Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks

Behavioural Brain Research

Volumn 193, Issue 2, 2008, Pages 174-182

  Bour, Alexandra ^a   Grootendorst, Jeannette ^a   Vogel, Elise ^a   Kelche, Christian ^a   Dodart, Jean Cosme ^c   Bales, Kelly ^c   Moreau, Pierre Henri ^a   Sullivan, Patrick M ^b   Mathis, Chantal ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b Center for Aging   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

Alzheimer's disease; ApoE isoform; Avoidance response; Cognitive decline; Gender differences; Gene targeted mouse; Knock in mouse; Spatial memory

Indexed keywords

APOLIPOPROTEIN E3; APOLIPOPROTEIN E4;

AGING; ALZHEIMER DISEASE; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENOTYPE; HIPPOCAMPUS; KNOCKOUT MOUSE; MALE; MAZE TEST; MEMORY CONSOLIDATION; MEMORY DISORDER; MIDDLE AGED; MOUSE; NONHUMAN; PASSIVE AVOIDANCE; PRIORITY JOURNAL; SPATIAL MEMORY; TASK PERFORMANCE;

ANIMALS; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; COGNITION; EXPLORATORY BEHAVIOR; FEMALE; GENOTYPE; HUMANS; MALE; MAZE LEARNING; MEMORY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MIDDLE AGED; RETENTION (PSYCHOLOGY); SPATIAL BEHAVIOR;

EID: 48949099311     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2008.05.008     Document Type: Article

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