Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors

Journal of Biological Chemistry

Volumn 286, Issue 19, 2011, Pages 17217-17226

  Brodbeck, Jens ^a   McGuire, Jim ^a   Liu, Zhaoping ^a   Meyer Franke, Anke ^a   Balestra, Maureen E ^a   Jeong, Dah Eun ^a   Pleiss, Mike ^a   McComas, Casey ^c   Hess, Fred ^c   Witter, David ^c   Peterson, Scott ^c   Childers, Matthew ^c   Goulet, Mark ^c   Liverton, Nigel ^c   Hargreaves, Richard ^c   Freedman, Stephen ^a   Weisgraber, Karl H ^a   Mahley, Robert W ^a,b   Huang, Yadong ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPROTEINS; MOLECULAR BIOLOGY; MOLECULES; PHOTOBLEACHING; PROTEINS; SYNTHESIS (CHEMICAL);

AMYLOID PRECURSOR PROTEINS; DOMAIN INTERACTIONS; ENDOPLASMIC RETICULUM; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; INTRACELLULAR TRAFFICKING; PATHOLOGICAL STRUCTURES; PRIMARY HIPPOCAMPAL NEURONS; STRUCTURE DEPENDENT;

NEURONS;

AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; GREEN FLUORESCENT PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL MATURATION; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; DENDRITIC SPINE; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HUMAN; HUMAN CELL; MOUSE; NEURITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN IMMOBILIZATION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN STRUCTURE; PROTEIN TRANSPORT;

EID: 79955754372     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.217380     Document Type: Article

References (55)

1. Mahley, R. W. (1988) Science 240, 622-630
2. Weisgraber, K. H. (1994) Adv. Protein Chem. 45, 249-302
3. Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., and Pericak-Vance, M. A. (1993) Science 261, 921-923
4. Saunders, A. M., Strittmatter, W. J., Schmechel, D., George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., Hulette, C., Crain, B., Goldgaber, D., and Roses, A. D. (1993) Neurology 43, 1467-1472
5. Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., and Roses, A. D. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 1977-1981
6. Farrer, L. A., Cupples, L. A., Haines, J. L., Hyman, B., Kukull, W. A., Mayeux, R., Myers, R. H., Pericak-Vance, M. A., Risch, N., and Van Duijn, C. M. (1997) J. Am. Med. Assoc. 278, 1349-1356
7. Morrow, J. A., Hatters, D. M., Lu, B., Hochtl, P., Oberg, K. A., Rupp, B., and Weisgraber, K. H. (2002) J. Biol. Chem. 277, 50380-50385
8. Hatters, D. M., Peters-Libeu, C. A., and Weisgraber, K. H. (2005) J. Biol. Chem. 280, 26477-26482
9. Dong, L. M., Wilson, C., Wardell, M. R., Simmons, T., Mahley, R. W., Weisgraber, K. H., and Agard, D. A. (1994) J. Biol. Chem. 269, 22358-22365
10. Dong, L. M., and Weisgraber, K. H. (1996) J. Biol. Chem. 271, 19053-19057
11. Zhong, N., and Weisgraber, K. H. (2009) J. Biol. Chem. 284, 6027-6031
12. Raffai, R. L., Dong, L. M., Farese, R. V., Jr., and Weisgraber, K. H. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 11587-11591
13. Xu, Q., Brecht, W. J., Weisgraber, K. H., Mahley, R. W., and Huang, Y. (2004) J. Biol. Chem. 279, 25511-25516
14. Mahley, R. W., Weisgraber, K. H., and Huang, Y. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 5644-5651
15. Huang, Y. (2006) Curr. Opin. Drug Discov. Devel. 9, 627-641
16. Huang, Y. (2010) Trends Mol. Med. 16, 287-294
17. Elshourbagy, N. A., Liao, W. S., Mahley, R. W., and Taylor, J. M. (1985) Proc. Natl. Acad. Sci. U.S.A. 82, 203-207
18. Linton, M. F., Gish, R., Hubl, S. T., Bütler, E., Esquivel, C., Bry, W. I., Boyles, J. K., Wardell, M. R., and Young, S. G. (1991) J. Clin. Invest. 88, 270-281
19. Boyles, J. K., Pitas, R. E., Wilson, E., Mahley, R. W., and Taylor, J. M. (1985) J. Clin. Invest. 76, 1501-1513
20. Pitas, R. E., Boyles, J. K., Lee, S. H., Foss, D., and Mahley, R. W. (1987) Biochim. Biophys. Acta 917, 148-161
21. Xu, P. T., Gilbert, J. R., Qiu, H. L., Ervin, J., Rothrock-Christian, T. R., Hulette, C., and Schmechel, D. E. (1999) Am. J. Pathol. 154, 601-611
22. Messmer-Joudrier, S., Sagot, Y., Mattenberger, L., James, R. W., and Kato, A. C. (1996) Eur. J. Neurosci. 8, 2652-2661
23. Boschert, U., Merlo-Pich, E., Higgins, G., Roses, A. D., and Catsicas, S. (1999) Neurobiol. Dis. 6, 508-514
24. Harris, F. M., Tesseur, I., Brecht, W. J., Xu, Q., Mullendorff, K., Chang, S., Wyss-Coray, T., Mahley, R. W., and Huang, Y. (2004) J. Biol. Chem. 279, 3862-3868
25. Xu, Q., Bernardo, A., Walker, D., Kanegawa, T., Mahley, R. W., and Huang, Y. (2006) J. Neurosci. 26, 4985-4994
26. Xu, Q., Walker, D., Bernardo, A., Brodbeck, J., Balestra, M. E., and Huang, Y. (2008) J. Neurosci. 28, 1452-1459
27. Sitia, R., and Braakman, I. (2003) Nature 426, 891-894
28. Römisch, K. (2004) Traffic 5, 815-820
29. Anelli, T., and Sitia, R. (2008) EMBO J. 27, 315-327
30. Ellgaard, L., and Helenius, A. (2003) Nat. Rev. Mol. Cell Biol. 4, 181-191
31. Trombetta, E. S., and Parodi, A. J. (2003) Annu. Rev. Cell Dev. Biol. 19, 649-676
32. Diliberto, E. J., Jr., and Axelrod, J. (1976) J. Neurochem. 26, 1159-1165
33. Li, G., Bien-Ly, N., Andrews-Zwilling, Y., Xu, Q., Bernardo, A., Ring, K., Halabisky, B., Deng, C., Mahley, R. W., and Huang, Y. (2009) Cell Stem Cell 5, 634-645
34. Brodbeck, J., Balestra, M. E., Saunders, A. M., Roses, A. D., Mahley, R. W., and Huang, Y. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 1343-1346
35. Chang, S., ran Ma, T., Miranda, R. D., Balestra, M. E., Mahley, R. W., and Huang, Y. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 18694-18699
36. Ye, S., Huang, Y., Müllendorff, K., Dong, L., Giedt, G., Meng, E. C., Cohen, F. E., Kuntz, I. D., Weisgraber, K. H., and Mahley, R. W. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 18700-18705
37. Zhong, N., Ramaswamy, G., and Weisgraber, K. H. (2009) J. Biol. Chem. 284, 27273-27280
38. Bellosta, S., Nathan, B. P., Orth, M., Dong, L. M., Mahley, R. W., and Pitas, R. E. (1995) J. Biol. Chem. 270, 27063-27071
39. Ji, Y., Gong, Y., Gan, W., Beach, T., Holtzman, D. M., and Wisniewski, T. (2003) Neuroscience 122, 305-315
40. Dumanis, S. B., Tesoriero, J. A., Babus, L. W., Nguyen, M. T., Trotter, J. H., Ladu, M. J., Weeber, E. J., Turner, R. S., Xu, B., Rebeck, G. W., and Hoe, H. S. (2009) J. Neurosci. 29, 15317-15322
41. Nathan, B. P., Bellosta, S., Sanan, D. A., Weisgraber, K. H., Mahley, R. W., and Pitas, R. E. (1994) Science 264, 850-852
42. Nathan, B. P., Chang, K. C., Bellosta, S., Brisch, E., Ge, N., Mahley, R. W., and Pitas, R. E. (1995) J. Biol. Chem. 270, 19791-19799
43. Holtzman, D. M., Pitas, R. E., Kilbridge, J., Nathan, B., Mahley, R. W., Bu, G., and Schwartz, A. L. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 9480-9484
44. Huang, Y., Liu, X. Q., Wyss-Coray, T., Brecht, W. J., Sanan, D. A., and Mahley, R. W. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 8838-8843
45. Harris, F. M., Brecht, W. J., Xu, Q., Tesseur, I., Kekonius, L., Wyss-Coray, T., Fish, J. D., Masliah, E., Hopkins, P. C., Scearce-Levie, K., Weisgraber, K. H., Mucke, L., Mahley, R. W., and Huang, Y. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 10966-10971
46. Brecht, W. J., Harris, F. M., Chang, S., Tesseur, I., Yu, G. Q., Xu, Q., Dee, Fish, J., Wyss-Coray, T., Buttini, M., Mucke, L., Mahley, R. W., and Huang, Y. (2004) J. Neurosci. 24, 2527-2534
47. Buttini, M., Masliah, E., Yu, G. Q., Palop, J. J., Chang, S., Bernardo, A., Lin, C., Wyss-Coray, T., Huang, Y., and Mucke, L. (2010) Am. J. Pathol. 177, 563-569
48. DeMattos, R. B., Brendza, R. P., Heuser, J. E., Kierson, M., Cirrito, J. R., Fryer, J., Sullivan, P. M., Fagan, A. M., Han, X., and Holtzman, D. M. (2001) Neurochem. Int. 39, 415-425
49. Kalid, O., Mense, M., Fischman, S., Shitrit, A., Bihler, H., Ben-Zeev, E., Schutz, N., Pedemonte, N., Thomas, P. J., Bridges, R. J., Wetmore, D. R., Marantz, Y., and Senderowitz, H. (2010) J. Comput. Aided Mol. Des. 24, 971-991
50. Wang, W., and El-Deiry, W. S. (2008) Curr. Opin. Oncol. 20, 90-96
51. Swaminathan, R., Hoang, C. P., and Verkman, A. S. (1997) Biophys. J. 72, 1900-1907
52. Dayel, M. J., Hom, E. F., and Verkman, A. S. (1999) Biophys. J. 76, 2843-2851
53. Nehls, S., Snapp, E. L., Cole, N. B., Zaal, K. J., Kenworthy, A. K., Roberts, T. H., Ellenberg, J., Presley, J. F., Siggia, E., and Lippincott-Schwartz, J. (2000) Nat. Cell Biol. 2, 288-295
54. Cole, N. B., Smith, C. L., Sciaky, N., Terasaki, M., Edidin, M., and Lippincott-Schwartz, J. (1996) Science 273, 797-801
55. Adams, C. L., Chen, Y. T., Smith, S. J., and Nelson, W. J. (1998) J. Cell. Biol. 142, 1105-1119