Ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy: A multi-centered randomized controlled trial

European Review for Medical and Pharmacological Sciences

Volumn 19, Issue 19, 2015, Pages 3770-3776

  Zhang, L ^a   Liu, X H ^a   Qi, H B ^b   Li, Z ^c   Fu, X D ^d   Chen, L ^e   Shao, Y ^b  

^a SICHUAN UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

^c THIRD MILITARY MEDICAL UNIVERSITY   (China)

^d SOUTHWEST MEDICAL UNIVERSITY   (China)

^e SICHUAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Intrahepatic cholestasis of pregnancy; S adenosylmethionine; Ursodesoxycholic acid

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILE ACID; BILIRUBIN; S ADENOSYLMETHIONINE; URSODEOXYCHOLIC ACID; CHOLAGOGUE;

ABSENCE OF SIDE EFFECTS; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE ACID BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; INTRAHEPATIC CHOLESTASIS; INTRAHEPATIC CHOLESTASIS OF PREGNANCY; MAJOR CLINICAL STUDY; MONOTHERAPY; MULTICENTER STUDY; OUTCOME ASSESSMENT; PREGNANCY DISORDER; RANDOMIZED CONTROLLED TRIAL; SKIN PRURITUS; TERTIARY CARE CENTER; TREATMENT DURATION; TREATMENT INDICATION; CHOLESTASIS, INTRAHEPATIC; CLINICAL TRIAL; PATHOLOGY; PREGNANCY; PREGNANCY COMPLICATIONS;

ADULT; CHOLAGOGUES AND CHOLERETICS; CHOLESTASIS, INTRAHEPATIC; FEMALE; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS; S-ADENOSYLMETHIONINE; URSODEOXYCHOLIC ACID;

EID: 84966293715     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. PATHAK B, SHEIBANI L, LEE RH. Cholestasis of pregnancy. Obstet Gynecol Clin North Am 2010; 37: 269-282.
2. JOSHI D, JAMES A, QUAGLIA A, WESTBROOK RH, HENEGHAN MA. Liver disease in pregnancy. Lancet 2010; 375: 594-605.
3. Geenes V, Williamson C. Intrahepatic cholestasis of pregnancy. World J Gastroenterol 2009; 15: 2049-2066.
4. WANG XD, PENG B, YAO Q, ZHANG L, AI Y, XING AY, LIU XH, LIU SY. Perinatal outcomes of intrahepatic cholestasis of pregnancy: analysis of 1210 cases. Zhonghua Yi Xue Za Zhi 2006; 86: 446-449.
5. QI HB, SHAO Y, WU WX, ZHANG JH. Grading of intrahepatic cholestasis of pregnancy. Zhonghua Fu Chan Ke Za Zhi 2004; 39:14-17.
6. PATA O, VARDARELI E, OZCAN A, SERTESER M, UNSAL I, SARUÇ M, UNLÜ C, TÖZÜN N. Intrahepatic cholestasis of pregnancy: correlation of preterm delivery with bile acids. Turk J Gastroenterol 2011; 22: 602-605.
7. HE J, CHEN L, LIANG C. Clinical analysis of fetal death cases in intrahepatic cholestasis of pregnancy. Zhonghua Fu Chan Ke Za Zhi 2011; 46: 333-337.
8. WONG LF, SHALLOW H, O'CONNELL MP. Comparative study on the outcome of obstetric cholestasis. J Matern Fetal Neonatal Med 2008; 21: 327-330.
9. KONDRACKIENE J, KUPCINSKAS L. Intrahepatic cholestasis of pregnancy-current achievements and unsolved problems.World J Gastroenterol 2008; 14: 5781-5788.
10. CAREY EJ, LINDOR KD. Current pharmacotherapy for cholestatic liver disease. Expert Opin Pharmacother 2012; 13: 2473-2484.
11. PALMA J, REYES H, RIBALTA J, HERNÁNDEZ I, SANDOVAL L, ALMUNA R, LIEPINS J, LIRA F, SEDANO M, SILVA O, TOHÁ D, SILVA JJ. Ursodeoxycholic acid in the treatment of cholestasis of pregnancy: a randomized, double-blind study controlled with placebo. J Hepatol 1997; 27: 1022-1028.
12. LIU Y, QIAO F, LIU H, LIU D. Ursodeoxycholic acid in the treatment of intraheptic cholestasis of pregnancy. J Huazhong Univ Sci Technolog Med Sci 2006; 26: 350-352.
13. ZAPATA R, SANDOVAL L, PALMA J, HERNÁNDEZ I, RIBALTA J, REYES H, SEDANO M, TOHÁ D, SILVA JJ. Ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy. A 12-year experience. Liver Int 2005; 25: 548-554.
14. GLANTZ A, MARSCHALL HU, LAMMERT F, MATTSSON LA. Intrahepatic cholestasis of pregnancy: a randomized controlled trial comparing dexamethasone and ursodeoxycholic acid. Hepatology 2005; 42: 1399-1405.
15. KONDRACKIENE J, BEUERS U, KUPCINSKAS L. Efficacy and safety of ursodeoxycholic acid versus cholestyramine in intrahepatic cholestasis of pregnancy. Gastroenterology 2005; 129: 894-901.
16. FREZZA M, CENTINI G, CAMMARERI G, LE GRAZIE C, DI PADOVA C. S-adenosylmethionine for the treatment of intrahepatic cholestasis of pregnancy. Results of a controlled clinical trial. Hepatogastroenterology 1990; 37(Suppl 2): 122-125.
17. BEUERS U. Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis. Nat Clin Pract Gastroenterol Hepatol 2006; 3: 318-328.
18. ALMASIO P, BORTOLINI M, PAGLIARO L, COLTORTI M. Role of S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis. Drugs 1990; 40(Suppl 3): 111-123.
19. BINDER T, SALAJ P, ZIMA T, VÍTEK L. Randomized prospective comparative study of ursodeoxycholic acid and S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis of pregnancy. J Perinat Med 2006; 34: 383-391.
20. NICASTRI PL, DIAFERIA A, TARTAGNI M, LOIZZI P, FANELLI M. A randomised placebo-controlled trial of ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy. Br J Obstet Gynaecol 1998; 105: 1205-1207.
21. RONCAGLIA N, LOCATELLI A, ARREGHINI A, ASSI F, CAMERONI I, PEZZULLO JC, GHIDINI A. A randomised controlled trial of ursodeoxycholic acid and Sadenosyl-l-methionine in the treatment of gestational cholestasis. Br J Obstet Gynaecol 2004; 111: 17-21.
22. FLOREANI A, PATERNOSTER D, MELIS A, GRELLA PV. Sadenosylmethionine versus ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy: preliminary results of a controlled trial. Eur J Obstet Gynecol Reprod Biol 1996; 67: 109-113.
23. AZZAROLI F, TURCO L, LISOTTI A, CALVANESE C, MAZZELLA G. The pharmacological management of intrahepatic cholestasis of pregnancy. Curr Clin Pharmacol 2011; 6: 12-17.
24. BACQ Y, SENTILHES L, REYES HB, GLANTZ A, KONDRACKIENE J, BINDER T, NICASTRI PL, LOCATELLI A, FLOREANI A, HERNANDEZ I, DI MARTINO V. Efficacy of ursodeoxycholic acid in treating intrahepatic cholestasis of pregnancy: a meta-analysis. Gastroenterology 2012; 143: 1492-1501.