-
1
-
-
41949138804
-
PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosis
-
Barish GD, Atkins AR, Downes M, Olson P, Chong LW, Nelson M, Zou Y, Hwang HS, Kang HJ, Curtiss L, Evans RM, Lee CH. PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosis. Proc Nati Acad Sci USA 2008;105:4271-6
-
(2008)
Proc Nati Acad Sci USA
, vol.105
, pp. 4271-4276
-
-
Barish, G.D.1
Atkins, A.R.2
Downes, M.3
Olson, P.4
Chong, L.W.5
Nelson, M.6
Zou, Y.7
Hwang, H.S.8
Kang, H.J.9
Curtiss, L.10
Evans, R.M.11
Lee, C.H.12
-
4
-
-
30944455145
-
Insulin resistance: A metabolic pathway to chronic liver disease
-
Bugianesi E, McCullough AJ, Marchesini G. Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 2005;42:987-1000
-
(2005)
Hepatology
, vol.42
, pp. 987-1000
-
-
Bugianesi, E.1
McCullough, A.J.2
Marchesini, G.3
-
5
-
-
1942518840
-
PPARs and the complex journey to obesity
-
Evans RM, Barish GD, Wang YX. PPARs and the complex journey to obesity. Nat Med 2004;10:355-61
-
(2004)
Nat Med
, vol.10
, pp. 355-361
-
-
Evans, R.M.1
Barish, G.D.2
Wang, Y.X.3
-
6
-
-
38549127422
-
Suppression of proinflammatory adhesion molecules by PPAR-delta in human vascular endothelial cells
-
Fan Y, Wang Y, Tang Z, Zhang H, Qin X, Zhu Y, Guan Y, Wang X, Staels B, Chien S, Wang N. Suppression of proinflammatory adhesion molecules by PPAR-delta in human vascular endothelial cells. Arterioscler Thromb Vasc Biol 2008;28:315-21
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 315-321
-
-
Fan, Y.1
Wang, Y.2
Tang, Z.3
Zhang, H.4
Qin, X.5
Zhu, Y.6
Guan, Y.7
Wang, X.8
Staels, B.9
Chien, S.10
Wang, N.11
-
7
-
-
1842531067
-
Monocyte chemoattractant protein 1 expression is stimulated by growth hormone and interleukin-6 in 3T3-L1 adipocytes
-
Fasshauer M, Klein J, Kralisch S, Klier M, Lossner U, Bluher M, Paschke R. Monocyte chemoattractant protein 1 expression is stimulated by growth hormone and interleukin-6 in 3T3-L1 adipocytes. Biochem Biophys Res Commun 2004;317:598-604
-
(2004)
Biochem Biophys Res Commun
, vol.317
, pp. 598-604
-
-
Fasshauer, M.1
Klein, J.2
Kralisch, S.3
Klier, M.4
Lossner, U.5
Bluher, M.6
Paschke, R.7
-
8
-
-
77956921023
-
The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways
-
Gao D, Nong S, Huang X, Lu Y, Zhao H, Lin Y, Man Y, Wang S, Yang J, Li J. The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways. J Biol Chem 2010;285:29965-73
-
(2010)
J Biol Chem
, vol.285
, pp. 29965-29973
-
-
Gao, D.1
Nong, S.2
Huang, X.3
Lu, Y.4
Zhao, H.5
Lin, Y.6
Man, Y.7
Wang, S.8
Yang, J.9
Li, J.10
-
9
-
-
84855161933
-
Inhibition of NF-κB prevents high glucose-induced proliferation and plasminogen activator inhibitor-1 expression in vascular smooth muscle cells
-
Jeong IK, Oh DH, Park SJ, Kang JH, Kim S, Lee MS, Kim MJ, Hwang YC, Ahn KJ, Chung HY, Chae MK, Yoo HJ. Inhibition of NF-κB prevents high glucose-induced proliferation and plasminogen activator inhibitor-1 expression in vascular smooth muscle cells. Exp Mol Med 2011;43:684-92
-
(2011)
Exp Mol Med
, vol.43
, pp. 684-692
-
-
Jeong, I.K.1
Oh, D.H.2
Park, S.J.3
Kang, J.H.4
Kim, S.5
Lee, M.S.6
Kim, M.J.7
Hwang, Y.C.8
Ahn, K.J.9
Chung, H.Y.10
Chae, M.K.11
Yoo, H.J.12
-
10
-
-
34548746833
-
Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes
-
Joshi-Barve S, Barve SS, Amancherla K, Gobejishvili L, Hill D, Cave M, Hote P, McClain CJ. Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes. Hepatology 2007;46:823-30
-
(2007)
Hepatology
, vol.46
, pp. 823-830
-
-
Joshi-Barve, S.1
Barve, S.S.2
Amancherla, K.3
Gobejishvili, L.4
Hill, D.5
Cave, M.6
Hote, P.7
McClain, C.J.8
-
11
-
-
0027219143
-
Effect of gemfibrozil on high density lipoprotein subspecies in non-insulin dependent diabetes mellitus. Relations to lipolytic enzymes and to the cholesteryl ester transfer protein activity
-
Kahri J, Vuorinen-Markkola H, Tilly-Kiesi M, Landenpera S, Taskinen MR. Effect of gemfibrozil on high density lipoprotein subspecies in non-insulin dependent diabetes mellitus. Relations to lipolytic enzymes and to the cholesteryl ester transfer protein activity. Atherosclerosis 1993;102:79-89
-
(1993)
Atherosclerosis
, vol.102
, pp. 79-89
-
-
Kahri, J.1
Vuorinen-Markkola, H.2
Tilly-Kiesi, M.3
Landenpera, S.4
Taskinen, M.R.5
-
12
-
-
0033617520
-
Orphan nuclear receptors: Shifting endocrinology into reverse
-
Kliewer SA, Lehmann JM, Willson TM. Orphan nuclear receptors: shifting endocrinology into reverse. Science 1999;284:757-60
-
(1999)
Science
, vol.284
, pp. 757-760
-
-
Kliewer, S.A.1
Lehmann, J.M.2
Willson, T.M.3
-
13
-
-
2442701392
-
PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3
-
Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, Kulkarni R, Evans RM, Olefsky J, Montminy M. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat Med 2004;10:530-4
-
(2004)
Nat Med
, vol.10
, pp. 530-534
-
-
Koo, S.H.1
Satoh, H.2
Herzig, S.3
Lee, C.H.4
Hedrick, S.5
Kulkarni, R.6
Evans, R.M.7
Olefsky, J.8
Montminy, M.9
-
14
-
-
0031721754
-
Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models of endotoxin and Fas-antibody-induced liver injury
-
Lawson JA, Fisher MA, Simmons CA, Farhood A, Jaeschke H. Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models of endotoxin and Fas-antibody-induced liver injury. Hepatology 1998;28:761-7
-
(1998)
Hepatology
, vol.28
, pp. 761-767
-
-
Lawson, J.A.1
Fisher, M.A.2
Simmons, C.A.3
Farhood, A.4
Jaeschke, H.5
-
15
-
-
33751011308
-
PGC-1 alpha: A key regulator of energy metabolism
-
Liang H, Ward WF. PGC-1 alpha: a key regulator of energy metabolism. Adv Physiol Educ 2006;30:145-51
-
(2006)
Adv Physiol Educ
, vol.30
, pp. 145-151
-
-
Liang, H.1
Ward, W.F.2
-
16
-
-
0037102256
-
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres
-
Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, Spiegelman BM. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 2002;418:797-801
-
(2002)
Nature
, vol.418
, pp. 797-801
-
-
Lin, J.1
Wu, H.2
Tarr, P.T.3
Zhang, C.Y.4
Wu, Z.5
Boss, O.6
Michael, L.F.7
Puigserver, P.8
Isotani, E.9
Olson, E.N.10
Lowell, B.B.11
Bassel-Duby, R.12
Spiegelman, B.M.13
-
17
-
-
0037382786
-
Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
-
Marchesini G, Bugianesi E, Forlani G, Cerrelli F, Lenzi M, Manini R, Natale S, Vanni E, Villanova N, Melchionda N, Rizzetto M. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003;37:917-23
-
(2003)
Hepatology
, vol.37
, pp. 917-923
-
-
Marchesini, G.1
Bugianesi, E.2
Forlani, G.3
Cerrelli, F.4
Lenzi, M.5
Manini, R.6
Natale, S.7
Vanni, E.8
Villanova, N.9
Melchionda, N.10
Rizzetto, M.11
-
18
-
-
33748150370
-
Pathophysiology of nonalcoholic steatohepatitis
-
McCullough AJ. Pathophysiology of nonalcoholic steatohepatitis. J Clin Gastroenterol 2006;40:517-29
-
(2006)
J Clin Gastroenterol
, vol.40
, pp. 517-529
-
-
McCullough, A.J.1
-
19
-
-
0035957375
-
Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1
-
Michael LF, Wu Z, Cheatham RB, Puigserver P, Adelmant G, Lehman JJ, Kelly DP, Spiegelman BM. Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1. Proc Natl Acad Sci USA 2001;98:3820-5
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3820-3825
-
-
Michael, L.F.1
Wu, Z.2
Cheatham, R.B.3
Puigserver, P.4
Adelmant, G.5
Lehman, J.J.6
Kelly, D.P.7
Spiegelman, B.M.8
-
20
-
-
0034833667
-
Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone
-
Miyazaki Y, Mahankali A, Matsuda M, Glass L, Mahankali S, Ferrannini E, Cusi K, Mandarino LJ, DeFronzo RA. Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone. Diabetes Care 2001;24:710-9
-
(2001)
Diabetes Care
, vol.24
, pp. 710-719
-
-
Miyazaki, Y.1
Mahankali, A.2
Matsuda, M.3
Glass, L.4
Mahankali, S.5
Ferrannini, E.6
Cusi, K.7
Mandarino, L.J.8
Defronzo, R.A.9
-
21
-
-
0027983920
-
Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone
-
Nolan JJ, Ludvik B, Beerdsen P, Joyce M, Olefsky J. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N Engl J Med 1994; 331:1188-93
-
(1994)
N Engl J Med
, vol.331
, pp. 1188-1193
-
-
Nolan, J.J.1
Ludvik, B.2
Beerdsen, P.3
Joyce, M.4
Olefsky, J.5
-
22
-
-
0035942162
-
A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport
-
Oliver WR Jr, Shenk JL, Snaith MR, Russell CS, Plunket KD, Bodkin NL, Lewis MC, Winegar DA, Sznaidman ML, Lambert MH, Xu HE, Sternbach DD, Kliewer SA, Hansen BC, Willson TM. A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc Natl Acad Sci USA 2001;98:5306-11
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 5306-5311
-
-
Oliver Jr., W.R.1
Shenk, J.L.2
Snaith, M.R.3
Russell, C.S.4
Plunket, K.D.5
Bodkin, N.L.6
Lewis, M.C.7
Winegar, D.A.8
Sznaidman, M.L.9
Lambert, M.H.10
Xu, H.E.11
Sternbach, D.D.12
Kliewer, S.A.13
Hansen, B.C.14
Willson, T.M.15
-
23
-
-
50949105881
-
Activation of peroxisome proliferator-activated receptor beta/delta inhibits lipopolysaccharide-induced cytokine production in adipocytes by lowering nuclear factor-kappaB activity via extracellular signal-related kinase 1/2
-
Rodriguez-Calvo R, Serrano L, Coll T, Moullan N, Sanchez RM, Merlos M, Palomer X, Laguna JC, Michalik L, Wahli W, Vázquez-Carrera M. Activation of peroxisome proliferator-activated receptor beta/delta inhibits lipopolysaccharide-induced cytokine production in adipocytes by lowering nuclear factor-kappaB activity via extracellular signal-related kinase 1/2. Diabetes 2008;57:2149-57
-
(2008)
Diabetes
, vol.57
, pp. 2149-2157
-
-
Rodriguez-Calvo, R.1
Serrano, L.2
Coll, T.3
Moullan, N.4
Sanchez, R.M.5
Merlos, M.6
Palomer, X.7
Laguna, J.C.8
Michalik, L.9
Wahli, W.10
Vázquez-Carrera, M.11
-
24
-
-
34247857663
-
Obesity, inflammation, and insulin resistance
-
Shoelson SE, Herrero L, Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterology 2007;132:2169-80
-
(2007)
Gastroenterology
, vol.132
, pp. 2169-2180
-
-
Shoelson, S.E.1
Herrero, L.2
Naaz, A.3
-
25
-
-
9144271149
-
Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome
-
Tanaka T, Yamamoto J, Iwasaki S, Asaba H, Hamura H, Ikeda Y, Watanabe M, Magoori K, loka RX, Tachibana K, Watanabe Y, Uchiyama Y, Sumi K, Iguchi H, Ito S, Doi T, Hamakubo T, Naito M, Auwerx J, Yanagisawa M, Kodama T, Sakai J. Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc Natl Acad Sci USA 2003;100:15924-9
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 15924-15929
-
-
Tanaka, T.1
Yamamoto, J.2
Iwasaki, S.3
Asaba, H.4
Hamura, H.5
Ikeda, Y.6
Watanabe, M.7
Magoori, K.8
Loka, R.X.9
Tachibana, K.10
Watanabe, Y.11
Uchiyama, Y.12
Sumi, K.13
Iguchi, H.14
Ito, S.15
Doi, T.16
Hamakubo, T.17
Naito, M.18
Auwerx, J.19
Yanagisawa, M.20
Kodama, T.21
Sakai, J.22
more..
-
26
-
-
78049503241
-
Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/ adipokine imbalance
-
Tarantino G, Savastano S, Colao A. Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/ adipokine imbalance. World J Gastroenterol 2010;16: 4773-83
-
(2010)
World J Gastroenterol
, vol.16
, pp. 4773-4783
-
-
Tarantino, G.1
Savastano, S.2
Colao, A.3
|