Kuipers, F.11
-
163
-
-
0034669171
-
Role of LXRs in control of lipogenesis
-
Schultz, J.R.; Tu, H.; Luk, A.; Repa, J.J.; Medina, J.C.; Li, L.; Schwendner, S.; Wang, S.; Thoolen, M.; Mangelsdorf, D.J.; Lustig, K.D.; Shan, B., Role of LXRs in control of lipogenesis. Genes Dev, 2000, 14, (22), 2831-2838.
-
(2000)
Genes Dev
, vol.14
, Issue.22
, pp. 2831-2838
-
-
Schultz, J.R.1
Tu, H.2
Luk, A.3
Repa, J.J.4
Medina, J.C.5
Li, L.6
Schwendner, S.7
Wang, S.8
Thoolen, M.9
Mangelsdorf, D.J.10
Lustig, K.D.11
Shan, B.12
-
164
-
-
0032966295
-
The RXR agonist LG100268 causes hepatomegaly, improves glycaemic control and decreases cardiovascular risk and cachexia in diabetic mice suffering from pancreatic beta-cell dysfunction
-
Lenhard, J.M.; Lancaster, M.E.; Paulik, M.A.; Weiel, J.E.; Binz, J.G.; Sundseth, S.S.; Gaskill, B.A.; Lightfoot, R.M.; Brown, H.R., The RXR agonist LG100268 causes hepatomegaly, improves glycaemic control and decreases cardiovascular risk and cachexia in diabetic mice suffering from pancreatic beta-cell dysfunction. Diabetologia, 1999, 42, (5), 545-554.
-
(1999)
Diabetologia
, vol.42
, Issue.5
, pp. 545-554
-
-
Lenhard, J.M.1
Lancaster, M.E.2
Paulik, M.A.3
Weiel, J.E.4
Binz, J.G.5
Sundseth, S.S.6
Gaskill, B.A.7
Lightfoot, R.M.8
Brown, H.R.9
-
165
-
-
84875639160
-
Amyloid beta inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor alpha agonist
-
Goncalves, M.B.; Clarke, E.; Hobbs, C.; Malmqvist, T.; Deacon, R.; Jack, J.; Corcoran, J.P., Amyloid beta inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor alpha agonist. Eur J Neurosci, 2013, 37, (7), 1182-1192.
-
(2013)
Eur J Neurosci
, vol.37
, Issue.7
, pp. 1182-1192
-
-
Goncalves, M.B.1
Clarke, E.2
Hobbs, C.3
Malmqvist, T.4
Deacon, R.5
Jack, J.6
Corcoran, J.P.7
|