Prevention of diet-induced fatty liver in experimental animals by the oral administration of a fatty acid bile acid conjugate (FABAC)

Hepatology

Volumn 38, Issue 2, 2003, Pages 436-442

  Gilat, Tuvia ^a   Leikin Frenkel, Alicia ^a   Goldiner, Ilana ^a   Juhel, Christine ^b   Lafont, Huguette ^b   Gobbi, Diana ^a   Konikoff, Fred M ^a,c  

^a TEL AVIV UNIVERSITY   (Israel)

^b INSERM   (France)

^c TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDYLAMIDOCHOLANOIC ACID; BILE ACID CONJUGATE; FATTY ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BILE LEVEL; CONTROLLED STUDY; DIET; FATTY LIVER; GALLSTONE; HAMSTER; LIPID ABSORPTION; LIPID DIET; NONHUMAN; PRIORITY JOURNAL; RAT; SCORING SYSTEM; SOLUBILIZATION; STONE FORMATION; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0041764976     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2003.50348     Document Type: Article

References (15)

1. Gilat T, Somjen GJ, Mazur Y, Leikin-Frenkel A, Rosenberg R, Halpern Z, Konikoff FM. Fatty acid bile acid conjugates (FABACs) - new molecules for the prevention of cholesterol crystallisation in bile. Gut 2001;48:75-79.
2. Gilat T, Goldiner I, Frenkel A, Laufer H, Halpern Z, Konikoff FM. Arachidyl amido cholanoic acid (Aramchol) is a cholesterol solubilizer and prevents the formation of cholesterol gallstones in vivo. Lipids 2001;36:1135-1140.
3. Gilat T, Leikin-Frenkel A, Goldiner I, Halpern Z, Konikoff FM. Dissolution of cholesterol gallstones in mice by the oral administration of a fatty acid bile acid conjugate (FABAC). HEPATOLOGY 2002;35:597-600.
4. Ayyad N, Cohen BI, Mosbach EH, Miki S. Palmitic acid enhances cholesterol gallstone incidence in Sasco hamsters fed cholesterol enriched diets. Lipids 1992;27:993-998.
5. Paigen B, Morrow A, Holmes PA, Mitchell D, Williams RA. Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis 1987;8:231-240.
6. Khanuja B, Cheah YC, Hunt M, Nishina PM, Wang DQ-H, Chen HW, Billheimer JT, et al. Lith1, a major gene affecting cholesterol gallstone formation among inbred strains of mice. Proc Natl Acad Sci U S A 1995;92:7729-7733.
7. Folch J, Lees M, Stanley GHS. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957;226:497-509.
8. Leikin AI, Brenner RR. Lipid-binding properties of a factor necessary for linoleic acid desaturation. Lipids 1979;14:1021-1026.
9. Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-254.
10. Bitman J, Wood DL, Ruth JM. Two stage one dimensional thin layer chromatographic method for separation of lipid classes. J Liq Chromatogr 1981;4:1007-1021.
11. Goldiner I, Leikin-Frenkel A, Gilat T, Konikoff FM, Groen AK. ABCA 1 dependent but Apo A1 independent cholesterol and phosphatidylcholine efflux mediated by FABAC. 25th ELC (European Lipoprotein Club) Annual Meeting, September 9-12, 2002.
12. Leikin-Frenkel A, Parini P, Leikin-Gobbi D, Einarsson C, Gilat T, Konikoff FM. Fatty acid bile acid conjugates (FABACs) prevent diet induced fatty liver and restore enzyme activities involved in lipid metabolism [Abstract]. Chem Phys Lipids 2002;118:98.
13. Gonen A, Shaish A, Leikin-Frenkel A, Gilat T, Harats D. Fatty acid bile acid conjugates (FABACs) inhibit atherosclerosis in the C57BL/6 mouse model. Pathobiology 2003;70:215-218.
14. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002;346:1221-1231.
15. Konikoff FM, Leikin-Frenkel A, Goldiner I, Michowich M, Brezovsky E, Harats D, Gilat T. Biliary and systemic effects of fatty acid bile acid conjugates (FABACs). Eur J Gastroenterol Hepatol 2003;15:1-8.