Dysregulated hepatic methionine metabolism drives homocysteine elevation in diet-induced nonalcoholic fatty liver disease

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Pacana, Tommy ^a   Cazanave, Sophie ^a   Verdianelli, Aurora ^a   Patel, Vaishali ^a   Min, Hae Ki ^a   Mirshahi, Faridoddin ^a   Quinlivan, Eoin ^b   Sanyal, Arun J ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE DERIVATIVE; BETAINE HOMOCYSTEINE METHYLTRANSFERASE; CASPASE 3; CYSTATHIONINE; CYSTATHIONINE BETA SYNTHASE; CYSTEINE; DNA METHYLTRANSFERASE 3A; FATTY ACID SYNTHASE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLYCINE METHYLTRANSFERASE; HOMOCYSTEINE; HYDROLASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; METHIONINE; METHIONINE ADENOSYLTRANSFERASE 1A; METHIONINE SYNTHASE; MONOMETHYLARGININE; N(G),N(G) DIMETHYLARGININE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLETHANOLAMINE METHYLTRANSFERASE; PROTEIN ARGININE METHYTRANSFERASE 1; PROTEIN BCL 2; PROTEIN C JUN; S ADENOSYLMETHIONINE; S ADENOSYLMETHIONINE HYDROLASE; SERINE; UNCLASSIFIED DRUG; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A; 5 METHYLTETRAHYDROFOLATE HOMOCYSTEINE METHYLTRANSFERASE; ACYL COENZYME A; ADENOSYLHOMOCYSTEINASE; DIPEPTIDE; GAMMA-GLUTAMYLCYSTEINE; METHIONINE ADENOSYLTRANSFERASE;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BCL 2 GENE; C JUN GENE; CASPASE 3 GENE; CHOLESTEROL DIET; CONTROLLED STUDY; DNA METHYLATION; ENZYME ACTIVITY; EPIGENETICS; FASN GENE; FATTY LIVER; FEMALE; GENE; GENE EXPRESSION; HMGCR GENE; HOMOCYSTEINE REMETHYLATION; HOMOCYSTEINE TRANSSULFURATION; LIPID DIET; LIVER FIBROSIS; LIVER METABOLISM; METABOLIC REGULATION; METABOLOMICS; METHIONINE METABOLISM; METHYLATION; MOUSE; NF KAPPA B1 GENE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PROTEIN EXPRESSION; WEIGHT GAIN; ANIMAL; B LYMPHOCYTE; BIOSYNTHESIS; BLOOD ANALYSIS; C57BL MOUSE; GENETICS; LIVER; METABOLISM; METABOLOME; PHYSIOLOGY; RANDOMIZATION;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; ACYL COENZYME A; ADENOSYLHOMOCYSTEINASE; ANIMALS; B-LYMPHOCYTES; BETAINE-HOMOCYSTEINE S-METHYLTRANSFERASE; BLOOD CHEMICAL ANALYSIS; CYSTATHIONINE BETA-SYNTHASE; CYSTEINE; DIET, HIGH-FAT; DIPEPTIDES; DNA METHYLATION; FEMALE; GLUTATHIONE; GLYCINE N-METHYLTRANSFERASE; HOMOCYSTEINE; LIVER; METABOLIC NETWORKS AND PATHWAYS; METABOLOME; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; MICE; MICE, INBRED C57BL; NON-ALCOHOLIC FATTY LIVER DISEASE; RANDOM ALLOCATION;

EID: 84943242784     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0136822     Document Type: Article

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