Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins

Journal of Biological Chemistry

Volumn 271, Issue 32, 1996, Pages 19053-19057

  Dong, Li Ming ^a   Weisgraber, Karl H ^a,b  

^a GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E4; HIGH DENSITY LIPOPROTEIN; MUTANT PROTEIN; VERY LOW DENSITY LIPOPROTEIN;

AMINO ACID ANALYSIS; AMINO ACID SUBSTITUTION; ARTICLE; HUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION;

APOLIPOPROTEIN E4; APOLIPOPROTEINS E; ARGININE; GLUTAMIC ACID; HUMANS; LIPOPROTEINS, VLDL; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; SEQUENCE DELETION;

EID: 0029766916     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.32.19053     Document Type: Article

References (47)

1. Mahley, R. W. (1988) Science 240, 622-630
2. Weisgraber, K. H. (1994) Adv. Protein Chem. 45, 249-302
3. Weisgraber, K. H., Rall, S. C., Jr., and Mahley, R. W. (1981) J. Biol. Chem. 256, 9077-9083
4. Davignon, J., Gregg, R. E., and Sing, C. F. (1988) Arteriosclerosis 8, 1-21
5. Stengård, J. H., Zerba, K. E., Pekkanen, J., Ehnholm, C., Nissinen, A., and Sing, C. F. (1995) Circulation 91, 265-269
6. Tiret, L., de Knijff, P., Menzel, H.-J., Ehnholm, C., Nicaud, V., and Havekes, L. M. (1994) Arterioscler. Thromb. 14, 1617-1624
7. Utermann, G., Pruin, N., and Steinmetz, A. (1979) Clin. Genet. 15, 63-72
8. Wilson, P. W. F. (1995) Clin. Chem. 41, 165-169
9. Gregg, R. E., Zech, L. A., Schaefer, E. J., Stark, D., Wilson, D., and Brewer, H. B., Jr. (1986) J. Clin. Invest. 78, 815-821
10. Steinmetz, A., Jakobs, C., Motzny, S., and Kaffarnik, H. (1989) Arteriosclerosis 9, 405-411
11. Weisgraber, K. H. (1990) J. Lipid Res. 31, 1503-1511
12. Mahley, R. W., Nathan, B. P., Bellosta, S., and Pitas, R. E. (1995) Curr. Opin. Lipidol. 6, 86-91
13. Weisgraber, K. H., Pitas, R. E., and Mahley, R. W. (1994) Curr. Opin. Struct. Biol. 4, 507-515
14. Strittmatter, W. J., and Roses, A. D. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 4725-4727
15. Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., and Pericak-Vance, M. A. (1993) Science 261, 921-923
16. Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., Hulette, C., Crain, B., Goldgaber, D., and Roses, A. D. (1993) Neurology 43, 1467-1472
17. Wetterau, J. R., Aggerbeck, L. P., Rall, S. C., Jr., and Weisgraber, K. H. (1988) J. Biol. Chem. 263, 6240-6248
18. Aggerbeck, L. P., Wetterau, J. R., Weisgraber, K. H., Wu, C.-S. C., and Lindgren, F. T. (1988) J. Biol. Chem. 263, 6249-6258
19. Innerarity, T. L., Friedlander, E. J., Rall, S. C., Jr., Weisgraber, K. H., and Mahley, R. W. (1983) J. Biol. Chem. 258, 12341-12347
20. Weisgraber, K. H., Innerarity, T. L., Harder, K. J., Mahley, R. W., Milne, R. W., Marcel, Y. L., and Sparrow, J. T. (1983) J. Biol. Chem. 258, 12348-12354
21. Lalazar, A., Weisgraber, K. H., Rall, S. C., Jr., Giladi, H., Innerarity, T. L., Levanon, A. Z., Boyles, J. K., Amit, B., Gorecki, M., Mahley, R. W., and Vogel, T. (1988) J. Biol. Chem. 263, 3542-3545
22. Dong, L.-M., Wilson, C., Wardell, M. R., Simmons, T., Mahley, R. W., Weisgraber, K. H., and Agard, D. A. (1994) J. Biol. Chem. 269, 22358-22365
23. Gianturco, S. H., Gotto, A. M., Jr., Hwang, S.-L. C., Karlin, J. B., Lin, A. H. Y., Prasad, S. C., and Bradley, W. A. (1983) J. Biol. Chem. 258, 4526-4533
24. Westerlund, J. A., and Weisgraber, K. H. (1993) J. Biol. Chem. 268, 15745-15750
25. Innerarity, T. L., Weisgraber, K. H., Arnold, K. S., Rall, S. C., Jr., and Mahley, R. W. (1984) J. Biol. Chem. 259, 7261-7267
26. Wardell, M. R., Weisgraber, K. H., Havekes, L. M., and Rall, S. C., Jr. (1989) J. Biol. Chem. 264, 21205-21210
27. Pittman, R. C., Glass, C. K., Atkinson, D., and Small, D. M. (1987) J. Biol. Chem. 262, 2435-2442
28. Spooner, P. J. R., Clark, S. B., Gantz, D. L., Hamilton, J. A., and Small, D. M. (1988) J. Biol. Chem. 263, 1444-1453
29. Bellosta, S., Nathan, B. P., Orth, M., Dong, L.-M., Mahley, R. W., and Pitas, R. E. (1995) J. Biol. Chem. 270, 27063-27071
30. Smith, D. B., and Johnson, K. S. (1988) Gene (Amst.) 67, 31-40
31. Rall, S. C., Jr., Weisgraber, K. H., and Mahley, R. W. (1986) Methods Enzymol. 128, 273-287
32. Innerarity, T. L., Pitas, R. E., and Mahley, R. W. (1979) J. Biol. Chem. 254, 4186-4190
33. Lalazar, A., Ou, S.-H. I., and Mahley, R. W. (1989) J. Biol. Chem. 264, 8447-8450
34. Segrest, J. P., Jones, M. K., De Loof, H., Brouillette, C. G., Venkatachalapathi, Y. V., and Anantharamaiah, G. M. (1992) J. Lipid Res. 33, 141-166
35. Nolte, R. T., and Atkinson, D. (1992) Biophys. J. 63, 1221-1239
36. Weintraub, M. S., Eisenberg, S., and Breslow, J. L. (1987) J. Clin. Invest. 80, 1571-1577
37. Bergeron, N., and Havel, R. J. (1996) J. Clin. Invest. 97, 65-72
38. Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L.-M., Salvesen, G. S., Pericak-Vance, M., Schmechel, D., Saunders, A. M., Goldgaber, D., and Roses, A. D. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 8098-8102
39. Ma, J., Yee, A., Brewer, H. B., Jr., Das, S., and Potter, H. (1994) Nature 372, 92-94
40. Sanan, D. A., Weisgraber, K. H., Russell, S. J., Mahley, R. W., Huang, D., Saunders, A., Schmechel, D., Wisniewski, T., Frangione, B., Roses, A. D., and Strittmatter, W. J. (1994) J. Clin. Invest. 94, 860-869
41. Wisniewski, T., Castaño, E. M., Golabek, A., Vogel, T., and Frangione, B. (1994) Am. J. Pathol. 145, 1030-1035
42. Pitas, R. E., Boyles, J. K., Lee, S. H., Hui, D., and Weisgraber, K. H. (1987) J. Biol. Chem. 262, 14352-14360
43. Müller, H. W., Gebicke-Härter, P. J., Hangen, D. H., and Shooter, E. M. (1985) Science 228, 499-501
44. Ignatius, M. J., Gebicke-Härter, P. J., Skene, J. H. P., Schilling, J. W., Weisgraber, K. H., Mahley, R. W., and Shooter, E. M. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 1125-1129
45. Boyles, J. K., Zoellner, C. D., Anderson, L. J., Kosik, L. M., Pitas, R. E., Weisgraber, K. H., Hui, D. Y., Mahley, R. W., Gebicke-Haerter, P. J., Ignatius, M. J., and Shooter, E. M. (1989) J. Clin. Invest. 83, 1015-1031
46. Weisgraber, K. H., and Mahley, R. W. (1996) FASEB J., in press
47. Nathan, B. P., Bellosta, S., Sanan, D. A., Weisgraber, K. H., Mahley, R. W., and Pitas, R. E. (1994) Science 264, 850-852