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Volumn , Issue , 2011, Pages

Introducing human APOE into Aβ transgenic mouse models

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E;

EID: 84855263811     PISSN: None     EISSN: 20900252     Source Type: Journal    
DOI: 10.4061/2011/810981     Document Type: Review
Times cited : (49)

References (90)
  • 1
    • 67651180986 scopus 로고    scopus 로고
    • The amyloid hypothesis for Alzheimer's disease: A critical reappraisal
    • Hardy J., The amyloid hypothesis for Alzheimer's disease: a critical reappraisal Journal of Neurochemistry 2009 110 4 1129 1134
    • (2009) Journal of Neurochemistry , vol.110 , Issue.4 , pp. 1129-1134
    • Hardy, J.1
  • 2
    • 77956057086 scopus 로고    scopus 로고
    • Murine models of Alzheimer's disease and their use in developing immunotherapies
    • Wisniewski T., Sigurdsson E. M., Murine models of Alzheimer's disease and their use in developing immunotherapies Biochimica et Biophysica Acta 2010 1802 10 847 859
    • (2010) Biochimica et Biophysica Acta , vol.1802 , Issue.10 , pp. 847-859
    • Wisniewski, T.1    Sigurdsson, E.M.2
  • 4
    • 79951713725 scopus 로고    scopus 로고
    • Apolipoprotein e in Alzheimer's disease and other neurological disorders
    • Verghese P. B., Castellano J. M., Holtzman D. M., Apolipoprotein E in Alzheimer's disease and other neurological disorders The Lancet Neurology 2011 10 3 241 252
    • (2011) The Lancet Neurology , vol.10 , Issue.3 , pp. 241-252
    • Verghese, P.B.1    Castellano, J.M.2    Holtzman, D.M.3
  • 5
    • 67349270965 scopus 로고    scopus 로고
    • Apolipoprotein e and its receptors in Alzheimer's disease: Pathways, pathogenesis and therapy
    • Bu G., Apolipoprotein e and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy Nature Reviews Neuroscience 2009 10 5 333 344
    • (2009) Nature Reviews Neuroscience , vol.10 , Issue.5 , pp. 333-344
    • Bu, G.1
  • 6
    • 84880187014 scopus 로고    scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis - An update and reappraisal
    • Hardy J., Alzheimer's disease: the amyloid cascade hypothesisan update and reappraisal Journal of Alzheimer's Disease 2006 9 3, supplement 151 153 (Pubitemid 44253307)
    • (2006) Journal of Alzheimer's Disease , vol.9 , Issue.SUPPL. 3 , pp. 151-153
    • Hardy, J.1
  • 7
    • 0036946621 scopus 로고    scopus 로고
    • Morphologically distinct plaque types differentially affect dendritic structure and organisation in the early and late states of Alzheimer's disease
    • DOI 10.1007/s00401-001-0476-6
    • Adlard P. A., Vickers J. C., Morphologically distinct plaque types differentially affect dendritic structure and organisation in the early and late states of Alzheimer's disease Acta Neuropathologica 2002 103 4 377 383 (Pubitemid 36097033)
    • (2002) Acta Neuropathologica , vol.103 , Issue.4 , pp. 377-383
    • Adlard, P.A.1    Vickers, J.C.2
  • 8
    • 0037756809 scopus 로고    scopus 로고
    • Diffuse amyloid deposition, but not plaque number, is reduced in amyloid precursor protein/presenilin 1 double-transgenic mice by pathway lesions
    • DOI 10.1016/S0306-4522(03)00215-X
    • van Groen T., Liu L., Ikonen S., Kadish I., Diffuse amyloid deposition, but not plaque number, is reduced in amyloid precursor protein/presenilin 1 double-transgenic mice by pathway lesions Neuroscience 2003 119 4 1185 1197 (Pubitemid 36776463)
    • (2003) Neuroscience , vol.119 , Issue.4 , pp. 1185-1197
    • Van Groen, T.1    Liu, L.2    Ikonen, S.3    Kadish, I.4
  • 10
    • 36248971777 scopus 로고    scopus 로고
    • Mechanisms of amyloid plaque pathogenesis
    • DOI 10.1007/s00401-007-0284-8
    • Fiala J. C., Mechanisms of amyloid plaque pathogenesis Acta Neuropathologica 2007 114 6 551 571 (Pubitemid 50003186)
    • (2007) Acta Neuropathologica , vol.114 , Issue.6 , pp. 551-571
    • Fiala, J.C.1
  • 11
    • 55149109190 scopus 로고    scopus 로고
    • Parenchymal and vascular A -deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease
    • Thal D. R., Griffin W. S. T., Braak H., Parenchymal and vascular A -deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease Journal of Cellular and Molecular Medicine 2008 12 5 1848 1862
    • (2008) Journal of Cellular and Molecular Medicine , vol.12 , Issue.5 , pp. 1848-1862
    • Thal, D.R.1    Griffin, W.S.T.2    Braak, H.3
  • 12
    • 0035898257 scopus 로고    scopus 로고
    • The morphological phenotype of β-amyloid plaques and associated neuritic changes in Alzheimer's disease
    • DOI 10.1016/S0306-4522(01)00169-5, PII S0306452201001695
    • Dickson T. C., Vickers J. C., The morphological phenotype of -amyloid plaques and associated neuritic changes in Alzheimer's disease Neuroscience 2001 105 1 99 107 (Pubitemid 32722097)
    • (2001) Neuroscience , vol.105 , Issue.1 , pp. 99-107
    • Dickson, T.C.1    Vickers, J.C.2
  • 13
    • 33646911081 scopus 로고    scopus 로고
    • Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus
    • DOI 10.1523/JNEUROSCI.5476-05.2006
    • Xu Q., Bernardo A., Walker D., Kanegawa T., Mahley R. W., Huang Y., Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus Journal of Neuroscience 2006 26 19 4985 4994 (Pubitemid 44315280)
    • (2006) Journal of Neuroscience , vol.26 , Issue.19 , pp. 4985-4994
    • Xu, Q.1    Bernardo, A.2    Walker, D.3    Kanegawa, T.4    Mahley, R.W.5    Huang, Y.6
  • 14
    • 68249134074 scopus 로고    scopus 로고
    • The role of apolipoprotein e in Alzheimer's disease
    • Kim J., Basak J. M., Holtzman D. M., The role of apolipoprotein E in Alzheimer's disease Neuron 2009 63 3 287 303
    • (2009) Neuron , vol.63 , Issue.3 , pp. 287-303
    • Kim, J.1    Basak, J.M.2    Holtzman, D.M.3
  • 16
    • 0028790904 scopus 로고
    • Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice
    • Gordon I., Grauer E., Genis I., Sehayek E., Michaelson D. M., Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice Neuroscience Letters 1995 199 1 1 4
    • (1995) Neuroscience Letters , vol.199 , Issue.1 , pp. 1-4
    • Gordon, I.1    Grauer, E.2    Genis, I.3    Sehayek, E.4    Michaelson, D.M.5
  • 17
    • 0242403213 scopus 로고    scopus 로고
    • Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients
    • DOI 10.1016/j.neuroscience.2003.08.007
    • Ji Y., Gong Y., Gan W., Beach T., Holtzman D. M., Wisniewski T., Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients Neuroscience 2003 122 2 305 315 (Pubitemid 37410162)
    • (2003) Neuroscience , vol.122 , Issue.2 , pp. 305-315
    • Ji, Y.1    Gong, Y.2    Gan, W.3    Beach, T.4    Holtzman, D.M.5    Wisniewski, T.6
  • 18
    • 78650169584 scopus 로고    scopus 로고
    • Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2
    • Klein R. C., Mace B. E., Moore S. D., Sullivan P. M., Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2 Neuroscience 2010 171 4 1265 1272
    • (2010) Neuroscience , vol.171 , Issue.4 , pp. 1265-1272
    • Klein, R.C.1    Mace, B.E.2    Moore, S.D.3    Sullivan, P.M.4
  • 22
    • 0032080231 scopus 로고    scopus 로고
    • Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: Astrocyte-specific expression and differing biological effects of astrocyte- secreted apoE3 and apoE4 lipoproteins
    • Sun Y., Wu S., Bu G., Onifade M. K., Patel S. N., LaDu M. J., Fagan A. M., Holtzman D. M., Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte- secreted apoE3 and apoE4 lipoproteins Journal of Neuroscience 1998 18 9 3261 3272 (Pubitemid 28186019)
    • (1998) Journal of Neuroscience , vol.18 , Issue.9 , pp. 3261-3272
    • Sun, Y.1    Wu, S.2    Bu, G.3    Onifade, M.K.4    Patel, S.N.5    LaDu, M.J.6    Fagan, A.M.7    Holtzman, D.M.8
  • 23
    • 0034870449 scopus 로고    scopus 로고
    • Behavioral phenotyping of GFAP-ApoE3 and -ApoE4 transgenic mice: ApoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology
    • DOI 10.1006/exnr.2001.7715
    • Hartman R. E., Wozniak D. F., Nardi A., Olney J. W., Sartorius L., Holtzman D. M., Behavioral phenotyping of GFAP-ApoE3 and -ApoE4 transgenic mice: ApoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology Experimental Neurology 2001 170 2 326 344 (Pubitemid 32758686)
    • (2001) Experimental Neurology , vol.170 , Issue.2 , pp. 326-344
    • Hartman, R.E.1    Wozniak, D.F.2    Nardi, A.3    Olney, J.W.4    Sartorius, L.5    Holtzman, D.M.6
  • 24
    • 33845299006 scopus 로고    scopus 로고
    • Impairments in spatial memory retention of GFAP-apoE4 female mice
    • DOI 10.1016/j.bbr.2006.10.024, PII S0166432806005833
    • van Meer P., Acevedo S., Raber J., Impairments in spatial memory retention of GFAP-apoE4 female mice Behavioural Brain Research 2007 176 2 372 375 (Pubitemid 44880100)
    • (2007) Behavioural Brain Research , vol.176 , Issue.2 , pp. 372-375
    • Van Meer, P.1    Acevedo, S.2    Raber, J.3
  • 25
    • 0033564771 scopus 로고    scopus 로고
    • Expression of human apolipoprotein E3 or E4 in the brains of Apoe(-/-) mice: Isoform-specific effects on neurodegeneration
    • Buttini M., Orth M., Bellosta S., Akeefe H., Pitas R. E., Wyss-Coray T., Mucke L., Mahley R. W., Expression of human apolipoprotein E3 or E4 in the brains of apoE-/-mice: isoform-specific effects on neurodegeneration Journal of Neuroscience 1999 19 12 4867 4880 (Pubitemid 29270123)
    • (1999) Journal of Neuroscience , vol.19 , Issue.12 , pp. 4867-4880
    • Buttini, M.1    Orth, M.2    Bellosta, S.3    Akeefe, H.4    Pitas, R.E.5    Wyss-Coray, T.6    Mucke, L.7    Mahley, R.W.8
  • 26
    • 0037115049 scopus 로고    scopus 로고
    • Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid β peptides but not on plaque formation
    • Buttini M., Yu G. Q., Shockley K., Huang Y., Jones B., Masliah E., Mallory M., Yeo T., Longo F. M., Mucke L., Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid peptides but not on plaque formation Journal of Neuroscience 2002 22 24 10539 10548 (Pubitemid 36005128)
    • (2002) Journal of Neuroscience , vol.22 , Issue.24 , pp. 10539-10548
    • Buttini, M.1    Yu, G.-Q.2    Shockley, K.3    Huang, Y.4    Jones, B.5    Masliah, E.6    Mallory, M.7    Yeo, T.8    Longo, F.M.9    Mucke, L.10
  • 27
    • 7244253060 scopus 로고    scopus 로고
    • Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase. Modulation by zinc
    • DOI 10.1074/jbc.M408127200
    • Harris F. M., Brecht W. J., Xu Q., Mahley R. W., Huang Y., Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase. Modulation by zinc The Journal of Biological Chemistry 2004 279 43 44795 44801 (Pubitemid 39430890)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.43 , pp. 44795-44801
    • Harris, F.M.1    Brecht, W.J.2    Xu, Q.3    Mahley, R.W.4    Huang, Y.5
  • 29
    • 49949103769 scopus 로고    scopus 로고
    • Human Apolipoprotein E4 Targeted Replacement Mice Show Increased Prevalence of Intracerebral Hemorrhage Associated with Vascular Amyloid Deposition
    • Sullivan P. M., Mace B. E., Estrada J. C., Schmechel D. E., Alberts M. J., Human Apolipoprotein E4 Targeted Replacement Mice Show Increased Prevalence of Intracerebral Hemorrhage Associated with Vascular Amyloid Deposition Journal of Stroke and Cerebrovascular Diseases 2008 17 5 303 311
    • (2008) Journal of Stroke and Cerebrovascular Diseases , vol.17 , Issue.5 , pp. 303-311
    • Sullivan, P.M.1    Mace, B.E.2    Estrada, J.C.3    Schmechel, D.E.4    Alberts, M.J.5
  • 32
    • 15744378392 scopus 로고    scopus 로고
    • Human apoE targeted replacement mouse lines: H-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior
    • DOI 10.1016/j.bbr.2004.09.019
    • Grootendorst J., Bour A., Vogel E., Kelche C., Sullivan P. M., Dodart J. C., Bales K., Mathis C., Human apoE targeted replacement mouse lines: H-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior Behavioural Brain Research 2005 159 1 1 14 (Pubitemid 40410579)
    • (2005) Behavioural Brain Research , vol.159 , Issue.1 , pp. 1-14
    • Grootendorst, J.1    Bour, A.2    Vogel, E.3    Kelche, C.4    Sullivan, P.M.5    Dodart, J.-C.6    Bales, K.7    Mathis, C.8
  • 35
    • 82755174052 scopus 로고    scopus 로고
    • Apolipoprotein e isoform-dependent effects on anxiety and cognition in female TR mice
    • In press
    • Siegel J. A., Haley G. E., Raber J., Apolipoprotein E isoform-dependent effects on anxiety and cognition in female TR mice. Neurobiology of Aging. In press
    • Neurobiology of Aging
    • Siegel, J.A.1    Haley, G.E.2    Raber, J.3
  • 38
    • 0030611097 scopus 로고    scopus 로고
    • Aβ deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse
    • Irizarry M. C., Soriano F., McNamara M., Page K. J., Schenk D., Games D., Hyman B. T., A deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse Journal of Neuroscience 1997 17 18 7053 7059 (Pubitemid 27427884)
    • (1997) Journal of Neuroscience , vol.17 , Issue.18 , pp. 7053-7059
    • Irizarry, M.C.1    Soriano, F.2    McNamara, M.3    Page, K.J.4    Schenk, D.5    Games, D.6    Hyman, B.T.7
  • 39
    • 0034107615 scopus 로고    scopus 로고
    • Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice
    • DOI 10.1006/nbdi.1999.0278
    • Dodart J. C., Mathis C., Saura J., Bales K. R., Paul S. M., Ungerer A., Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice Neurobiology of Disease 2000 7 2 71 85 (Pubitemid 30241204)
    • (2000) Neurobiology of Disease , vol.7 , Issue.2 , pp. 71-85
    • Dodart, J.-C.1    Mathis, C.2    Saura, J.3    Bales, K.R.4    Paul, S.M.5    Ungerer, A.6
  • 41
    • 0036233168 scopus 로고    scopus 로고
    • Human and murine apoE markedly alters Aβ metabolism before and after plaque formation in a mouse model of Alzheimer's Disease
    • DOI 10.1006/nbdi.2002.0483
    • Fagan A. M., Watson M., Parsadanian M., Bales K. R., Paul S. M., Holtzman D. M., Human and murine apoE markedly alters A metabolism before and after plaque formation in a mouse model of Alzheimer's Disease Neurobiology of Disease 2002 9 3 305 318 (Pubitemid 34442079)
    • (2002) Neurobiology of Disease , vol.9 , Issue.3 , pp. 305-318
    • Fagan, A.M.1    Watson, M.2    Parsadanian, M.3    Bales, K.R.4    Paul, S.M.5    Holtzman, D.M.6
  • 44
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
    • DOI 10.1126/science.274.5284.99
    • Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., Yang F., Cole G., Correlative memory deficits, A elevation, and amyloid plaques in transgenic mice Science 1996 274 5284 99 102 (Pubitemid 26332733)
    • (1996) Science , vol.274 , Issue.5284 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3    Eckman, C.4    Harigaya, Y.5    Younkin, S.6    Yang, F.7    Cole, G.8
  • 47
    • 15244340676 scopus 로고    scopus 로고
    • Human apolipoprotein E4 alters the amyloid-β 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model
    • DOI 10.1523/JNEUROSCI.5170-04.2005
    • Fryer J. D., Simmons K., Parsadanian M., Bales K. R., Paul S. M., Sullivan P. M., Holtzman D. M., Human apolipoprotein E4 alters the amyloid- 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model Journal of Neuroscience 2005 25 11 2803 2810 (Pubitemid 40389238)
    • (2005) Journal of Neuroscience , vol.25 , Issue.11 , pp. 2803-2810
    • Fryer, J.D.1    Simmons, K.2    Parsadanian, M.3    Bales, K.R.4    Paul, S.M.5    Sullivan, P.M.6    Holtzman, D.M.7
  • 49
    • 33749521100 scopus 로고    scopus 로고
    • Intraneuronal β-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: Potential factors in amyloid plaque formation
    • DOI 10.1523/JNEUROSCI.1202-06.2006
    • Oakley H., Cole S. L., Logan S., Maus E., Shao P., Craft J., Guillozet-Bongaarts A., Ohno M., Disterhoft J., Van Eldik L., Berry R., Vassar R., Intraneuronal -amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation Journal of Neuroscience 2006 26 40 10129 10140 (Pubitemid 44527407)
    • (2006) Journal of Neuroscience , vol.26 , Issue.40 , pp. 10129-10140
    • Oakley, H.1    Cole, S.L.2    Logan, S.3    Maus, E.4    Shao, P.5    Craft, J.6    Guillozet-Bongaarts, A.7    Ohno, M.8    Disterhoft, J.9    Van Eldik, L.10    Berry, R.11    Vassar, R.12
  • 52
    • 84855263956 scopus 로고    scopus 로고
    • The effects of human apoE on amyloid-beta (42) pathology and synaptic loss in a novel transgenic mouse model
    • Santa Fe, NM, USA Transactions of the American Society for Neurochemistry
    • Youmans K. L., The effects of human apoE on amyloid-beta (42) pathology and synaptic loss in a novel transgenic mouse model Proceedings of the American Society for Neurochemistry Meeting 2010 Santa Fe, NM, USA Transactions of the American Society for Neurochemistry
    • (2010) Proceedings of the American Society for Neurochemistry Meeting
    • Youmans, K.L.1
  • 54
    • 33746311471 scopus 로고    scopus 로고
    • Apolipoprotein E structure: insights into function
    • DOI 10.1016/j.tibs.2006.06.008, PII S0968000406001708
    • Hatters D. M., Peters-Libeu C. A., Weisgraber K. H., Apolipoprotein E structure: insights into function Trends in Biochemical Sciences 2006 31 8 445 454 (Pubitemid 44108662)
    • (2006) Trends in Biochemical Sciences , vol.31 , Issue.8 , pp. 445-454
    • Hatters, D.M.1    Peters-Libeu, C.A.2    Weisgraber, K.H.3
  • 55
    • 0033694470 scopus 로고    scopus 로고
    • Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord
    • Tesseur I., Van Dorpe J., Bruynseels K., Bronfman F., Sciot R., Van Lommel A., Van Leuven F., Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord American Journal of Pathology 2000 157 5 1495 1510
    • (2000) American Journal of Pathology , vol.157 , Issue.5 , pp. 1495-1510
    • Tesseur, I.1    Van Dorpe, J.2    Bruynseels, K.3    Bronfman, F.4    Sciot, R.5    Van Lommel, A.6    Van Leuven, F.7
  • 56
    • 0032424913 scopus 로고    scopus 로고
    • Human apolipoprotein E allele-specific brain expressing transgenic mice
    • DOI 10.1016/S0197-4580(98)00076-1, PII S0197458098000761
    • Smith J. D., Sikes J., Levin J. A., Human apolipoprotein E allele-specific brain expressing transgenic mice Neurobiology of Aging 1998 19 5 407 413 (Pubitemid 29065490)
    • (1998) Neurobiology of Aging , vol.19 , Issue.5 , pp. 407-413
    • Smith, J.D.1    Sikes, J.2    Levin, J.A.3
  • 57
    • 0034721963 scopus 로고    scopus 로고
    • Characterization of transgenic mice expressing Apolipoprotein E4(C112R) and Apolipoprotein E4(L28P; C112R)
    • Huber G., Mrz W., Martin J. R., Malherbe P., Richards J. G., Sueoka N., Ohm T., Hoffmann M. M., Characterization of transgenic mice expressing Apolipoprotein E4(C112R) and Apolipoprotein E4(L28P; C112R) Neuroscience 2000 101 1 211 218
    • (2000) Neuroscience , vol.101 , Issue.1 , pp. 211-218
    • Huber, G.1    Mrz, W.2    Martin, J.R.3    Malherbe, P.4    Richards, J.G.5    Sueoka, N.6    Ohm, T.7    Hoffmann, M.M.8
  • 59
    • 0033889344 scopus 로고    scopus 로고
    • Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice
    • Tesseur I., Van Dorpe J., Spittaels K., Van den Haute C., Moechars D., Van Leuven F., Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice American Journal of Pathology 2000 156 3 951 964 (Pubitemid 30626953)
    • (2000) American Journal of Pathology , vol.156 , Issue.3 , pp. 951-964
    • Tesseur, I.1    Van Dorpe, J.2    Spittaels, K.3    Van Den Haute, C.4    Moechars, D.5    Van Leuven, F.6
  • 61
    • 0028018114 scopus 로고
    • Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls
    • DOI 10.1006/exnr.1994.1108
    • Han S. H., Hulette C., Saunders A. M., Einstein G., Pericak-Vance M., Strittmatter W. J., Roses A. D., Schmechel D. E., Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls Experimental Neurology 1994 128 1 13 26 (Pubitemid 24278361)
    • (1994) Experimental Neurology , vol.128 , Issue.1 , pp. 13-26
    • Han, S.-H.1    Hulette, C.2    Saunders, A.M.3    Einstein, G.4    Pericak-Vance, M.5    Strittmatter, W.J.6    Roses, A.D.7    Schmechel, D.E.8
  • 65
    • 0032705473 scopus 로고    scopus 로고
    • Apolipoprotein E is found in astrocytes but not in microglia in the normal mouse brain
    • DOI 10.1016/S0168-0102(99)00075-9, PII S0168010299000759
    • Fujita S. C., Sakuta K., Tsuchiya R., Hamanaka H., Apolipoprotein E is found in astrocytes but not in microglia in the normal mouse brain Neuroscience Research 1999 35 2 123 133 (Pubitemid 29518403)
    • (1999) Neuroscience Research , vol.35 , Issue.2 , pp. 123-133
    • Fujita, S.C.1    Sakuta, K.2    Tsuchiya, R.3    Hamanaka, H.4
  • 66
    • 0031079601 scopus 로고    scopus 로고
    • Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro
    • DOI 10.1006/exnr.1996.6360
    • Stone D. J., Rozovsky I., Morgan T. E., Anderson C. P., Hajian H., Finch C. E., Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro Experimental Neurology 1997 143 2 313 318 (Pubitemid 27148235)
    • (1997) Experimental Neurology , vol.143 , Issue.2 , pp. 313-318
    • Stone, D.J.1    Rozovsky, I.2    Morgan, T.E.3    Anderson, C.P.4    Hajian, H.5    Finch, C.E.6
  • 67
    • 0035115847 scopus 로고    scopus 로고
    • Two distal downstream enhancers direct expression of the human apolipoprotein E gene to astrocytes in the brain
    • Grehan S., Tse E., Taylor J. M., Two distal downstream enhancers direct expression of the human apolipoprotein E gene to astrocytes in the brain Journal of Neuroscience 2001 21 3 812 822 (Pubitemid 32163122)
    • (2001) Journal of Neuroscience , vol.21 , Issue.3 , pp. 812-822
    • Grehan, S.1    Tse, E.2    Taylor, J.M.3
  • 68
    • 11444251445 scopus 로고    scopus 로고
    • Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease
    • DOI 10.1016/j.neurobiolaging.2004.09.003, PII S0197458004002933, Developmental Origins of Aging in the Brain and Blood Vessels
    • Poirier J., Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease Neurobiology of Aging 2005 26 3 355 361 (Pubitemid 40082719)
    • (2005) Neurobiology of Aging , vol.26 , Issue.3 , pp. 355-361
    • Poirier, J.1
  • 69
    • 38049115446 scopus 로고    scopus 로고
    • Apolipoprotein e represents a potent gene-based therapeutic target for the treatment of sporadic Alzheimer's disease
    • Poirier J., Apolipoprotein E represents a potent gene-based therapeutic target for the treatment of sporadic Alzheimer's disease Alzheimer's and Dementia 2008 4 1, supplement S91 S97
    • (2008) Alzheimer's and Dementia , vol.4 , Issue.1 SUPPL.
    • Poirier, J.1
  • 70
    • 27944466636 scopus 로고    scopus 로고
    • Effect of domain interaction on apolipoprotein E levels in mouse brain
    • DOI 10.1523/JNEUROSCI.1922-05.2005
    • Ramaswamy G., Xu Q., Huang Y., Weisgraber K. H., Effect of domain interaction on apolipoprotein E levels in mouse brain Journal of Neuroscience 2005 25 46 10658 10663 (Pubitemid 41681913)
    • (2005) Journal of Neuroscience , vol.25 , Issue.46 , pp. 10658-10663
    • Ramaswamy, G.1    Xu, Q.2    Huang, Y.3    Weisgraber, K.H.4
  • 72
    • 0029119753 scopus 로고
    • Association of apolipoprotein e genotype with brain levels of apolipoprotein e and apolipoprotein J (clusterin) in Alzheimer disease
    • Bertrand P., Poirier J., Oda T., Finch C. E., Pasinetti G. M., Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease Molecular Brain Research 1995 33 1 174 178
    • (1995) Molecular Brain Research , vol.33 , Issue.1 , pp. 174-178
    • Bertrand, P.1    Poirier, J.2    Oda, T.3    Finch, C.E.4    Pasinetti, G.M.5
  • 73
    • 0036837541 scopus 로고    scopus 로고
    • Genotype-related differences of hippocampal apolipoprotein e levels only in early stages of neuropathological changes in Alzheimer's disease
    • Glckner F., Meske V., Ohm T. G., Genotype-related differences of hippocampal apolipoprotein E levels only in early stages of neuropathological changes in Alzheimer's disease Neuroscience 2002 114 4 1103 1114
    • (2002) Neuroscience , vol.114 , Issue.4 , pp. 1103-1114
    • Glckner, F.1    Meske, V.2    Ohm, T.G.3
  • 74
    • 0032080231 scopus 로고    scopus 로고
    • Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: Astrocyte-specific expression and differing biological effects of astrocyte- secreted apoE3 and apoE4 lipoproteins
    • Sun Y., Wu S., Bu G., Onifade M. K., Patel S. N., LaDu M. J., Fagan A. M., Holtzman D. M., Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte- secreted apoE3 and apoE4 lipoproteins Journal of Neuroscience 1998 18 9 3261 3272 (Pubitemid 28186019)
    • (1998) Journal of Neuroscience , vol.18 , Issue.9 , pp. 3261-3272
    • Sun, Y.1    Wu, S.2    Bu, G.3    Onifade, M.K.4    Patel, S.N.5    LaDu, M.J.6    Fagan, A.M.7    Holtzman, D.M.8
  • 75
    • 68849085523 scopus 로고    scopus 로고
    • Observation of the density and size of cells in hippocampus and vascular lesion in thalamus of GFAP-apoE transgenic mice
    • Tang K. F., Cai L., Zhou J. N., Observation of the density and size of cells in hippocampus and vascular lesion in thalamus of GFAP-apoE transgenic mice Neuroscience Bulletin 2009 25 4 167 178
    • (2009) Neuroscience Bulletin , vol.25 , Issue.4 , pp. 167-178
    • Tang, K.F.1    Cai, L.2    Zhou, J.N.3
  • 77
    • 0037111263 scopus 로고    scopus 로고
    • V717F transgenic mice
    • DOI 10.1016/S0006-8993(02)03437-6, PII S0006899302034376
    • Dodart J. C., Bales K. R., Johnstone E. M., Little S. P., Paul S. M., Apolipoprotein E alters the processing of the -amyloid precursor protein in APPV717F transgenic mice Brain Research 2002 955 1-2 191 199 (Pubitemid 35284849)
    • (2002) Brain Research , vol.955 , Issue.1-2 , pp. 191-199
    • Dodart, J.-C.1    Bales, K.R.2    Johnstone, E.M.3    Little, S.P.4    Paul, S.M.5
  • 82
    • 0036896994 scopus 로고    scopus 로고
    • Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease
    • Hartman R. E., Laurer H., Longhi L., Bales K. R., Paul S. M., McIntosh T. K., Holtzman D. M., Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease Journal of Neuroscience 2002 22 23 10083 10087 (Pubitemid 35416846)
    • (2002) Journal of Neuroscience , vol.22 , Issue.23 , pp. 10083-10087
    • Hartman, R.E.1    Laurer, H.2    Longhi, L.3    Bales, K.R.4    Paul, S.M.5    McIntosh, T.K.6    Holtzman, D.M.7
  • 84
    • 44649090171 scopus 로고    scopus 로고
    • Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits
    • Belinson H., Lev D., Masliah E., Michaelson D. M., Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits Journal of Neuroscience 2008 28 18 4690 4701
    • (2008) Journal of Neuroscience , vol.28 , Issue.18 , pp. 4690-4701
    • Belinson, H.1    Lev, D.2    Masliah, E.3    Michaelson, D.M.4
  • 85
    • 4644230845 scopus 로고    scopus 로고
    • A nontransgenic mouse model shows inducible amyloid-β (Aβ) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade
    • DOI 10.1073/pnas.0404458101
    • Dolev I., Michaelson D. M., A nontransgenic mouse model shows inducible amyloid- (A ) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade Proceedings of the National Academy of Sciences of the United States of America 2004 101 38 13909 13914 (Pubitemid 39298506)
    • (2004) Proceedings of the National Academy of Sciences of the United States of America , vol.101 , Issue.38 , pp. 13909-13914
    • Dolev, I.1    Michaelson, D.M.2
  • 86
    • 0042697305 scopus 로고    scopus 로고
    • Triple-transgenic model of Alzheimer's Disease with plaques and tangles: Intracellular Aβ and synaptic dysfunction
    • DOI 10.1016/S0896-6273(03)00434-3
    • Oddo S., Caccamo A., Shepherd J. D., Murphy M. P., Golde T. E., Kayed R., Metherate R., Mattson M. P., Akbari Y., LaFerla F. M., Triple-transgenic model of Alzheimer's Disease with plaques and tangles: intracellular A and synaptic dysfunction Neuron 2003 39 3 409 421 (Pubitemid 36937044)
    • (2003) Neuron , vol.39 , Issue.3 , pp. 409-421
    • Oddo, S.1    Caccamo, A.2    Shepherd, J.D.3    Murphy, M.P.4    Golde, T.E.5    Kayed, R.6    Metherate, R.7    Mattson, M.P.8    Akbari, Y.9    LaFerla, F.M.10
  • 87
    • 30344448543 scopus 로고    scopus 로고
    • A dynamic relationship between intracellular and extracellular pools of Aβ
    • DOI 10.2353/ajpath.2006.050593
    • Oddo S., Caccamo A., Smith I. F., Green K. N., LaFerla F. M., A dynamic relationship between intracellular and extracellular pools of A American Journal of Pathology 2006 168 1 184 194 (Pubitemid 43062572)
    • (2006) American Journal of Pathology , vol.168 , Issue.1 , pp. 184-194
    • Oddo, S.1    Caccamo, A.2    Smith, I.F.3    Green, K.N.4    LaFerla, F.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.