메뉴 건너뛰기




Volumn 49, Issue 3, 2009, Pages 887-900

Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB - Regulated signaling in rat hepatic stellate cells

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; IRON; KIDNEY INJURY MOLECULE 2; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C ZETA; PROTEIN P50; RANTES; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PROTEIN KINASE C;

EID: 63349103637     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.22716     Document Type: Article
Times cited : (254)

References (41)
  • 1
    • 38049054790 scopus 로고    scopus 로고
    • New functions for an iron storage protein: The role of ferritin in immunity and autoimmunity
    • Recalcati S, Invernizzi P, Arosio P, Cairo G. New functions for an iron storage protein: The role of ferritin in immunity and autoimmunity. J Autoimmun 2008;30:84-89.
    • (2008) J Autoimmun , vol.30 , pp. 84-89
    • Recalcati, S.1    Invernizzi, P.2    Arosio, P.3    Cairo, G.4
  • 2
    • 43549101420 scopus 로고    scopus 로고
    • Screening for hemochromatosis by measuring ferritin levels: A more effective approach
    • Waalen J, Felitti VJ, Gelbart T, Beutler E. Screening for hemochromatosis by measuring ferritin levels: A more effective approach. Blood 2008;111: 3373-3376.
    • (2008) Blood , vol.111 , pp. 3373-3376
    • Waalen, J.1    Felitti, V.J.2    Gelbart, T.3    Beutler, E.4
  • 3
    • 0037093202 scopus 로고    scopus 로고
    • Regulation of ferritin genes and protein
    • Torti FM, Torti SV. Regulation of ferritin genes and protein. Blood 2002; 99:3505-3516.
    • (2002) Blood , vol.99 , pp. 3505-3516
    • Torti, F.M.1    Torti, S.V.2
  • 5
    • 0028946727 scopus 로고
    • Iron storage, lipid peroxidation and glutathione turnover in chronic anti-HCV positive hepatitis
    • Farinati F, Cardin R, De Maria N, Della Libera G, Marafin C, Lecis E, et al. Iron storage, lipid peroxidation and glutathione turnover in chronic anti-HCV positive hepatitis. J Hepatol 1995;22:449-456.
    • (1995) J Hepatol , vol.22 , pp. 449-456
    • Farinati, F.1    Cardin, R.2    De Maria, N.3    Della Libera, G.4    Marafin, C.5    Lecis, E.6
  • 6
    • 35948954244 scopus 로고    scopus 로고
    • Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver
    • Friedman SL. Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 2008;88:125-172.
    • (2008) Physiol Rev , vol.88 , pp. 125-172
    • Friedman, S.L.1
  • 7
    • 0028338934 scopus 로고
    • Identification and characterization of a receptor for tissue ferritin on activated rat lipocytes
    • Ramm GA, Britton RS, O'Neill R, Bacon BR. Identification and characterization of a receptor for tissue ferritin on activated rat lipocytes. J Clin Invest 1994;94:9-15.
    • (1994) J Clin Invest , vol.94 , pp. 9-15
    • Ramm, G.A.1    Britton, R.S.2    O'Neill, R.3    Bacon, B.R.4
  • 8
    • 0029882435 scopus 로고    scopus 로고
    • Rat liver ferritin selectively inhibits expression of alpha-smooth muscle actin in cultured rat lipocytes
    • Ramm GA, Britton RS, O'Neill R, Kohn HD, Bacon BR. Rat liver ferritin selectively inhibits expression of alpha-smooth muscle actin in cultured rat lipocytes. Am J Physiol 1996;270:G370-375.
    • (1996) Am J Physiol , vol.270
    • Ramm, G.A.1    Britton, R.S.2    O'Neill, R.3    Kohn, H.D.4    Bacon, B.R.5
  • 9
    • 34548321204 scopus 로고    scopus 로고
    • Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis
    • Elsharkawy AM, Mann DA. Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis. HEPATOLOGY 2007;46:590-597.
    • (2007) HEPATOLOGY , vol.46 , pp. 590-597
    • Elsharkawy, A.M.1    Mann, D.A.2
  • 10
    • 4544335155 scopus 로고    scopus 로고
    • Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients
    • Ribeiro PS, Cortez-Pinto H, Sola S, Castro RE, Ramalho RM, Baptista A, et al. Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients. Am J Gastroenterol 2004;99:1708-1717.
    • (2004) Am J Gastroenterol , vol.99 , pp. 1708-1717
    • Ribeiro, P.S.1    Cortez-Pinto, H.2    Sola, S.3    Castro, R.E.4    Ramalho, R.M.5    Baptista, A.6
  • 11
    • 0037406902 scopus 로고    scopus 로고
    • Identification and characterization of the hepatic stellate cell transferrin receptor
    • Bridle KR, Crawford DH, Ramm GA. Identification and characterization of the hepatic stellate cell transferrin receptor. Am J Pathol 2003;162: 1661-1667.
    • (2003) Am J Pathol , vol.162 , pp. 1661-1667
    • Bridle, K.R.1    Crawford, D.H.2    Ramm, G.A.3
  • 12
    • 0031831851 scopus 로고    scopus 로고
    • Isolation and culture of rat hepatic stellate cells
    • Ramm GA. Isolation and culture of rat hepatic stellate cells. J Gastroenterol Hepatol 1998;13:846-851.
    • (1998) J Gastroenterol Hepatol , vol.13 , pp. 846-851
    • Ramm, G.A.1
  • 13
    • 0027198736 scopus 로고
    • Production and characterization of recombinant heteropolymers of human ferritin H and L chains
    • Santambrogio P, Levi S, Cozzi A, Rovida E, Albertini A, Arosio P. Production and characterization of recombinant heteropolymers of human ferritin H and L chains. J Biol Chem 1993;268:12744-12748.
    • (1993) J Biol Chem , vol.268 , pp. 12744-12748
    • Santambrogio, P.1    Levi, S.2    Cozzi, A.3    Rovida, E.4    Albertini, A.5    Arosio, P.6
  • 14
    • 0025261680 scopus 로고
    • Preparation of extracts from higher eukaryotes
    • Dignam JD. Preparation of extracts from higher eukaryotes. Methods Enzymol 1990;182:194-203.
    • (1990) Methods Enzymol , vol.182 , pp. 194-203
    • Dignam, J.D.1
  • 15
    • 0032841856 scopus 로고    scopus 로고
    • Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IkappaB family proteins
    • Elsharkawy AM, Wright MC, Hay RT, Arthur MJ, Hughes T, Bahr MJ, et al. Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IkappaB family proteins. HEPATOLOGY 1999;30:761-769.
    • (1999) HEPATOLOGY , vol.30 , pp. 761-769
    • Elsharkawy, A.M.1    Wright, M.C.2    Hay, R.T.3    Arthur, M.J.4    Hughes, T.5    Bahr, M.J.6
  • 16
    • 0034234599 scopus 로고    scopus 로고
    • Cytokine regulation of chemokine (IL-8, MCP-1, and RANTES) gene expression in human pancreatic periacinar myofibroblasts
    • Andoh A, Takaya H, Saotome T, Shimada M, Hata K, Araki Y, et al. Cytokine regulation of chemokine (IL-8, MCP-1, and RANTES) gene expression in human pancreatic periacinar myofibroblasts. Gastroenterology 2000;119:211-219.
    • (2000) Gastroenterology , vol.119 , pp. 211-219
    • Andoh, A.1    Takaya, H.2    Saotome, T.3    Shimada, M.4    Hata, K.5    Araki, Y.6
  • 17
    • 0035997253 scopus 로고    scopus 로고
    • Role of P38 MAPK, AP-1, and NF-kappaB in interleukin-1beta-induced IL-8 expression in human vascular smooth muscle cells
    • Jung YD, Fan F, McConkey DJ, Jean ME, Liu W, Reinmuth N, et al. Role of P38 MAPK, AP-1, and NF-kappaB in interleukin-1beta-induced IL-8 expression in human vascular smooth muscle cells. Cytokine 2002;18:206-213.
    • (2002) Cytokine , vol.18 , pp. 206-213
    • Jung, Y.D.1    Fan, F.2    McConkey, D.J.3    Jean, M.E.4    Liu, W.5    Reinmuth, N.6
  • 18
    • 11144325650 scopus 로고    scopus 로고
    • Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis
    • Oakley F, Meso M, Iredale JP, Green K, Marek CJ, Zhou X, et al. Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis. Gastroenterology 2005; 128:108-120.
    • (2005) Gastroenterology , vol.128 , pp. 108-120
    • Oakley, F.1    Meso, M.2    Iredale, J.P.3    Green, K.4    Marek, C.J.5    Zhou, X.6
  • 19
    • 0031961752 scopus 로고    scopus 로고
    • Stimulation of inducible nitric oxide synthase in rat liver by hyaluronan fragments
    • Rockey DC, Chung JJ, McKee CM, Noble PW. Stimulation of inducible nitric oxide synthase in rat liver by hyaluronan fragments. HEPATOLOGY 1998;27:86-92.
    • (1998) HEPATOLOGY , vol.27 , pp. 86-92
    • Rockey, D.C.1    Chung, J.J.2    McKee, C.M.3    Noble, P.W.4
  • 20
    • 33845192458 scopus 로고    scopus 로고
    • Activation of nuclear factor kappa B (NF-kappaB) by connective tissue growth factor (CCN2) is involved in sustaining the survival of primary rat hepatic stellate cells
    • Gao R, Brigstock DR. Activation of nuclear factor kappa B (NF-kappaB) by connective tissue growth factor (CCN2) is involved in sustaining the survival of primary rat hepatic stellate cells. Cell Commun Signal 2005;3: 14.
    • (2005) Cell Commun Signal , vol.3 , pp. 14
    • Gao, R.1    Brigstock, D.R.2
  • 21
    • 25844475970 scopus 로고    scopus 로고
    • TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis
    • Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, et al. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J Exp Med 2005;202:955-965.
    • (2005) J Exp Med , vol.202 , pp. 955-965
    • Chen, T.T.1    Li, L.2    Chung, D.H.3    Allen, C.D.4    Torti, S.V.5    Torti, F.M.6
  • 22
    • 0029965452 scopus 로고    scopus 로고
    • Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction
    • Wymann MP, Bulgarelli-Leva G, Zvelebil MJ, Pirola L, Vanhaesebroeck B, Waterfield MD, et al. Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction. Mol Cell Biol 1996;16:1722-1733.
    • (1996) Mol Cell Biol , vol.16 , pp. 1722-1733
    • Wymann, M.P.1    Bulgarelli-Leva, G.2    Zvelebil, M.J.3    Pirola, L.4    Vanhaesebroeck, B.5    Waterfield, M.D.6
  • 23
    • 0642376906 scopus 로고    scopus 로고
    • Protein kinase Czeta (PKCzeta): Activation mechanisms and cellular functions
    • Hirai T, Chida K. Protein kinase Czeta (PKCzeta): Activation mechanisms and cellular functions. J Biochem (Tokyo) 2003;133:1-7.
    • (2003) J Biochem (Tokyo) , vol.133 , pp. 1-7
    • Hirai, T.1    Chida, K.2
  • 24
    • 0029758505 scopus 로고    scopus 로고
    • PDGF induction of alpha 2 integrin gene expression is mediated by protein kinase C-zeta
    • Xu J, Zutter MM, Santoro SA, Clark RA. PDGF induction of alpha 2 integrin gene expression is mediated by protein kinase C-zeta. J Cell Biol 1996;134:1301-1311.
    • (1996) J Cell Biol , vol.134 , pp. 1301-1311
    • Xu, J.1    Zutter, M.M.2    Santoro, S.A.3    Clark, R.A.4
  • 25
    • 0029617910 scopus 로고
    • Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta
    • Berra E, Diaz-Meco MT, Lozano J, Frutos S, Municio MM, Sanchez P, et al. Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta. EMBO J 1995;14:6157-6163.
    • (1995) EMBO J , vol.14 , pp. 6157-6163
    • Berra, E.1    Diaz-Meco, M.T.2    Lozano, J.3    Frutos, S.4    Municio, M.M.5    Sanchez, P.6
  • 26
    • 0023912979 scopus 로고
    • Interactions between isolated hepatocytes and Kupffer cells in iron metabolism: A possible role for ferritin as an iron carrier protein
    • Sibille JC, Kondo H, Aisen P. Interactions between isolated hepatocytes and Kupffer cells in iron metabolism: A possible role for ferritin as an iron carrier protein. HEPATOLOGY 1988;8:296-301.
    • (1988) HEPATOLOGY , vol.8 , pp. 296-301
    • Sibille, J.C.1    Kondo, H.2    Aisen, P.3
  • 27
    • 0025615203 scopus 로고
    • Ferritin
    • Worwood M. Ferritin. Blood Rev 1990;4:259-269.
    • (1990) Blood Rev , vol.4 , pp. 259-269
    • Worwood, M.1
  • 28
    • 0019835872 scopus 로고
    • Detection of a glycosylated subunit in human serum ferritin
    • Cragg SJ, Wagstaff M, Worwood M. Detection of a glycosylated subunit in human serum ferritin. Biochem J 1981;199:565-571.
    • (1981) Biochem J , vol.199 , pp. 565-571
    • Cragg, S.J.1    Wagstaff, M.2    Worwood, M.3
  • 29
    • 0028133060 scopus 로고
    • Serum ferritin and transferrin saturation in patients with chronic alcoholic and non-alcoholic liver diseases
    • Bell H, Skinningsrud A, Raknerud N, Try K. Serum ferritin and transferrin saturation in patients with chronic alcoholic and non-alcoholic liver diseases. J Intern Med 1994;236:315-322.
    • (1994) J Intern Med , vol.236 , pp. 315-322
    • Bell, H.1    Skinningsrud, A.2    Raknerud, N.3    Try, K.4
  • 30
    • 0034891077 scopus 로고    scopus 로고
    • Hyperferritinemia, iron overload, and multiple metabolic alterations identify patients at risk for nonalcoholic steatohepatitis
    • Fargion S, Mattioli M, Fracanzani AL, Sampietro M, Tavazzi D, Fociani P, et al. Hyperferritinemia, iron overload, and multiple metabolic alterations identify patients at risk for nonalcoholic steatohepatitis. Am J Gastroenterol 2001;96:2448-2455.
    • (2001) Am J Gastroenterol , vol.96 , pp. 2448-2455
    • Fargion, S.1    Mattioli, M.2    Fracanzani, A.L.3    Sampietro, M.4    Tavazzi, D.5    Fociani, P.6
  • 32
    • 0033623899 scopus 로고    scopus 로고
    • Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells
    • Lang A, Schoonhoven R, Tuvia S, Brenner DA, Rippe RA. Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. J Hepatol 2000;33:49-58.
    • (2000) J Hepatol , vol.33 , pp. 49-58
    • Lang, A.1    Schoonhoven, R.2    Tuvia, S.3    Brenner, D.A.4    Rippe, R.A.5
  • 33
  • 34
    • 33645510600 scopus 로고    scopus 로고
    • Interleukin-1 beta up-regulates tissue inhibitor of matrix metalloproteinase-1 mRNA and phosphorylation of c-jun N-terminal kinase and p38 in hepatic stellate cells
    • Zhang YP, Yao XX, Zhao X. Interleukin-1 beta up-regulates tissue inhibitor of matrix metalloproteinase-1 mRNA and phosphorylation of c-jun N-terminal kinase and p38 in hepatic stellate cells. World J Gastroenterol 2006;12:1392-1396.
    • (2006) World J Gastroenterol , vol.12 , pp. 1392-1396
    • Zhang, Y.P.1    Yao, X.X.2    Zhao, X.3
  • 35
    • 0030772376 scopus 로고    scopus 로고
    • Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo
    • Pierce JW, Schoenleber R, Jesmok G, Best J, Moore SA, Collins T, et al. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem 1997;272:21096-21103.
    • (1997) J Biol Chem , vol.272 , pp. 21096-21103
    • Pierce, J.W.1    Schoenleber, R.2    Jesmok, G.3    Best, J.4    Moore, S.A.5    Collins, T.6
  • 36
    • 0032577485 scopus 로고    scopus 로고
    • Human H-kininogen is a ferritin-binding protein
    • Torti SV, Torti FM. Human H-kininogen is a ferritin-binding protein. J Biol Chem 1998;273:13630-13635.
    • (1998) J Biol Chem , vol.273 , pp. 13630-13635
    • Torti, S.V.1    Torti, F.M.2
  • 37
    • 2342462210 scopus 로고    scopus 로고
    • Regulation of LIP level and ROS formation through interaction of H-ferritin with G-CSF receptor
    • Yuan X, Cong Y, Hao J, Shan Y, Zhao Z, Wang S, et al. Regulation of LIP level and ROS formation through interaction of H-ferritin with G-CSF receptor. J Mol Biol 2004;339:131-144.
    • (2004) J Mol Biol , vol.339 , pp. 131-144
    • Yuan, X.1    Cong, Y.2    Hao, J.3    Shan, Y.4    Zhao, Z.5    Wang, S.6
  • 38
    • 0037057655 scopus 로고    scopus 로고
    • Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2
    • Kumanogoh A, Marukawa S, Suzuki K, Takegahara N, Watanabe C, Ch'ng E, et al. Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2. Nature 2002;419:629-633.
    • (2002) Nature , vol.419 , pp. 629-633
    • Kumanogoh, A.1    Marukawa, S.2    Suzuki, K.3    Takegahara, N.4    Watanabe, C.5    Ch'ng, E.6
  • 39
    • 0026705752 scopus 로고
    • Functional roles of the ferritin receptors of human liver, hepatoma, lymphoid and erythroid cells
    • Moss D, Fargion S, Fracanzani AL, Levi S, Cappellini MD, Arosio P, et al. Functional roles of the ferritin receptors of human liver, hepatoma, lymphoid and erythroid cells. J Inorg Biochem 1992;47:219-227.
    • (1992) J Inorg Biochem , vol.47 , pp. 219-227
    • Moss, D.1    Fargion, S.2    Fracanzani, A.L.3    Levi, S.4    Cappellini, M.D.5    Arosio, P.6
  • 40
    • 34648830569 scopus 로고    scopus 로고
    • Role of iron in hepatic fibrosis: One piece in the puzzle
    • Philippe MA, Ruddell RG, Ramm GA. Role of iron in hepatic fibrosis: One piece in the puzzle. World J Gastroenterol 2007;13:4746-4754.
    • (2007) World J Gastroenterol , vol.13 , pp. 4746-4754
    • Philippe, M.A.1    Ruddell, R.G.2    Ramm, G.A.3
  • 41
    • 0023277011 scopus 로고
    • Effect of iron chelators on placental uptake and transfer of iron in rat
    • Wong CT, McArdle HJ, Morgan EH. Effect of iron chelators on placental uptake and transfer of iron in rat. Am J Physiol 1987;252:C477-482.
    • (1987) Am J Physiol , vol.252
    • Wong, C.T.1    McArdle, H.J.2    Morgan, E.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.