Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles

Journal of Hepatology

Volumn 64, Issue 3, 2016, Pages 651-660

  Verma, Vikas K ^a   Li, Haiyang ^a,b   Wang, Ruisi ^a   Hirsova, Petra ^a   Mushref, Malek ^a   Liu, Yaming ^a,c   Cao, Sheng ^a   Contreras, Patricia C ^d   Malhi, Harmeet ^a   Kamath, Patrick S ^a   Gores, Gregory J ^a   Shah, Vijay H ^a  

^a MAYO CLINIC   (United States)

^b GUIZHOU MEDICAL UNIVERSITY   (China)

^c THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^d Conatus Pharmaceuticals ^*  (United States)

Author keywords

Alcohol; Alcoholic hepatitis; Caspase inhibitor; CD40L; Cyp2E1; Exosomes; Hepatocyte; Inflammation; Liver; Macrophage; TNF

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; BIOLOGICAL MARKER; CASPASE 3; CD40 LIGAND; FASUDIL; RHO KINASE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR; CASPASE; CYTOCHROME P450 2E1;

ALCOHOL LIVER DISEASE; ALCOHOL METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; EXOSOME; FEMALE; GENE DELETION; HEPATITIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; LIVER INJURY; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; DRUG EFFECTS; HEP-G2 CELL LINE; LIVER DISEASES, ALCOHOLIC; METABOLISM; PHYSIOLOGY;

ANIMALS; APOPTOSIS; CASPASES; CD40 LIGAND; CYTOCHROME P-450 CYP2E1; ETHANOL; EXTRACELLULAR VESICLES; FEMALE; HEP G2 CELLS; HEPATOCYTES; HUMANS; LIVER DISEASES, ALCOHOLIC; MACROPHAGE ACTIVATION; MICE; MICE, INBRED C57BL;

EID: 84958835221     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2015.11.020     Document Type: Article

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