메뉴 건너뛰기




Volumn 205, Issue 4, 2008, Pages 915-927

Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids

Author keywords

[No Author keywords available]

Indexed keywords

HERMES ANTIGEN; HYALURONIC ACID; LIPOPOLYSACCHARIDE; MONOCLONA ANTIBODY CD44; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

EID: 42249087107     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20071765     Document Type: Article
Times cited : (278)

References (62)
  • 1
    • 0025891436 scopus 로고
    • Sepsis, the sepsis syndrome, multi-organ failure: A plea for comparable definitions
    • Bone, R.C. 1991. Sepsis, the sepsis syndrome, multi-organ failure: a plea for comparable definitions. Ann. Intern. Med. 114:332-333.
    • (1991) Ann. Intern. Med , vol.114 , pp. 332-333
    • Bone, R.C.1
  • 4
    • 0026761609 scopus 로고
    • Endotoxin, septic shock and acute lung injury: Neutrophils, macrophages and inflammatory mediators
    • Welbourn, C.R., and Y. Young. 1992. Endotoxin, septic shock and acute lung injury: neutrophils, macrophages and inflammatory mediators. Br. J. Surg. 79:998-1003.
    • (1992) Br. J. Surg , vol.79 , pp. 998-1003
    • Welbourn, C.R.1    Young, Y.2
  • 6
    • 0021971041 scopus 로고
    • A nasty shock from antibiotics?
    • Hopkin, B.D. 1985. A nasty shock from antibiotics? Lancet. 2:594.
    • (1985) Lancet , vol.2 , pp. 594
    • Hopkin, B.D.1
  • 7
    • 0037453125 scopus 로고    scopus 로고
    • A new paradigm for the treatment of sepsis: Is it time to consider combination therapy?
    • Cross, A.S., and S.M. Opal. 2003. A new paradigm for the treatment of sepsis: is it time to consider combination therapy? Ann. Intern. Med. 138:502-505.
    • (2003) Ann. Intern. Med , vol.138 , pp. 502-505
    • Cross, A.S.1    Opal, S.M.2
  • 9
    • 0026677368 scopus 로고
    • Chemoattractant- induced firm adhesion of leukocytes to vascular endothelium in vivo is critically dependent on initial leukocyte rolling
    • Lindbom, L., X. Xie, J. Raud, and P. Hedqvist. 1992. Chemoattractant- induced firm adhesion of leukocytes to vascular endothelium in vivo is critically dependent on initial leukocyte rolling. Acta Physiol. Scand. 146:415-421.
    • (1992) Acta Physiol. Scand , vol.146 , pp. 415-421
    • Lindbom, L.1    Xie, X.2    Raud, J.3    Hedqvist, P.4
  • 11
    • 0037324293 scopus 로고    scopus 로고
    • Molecular mechanisms of leukocyte recruitment: Organ-specific mechanisms of action
    • Liu, L., and P. Kubes. 2003. Molecular mechanisms of leukocyte recruitment: organ-specific mechanisms of action. Thromb. Haemost. 89:213-220.
    • (2003) Thromb. Haemost , vol.89 , pp. 213-220
    • Liu, L.1    Kubes, P.2
  • 12
    • 0031408177 scopus 로고    scopus 로고
    • Cell adhesion and migration. III. Leukocyte adhesion and transmigration in the liver vasculature
    • Jaeschke, H., and C.W. Smith. 1997. Cell adhesion and migration. III. Leukocyte adhesion and transmigration in the liver vasculature. Am. J. Physiol. 273:G1169-G1173.
    • (1997) Am. J. Physiol , vol.273
    • Jaeschke, H.1    Smith, C.W.2
  • 13
    • 0031010858 scopus 로고    scopus 로고
    • A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature
    • Wong, J., B. Johnston, S.S. Lee, D.C. Bullard, C.W. Smith, A.L. Beaudet, and P. Kubes. 1997. A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature. J. Clin. Invest. 99:2782-2790.
    • (1997) J. Clin. Invest , vol.99 , pp. 2782-2790
    • Wong, J.1    Johnston, B.2    Lee, S.S.3    Bullard, D.C.4    Smith, C.W.5    Beaudet, A.L.6    Kubes, P.7
  • 14
    • 1842329163 scopus 로고    scopus 로고
    • Mechanisms of neutrophil-induced parenchymal cell injury
    • Jaeschke, H., and C.W. Smith. 1997. Mechanisms of neutrophil-induced parenchymal cell injury. J. Leukoc. Biol. 61:647-653.
    • (1997) J. Leukoc. Biol , vol.61 , pp. 647-653
    • Jaeschke, H.1    Smith, C.W.2
  • 15
    • 0030278393 scopus 로고    scopus 로고
    • Sequestration of neutrophils in the hepatic vasculature during endotoxemia is independent of beta 2 integrins and intercellular adhesion molecule-1
    • Jaeschke, H., A. Farhood, M.A. Fisher, and C.W. Smith. 1996. Sequestration of neutrophils in the hepatic vasculature during endotoxemia is independent of beta 2 integrins and intercellular adhesion molecule-1. Shock. 6:351-356.
    • (1996) Shock , vol.6 , pp. 351-356
    • Jaeschke, H.1    Farhood, A.2    Fisher, M.A.3    Smith, C.W.4
  • 16
    • 0034011590 scopus 로고    scopus 로고
    • Molecular mechanisms of tumor necrosis factor alpha-stimulated leukocyte recruitment into the murine hepatic circulation
    • Fox-Robichaud, A., and P. Kubes. 2000. Molecular mechanisms of tumor necrosis factor alpha-stimulated leukocyte recruitment into the murine hepatic circulation. Hepatology. 31:1123-1127.
    • (2000) Hepatology , vol.31 , pp. 1123-1127
    • Fox-Robichaud, A.1    Kubes, P.2
  • 17
    • 0025218924 scopus 로고
    • VLA proteins in the integrin family: Structures, functions, and their role on leukocytes
    • Hemler, M.E. 1990. VLA proteins in the integrin family: structures, functions, and their role on leukocytes. Annu. Rev. Immunol. 8:365-400.
    • (1990) Annu. Rev. Immunol , vol.8 , pp. 365-400
    • Hemler, M.E.1
  • 19
    • 0034744558 scopus 로고    scopus 로고
    • Functional alpha4-integrin: A newly identified pathway of neutrophil recruitment in critically ill septic patients
    • Ibbotson, G.C., C. Doig, J. Kaur, V. Gill, L. Ostrovsky, T. Fairhead, and P. Kubes. 2001. Functional alpha4-integrin: a newly identified pathway of neutrophil recruitment in critically ill septic patients. Nat. Med. 7:465-470.
    • (2001) Nat. Med , vol.7 , pp. 465-470
    • Ibbotson, G.C.1    Doig, C.2    Kaur, J.3    Gill, V.4    Ostrovsky, L.5    Fairhead, T.6    Kubes, P.7
  • 20
    • 0028120743 scopus 로고
    • Reductions in physiologic shear rates lead to CD11/CD18-dependent, selectin-independent leukocyte rolling in vivo
    • Gaboury, J.P., and P. Kubes. 1994. Reductions in physiologic shear rates lead to CD11/CD18-dependent, selectin-independent leukocyte rolling in vivo. Blood. 83:345-350.
    • (1994) Blood , vol.83 , pp. 345-350
    • Gaboury, J.P.1    Kubes, P.2
  • 21
    • 5444276621 scopus 로고    scopus 로고
    • C1q governs deposition of circulating immune complexes and leukocyte Fcγ receptors mediate subsequent neutrophil recruitment
    • Stokol, T., P. O'Donnell, L. Xiao, S. Knight, G. Stavrakis, M. Botto, U.H. von Andrian, and T.N. Mayadas. 2004. C1q governs deposition of circulating immune complexes and leukocyte Fcγ receptors mediate subsequent neutrophil recruitment. J. Exp. Med. 200:835-846.
    • (2004) J. Exp. Med , vol.200 , pp. 835-846
    • Stokol, T.1    O'Donnell, P.2    Xiao, L.3    Knight, S.4    Stavrakis, G.5    Botto, M.6    von Andrian, U.H.7    Mayadas, T.N.8
  • 22
    • 0032786981 scopus 로고    scopus 로고
    • Activation and interaction of CD44 and hyaluronan in immunological systems
    • Siegelman, M.H., H.C. DeGrendele, and P. Estess. 1999. Activation and interaction of CD44 and hyaluronan in immunological systems. J. Leukoc. Biol. 66:315-321.
    • (1999) J. Leukoc. Biol , vol.66 , pp. 315-321
    • Siegelman, M.H.1    DeGrendele, H.C.2    Estess, P.3
  • 25
    • 1842633889 scopus 로고    scopus 로고
    • Bimolecular complex between rolling and firm adhesion receptors required for cell arrest; CD44 association with VLA-4 in T cell extravasation
    • Nandi, A., P. Estess, and M. Siegelman. 2004. Bimolecular complex between rolling and firm adhesion receptors required for cell arrest; CD44 association with VLA-4 in T cell extravasation. Immunity. 20:455-465.
    • (2004) Immunity , vol.20 , pp. 455-465
    • Nandi, A.1    Estess, P.2    Siegelman, M.3
  • 26
    • 33745067805 scopus 로고    scopus 로고
    • Use of CD44 by CD4+ Th1 and Th2 lymphocytes to roll and adhere
    • Bonder, C.S., S.R. Clark, M.U. Norman, P. Johnson, and P. Kubes. 2006. Use of CD44 by CD4+ Th1 and Th2 lymphocytes to roll and adhere. Blood. 107:4798-4806.
    • (2006) Blood , vol.107 , pp. 4798-4806
    • Bonder, C.S.1    Clark, S.R.2    Norman, M.U.3    Johnson, P.4    Kubes, P.5
  • 28
    • 42249091472 scopus 로고    scopus 로고
    • Parker, J.C., M.A. Perry, and A.E. Taylor. 1984. Permeability of the microvascular barrier. In Edema. N.C. Staub and A.E. Taylor, editors. Raven, New York. 143-187.
    • Parker, J.C., M.A. Perry, and A.E. Taylor. 1984. Permeability of the microvascular barrier. In Edema. N.C. Staub and A.E. Taylor, editors. Raven, New York. 143-187.
  • 31
    • 0026537561 scopus 로고
    • Requirements for hyaluronic acid binding by CD44: A role for the cytoplasmic domain and activation by antibody
    • Lesley, J., Q. He, K. Miyake, A. Hamann, R. Hyman, and P.W. Kincade. 1992. Requirements for hyaluronic acid binding by CD44: a role for the cytoplasmic domain and activation by antibody. J. Exp. Med. 175:257-266.
    • (1992) J. Exp. Med , vol.175 , pp. 257-266
    • Lesley, J.1    He, Q.2    Miyake, K.3    Hamann, A.4    Hyman, R.5    Kincade, P.W.6
  • 32
    • 0037969876 scopus 로고    scopus 로고
    • Mononuclear leukocytes bind to specific hyaluronan structures on colon mucosal smooth muscle cells treated with polyinosinic acid:polycytidylic acid: Inter-alpha-trypsin inhibitor is crucial to structure and function
    • de la Motte, C.A., V.C. Hascall, J. Drazba, S.K. Bandyopadhyay, and S.A. Strong. 2003. Mononuclear leukocytes bind to specific hyaluronan structures on colon mucosal smooth muscle cells treated with polyinosinic acid:polycytidylic acid: inter-alpha-trypsin inhibitor is crucial to structure and function. Am. J. Pathol. 163:121-133.
    • (2003) Am. J. Pathol , vol.163 , pp. 121-133
    • de la Motte, C.A.1    Hascall, V.C.2    Drazba, J.3    Bandyopadhyay, S.K.4    Strong, S.A.5
  • 33
    • 0036914356 scopus 로고    scopus 로고
    • The role of selectins and integrins in adenovirus vector-induced neutrophil recruitment to the liver
    • Li, Y., D.A. Muruve, R.G. Collins, S.S. Lee, and P. Kubes. 2002. The role of selectins and integrins in adenovirus vector-induced neutrophil recruitment to the liver. Eur. J. Immunol. 32:3443-3452.
    • (2002) Eur. J. Immunol , vol.32 , pp. 3443-3452
    • Li, Y.1    Muruve, D.A.2    Collins, R.G.3    Lee, S.S.4    Kubes, P.5
  • 34
    • 0036130188 scopus 로고    scopus 로고
    • Leukocyte recruitment in hepatic injury: Selectin-mediated leukocyte rolling is a prerequisite for CD18-dependent firm adhesion
    • Klintman, D., R. Schramm, M.D. Menger, and H. Thorlacius. 2002. Leukocyte recruitment in hepatic injury: selectin-mediated leukocyte rolling is a prerequisite for CD18-dependent firm adhesion. J. Hepatol. 36:53-59.
    • (2002) J. Hepatol , vol.36 , pp. 53-59
    • Klintman, D.1    Schramm, R.2    Menger, M.D.3    Thorlacius, H.4
  • 35
    • 0025219115 scopus 로고
    • Mac-1 (CD11b/CD18) mediates adherence-dependent hydrogen peroxide production by human and canine neutrophils
    • Shappell, S.B., C. Toman, D.C. Anderson, A.A. Taylor, M.L. Entman, and C.W. Smith. 1990. Mac-1 (CD11b/CD18) mediates adherence-dependent hydrogen peroxide production by human and canine neutrophils. J. Immunol. 144:2702-2711.
    • (1990) J. Immunol , vol.144 , pp. 2702-2711
    • Shappell, S.B.1    Toman, C.2    Anderson, D.C.3    Taylor, A.A.4    Entman, M.L.5    Smith, C.W.6
  • 36
    • 0035809925 scopus 로고    scopus 로고
    • alpha(4)-integrin mediates neutrophil-induced free radical injury to cardiac myocytes
    • Poon, B.Y., C.A. Ward, C.B. Cooper, W.R. Giles, A.R. Burns, and P. Kubes. 2001. alpha(4)-integrin mediates neutrophil-induced free radical injury to cardiac myocytes. J. Cell Biol. 152:857-866.
    • (2001) J. Cell Biol , vol.152 , pp. 857-866
    • Poon, B.Y.1    Ward, C.A.2    Cooper, C.B.3    Giles, W.R.4    Burns, A.R.5    Kubes, P.6
  • 38
    • 0029911316 scopus 로고    scopus 로고
    • Inhibition of delayed-type contact hypersensitivity in mice deficient in both E-selectin and P-selectin
    • Staite, N.D., J.M. Justen, I.M. Sly, A.I. Deaudet, and D.C. Bullard. 1996. Inhibition of delayed-type contact hypersensitivity in mice deficient in both E-selectin and P-selectin. Blood. 88:2973-2979.
    • (1996) Blood , vol.88 , pp. 2973-2979
    • Staite, N.D.1    Justen, J.M.2    Sly, I.M.3    Deaudet, A.I.4    Bullard, D.C.5
  • 39
    • 2442422128 scopus 로고    scopus 로고
    • A critical temporal window for selectin-dependent CD4 + lymphocyte homing and initiation of late phase inflammation in contact sensitivity
    • Hwang, J., J. Yamanouchi, P. Santamaria, and P. Kubes. 2004. A critical temporal window for selectin-dependent CD4 + lymphocyte homing and initiation of late phase inflammation in contact sensitivity. J. Exp. Med. 199:1223-1234.
    • (2004) J. Exp. Med , vol.199 , pp. 1223-1234
    • Hwang, J.1    Yamanouchi, J.2    Santamaria, P.3    Kubes, P.4
  • 40
    • 0026654882 scopus 로고
    • Mechanisms of lipopolysaccharide-induced neutrophil retention. Relative contributions of adhesive and cellular mechanical properties
    • Erzurum, S.C., G.P. Downey, D.E. Doherty, B. Schwab III, E.L. Elson, and G.S. Worthen. 1992. Mechanisms of lipopolysaccharide-induced neutrophil retention. Relative contributions of adhesive and cellular mechanical properties. J. Immunol. 149:154-162.
    • (1992) J. Immunol , vol.149 , pp. 154-162
    • Erzurum, S.C.1    Downey, G.P.2    Doherty, D.E.3    Schwab III, B.4    Elson, E.L.5    Worthen, G.S.6
  • 42
    • 0030690228 scopus 로고    scopus 로고
    • Requirement for CD44 in activated T cell extravasation into an inflammatory site
    • DeGrendele, H.C., P. Estess, and M.H. Siegelman. 1997. Requirement for CD44 in activated T cell extravasation into an inflammatory site. Science. 278:672-675.
    • (1997) Science , vol.278 , pp. 672-675
    • DeGrendele, H.C.1    Estess, P.2    Siegelman, M.H.3
  • 44
    • 0030478745 scopus 로고    scopus 로고
    • Localization of hyaluronan in human liver sinusoids: A histochemical study using hyaluronan-binding protein
    • Ichida, T., S. Sugitani, T. Satoh, Y. Matsuda, M. Sugiyama, K. Yonekura, T. Ishikawa, and H. Asakura. 1996. Localization of hyaluronan in human liver sinusoids: a histochemical study using hyaluronan-binding protein. Liver. 16:365-371.
    • (1996) Liver , vol.16 , pp. 365-371
    • Ichida, T.1    Sugitani, S.2    Satoh, T.3    Matsuda, Y.4    Sugiyama, M.5    Yonekura, K.6    Ishikawa, T.7    Asakura, H.8
  • 45
    • 0031985770 scopus 로고    scopus 로고
    • Proinflammatory stimuli regulate endothelial hyaluronan expression and CD44/HA-dependent primary adhesion
    • Mohamadzadeh, M., H. DeGrendele, H. Arizpe, P. Estess, and M. Siegelman. 1998. Proinflammatory stimuli regulate endothelial hyaluronan expression and CD44/HA-dependent primary adhesion. J. Clin. Invest. 101:97-108.
    • (1998) J. Clin. Invest , vol.101 , pp. 97-108
    • Mohamadzadeh, M.1    DeGrendele, H.2    Arizpe, H.3    Estess, P.4    Siegelman, M.5
  • 46
    • 0034685935 scopus 로고    scopus 로고
    • Hyaluronan anchoring and regulation on the surface of vascular endothelial cells is mediated through the functionally active form of CD44
    • Nandi, A., P. Estess, and M.H. Siegelman. 2000. Hyaluronan anchoring and regulation on the surface of vascular endothelial cells is mediated through the functionally active form of CD44. J. Biol. Chem. 275:14939-14948.
    • (2000) J. Biol. Chem , vol.275 , pp. 14939-14948
    • Nandi, A.1    Estess, P.2    Siegelman, M.H.3
  • 47
    • 0034529081 scopus 로고    scopus 로고
    • Identification of the hyaluronan receptor for endocytosis (HARE)
    • Zhou, B., J.A. Weigel, L. Fauss, and P.H. Weigel. 2000. Identification of the hyaluronan receptor for endocytosis (HARE). J. Biol. Chem. 275:37733-37741.
    • (2000) J. Biol. Chem , vol.275 , pp. 37733-37741
    • Zhou, B.1    Weigel, J.A.2    Fauss, L.3    Weigel, P.H.4
  • 48
    • 0038660589 scopus 로고    scopus 로고
    • A blocking antibody to the hyaluronan receptor for endocytosis (HARE) inhibits hyaluronan clearance by perfused liver
    • Weigel, J.A., R.C. Raymond, C. McGary, A. Singh, and P.H. Weigel. 2003. A blocking antibody to the hyaluronan receptor for endocytosis (HARE) inhibits hyaluronan clearance by perfused liver. J. Biol. Chem. 278:9808-9812.
    • (2003) J. Biol. Chem , vol.278 , pp. 9808-9812
    • Weigel, J.A.1    Raymond, R.C.2    McGary, C.3    Singh, A.4    Weigel, P.H.5
  • 49
    • 0031573628 scopus 로고    scopus 로고
    • Cytokine induction of the ability of human monocyte CD44 to bind hyaluronan is mediated primarily by TNF-alpha and is inhibited by IL-4 and IL-13
    • Levesque, M.C., and B.F. Haynes. 1997. Cytokine induction of the ability of human monocyte CD44 to bind hyaluronan is mediated primarily by TNF-alpha and is inhibited by IL-4 and IL-13. J. Immunol. 159:6184-6194.
    • (1997) J. Immunol , vol.159 , pp. 6184-6194
    • Levesque, M.C.1    Haynes, B.F.2
  • 50
    • 0034852360 scopus 로고    scopus 로고
    • A crucial role for CD44 in inflammation
    • Pure, E., and C.A. Cuff. 2001. A crucial role for CD44 in inflammation. Trends Mol. Med. 7:213-221.
    • (2001) Trends Mol. Med , vol.7 , pp. 213-221
    • Pure, E.1    Cuff, C.A.2
  • 51
    • 0034282677 scopus 로고    scopus 로고
    • Hyaluronan binding by cell surface CD44
    • Lesley, J., V.C. Hascall, M. Tammi, and R. Hyman. 2000. Hyaluronan binding by cell surface CD44. J. Biol. Chem. 275:26967-26975.
    • (2000) J. Biol. Chem , vol.275 , pp. 26967-26975
    • Lesley, J.1    Hascall, V.C.2    Tammi, M.3    Hyman, R.4
  • 52
    • 3042745689 scopus 로고    scopus 로고
    • The globular domains of PG-M/versican modulate the proliferation-apoptosis equilibrium and invasive capabilities of tumor cells
    • Cattaruzza, S., M. Schiappacassi, K. Kimata, A. Colombatti, and R. Perris. 2004. The globular domains of PG-M/versican modulate the proliferation-apoptosis equilibrium and invasive capabilities of tumor cells. FASEB J. 18:779-781.
    • (2004) FASEB J , vol.18 , pp. 779-781
    • Cattaruzza, S.1    Schiappacassi, M.2    Kimata, K.3    Colombatti, A.4    Perris, R.5
  • 53
    • 33751525386 scopus 로고    scopus 로고
    • Intraluminal crawling of neutrophils to emigration sites: A molecularly distinct process from adhesion in the recruitment cascade
    • Phillipson, M., B. Heit, P. Colarusso, L. Liu, C.M. Ballantyne, and P. Kubes. 2006. Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade. J. Exp. Med. 203:2569-2575.
    • (2006) J. Exp. Med , vol.203 , pp. 2569-2575
    • Phillipson, M.1    Heit, B.2    Colarusso, P.3    Liu, L.4    Ballantyne, C.M.5    Kubes, P.6
  • 56
    • 0033568296 scopus 로고    scopus 로고
    • Molecular mechanisms underlying IL-4-induced leukocyte recruitment in vivo: A critical role for the alpha 4 integrin
    • Hickey, M.J., D.N. Granger, and P. Kubes. 1999. Molecular mechanisms underlying IL-4-induced leukocyte recruitment in vivo: a critical role for the alpha 4 integrin. J. Immunol. 163:3441-3448.
    • (1999) J. Immunol , vol.163 , pp. 3441-3448
    • Hickey, M.J.1    Granger, D.N.2    Kubes, P.3
  • 58
    • 0034623813 scopus 로고    scopus 로고
    • A role for platelets and endothelial selectins in tumor necrosis factor-alpha-induced leukocyte recruitment in the brain microvasculature
    • Carvalho-Tavares, J., M.J. Hickey, J. Hutchison, J. Michaud, I.T. Sutcliffe, and P. Kubes. 2000. A role for platelets and endothelial selectins in tumor necrosis factor-alpha-induced leukocyte recruitment in the brain microvasculature. Circ. Res. 87:1141-1148.
    • (2000) Circ. Res , vol.87 , pp. 1141-1148
    • Carvalho-Tavares, J.1    Hickey, M.J.2    Hutchison, J.3    Michaud, J.4    Sutcliffe, I.T.5    Kubes, P.6
  • 59
    • 0347994956 scopus 로고    scopus 로고
    • Essential role for neutrophil recruitment to the liver in concanavalin A-induced hepatitis
    • Bonder, C.S., M.N. Ajuebor, L.D. Zbytnuik, P. Kubes, and M.G. Swain. 2004. Essential role for neutrophil recruitment to the liver in concanavalin A-induced hepatitis. J. Immunol. 172:45-53.
    • (2004) J. Immunol , vol.172 , pp. 45-53
    • Bonder, C.S.1    Ajuebor, M.N.2    Zbytnuik, L.D.3    Kubes, P.4    Swain, M.G.5
  • 60
    • 33646468932 scopus 로고    scopus 로고
    • Reevaluation of P-selectin and alpha 4 integrin as targets for the treatment of experimental autoimmune encephalomyelitis
    • Kerfoot, S.M., M.U. Norman, B.M. Lapointe, C.S. Bonder, L. Zbytnuik, and P. Kubes. 2006. Reevaluation of P-selectin and alpha 4 integrin as targets for the treatment of experimental autoimmune encephalomyelitis. J. Immunol. 176:6225-6234.
    • (2006) J. Immunol , vol.176 , pp. 6225-6234
    • Kerfoot, S.M.1    Norman, M.U.2    Lapointe, B.M.3    Bonder, C.S.4    Zbytnuik, L.5    Kubes, P.6
  • 62
    • 0031843289 scopus 로고    scopus 로고
    • Chimeric CD4/CD44 molecules associate with CD44 via the transmembrane region and reduce hyaluronan binding in T cell lines
    • Li, R., J.R. Walker, and P. Johnson. 1998. Chimeric CD4/CD44 molecules associate with CD44 via the transmembrane region and reduce hyaluronan binding in T cell lines. Eur. J. Immunol. 28:1745-1754.
    • (1998) Eur. J. Immunol , vol.28 , pp. 1745-1754
    • Li, R.1    Walker, J.R.2    Johnson, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.