NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation

Journal of Clinical Investigation

Volumn 125, Issue 4, 2015, Pages 1579-1590

  Xu, Jun ^a,b   Chi, Feng ^a   Guo, Tongsheng ^c   Punj, Vasu ^a   Paul Lee, W N ^d   French, Samuel W ^a,e   Tsukamoto, Hidekazu ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c BEIJING 302 HOSPITAL   (China)

^d LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE   (United States)

^e HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME B; CYTOCHROME C OXIDASE; GLUCOSE; INDUCIBLE NITRIC OXIDE SYNTHASE; NOTCH1 RECEPTOR; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE PHOSPHATASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; NITRIC OXIDE; NOTCH1 PROTEIN, MOUSE; PYRUVATE DEHYDROGENASE COMPLEX; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL METABOLISM; CITRIC ACID CYCLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; FATTY ACID OXIDATION; GENE EXPRESSION; GENE INDUCTION; GLUCOSE METABOLISM; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; MACROPHAGE ACTIVATION; MITOCHONDRIAL DNA REPLICATION; MITOCHONDRIAL GENE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; RESPIRATORY CHAIN; TRANSCRIPTION INITIATION; TRANSCRIPTION INITIATION SITE; ALCOHOLIC FATTY LIVER; ANIMAL; ANTAGONISTS AND INHIBITORS; BONE MARROW CELL; C57BL MOUSE; CELL LINE; COMPLICATION; DEFICIENCY; ELECTRON TRANSPORT; ENDOTOXEMIA; FEEDBACK SYSTEM; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; INFLAMMATION; KNOCKOUT MOUSE; LIVER FAILURE, ACUTE; MALE; METABOLISM; MITOCHONDRION; PATHOLOGY; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; CELL LINE; ELECTRON TRANSPORT; ENDOTOXEMIA; FATTY LIVER, ALCOHOLIC; FEEDBACK, PHYSIOLOGICAL; GENE EXPRESSION REGULATION; GLUCOSE; INFLAMMATION; LIVER FAILURE, ACUTE; MACROPHAGE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; MYELOID CELLS; NITRIC OXIDE; OXIDATIVE PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE; PYRUVATE DEHYDROGENASE COMPLEX; REACTIVE OXYGEN SPECIES; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 84926308649     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI76468     Document Type: Article

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