메뉴 건너뛰기




Volumn 127, Issue 1, 2017, Pages 55-64

Liver inflammation and fibrosis

Author keywords

[No Author keywords available]

Indexed keywords

DENDRITIC CELL; DISEASE ASSOCIATION; HEPATITIS; HUMAN; KUPFFER CELL; LIVER FIBROSIS; LIVER INJURY; LIVER METABOLISM; MACROPHAGE; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; ANIMAL; HEPATIC STELLATE CELL; IMMUNOLOGY; INFLAMMATION; LIVER; LIVER CIRRHOSIS; MYOFIBROBLAST; PATHOLOGY;

EID: 85008400938     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI88881     Document Type: Review
Times cited : (898)

References (155)
  • 1
    • 85008328881 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention., United States, Web Site. CDC Web site. Updated April 27, 2016. Accessed November 11, 2016
    • Centers for Disease Control and Prevention. Health, United States, 2015 Web Site. CDC Web site. http://www.cdc.gov/nchs/hus/contents2015.htm#017. Updated April 27, 2016. Accessed November 11, 2016.
    • (2015) Health
  • 2
    • 84908123659 scopus 로고    scopus 로고
    • Liver cirrhosis mortality in 187 countries between 1980 and 2010: A systematic analysis
    • Mokdad AA, et al. Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis. BMC Med. 2014;12:145.
    • (2014) BMC Med , vol.12 , pp. 145
    • Mokdad, A.A.1
  • 3
    • 84949907813 scopus 로고    scopus 로고
    • Epidemiology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in the United States and the rest of the world
    • Sayiner M, Koenig A, Henry L, Younossi ZM. Epidemiology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in the United States and the rest of the world. Clin Liver Dis. 2016;20(2):205-214.
    • (2016) Clin Liver Dis. , vol.20 , Issue.2 , pp. 205-214
    • Sayiner, M.1    Koenig, A.2    Henry, L.3    Younossi, Z.M.4
  • 4
    • 84941929364 scopus 로고    scopus 로고
    • Epidemiology and natural history of nonalcoholic fatty liver disease
    • Satapathy SK, Sanyal AJ. Epidemiology and natural history of nonalcoholic fatty liver disease. Semin Liver Dis. 2015;35(3):221-235.
    • (2015) Semin Liver Dis , vol.35 , Issue.3 , pp. 221-235
    • Satapathy, S.K.1    Sanyal, A.J.2
  • 5
    • 83755177737 scopus 로고    scopus 로고
    • Mechanisms of lysophosphatidylcholine- induced hepatocyte lipoapoptosis
    • Kakisaka K, et al. Mechanisms of lysophosphatidylcholine- induced hepatocyte lipoapoptosis. Am J Physiol Gastrointest Liver Physiol. 2012;302(1):G77-G84.
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.302 , Issue.1 , pp. G77-G84
    • Kakisaka, K.1
  • 6
    • 84893817138 scopus 로고    scopus 로고
    • Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis
    • Ibrahim SH, et al. Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis. Liver Int. 2014;34(3):427-437.
    • (2014) Liver Int , vol.34 , Issue.3 , pp. 427-437
    • Ibrahim, S.H.1
  • 7
    • 84907978697 scopus 로고    scopus 로고
    • Obesity-induced CerS6- dependent C16:0 ceramide production promotes weight gain and glucose intolerance
    • Turpin SM, et al. Obesity-induced CerS6- dependent C16:0 ceramide production promotes weight gain and glucose intolerance. Cell Metab. 2014;20(4):678-686.
    • (2014) Cell Metab , vol.20 , Issue.4 , pp. 678-686
    • Turpin, S.M.1
  • 8
    • 84995768489 scopus 로고    scopus 로고
    • Extracellular vesicles in liver pathobiology: Small particles with big impact [published online ahead of print September 15, 2016]
    • Hirsova P, et al. Extracellular vesicles in liver pathobiology: small particles with big impact [published online ahead of print September 15, 2016]. Hepatology. doi:10.1002/hep.28814.
    • Hepatology
    • Hirsova, P.1
  • 9
    • 84949883269 scopus 로고    scopus 로고
    • Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes
    • Ibrahim SH, et al. Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes. Hepatology. 2016;63(3):731-744.
    • (2016) Hepatology , vol.63 , Issue.3 , pp. 731-744
    • Ibrahim, S.H.1
  • 10
    • 84963837839 scopus 로고    scopus 로고
    • Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner
    • Kakazu E, Mauer AS, Yin M, Malhi H. Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner. J Lipid Res. 2016;57(2):233-245.
    • (2016) J Lipid Res , vol.57 , Issue.2 , pp. 233-245
    • Kakazu, E.1    Mauer, A.S.2    Yin, M.3    Malhi, H.4
  • 11
    • 84975747692 scopus 로고    scopus 로고
    • Lipid-induced signaling causes release of inflammatory extracellular vesicles from hepatocytes
    • Hirsova P, et al. Lipid-induced signaling causes release of inflammatory extracellular vesicles from hepatocytes. Gastroenterology. 2016;150(4):956-967.
    • (2016) Gastroenterology , vol.150 , Issue.4 , pp. 956-967
    • Hirsova, P.1
  • 12
    • 85002246051 scopus 로고    scopus 로고
    • Extracellular vesicles released by hepatocytes from gastric infusion model of ALD contain a miRNA barcode that can be detected in blood [published online ahead of print September 17, 2016]
    • Eguchi A, et al. Extracellular vesicles released by hepatocytes from gastric infusion model of ALD contain a miRNA barcode that can be detected in blood [published online ahead of print September 17, 2016]. Hepatology. doi:10.1002/hep.28838.
    • Hepatology
    • Eguchi, A.1
  • 13
    • 84958835221 scopus 로고    scopus 로고
    • Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles
    • Verma VK, et al. Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles. J Hepatol. 2016;64(3):651-660.
    • (2016) J Hepatol , vol.64 , Issue.3 , pp. 651-660
    • Verma, V.K.1
  • 14
    • 0042165989 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
    • Feldstein AE, et al. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology. 2003;125(2):437-443.
    • (2003) Gastroenterology , vol.125 , Issue.2 , pp. 437-443
    • Feldstein, A.E.1
  • 15
    • 80655149472 scopus 로고    scopus 로고
    • Death receptor 5 signaling promotes hepatocyte lipoapoptosis
    • Cazanave SC, et al. Death receptor 5 signaling promotes hepatocyte lipoapoptosis. J Biol Chem. 2011;286(45):39336-39348.
    • (2011) J Biol Chem , vol.286 , Issue.45 , pp. 39336-39348
    • Cazanave, S.C.1
  • 16
    • 84927797559 scopus 로고    scopus 로고
    • TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess
    • Idrissova L, et al. TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess. J Hepatol. 2015;62(5):1156-1163.
    • (2015) J Hepatol , vol.62 , Issue.5 , pp. 1156-1163
    • Idrissova, L.1
  • 17
    • 84942872734 scopus 로고    scopus 로고
    • Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis
    • Afonso MB, et al. Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis. Clin Sci. 2015;129(8):721-739.
    • (2015) Clin Sci , vol.129 , Issue.8 , pp. 721-739
    • Afonso, M.B.1
  • 18
    • 20544442905 scopus 로고    scopus 로고
    • Alarmins: Chemotactic activators of immune responses
    • Oppenheim JJ, Yang D. Alarmins: chemotactic activators of immune responses. Curr Opin Immunol. 2005;17(4):359-365.
    • (2005) Curr Opin Immunol. , vol.17 , Issue.4 , pp. 359-365
    • Oppenheim, J.J.1    Yang, D.2
  • 19
    • 33747751590 scopus 로고    scopus 로고
    • Alarmin(g) news about danger: Workshop on innate danger signals and HMGB1
    • Harris HE, Raucci A. Alarmin(g) news about danger: workshop on innate danger signals and HMGB1. EMBO Rep. 2006;7(8):774-778.
    • (2006) EMBO Rep. , vol.7 , Issue.8 , pp. 774-778
    • Harris, H.E.1    Raucci, A.2
  • 21
    • 0036401433 scopus 로고    scopus 로고
    • Cytokine expression in three mouse models of experimental hepatitis
    • Sass G, Heinlein S, Agli A, Bang R, Schumann J, Tiegs G. Cytokine expression in three mouse models of experimental hepatitis. Cytokine. 2002;19(3):115-120.
    • (2002) Cytokine , vol.19 , Issue.3 , pp. 115-120
    • Sass, G.1    Heinlein, S.2    Agli, A.3    Bang, R.4    Schumann, J.5    Tiegs, G.6
  • 22
    • 77955142252 scopus 로고    scopus 로고
    • Interleukin-33 overexpression is associated with liver fibrosis in mice and humans
    • Marvie P, et al. Interleukin-33 overexpression is associated with liver fibrosis in mice and humans. J Cell Mol Med. 2010;14(6B):1726-1739.
    • (2010) J Cell Mol Med. , vol.14 , Issue.6 , pp. 1726-1739
    • Marvie, P.1
  • 23
    • 79960721309 scopus 로고    scopus 로고
    • NKT cells are required to induce high IL-33 expression in hepatocytes during ConA-induced acute hepatitis
    • Arshad MI, et al. NKT cells are required to induce high IL-33 expression in hepatocytes during ConA-induced acute hepatitis. Eur J Immunol. 2011;41(8):2341-2348.
    • (2011) Eur J Immunol , vol.41 , Issue.8 , pp. 2341-2348
    • Arshad, M.I.1
  • 24
    • 80055043169 scopus 로고    scopus 로고
    • Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice
    • Li L, et al. Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice. Hepatology. 2011;54(5):1620-1630.
    • (2011) Hepatology , vol.54 , Issue.5 , pp. 1620-1630
    • Li, L.1
  • 25
    • 77957943307 scopus 로고    scopus 로고
    • Intravascular danger signals guide neutrophils to sites of sterile inflammation
    • McDonald B, et al. Intravascular danger signals guide neutrophils to sites of sterile inflammation. Science. 2010;330(6002):362-366.
    • (2010) Science , vol.330 , Issue.6002 , pp. 362-366
    • McDonald, B.1
  • 26
    • 34548707231 scopus 로고    scopus 로고
    • Selective inactivation of NF-κB in the liver using NF-κB decoy suppresses CCl4-induced liver injury and fibrosis
    • Son G, Iimuro Y, Seki E, Hirano T, Kaneda Y, Fujimoto J. Selective inactivation of NF-κB in the liver using NF-κB decoy suppresses CCl4-induced liver injury and fibrosis. Am J Physiol Gastrointest Liver Physiol. 2007;293(3):G631-G639.
    • (2007) Am J Physiol Gastrointest Liver Physiol. , vol.293 , Issue.3 , pp. G631-G639
    • Son, G.1    Iimuro, Y.2    Seki, E.3    Hirano, T.4    Kaneda, Y.5    Fujimoto, J.6
  • 27
    • 84915821030 scopus 로고    scopus 로고
    • Neurotropin suppresses inflammatory cytokine expression and cell death through suppression of NF-κB and JNK in hepatocytes
    • Zhang B, et al. Neurotropin suppresses inflammatory cytokine expression and cell death through suppression of NF-κB and JNK in hepatocytes. PLoS One. 2014;9(12):e114071.
    • (2014) PLoS One , vol.9 , Issue.12 , pp. e114071
    • Zhang, B.1
  • 28
    • 84938404066 scopus 로고    scopus 로고
    • Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease
    • Petrasek J, et al. Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease. J Leukoc Biol. 2015;98(2):249-256.
    • (2015) J Leukoc Biol , vol.98 , Issue.2 , pp. 249-256
    • Petrasek, J.1
  • 29
    • 84931272963 scopus 로고    scopus 로고
    • Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat-cholesterol-sugar diet model in mice
    • Ganz M, et al. Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat-cholesterol-sugar diet model in mice. J Transl Med. 2015;13:193.
    • (2015) J Transl Med. , vol.13 , pp. 193
    • Ganz, M.1
  • 30
    • 58749112734 scopus 로고    scopus 로고
    • A core gut microbiome in obese and lean twins
    • Turnbaugh PJ, et al. A core gut microbiome in obese and lean twins. Nature. 2009;457(7228):480-484.
    • (2009) Nature , vol.457 , Issue.7228 , pp. 480-484
    • Turnbaugh, P.J.1
  • 31
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444(7122):1027-1031.
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5    Gordon, J.I.6
  • 32
    • 84872112919 scopus 로고    scopus 로고
    • Divergent metabolic outcomes arising from targeted manipulation of the gut microbiota in diet-induced obesity
    • Murphy EF, et al. Divergent metabolic outcomes arising from targeted manipulation of the gut microbiota in diet-induced obesity. Gut. 2013;62(2):220-226.
    • (2013) Gut , vol.62 , Issue.2 , pp. 220-226
    • Murphy, E.F.1
  • 33
    • 84867074831 scopus 로고    scopus 로고
    • A metagenome-wide association study of gut microbiota in type 2 diabetes
    • Qin J, et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature. 2012;490(7418):55-60.
    • (2012) Nature , vol.490 , Issue.7418 , pp. 55-60
    • Qin, J.1
  • 34
    • 84866738529 scopus 로고    scopus 로고
    • Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome
    • Vrieze A, et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology. 2012;143(4):913-6.
    • (2012) Gastroenterology , vol.143 , Issue.4 , pp. 913-916
    • Vrieze, A.1
  • 35
    • 84898824175 scopus 로고    scopus 로고
    • Interactions between the intestinal microbiome and liver diseases
    • Schnabl B, Brenner DA. Interactions between the intestinal microbiome and liver diseases. Gastroenterology. 2014;146(6):1513-1524.
    • (2014) Gastroenterology , vol.146 , Issue.6 , pp. 1513-1524
    • Schnabl, B.1    Brenner, D.A.2
  • 36
    • 84954288595 scopus 로고    scopus 로고
    • The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota
    • Boursier J, et al. The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota. Hepatology. 2016;63(3):764-775.
    • (2016) Hepatology , vol.63 , Issue.3 , pp. 764-775
    • Boursier, J.1
  • 37
    • 0022552278 scopus 로고
    • Quantitation, tissue distribution and proliferation kinetics of Kupffer cells in normal rat liver
    • Bouwens L, Baekeland M, De Zanger, R, Wisse E. Quantitation, tissue distribution and proliferation kinetics of Kupffer cells in normal rat liver. Hepatology. 1986;6(4):718-722.
    • (1986) Hepatology , vol.6 , Issue.4 , pp. 718-722
    • Bouwens, L.1    Baekeland, M.2    Wisse, E.3    De Zanger, R.4
  • 38
    • 0024373212 scopus 로고
    • Development, differentiation, and maturation of fetal mouse yolk sac macrophages in cultures
    • Naito M, Yamamura F, Nishikawa S, Takahashi K. Development, differentiation, and maturation of fetal mouse yolk sac macrophages in cultures. J Leukoc Biol. 1989;46(1):1-10.
    • (1989) J Leukoc Biol , vol.46 , Issue.1 , pp. 1-10
    • Naito, M.1    Yamamura, F.2    Nishikawa, S.3    Takahashi, K.4
  • 39
    • 84925465211 scopus 로고    scopus 로고
    • Tissue-resident macrophages originate from yolk-sacderived erythro-myeloid progenitors
    • Gomez Perdiguero E, et al. Tissue-resident macrophages originate from yolk-sacderived erythro-myeloid progenitors. Nature. 2015;518(7540):547-551.
    • (2015) Nature , vol.518 , Issue.7540 , pp. 547-551
    • Gomez, P.E.1
  • 40
    • 0018476272 scopus 로고
    • Origin and kinetics of Kupffer cells during an acute inflammatory response
    • Diesselhoff-den Dulk MM, Crofton RW, van Furth, R. Origin and kinetics of Kupffer cells during an acute inflammatory response. Immunology. 1979;37(1):7-14.
    • (1979) Immunology , vol.37 , Issue.1 , pp. 7-14
    • Diesselhoff-Den, D.M.M.1    Crofton, R.W.2    Van Furth, R.3
  • 41
    • 84955567750 scopus 로고    scopus 로고
    • Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
    • Scott CL, et al. Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells. Nat Commun. 2016;7:10321.
    • (2016) Nat Commun , vol.7 , pp. 10321
    • Scott, C.L.1
  • 42
    • 84864298329 scopus 로고    scopus 로고
    • Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages
    • Hoeffel G, et al. Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages. J Exp Med. 2012;209(6):1167-1181.
    • (2012) J Exp Med , vol.209 , Issue.6 , pp. 1167-1181
    • Hoeffel, G.1
  • 43
    • 84940984138 scopus 로고    scopus 로고
    • Most tissue-resident macrophages except microglia are derived from fetal hematopoietic stem cells
    • Sheng J, Ruedl C, Karjalainen K. Most tissue-resident macrophages except microglia are derived from fetal hematopoietic stem cells. Immunity. 2015;43(2):382-393.
    • (2015) Immunity , vol.43 , Issue.2 , pp. 382-393
    • Sheng, J.1    Ruedl, C.2    Karjalainen, K.3
  • 44
    • 84859508307 scopus 로고    scopus 로고
    • A lineage of myeloid cells independent of Myb and hematopoietic stem cells
    • Schulz C, et al. A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science. 2012;336(6077):86-90.
    • (2012) Science , vol.336 , Issue.6077 , pp. 86-90
    • Schulz, C.1
  • 45
    • 84894798789 scopus 로고    scopus 로고
    • M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease
    • Wan J, et al. M2 Kupffer cells promote M1 Kupffer cell apoptosis: a protective mechanism against alcoholic and nonalcoholic fatty liver disease. Hepatology. 2014;59(1):130-142.
    • (2014) Hepatology , vol.59 , Issue.1 , pp. 130-142
    • Wan, J.1
  • 46
    • 0035865249 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta
    • Seki E, et al. Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta. J Immunol. 2001;166(4):2651-2657.
    • (2001) J Immunol , vol.166 , Issue.4 , pp. 2651-2657
    • Seki, E.1
  • 47
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol. 2008;8(12):958-969.
    • (2008) Nat Rev Immunol. , vol.8 , Issue.12 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 48
    • 84982279514 scopus 로고    scopus 로고
    • TGF-β induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype [published online ahead of print July 13, 2016]
    • Zhang F, et al. TGF-β induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype [published online ahead of print July 13, 2016]. Oncotarget. doi:10.18632/oncotarget.10561.
    • Oncotarget
    • Zhang, F.1
  • 49
    • 84926308649 scopus 로고    scopus 로고
    • NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation
    • Xu J, et al. NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation. J Clin Invest. 2015;125(4):1579-1590.
    • (2015) J Clin Invest , vol.125 , Issue.4 , pp. 1579-1590
    • Xu, J.1
  • 50
    • 0032102990 scopus 로고    scopus 로고
    • Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: Competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype
    • Munder M, Eichmann K, Modolell M. Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype. J Immunol. 1998;160(11):5347-5354.
    • (1998) J Immunol , vol.160 , Issue.11 , pp. 5347-5354
    • Munder, M.1    Eichmann, K.2    Modolell, M.3
  • 51
    • 84894102230 scopus 로고    scopus 로고
    • Transcriptome-based network analysis reveals a spectrum model of human macrophage activation
    • Xue J, et al. Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity. 2014;40(2):274-288.
    • (2014) Immunity , vol.40 , Issue.2 , pp. 274-288
    • Xue, J.1
  • 52
    • 84869208905 scopus 로고    scopus 로고
    • Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis
    • Ramachandran P, et al. Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Proc Natl Acad Sci U S A. 2012;109(46):E3186-E3195.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.46 , pp. E3186-E3195
    • Ramachandran, P.1
  • 53
    • 84962762646 scopus 로고    scopus 로고
    • A reservoir of mature cavity macrophages that can rapidly invade visceral organs to affect tissue repair
    • Wang J, Kubes P. A reservoir of mature cavity macrophages that can rapidly invade visceral organs to affect tissue repair. Cell. 2016;165(3):668-678.
    • (2016) Cell , vol.165 , Issue.3 , pp. 668-678
    • Wang, J.1    Kubes, P.2
  • 54
    • 67651174837 scopus 로고    scopus 로고
    • Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis
    • Karlmark KR, et al. Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis. Hepatology. 2009;50(1):261-274.
    • (2009) Hepatology , vol.50 , Issue.1 , pp. 261-274
    • Karlmark, K.R.1
  • 55
    • 77955096540 scopus 로고    scopus 로고
    • Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis
    • Zimmermann HW, et al. Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis. PLoS One. 2010;5(6):e11049.
    • (2010) PLoS One , vol.5 , Issue.6 , pp. e11049
    • Zimmermann, H.W.1
  • 56
    • 67651156353 scopus 로고    scopus 로고
    • CCR2 promotes hepatic fibrosis in mice
    • Seki E, et al. CCR2 promotes hepatic fibrosis in mice. Hepatology. 2009;50(1):185-197.
    • (2009) Hepatology , vol.50 , Issue.1 , pp. 185-197
    • Seki, E.1
  • 57
    • 65649094468 scopus 로고    scopus 로고
    • Dual role of CCR2 in the constitution and the resolution of liver fibrosis in mice
    • Mitchell C, et al. Dual role of CCR2 in the constitution and the resolution of liver fibrosis in mice. Am J Pathol. 2009;174(5):1766-1775.
    • (2009) Am J Pathol. , vol.174 , Issue.5 , pp. 1766-1775
    • Mitchell, C.1
  • 58
    • 84907552775 scopus 로고    scopus 로고
    • Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice
    • Wang M, You Q, Lor K, Chen F, Gao B, Ju C. Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice. J Leukoc Biol. 2014;96(4):657-665.
    • (2014) J Leukoc Biol , vol.96 , Issue.4 , pp. 657-665
    • Wang, M.1    You, Q.2    Lor, K.3    Chen, F.4    Gao, B.5    Ju, C.6
  • 59
    • 76249095169 scopus 로고    scopus 로고
    • Development of monocytes, macrophages, and dendritic cells
    • Geissmann F, Manz MG, Jung S, Sieweke MH, Merad M, Ley K. Development of monocytes, macrophages, and dendritic cells. Science. 2010;327(5966):656-661.
    • (2010) Science , vol.327 , Issue.5966 , pp. 656-661
    • Geissmann, F.1    Manz, M.G.2    Jung, S.3    Sieweke, M.H.4    Merad, M.5    Ley, K.6
  • 60
    • 84903625203 scopus 로고    scopus 로고
    • Infiltrating monocyte-derived macrophages and resident kupffer cells display different ontogeny and functions in acute liver injury
    • Zigmond E, et al. Infiltrating monocyte-derived macrophages and resident kupffer cells display different ontogeny and functions in acute liver injury. J Immunol. 2014;193(1):344-353.
    • (2014) J Immunol. , vol.193 , Issue.1 , pp. 344-353
    • Zigmond, E.1
  • 61
    • 84865460082 scopus 로고    scopus 로고
    • Dendritic cells promote macrophage infiltration and comprise a substantial proportion of obesity-associated increases in CD11c+ cells in adipose tissue and liver
    • Stefanovic-Racic M, et al. Dendritic cells promote macrophage infiltration and comprise a substantial proportion of obesity-associated increases in CD11c+ cells in adipose tissue and liver. Diabetes. 2012;61(9):2330-2339.
    • (2012) Diabetes , vol.61 , Issue.9 , pp. 2330-2339
    • Stefanovic-Racic, M.1
  • 62
    • 0031010858 scopus 로고    scopus 로고
    • A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature
    • Wong J, et al. A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature. J Clin Invest. 1997;99(11):2782-2790.
    • (1997) J Clin Invest , vol.99 , Issue.11 , pp. 2782-2790
    • Wong, J.1
  • 63
    • 42249087107 scopus 로고    scopus 로고
    • Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids
    • McDonald B, et al. Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids. J Exp Med. 2008;205(4):915-927.
    • (2008) J Exp Med , vol.205 , Issue.4 , pp. 915-927
    • McDonald, B.1
  • 64
    • 84896405331 scopus 로고    scopus 로고
    • A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse
    • Moles A, et al. A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. J Hepatol. 2014;60(4):782-791.
    • (2014) J Hepatol. , vol.60 , Issue.4 , pp. 782-791
    • Moles, A.1
  • 65
    • 84948614431 scopus 로고    scopus 로고
    • The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis
    • Huebener P, et al. The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis. J Clin Invest. 2015;125(2):539-550.
    • (2015) J Clin Invest , vol.125 , Issue.2 , pp. 539-550
    • Huebener, P.1
  • 66
    • 84899560268 scopus 로고    scopus 로고
    • Metabolically induced liver inflammation leads to NASH and differs from LPS- or IL-1β-induced chronic inflammation
    • Liang W, et al. Metabolically induced liver inflammation leads to NASH and differs from LPS- or IL-1β-induced chronic inflammation. Lab Invest. 2014;94(5):491-502.
    • (2014) Lab Invest , vol.94 , Issue.5 , pp. 491-502
    • Liang, W.1
  • 67
    • 71149086343 scopus 로고    scopus 로고
    • Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis
    • Rensen SS, et al. Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis. Am J Pathol. 2009;175(4):1473-1482.
    • (2009) Am J Pathol , vol.175 , Issue.4 , pp. 1473-1482
    • Rensen, S.S.1
  • 69
    • 84954441801 scopus 로고    scopus 로고
    • Increased ratio of neutrophil elastase to α1-antitrypsin is closely associated with liver inflammation in patients with nonalcoholic steatohepatitis
    • Zang S, et al. Increased ratio of neutrophil elastase to α1-antitrypsin is closely associated with liver inflammation in patients with nonalcoholic steatohepatitis. Clin Exp Pharmacol Physiol. 2016;43(1):13-21.
    • (2016) Clin Exp Pharmacol Physiol , vol.43 , Issue.1 , pp. 13-21
    • Zang, S.1
  • 70
    • 51349158548 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells mediate oral tolerance
    • Goubier A, et al. Plasmacytoid dendritic cells mediate oral tolerance. Immunity. 2008;29(3):464-475.
    • (2008) Immunity , vol.29 , Issue.3 , pp. 464-475
    • Goubier, A.1
  • 71
    • 84926659037 scopus 로고    scopus 로고
    • The complex myeloid network of the liver with diverse functional capacity at steady state and in inflammation
    • Eckert C, Klein N, Kornek M, Lukacs-Kornek V. The complex myeloid network of the liver with diverse functional capacity at steady state and in inflammation. Front Immunol. 2015;6:179.
    • (2015) Front Immunol , vol.6 , pp. 179
    • Eckert, C.1    Klein, N.2    Kornek, M.3    Lukacs-Kornek, V.4
  • 72
    • 84956782591 scopus 로고    scopus 로고
    • Immunology in the liver- -from homeostasis to disease
    • Heymann F, Tacke F. Immunology in the liver- -from homeostasis to disease. Nat Rev Gastroenterol Hepatol. 2016;13(2):88-110.
    • (2016) Nat Rev Gastroenterol Hepatol. , vol.13 , Issue.2 , pp. 88-110
    • Heymann, F.1    Tacke, F.2
  • 73
    • 0037131976 scopus 로고    scopus 로고
    • Mouse plasmacytoid cells: Long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8(+) dendritic cells only after microbial stimulus
    • O'Keeffe M, et al. Mouse plasmacytoid cells: long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8(+) dendritic cells only after microbial stimulus. J Exp Med. 2002;196(10):1307-1319.
    • (2002) J Exp Med. , vol.196 , Issue.10 , pp. 1307-1319
    • O'Keeffe, M.1
  • 74
    • 55549148718 scopus 로고    scopus 로고
    • Poor allostimulatory function of liver plasmacytoid DC is associated with proapoptotic activity, dependent on regulatory T cells
    • Tokita D, et al. Poor allostimulatory function of liver plasmacytoid DC is associated with proapoptotic activity, dependent on regulatory T cells. J Hepatol. 2008;49(6):1008-1018.
    • (2008) J Hepatol , vol.49 , Issue.6 , pp. 1008-1018
    • Tokita, D.1
  • 75
    • 84155175629 scopus 로고    scopus 로고
    • Dendritic cell regulation of carbon tetrachloride-induced murine liver fibrosis regression
    • Jiao J, et al. Dendritic cell regulation of carbon tetrachloride-induced murine liver fibrosis regression. Hepatology. 2012;55(1):244-255.
    • (2012) Hepatology , vol.55 , Issue.1 , pp. 244-255
    • Jiao, J.1
  • 76
    • 84865461206 scopus 로고    scopus 로고
    • Identification of adipose tissue dendritic cells correlated with obesityassociated insulin-resistance and inducing Th17 responses in mice and patients
    • Bertola A, et al. Identification of adipose tissue dendritic cells correlated with obesityassociated insulin-resistance and inducing Th17 responses in mice and patients. Diabetes. 2012;61(9):2238-2247.
    • (2012) Diabetes , vol.61 , Issue.9 , pp. 2238-2247
    • Bertola, A.1
  • 77
    • 61949356502 scopus 로고    scopus 로고
    • The interleukin-17 pathway is involved in human alcoholic liver disease
    • Lemmers A, et al. The interleukin-17 pathway is involved in human alcoholic liver disease. Hepatology. 2009;49(2):646-657.
    • (2009) Hepatology , vol.49 , Issue.2 , pp. 646-657
    • Lemmers, A.1
  • 78
    • 77249158089 scopus 로고    scopus 로고
    • Implication of Th17 and Th1 cells in patients with chronic active hepatitis B
    • Ge J, Wang K, Meng QH, Qi ZX, Meng FL, Fan YC. Implication of Th17 and Th1 cells in patients with chronic active hepatitis B. J Clin Immunol. 2010;30(1):60-67.
    • (2010) J Clin Immunol. , vol.30 , Issue.1 , pp. 60-67
    • Ge, J.1    Wang, K.2    Meng, Q.H.3    Qi, Z.X.4    Meng, F.L.5    Fan, Y.C.6
  • 79
    • 84865461464 scopus 로고    scopus 로고
    • Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice
    • Meng F, et al. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Gastroenterology. 2012;143(3):765-776.
    • (2012) Gastroenterology , vol.143 , Issue.3 , pp. 765-776
    • Meng, F.1
  • 80
    • 84953259630 scopus 로고    scopus 로고
    • Progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis is marked by a higher frequency of Th17 cells in the liver and an increased Th17/resting regulatory T cell ratio in peripheral blood and in the liver
    • Rau M, et al. Progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis is marked by a higher frequency of Th17 cells in the liver and an increased Th17/resting regulatory T cell ratio in peripheral blood and in the liver. J Immunol. 2016;196(1):97-105.
    • (2016) J Immunol. , vol.196 , Issue.1 , pp. 97-105
    • Rau, M.1
  • 81
    • 77958072084 scopus 로고    scopus 로고
    • Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis
    • Hueber W, et al. Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis. Sci Transl Med. 2010;2(52):52-72.
    • (2010) Sci Transl Med , vol.2 , Issue.52 , pp. 52-72
    • Hueber, W.1
  • 83
    • 79251585935 scopus 로고    scopus 로고
    • Human MAIT cells are xenobiotic- resistant, tissue-targeted, CD161hi IL-17- secreting T cells
    • Dusseaux M, et al. Human MAIT cells are xenobiotic- resistant, tissue-targeted, CD161hi IL-17- secreting T cells. Blood. 2011;117(4):1250-1259.
    • (2011) Blood , vol.117 , Issue.4 , pp. 1250-1259
    • Dusseaux, M.1
  • 84
    • 84975726320 scopus 로고    scopus 로고
    • Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1
    • Jeffery HC, et al. Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1. J Hepatol. 2016;64(5):1118-1127.
    • (2016) J Hepatol , vol.64 , Issue.5 , pp. 1118-1127
    • Jeffery, H.C.1
  • 85
    • 84926318323 scopus 로고    scopus 로고
    • Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients
    • Magalhaes I, et al. Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients. J Clin Invest. 2015;125(4):1752-1762.
    • (2015) J Clin Invest , vol.125 , Issue.4 , pp. 1752-1762
    • Magalhaes, I.1
  • 86
    • 70149090633 scopus 로고    scopus 로고
    • Liver natural killer and natural killer T cells: Immunobiology and emerging roles in liver diseases
    • Gao B, Radaeva S, Park O. Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases. J Leukoc Biol. 2009;86(3):513-528.
    • (2009) J Leukoc Biol , vol.86 , Issue.3 , pp. 513-528
    • Gao, B.1    Radaeva, S.2    Park, O.3
  • 87
    • 84925349264 scopus 로고    scopus 로고
    • Inhibition of type I natural killer T cells by retinoids or following sulfatide-mediated activation of type II natural killer T cells attenuates alcoholic liver disease in mice
    • Maricic I, et al. Inhibition of type I natural killer T cells by retinoids or following sulfatide-mediated activation of type II natural killer T cells attenuates alcoholic liver disease in mice. Hepatology. 2015;61(4):1357-1369.
    • (2015) Hepatology , vol.61 , Issue.4 , pp. 1357-1369
    • Maricic, I.1
  • 88
    • 68349148211 scopus 로고    scopus 로고
    • Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
    • Feuerer M, et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med. 2009;15(8):930-939.
    • (2009) Nat Med , vol.15 , Issue.8 , pp. 930-939
    • Feuerer, M.1
  • 89
    • 84876461373 scopus 로고    scopus 로고
    • Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk
    • Wagner NM, et al. Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk. Obesity (Silver Spring). 2013;21(3):461-468.
    • (2013) Obesity (Silver Spring) , vol.21 , Issue.3 , pp. 461-468
    • Wagner, N.M.1
  • 90
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    • Salomon B, et al. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity. 2000;12(4):431-440.
    • (2000) Immunity , vol.12 , Issue.4 , pp. 431-440
    • Salomon, B.1
  • 91
    • 84930752976 scopus 로고    scopus 로고
    • CD28 deletion improves obesityinduced liver steatosis but increases adiposity in mice
    • Poggi M, et al. CD28 deletion improves obesityinduced liver steatosis but increases adiposity in mice. Int J Obes (Lond). 2015;39(6):977-985.
    • (2015) Int J Obes (Lond) , vol.39 , Issue.6 , pp. 977-985
    • Poggi, M.1
  • 92
    • 84927761703 scopus 로고    scopus 로고
    • Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation
    • Chatzigeorgiou A, et al. Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation. Hepatology. 2014;60(4):1196-1210.
    • (2014) Hepatology , vol.60 , Issue.4 , pp. 1196-1210
    • Chatzigeorgiou, A.1
  • 94
    • 84862195154 scopus 로고    scopus 로고
    • Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis
    • Kisseleva T, et al. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A. 2012;109(24):9448-9453.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.24 , pp. 9448-9453
    • Kisseleva, T.1
  • 95
    • 14244257340 scopus 로고    scopus 로고
    • Adipogenic transcriptional regulation of hepatic stellate cells
    • She H, Xiong S, Hazra S, Tsukamoto H. Adipogenic transcriptional regulation of hepatic stellate cells. J Biol Chem. 2005;280(6):4959-4967.
    • (2005) J Biol Chem , vol.280 , Issue.6 , pp. 4959-4967
    • She, H.1    Xiong, S.2    Hazra, S.3    Tsukamoto, H.4
  • 96
    • 67349229867 scopus 로고    scopus 로고
    • Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage
    • Blaner WS, et al. Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage. Biochim Biophys Acta. 2009;1791(6):467-473.
    • (2009) Biochim Biophys Acta , vol.1791 , Issue.6 , pp. 467-473
    • Blaner, W.S.1
  • 97
    • 0033855572 scopus 로고    scopus 로고
    • Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells
    • Marra F, et al. Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells. Gastroenterology. 2000;119(2):466-478.
    • (2000) Gastroenterology , vol.119 , Issue.2 , pp. 466-478
    • Marra, F.1
  • 99
    • 84884984479 scopus 로고    scopus 로고
    • Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice
    • Pradere JP, et al. Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice. Hepatology. 2013;58(4):1461-1473.
    • (2013) Hepatology , vol.58 , Issue.4 , pp. 1461-1473
    • Pradere, J.P.1
  • 100
    • 11144325650 scopus 로고    scopus 로고
    • Inhibition of inhibitor of κB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis
    • Oakley F, et al. Inhibition of inhibitor of κB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis. Gastroenterology. 2005;128(1):108-120.
    • (2005) Gastroenterology , vol.128 , Issue.1 , pp. 108-120
    • Oakley, F.1
  • 101
    • 77953891627 scopus 로고    scopus 로고
    • Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1β in mice
    • Miura K, et al. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1β in mice. Gastroenterology. 2010;139(1):323-34.
    • (2010) Gastroenterology , vol.139 , Issue.1 , pp. 323-334
    • Miura, K.1
  • 102
    • 0037335208 scopus 로고    scopus 로고
    • Influence of leptin in the development of hepatic fibrosis produced in mice by Schistosoma mansoni infection and by chronic carbon tetrachloride administration
    • Potter JJ, Rennie-Tankesley L, Mezey E. Influence of leptin in the development of hepatic fibrosis produced in mice by Schistosoma mansoni infection and by chronic carbon tetrachloride administration. J Hepatol. 2003;38(3):281-288.
    • (2003) J Hepatol , vol.38 , Issue.3 , pp. 281-288
    • Potter, J.J.1    Rennie-Tankesley, L.2    Mezey, E.3
  • 103
    • 0036234147 scopus 로고    scopus 로고
    • Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat
    • Ikejima K, et al. Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat. Gastroenterology. 2002;122(5):1399-1410.
    • (2002) Gastroenterology , vol.122 , Issue.5 , pp. 1399-1410
    • Ikejima, K.1
  • 104
    • 67650963803 scopus 로고    scopus 로고
    • Kupffer cells mediate leptininduced liver fibrosis
    • Wang J, et al. Kupffer cells mediate leptininduced liver fibrosis. Gastroenterology. 2009;137(2):713-723.
    • (2009) Gastroenterology , vol.137 , Issue.2 , pp. 713-723
    • Wang, J.1
  • 105
    • 78449240951 scopus 로고    scopus 로고
    • Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway
    • Choi SS, et al. Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway. J Biol Chem. 2010;285(47):36551-36560.
    • (2010) J Biol Chem. , vol.285 , Issue.47 , pp. 36551-36560
    • Choi, S.S.1
  • 106
    • 0034680787 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptors and hepatic stellate cell activation
    • Miyahara T, et al. Peroxisome proliferatoractivated receptors and hepatic stellate cell activation. J Biol Chem. 2000;275(46):35715-35722.
    • (2000) J Biol Chem. , vol.275 , Issue.46 , pp. 35715-35722
    • Miyahara, T.1
  • 107
    • 0033607653 scopus 로고    scopus 로고
    • Glutathione levels discriminate between oxidative stress and transforming growth factor-β signaling in activated rat hepatic stellate cells
    • De Bleser, PJ, Xu G, Rombouts K, Rogiers V, Geerts A. Glutathione levels discriminate between oxidative stress and transforming growth factor-β signaling in activated rat hepatic stellate cells. J Biol Chem. 1999;274(48):33881-33887.
    • (1999) J Biol Chem. , vol.274 , Issue.48 , pp. 33881-33887
    • Xu, G.1    Rombouts, K.2    Rogiers, V.3    Geerts, A.4    De Bleser, P.J.5
  • 108
    • 79955091590 scopus 로고    scopus 로고
    • The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice
    • Paik YH, et al. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Hepatology. 2011;53(5):1730-1741.
    • (2011) Hepatology , vol.53 , Issue.5 , pp. 1730-1741
    • Paik, Y.H.1
  • 110
    • 58549101268 scopus 로고    scopus 로고
    • The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-β-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms
    • Sancho P, Bertran E, Caja L, Carmona-Cuenca I, Murillo MM, Fabregat I. The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-β-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms. Biochim Biophys Acta. 2009;1793(2):253-263.
    • (2009) Biochim Biophys Acta , vol.1793 , Issue.2 , pp. 253-263
    • Sancho, P.1    Bertran, E.2    Caja, L.3    Carmona-Cuenca, I.4    Murillo, M.M.5    Fabregat, I.6
  • 111
    • 84941653396 scopus 로고    scopus 로고
    • Deficiency of NOX1 or NOX4 prevents liver inflammation and fibrosis in mice through inhibition of hepatic stellate cell activation
    • Lan T, Kisseleva T, Brenner DA. Deficiency of NOX1 or NOX4 prevents liver inflammation and fibrosis in mice through inhibition of hepatic stellate cell activation. PLoS One. 2015;10(7):e0129743.
    • (2015) PLoS One , vol.10 , Issue.7 , pp. e0129743
    • Lan, T.1    Kisseleva, T.2    Brenner, D.A.3
  • 112
    • 84938093088 scopus 로고    scopus 로고
    • Hepatocyte nicotinamide adenine dinucleotide phosphate reduced oxidase 4 regulates stress signaling, fibrosis, and insulin sensitivity during development of steatohepatitis in mice
    • Bettaieb A, et al. Hepatocyte nicotinamide adenine dinucleotide phosphate reduced oxidase 4 regulates stress signaling, fibrosis, and insulin sensitivity during development of steatohepatitis in mice. Gastroenterology. 2015;149(2):468-80.
    • (2015) Gastroenterology , vol.149 , Issue.2 , pp. 468-480
    • Bettaieb, A.1
  • 113
    • 0038185316 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells
    • Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C, Brenner DA. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology. 2003;37(5):1043-1055.
    • (2003) Hepatology , vol.37 , Issue.5 , pp. 1043-1055
    • Paik, Y.H.1    Schwabe, R.F.2    Bataller, R.3    Russo, M.P.4    Jobin, C.5    Brenner, D.A.6
  • 114
    • 35948958955 scopus 로고    scopus 로고
    • TLR4 enhances TGF-β signaling and hepatic fibrosis
    • Seki E, et al. TLR4 enhances TGF-β signaling and hepatic fibrosis. Nat Med. 2007;13(11):1324-1332.
    • (2007) Nat Med , vol.13 , Issue.11 , pp. 1324-1332
    • Seki, E.1
  • 115
    • 63349103768 scopus 로고    scopus 로고
    • Functional linkage of cirrhosispredictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses
    • Guo J, et al. Functional linkage of cirrhosispredictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses. Hepatology. 2009;49(3):960-968.
    • (2009) Hepatology , vol.49 , Issue.3 , pp. 960-968
    • Guo, J.1
  • 116
    • 0033619255 scopus 로고    scopus 로고
    • Silencing of TGF-β signalling by the pseudoreceptor BAMBI
    • Onichtchouk D, et al. Silencing of TGF-β signalling by the pseudoreceptor BAMBI. Nature. 1999;401(6752):480-485.
    • (1999) Nature , vol.401 , Issue.6752 , pp. 480-485
    • Onichtchouk, D.1
  • 117
    • 33746561298 scopus 로고    scopus 로고
    • Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice
    • Czochra P, et al. Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice. J Hepatol. 2006;45(3):419-428.
    • (2006) J Hepatol , vol.45 , Issue.3 , pp. 419-428
    • Czochra, P.1
  • 118
    • 53149123286 scopus 로고    scopus 로고
    • Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation
    • Wang L, Johnson EE, Shi HN, Walker WA, Wessling-Resnick M, Cherayil BJ. Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation. J Immunol. 2008;181(4):2723-2731.
    • (2008) J Immunol. , vol.181 , Issue.4 , pp. 2723-2731
    • Wang, L.1    Johnson, E.E.2    Shi, H.N.3    Walker, W.A.4    Wessling-Resnick, M.5    Cherayil, B.J.6
  • 119
    • 0036293879 scopus 로고    scopus 로고
    • Underdiagnosis of hereditary haemochromatosis: Lack of presentation or penetration?
    • Ryan E, et al. Underdiagnosis of hereditary haemochromatosis: lack of presentation or penetration? Gut. 2002;51(1):108-112.
    • (2002) Gut , vol.51 , Issue.1 , pp. 108-112
    • Ryan, E.1
  • 120
    • 63349103637 scopus 로고    scopus 로고
    • Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C ζ/nuclear factor κB-regulated signaling in rat hepatic stellate cells
    • Ruddell RG, et al. Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C ζ/nuclear factor κB-regulated signaling in rat hepatic stellate cells. Hepatology. 2009;49(3):887-900.
    • (2009) Hepatology , vol.49 , Issue.3 , pp. 887-900
    • Ruddell, R.G.1
  • 121
    • 0037406902 scopus 로고    scopus 로고
    • Identification and characterization of the hepatic stellate cell transferrin receptor
    • Bridle KR, Crawford DH, Ramm GA. Identification and characterization of the hepatic stellate cell transferrin receptor. Am J Pathol. 2003;162(5):1661-1667.
    • (2003) Am J Pathol , vol.162 , Issue.5 , pp. 1661-1667
    • Bridle, K.R.1    Crawford, D.H.2    Ramm, G.A.3
  • 122
    • 85008423138 scopus 로고    scopus 로고
    • The spectrum of histologic findings in hepatic outflow obstruction
    • published online ahead of print September 28, 2016
    • Gonzalez RS, Gilger MA, Huh WJ, Washington K. The spectrum of histologic findings in hepatic outflow obstruction Arch Pathol Lab Med. [published online ahead of print September 28, 2016]. doi:10.5858/arpa.2015-0388-OA.
    • Arch Pathol Lab Med
    • Gonzalez, R.S.1    Gilger, M.A.2    Huh, W.J.3    Washington, K.4
  • 123
    • 37549060626 scopus 로고    scopus 로고
    • The role of inflammation in the pathogenesis of idiopathic pulmonary fibrosis
    • Bringardner BD, Baran CP, Eubank TD, Marsh CB. The role of inflammation in the pathogenesis of idiopathic pulmonary fibrosis. Antioxid Redox Signal. 2008;10(2):287-301.
    • (2008) Antioxid Redox Signal , vol.10 , Issue.2 , pp. 287-301
    • Bringardner, B.D.1    Baran, C.P.2    Eubank, T.D.3    Marsh, C.B.4
  • 124
    • 84976902092 scopus 로고    scopus 로고
    • Quantitative determination of saroglitazar, a predominantly PPARα agonist, in human plasma by a LC-MS/MS method utilizing electrospray ionization in a positive mode [published online ahead of print May 17, 2016]
    • Ghoghari A, et al. Quantitative determination of saroglitazar, a predominantly PPARα agonist, in human plasma by a LC-MS/MS method utilizing electrospray ionization in a positive mode [published online ahead of print May 17, 2016]. Biomed Chromatogr. doi:10.1002/bmc.3760.
    • Biomed Chromatogr
    • Ghoghari, A.1
  • 125
    • 84960140218 scopus 로고    scopus 로고
    • Elafibranor, an agonist of the peroxisome proliferator-activated receptor-α and -δ, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening
    • Ratziu V, et al. Elafibranor, an agonist of the peroxisome proliferator-activated receptor-α and -δ, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening. Gastroenterology. 2016;150(5):1147-1159.
    • (2016) Gastroenterology , vol.150 , Issue.5 , pp. 1147-1159
    • Ratziu, V.1
  • 126
    • 0035800772 scopus 로고    scopus 로고
    • Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor
    • Ananthanarayanan M, Balasubramanian N, Makishima M, Mangelsdorf DJ, Suchy FJ. Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J Biol Chem. 2001;276(31):28857-28865.
    • (2001) J Biol Chem , vol.276 , Issue.31 , pp. 28857-28865
    • Ananthanarayanan, M.1    Balasubramanian, N.2    Makishima, M.3    Mangelsdorf, D.J.4    Suchy, F.J.5
  • 127
    • 84864861866 scopus 로고    scopus 로고
    • Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease
    • Porez G, Prawitt J, Gross B, Staels B. Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease. J Lipid Res. 2012;53(9):1723-1737.
    • (2012) J Lipid Res , vol.53 , Issue.9 , pp. 1723-1737
    • Porez, G.1    Prawitt, J.2    Gross, B.3    Staels, B.4
  • 128
    • 84880664792 scopus 로고    scopus 로고
    • Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease
    • Mudaliar S, et al. Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease. Gastroenterology. 2013;145(3):574-582.
    • (2013) Gastroenterology , vol.145 , Issue.3 , pp. 574-582
    • Mudaliar, S.1
  • 129
    • 84929266699 scopus 로고    scopus 로고
    • Farnesoid X nuclear receptor ligand obeticholic acid for noncirrhotic, non-alcoholic steatohepatitis (FLINT): A multicentre, randomised, placebo-controlled trial
    • Neuschwander-Tetri BA, et al. Farnesoid X nuclear receptor ligand obeticholic acid for noncirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Lancet. 2015;385(9972):956-965.
    • (2015) Lancet , vol.385 , Issue.9972 , pp. 956-965
    • Neuschwander-Tetri, B.A.1
  • 130
    • 0041764976 scopus 로고    scopus 로고
    • Prevention of diet-induced fatty liver in experimental animals by the oral administration of a fatty acid bile acid conjugate (FABAC)
    • Gilat T, et al. Prevention of diet-induced fatty liver in experimental animals by the oral administration of a fatty acid bile acid conjugate (FABAC). Hepatology. 2003;38(2):436-442.
    • (2003) Hepatology , vol.38 , Issue.2 , pp. 436-442
    • Gilat, T.1
  • 131
    • 84918843434 scopus 로고    scopus 로고
    • The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease
    • Safadi R, et al. The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2014;12(12):2085-2091.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , Issue.12 , pp. 2085-2091
    • Safadi, R.1
  • 133
    • 68849118799 scopus 로고    scopus 로고
    • CCR1 and CCR5 promote hepatic fibrosis in mice
    • Seki E, et al. CCR1 and CCR5 promote hepatic fibrosis in mice. J Clin Invest. 2009;119(7):1858-1870.
    • (2009) J Clin Invest , vol.119 , Issue.7 , pp. 1858-1870
    • Seki, E.1
  • 134
    • 78049415469 scopus 로고    scopus 로고
    • Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice
    • Berres ML, et al. Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice. J Clin Invest. 2010;120(11):4129-4140.
    • (2010) J Clin Invest , vol.120 , Issue.11 , pp. 4129-4140
    • Berres, M.L.1
  • 135
    • 84960110717 scopus 로고    scopus 로고
    • Efficacy and safety study of cenicriviroc for the treatment of non-alcoholic steatohepatitis in adult subjects with liver fibrosis: CENTAUR Phase 2b study design
    • Friedman S, et al. Efficacy and safety study of cenicriviroc for the treatment of non-alcoholic steatohepatitis in adult subjects with liver fibrosis: CENTAUR Phase 2b study design. Contemp Clin Trials. 2016;47:356-365.
    • (2016) Contemp Clin Trials , vol.47 , pp. 356-365
    • Friedman, S.1
  • 136
    • 0242662539 scopus 로고    scopus 로고
    • Inhibition of fibrocyte differentiation by serum amyloid P
    • Pilling D, Buckley CD, Salmon M, Gomer RH. Inhibition of fibrocyte differentiation by serum amyloid P. J Immunol. 2003;171(10):5537-5546.
    • (2003) J Immunol , vol.171 , Issue.10 , pp. 5537-5546
    • Pilling, D.1    Buckley, C.D.2    Salmon, M.3    Gomer, R.H.4
  • 138
    • 35748946038 scopus 로고    scopus 로고
    • Reduction of bleomycin-induced pulmonary fibrosis by serum amyloid P
    • Pilling D, et al. Reduction of bleomycin-induced pulmonary fibrosis by serum amyloid P. J Immunol. 2007;179(6):4035-4044.
    • (2007) J Immunol. , vol.179 , Issue.6 , pp. 4035-4044
    • Pilling, D.1
  • 139
    • 84959906529 scopus 로고    scopus 로고
    • Recombinant human pentraxin-2 therapy in patients with idiopathic pulmonary fibrosis: Safety, pharmacokinetics and exploratory efficacy
    • van den Blink, B, et al. Recombinant human pentraxin-2 therapy in patients with idiopathic pulmonary fibrosis: safety, pharmacokinetics and exploratory efficacy. Eur Respir J. 2016;47(3):889-897.
    • (2016) Eur Respir J , vol.47 , Issue.3 , pp. 889-897
    • Van Den Blink, B.1
  • 140
    • 84872510074 scopus 로고    scopus 로고
    • Transforming growth factor β neutralization ameliorates pre-existing hepatic fibrosis and reduces cholangiocarcinoma in thioacetamide- Treated rats
    • Ling H, et al. Transforming growth factor β neutralization ameliorates pre-existing hepatic fibrosis and reduces cholangiocarcinoma in thioacetamide- Treated rats. PLoS One. 2013;8(1):e54499.
    • (2013) PLoS One , vol.8 , Issue.1 , pp. e54499
    • Ling, H.1
  • 141
    • 84925536864 scopus 로고    scopus 로고
    • Cutaneous keratoacanthomas/squamous cell carcinomas associated with neutralization of transforming growth factor β by the monoclonal antibody fresolimumab (GC1008)
    • Lacouture ME, et al. Cutaneous keratoacanthomas/squamous cell carcinomas associated with neutralization of transforming growth factor β by the monoclonal antibody fresolimumab (GC1008). Cancer Immunol Immunother. 2015;64(4):437-446.
    • (2015) Cancer Immunol Immunother , vol.64 , Issue.4 , pp. 437-446
    • Lacouture, M.E.1
  • 142
    • 84897566294 scopus 로고    scopus 로고
    • Phase I study of GC1008 (fresolimumab): A human anti-transforming growth factor- beta (TGFβ) monoclonal antibody in patients with advanced malignant melanoma or renal cell carcinoma
    • Morris JC, et al. Phase I study of GC1008 (fresolimumab): a human anti-transforming growth factor- beta (TGFβ) monoclonal antibody in patients with advanced malignant melanoma or renal cell carcinoma. PLoS One. 2014;9(3):e90353.
    • (2014) PLoS One , vol.9 , Issue.3 , pp. e90353
    • Morris, J.C.1
  • 143
    • 79956011495 scopus 로고    scopus 로고
    • A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment- resistant primary focal segmental glomerulosclerosis
    • Trachtman H, et al. A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment- resistant primary focal segmental glomerulosclerosis. Kidney Int. 2011;79(11):1236-1243.
    • (2011) Kidney Int , vol.79 , Issue.11 , pp. 1236-1243
    • Trachtman, H.1
  • 144
    • 84936791793 scopus 로고    scopus 로고
    • Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients
    • Rice LM, et al. Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients. J Clin Invest. 2015;125(7):2795-2807.
    • (2015) J Clin Invest , vol.125 , Issue.7 , pp. 2795-2807
    • Rice, L.M.1
  • 145
    • 84901922571 scopus 로고    scopus 로고
    • Effects of oral intake of hydrogen water on liver fibrogenesis in mice
    • Koyama Y, et al. Effects of oral intake of hydrogen water on liver fibrogenesis in mice. Hepatol Res. 2014;44(6):663-677.
    • (2014) Hepatol Res , vol.44 , Issue.6 , pp. 663-677
    • Koyama, Y.1
  • 146
    • 84861437351 scopus 로고    scopus 로고
    • Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist
    • Iwaisako K, et al. Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist. Proc Natl Acad Sci U S A. 2012;109(21):E1369-E1376.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.21 , pp. E1369-E1376
    • Iwaisako, K.1
  • 148
    • 84943242784 scopus 로고    scopus 로고
    • Dysregulated hepatic methionine metabolism drives homocysteine elevation in diet-induced nonalcoholic fatty liver disease
    • Pacana T, et al. Dysregulated hepatic methionine metabolism drives homocysteine elevation in diet-induced nonalcoholic fatty liver disease. PLoS One. 2015;10(8):e0136822.
    • (2015) PLoS One , vol.10 , Issue.8 , pp. e0136822
    • Pacana, T.1
  • 149
    • 84887367289 scopus 로고    scopus 로고
    • Clinical grading of intrahepatic cholestasis pregnancy
    • Pradhan M, Shao Y. Clinical grading of intrahepatic cholestasis pregnancy. JNMA J Nepal Med Assoc. 2013;52(190):413-419.
    • (2013) JNMA J Nepal Med Assoc. , vol.52 , Issue.190 , pp. 413-419
    • Pradhan, M.1    Shao, Y.2
  • 150
    • 84922733200 scopus 로고    scopus 로고
    • Pathophysiological analysis of primary biliary cirrhosis focusing on choline/phospholipid metabolism
    • Kohjima M, et al. Pathophysiological analysis of primary biliary cirrhosis focusing on choline/phospholipid metabolism. Liver Int. 2015;35(3):1095-1102.
    • (2015) Liver Int , vol.35 , Issue.3 , pp. 1095-1102
    • Kohjima, M.1
  • 151
    • 0035834579 scopus 로고    scopus 로고
    • Dilinoleoylphosphatidylcholine decreases ethanol-induced cytochrome P4502E1
    • Aleynik MK, Lieber CS. Dilinoleoylphosphatidylcholine decreases ethanol-induced cytochrome P4502E1. Biochem Biophys Res Commun. 2001;288(4):1047-1051.
    • (2001) Biochem Biophys Res Commun , vol.288 , Issue.4 , pp. 1047-1051
    • Aleynik, M.K.1    Lieber, C.S.2
  • 153
    • 84966293715 scopus 로고    scopus 로고
    • Ursodeoxycholic acid and Sadenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy: A multi-centered randomized controlled trial
    • Zhang L, et al. Ursodeoxycholic acid and Sadenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy: a multi-centered randomized controlled trial. Eur Rev Med Pharmacol Sci. 2015;19(19):3770-3776.
    • (2015) Eur Rev Med Pharmacol Sci. , vol.19 , Issue.19 , pp. 3770-3776
    • Zhang, L.1
  • 154
    • 68349137821 scopus 로고    scopus 로고
    • Normalization of obesity-associated insulin resistance through immunotherapy
    • Winer S, et al. Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med. 2009;15(8):921-929.
    • (2009) Nat Med. , vol.15 , Issue.8 , pp. 921-929
    • Winer, S.1
  • 155
    • 84929839467 scopus 로고    scopus 로고
    • Oral administration of OKT3 MAb to patients with NASH, promotes regulatory T-cell induction, and alleviates insulin resistance: Results of a phase IIa blinded placebo-controlled trial
    • Lalazar G, et al. Oral administration of OKT3 MAb to patients with NASH, promotes regulatory T-cell induction, and alleviates insulin resistance: results of a phase IIa blinded placebo-controlled trial. J Clin Immunol. 2015;35(4):399-407.
    • (2015) J Clin Immunol. , vol.35 , Issue.4 , pp. 399-407
    • Lalazar, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.