-
1
-
-
84963972074
-
-
Alzheimer's Association. Alzheimer's disease facts and figures. Alzheimers Dement. 2016;12(4):459–509.
-
(2016)
-
-
-
2
-
-
0025332027
-
Anti-inflammatory drugs and Alzheimer disease
-
McGeer PL, McGeer E, Rogers J, et al. Anti-inflammatory drugs and Alzheimer disease. Lancet. 1990;335:1037.
-
(1990)
Lancet
, vol.335
, pp. 1037
-
-
McGeer, P.L.1
McGeer, E.2
Rogers, J.3
-
3
-
-
0026597063
-
Alzheimer’s disease: the amyloid cascade hypothesis
-
Hardy JA, Higgins GA., Alzheimer’s disease:the amyloid cascade hypothesis. Science. 1992;256:184–185.
-
(1992)
Science
, vol.256
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
4
-
-
33748471099
-
Inflammation in Alzheimer disease: driving force, bystander or beneficial response?
-
Wyss-Coray T. Inflammation in Alzheimer disease:driving force, bystander or beneficial response? Nat Med. 2006;12(9):1005–1015.
-
(2006)
Nat Med
, vol.12
, Issue.9
, pp. 1005-1015
-
-
Wyss-Coray, T.1
-
5
-
-
84926370173
-
Neuroinflammation in Alzheimer’s disease
-
Heneka MT, Carson MJ, El Khoury J, et al. Neuroinflammation in Alzheimer’s disease. Lancet Neurol. 2015;14(4):388–405.
-
(2015)
Lancet Neurol
, vol.14
, Issue.4
, pp. 388-405
-
-
Heneka, M.T.1
Carson, M.J.2
El Khoury, J.3
-
6
-
-
84876907931
-
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease
-
Zhang B, Gaiteri C, Bodea LG, et al. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease. Cell. 2013;153(3):707–720.
-
(2013)
Cell
, vol.153
, Issue.3
, pp. 707-720
-
-
Zhang, B.1
Gaiteri, C.2
Bodea, L.G.3
-
7
-
-
84863672009
-
Microglia in Alzheimer’s disease: it’s all about context
-
Weitz TM, Town T. Microglia in Alzheimer’s disease:it’s all about context. Int J Alzheimers Dis. 2012;2012:314185.
-
(2012)
Int J Alzheimers Dis
, vol.2012
, pp. 314185
-
-
Weitz, T.M.1
Town, T.2
-
8
-
-
84904394690
-
Macrophage activation and polarization: nomenclature and experimental guidelines
-
Murray PJ, Allen JE, Biswas SK, et al. Macrophage activation and polarization:nomenclature and experimental guidelines. Immunity. 2014;41(1):14–20.
-
(2014)
Immunity
, vol.41
, Issue.1
, pp. 14-20
-
-
Murray, P.J.1
Allen, J.E.2
Biswas, S.K.3
-
9
-
-
65249170245
-
Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis
-
Mandrekar S, Jiang Q, Lee CY, et al. Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis. J Neurosci. 2009;29(13):4252–4262.
-
(2009)
J Neurosci
, vol.29
, Issue.13
, pp. 4252-4262
-
-
Mandrekar, S.1
Jiang, Q.2
Lee, C.Y.3
-
10
-
-
84882751308
-
Innate immunity in Alzheimer’s disease: a complex affair
-
Guillot-Sestier MV, Town T. Innate immunity in Alzheimer’s disease:a complex affair. CNS Neurol Disord Drug Targets. 2013;12(5):593–607.
-
(2013)
CNS Neurol Disord Drug Targets
, vol.12
, Issue.5
, pp. 593-607
-
-
Guillot-Sestier, M.V.1
Town, T.2
-
11
-
-
79960744467
-
Microglia demonstrate age-dependent interaction with amyloid-beta fibrils
-
Floden AM, Combs CK. Microglia demonstrate age-dependent interaction with amyloid-beta fibrils. J Alzheimers Dis. 2011;25(2):279–293.
-
(2011)
J Alzheimers Dis
, vol.25
, Issue.2
, pp. 279-293
-
-
Floden, A.M.1
Combs, C.K.2
-
12
-
-
84887174745
-
Microglial derived tumor necrosis factor-alpha drives Alzheimer’s disease-related neuronal cell cycle events
-
Bhaskar K, Maphis N, Xu G, et al. Microglial derived tumor necrosis factor-alpha drives Alzheimer’s disease-related neuronal cell cycle events. Neurobiol Dis. 2014;62:273–285.
-
(2014)
Neurobiol Dis
, vol.62
, pp. 273-285
-
-
Bhaskar, K.1
Maphis, N.2
Xu, G.3
-
13
-
-
84936891896
-
Inflammasomes: mechanism of action, role in disease, and therapeutics
-
Guo H, Callaway JB, Ting JP. Inflammasomes:mechanism of action, role in disease, and therapeutics. Nat Med. 2015;21(7):677–687.
-
(2015)
Nat Med
, vol.21
, Issue.7
, pp. 677-687
-
-
Guo, H.1
Callaway, J.B.2
Ting, J.P.3
-
14
-
-
84861687100
-
The role of astrocytes in amyloid beta-protein toxicity and clearance
-
Thal DR. The role of astrocytes in amyloid beta-protein toxicity and clearance. Exp Neurol. 2012;236(1):1–5.
-
(2012)
Exp Neurol
, vol.236
, Issue.1
, pp. 1-5
-
-
Thal, D.R.1
-
15
-
-
84866316014
-
Astrocyte senescence as a component of Alzheimer’s disease
-
Bhat R, Crowe EP, Bitto A, et al. Astrocyte senescence as a component of Alzheimer’s disease. PLoS One. 2012;7(9):e45069.
-
(2012)
PLoS One
, vol.7
, Issue.9
, pp. e45069
-
-
Bhat, R.1
Crowe, E.P.2
Bitto, A.3
-
16
-
-
0029811901
-
Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer’s disease: a review of 17 epidemiologic studies
-
McGeer PL, Schulzer M, McGeer EG. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer’s disease:a review of 17 epidemiologic studies. Neurology. 1996;47(2):425–432.
-
(1996)
Neurology
, vol.47
, Issue.2
, pp. 425-432
-
-
McGeer, P.L.1
Schulzer, M.2
McGeer, E.G.3
-
17
-
-
47249162481
-
Cyclooxygenase-1 and −2 in the different stages of Alzheimer’s disease pathology
-
Hoozemans JJ, Rozemuller JM, Van Haastert ES, et al. Cyclooxygenase-1 and −2 in the different stages of Alzheimer’s disease pathology. Curr Pharm Des. 2008;14(14):1419–1427.
-
(2008)
Curr Pharm Des
, vol.14
, Issue.14
, pp. 1419-1427
-
-
Hoozemans, J.J.1
Rozemuller, J.M.2
Van Haastert, E.S.3
-
18
-
-
0033526660
-
Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs
-
Yasojima K, Schwab C, McGeer EG, et al. Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs. Brain Res. 1999;830(2):226–236.
-
(1999)
Brain Res
, vol.830
, Issue.2
, pp. 226-236
-
-
Yasojima, K.1
Schwab, C.2
McGeer, E.G.3
-
19
-
-
33847339301
-
NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies
-
McGeer PL, McGeer EG. NSAIDs and Alzheimer disease:epidemiological, animal model and clinical studies. Neurobiol Aging. 2007;28(5):639–647.
-
(2007)
Neurobiol Aging
, vol.28
, Issue.5
, pp. 639-647
-
-
McGeer, P.L.1
McGeer, E.G.2
-
20
-
-
77953953898
-
Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid
-
Choi SH, Bosetti F. Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid. Aging (Albany NY). 2009;1(2):234–244.
-
(2009)
Aging (Albany NY)
, vol.1
, Issue.2
, pp. 234-244
-
-
Choi, S.H.1
Bosetti, F.2
-
21
-
-
39749188810
-
Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity
-
Kotilinek LA, Westerman MA, Wang Q, et al. Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity. Brain. 2008;131(Pt 3):651–664.
-
(2008)
Brain
, vol.131
, pp. 651-664
-
-
Kotilinek, L.A.1
Westerman, M.A.2
Wang, Q.3
-
22
-
-
84966309395
-
Untangling the web: toxic and protective effects of neuroinflammation and PGE2 signaling in Alzheimer’s disease
-
Woodling NS, Andreasson KI. Untangling the web:toxic and protective effects of neuroinflammation and PGE2 signaling in Alzheimer’s disease. ACS Chem Neurosci. 2016;7(4):454–463.
-
(2016)
ACS Chem Neurosci
, vol.7
, Issue.4
, pp. 454-463
-
-
Woodling, N.S.1
Andreasson, K.I.2
-
23
-
-
40349113502
-
Possible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage
-
Kukar T, Golde TE. Possible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage. Curr Top Med Chem. 2008;8(1):47–53.
-
(2008)
Curr Top Med Chem
, vol.8
, Issue.1
, pp. 47-53
-
-
Kukar, T.1
Golde, T.E.2
-
24
-
-
85047691727
-
NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo
-
Eriksen JL, Sagi SA, Smith TE, et al. NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J Clin Invest. 2003;112(3):440–449.
-
(2003)
J Clin Invest
, vol.112
, Issue.3
, pp. 440-449
-
-
Eriksen, J.L.1
Sagi, S.A.2
Smith, T.E.3
-
25
-
-
27144513779
-
Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects for Alzheimer’s beta-amyloid fibrils in vitro
-
Hirohata M, Ono K, Naiki H, et al. Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects for Alzheimer’s beta-amyloid fibrils in vitro. Neuropharmacology. 2005;49(7):1088–1099.
-
(2005)
Neuropharmacology
, vol.49
, Issue.7
, pp. 1088-1099
-
-
Hirohata, M.1
Ono, K.2
Naiki, H.3
-
26
-
-
0037200076
-
Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein
-
Avramovich Y, Amit T, Youdim MB. Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein. J Biol Chem. 2002;277(35):31466–31473.
-
(2002)
J Biol Chem
, vol.277
, Issue.35
, pp. 31466-31473
-
-
Avramovich, Y.1
Amit, T.2
Youdim, M.B.3
-
27
-
-
0031888958
-
PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
-
Jiang C, Ting AT, Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature. 1998;391(6662):82–86.
-
(1998)
Nature
, vol.391
, Issue.6662
, pp. 82-86
-
-
Jiang, C.1
Ting, A.T.2
Seed, B.3
-
28
-
-
0031013395
-
Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs
-
Lehmann JM, Lenhard JM, Oliver BB, et al. Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem. 1997;272(6):3406–3410.
-
(1997)
J Biol Chem
, vol.272
, Issue.6
, pp. 3406-3410
-
-
Lehmann, J.M.1
Lenhard, J.M.2
Oliver, B.B.3
-
29
-
-
0242609178
-
Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase
-
Sastre M, Dewachter I, Landreth GE, et al. Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. J Neurosci. 2003;23(30):9796–9804.
-
(2003)
J Neurosci
, vol.23
, Issue.30
, pp. 9796-9804
-
-
Sastre, M.1
Dewachter, I.2
Landreth, G.E.3
-
30
-
-
31044445398
-
Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma
-
Sastre M, Dewachter I, Rossner S, et al. Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. Proc Natl Acad Sci U S A. 2006;103(2):443–448.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.2
, pp. 443-448
-
-
Sastre, M.1
Dewachter, I.2
Rossner, S.3
-
31
-
-
84856428468
-
Increased NF-kappaB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer’s disease
-
Chen CH, Zhou W, Liu S, et al. Increased NF-kappaB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer’s disease. Int J Neuropsychopharmacol. 2012;15(1):77–90.
-
(2012)
Int J Neuropsychopharmacol
, vol.15
, Issue.1
, pp. 77-90
-
-
Chen, C.H.1
Zhou, W.2
Liu, S.3
-
32
-
-
0038375640
-
Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer’s disease: systematic review and meta-analysis of observational studies
-
Etminan M, Gill S, Samii A. Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer’s disease:systematic review and meta-analysis of observational studies. Bmj. 2003;327(7407):128.
-
(2003)
Bmj
, vol.327
, Issue.7407
, pp. 128
-
-
Etminan, M.1
Gill, S.2
Samii, A.3
-
33
-
-
3242803587
-
Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer’s disease: a systematic review
-
Szekely CA, Thorne JE, Zandi PP, et al. Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer’s disease:a systematic review. Neuroepidemiology. 2004;23(4):159–169.
-
(2004)
Neuroepidemiology
, vol.23
, Issue.4
, pp. 159-169
-
-
Szekely, C.A.1
Thorne, J.E.2
Zandi, P.P.3
-
34
-
-
11844255796
-
Meta-analysis of nonsteroidal antiinflammatory drug use and risk of dementia
-
De Craen AJ, Gussekloo J, Vrijsen B, et al. Meta-analysis of nonsteroidal antiinflammatory drug use and risk of dementia. Am J Epidemiol. 2005;161(2):114–120.•• Meta-analysis that challenges some of the views of other meta-analyses. This paper provides a good discussion of the biases inherent in epidemiologic studies.
-
(2005)
Am J Epidemiol
, vol.161
, Issue.2
, pp. 114-120
-
-
De Craen, A.J.1
Gussekloo, J.2
Vrijsen, B.3
-
35
-
-
34547605670
-
NSAIDs for the chemoprevention of Alzheimer’s disease
-
Szekely CA, Town T, Zandi PP. NSAIDs for the chemoprevention of Alzheimer’s disease. Subcell Biochem. 2007;42:229–248.
-
(2007)
Subcell Biochem
, vol.42
, pp. 229-248
-
-
Szekely, C.A.1
Town, T.2
Zandi, P.P.3
-
36
-
-
46049108790
-
No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies
-
Szekely CA, Green RC, Breitner JC, et al. No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies. Neurology. 2008;70(24):2291–2298.
-
(2008)
Neurology
, vol.70
, Issue.24
, pp. 2291-2298
-
-
Szekely, C.A.1
Green, R.C.2
Breitner, J.C.3
-
37
-
-
84921531052
-
Anti-inflammatory drugs and risk of Alzheimer’s disease: an updated systematic review and meta-analysis
-
Wang J, Tan L, Wang HF, et al. Anti-inflammatory drugs and risk of Alzheimer’s disease:an updated systematic review and meta-analysis. J Alzheimers Dis. 2015;44(2):385–396.
-
(2015)
J Alzheimers Dis
, vol.44
, Issue.2
, pp. 385-396
-
-
Wang, J.1
Tan, L.2
Wang, H.F.3
-
38
-
-
34547590424
-
Does NSAID use modify cognitive trajectories in the elderly? The Cache County study
-
Hayden KM, Zandi PP, Khachaturian AS, et al. Does NSAID use modify cognitive trajectories in the elderly? The Cache County study. Neurology. 2007;69(3):275–282.
-
(2007)
Neurology
, vol.69
, Issue.3
, pp. 275-282
-
-
Hayden, K.M.1
Zandi, P.P.2
Khachaturian, A.S.3
-
39
-
-
73949105768
-
Nonsteroidal anti-inflammatory drugs, aspirin, and cognitive function in the Baltimore longitudinal study of aging
-
Waldstein SR, Wendell CR, Seliger SL, et al. Nonsteroidal anti-inflammatory drugs, aspirin, and cognitive function in the Baltimore longitudinal study of aging. J Am Geriatr Soc. 2010;58(1):38–43.
-
(2010)
J Am Geriatr Soc
, vol.58
, Issue.1
, pp. 38-43
-
-
Waldstein, S.R.1
Wendell, C.R.2
Seliger, S.L.3
-
40
-
-
39749171156
-
Anti-inflammatory agents and cognitive decline in a bi-racial population
-
Grodstein F, Skarupski KA, Bienias JL, et al. Anti-inflammatory agents and cognitive decline in a bi-racial population. Neuroepidemiology. 2008;30(1):45–50.
-
(2008)
Neuroepidemiology
, vol.30
, Issue.1
, pp. 45-50
-
-
Grodstein, F.1
Skarupski, K.A.2
Bienias, J.L.3
-
41
-
-
85029338894
-
NSAID use does not affect dementia progression or survival in Alzheimer’s disease. The Cache County dementia progression study
-
Buckley T, Corcoran C, Schwartz S, et al. NSAID use does not affect dementia progression or survival in Alzheimer’s disease. The Cache County dementia progression study. Alzheimers Dement. 2011;7(4):S367.
-
(2011)
Alzheimers Dement
, vol.7
, Issue.4
, pp. S367
-
-
Buckley, T.1
Corcoran, C.2
Schwartz, S.3
-
43
-
-
0027268393
-
Clinical trial of indomethacin in Alzheimer’s disease
-
Rogers J, Kirby LC, Hempelman SR, et al. Clinical trial of indomethacin in Alzheimer’s disease. Neurology. 1993;43(8):1609–1611.
-
(1993)
Neurology
, vol.43
, Issue.8
, pp. 1609-1611
-
-
Rogers, J.1
Kirby, L.C.2
Hempelman, S.R.3
-
44
-
-
44849140748
-
No effect of one-year treatment with indomethacin on Alzheimer’s disease progression: a randomized controlled trial
-
De Jong D, Jansen R, Hoefnagels W, et al. No effect of one-year treatment with indomethacin on Alzheimer’s disease progression:a randomized controlled trial. PLoS One. 2008;3(1):e1475.
-
(2008)
PLoS One
, vol.3
, Issue.1
, pp. e1475
-
-
De Jong, D.1
Jansen, R.2
Hoefnagels, W.3
-
45
-
-
66849143701
-
A randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer’s disease
-
Pasqualetti P, Bonomini C, Dal Forno G, et al. A randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer’s disease. Aging Clin Exp Res. 2009;21(2):102–110.
-
(2009)
Aging Clin Exp Res
, vol.21
, Issue.2
, pp. 102-110
-
-
Pasqualetti, P.1
Bonomini, C.2
Dal Forno, G.3
-
46
-
-
0037638809
-
Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial
-
Aisen PS, Schafer KA, Grundman M, et al. Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression:a randomized controlled trial. JAMA. 2003;289(21):2819–2826.
-
(2003)
JAMA
, vol.289
, Issue.21
, pp. 2819-2826
-
-
Aisen, P.S.1
Schafer, K.A.2
Grundman, M.3
-
47
-
-
21144447586
-
A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment
-
Thal LJ, Ferris SH, Kirby L, et al. A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment. Neuropsychopharmacology. 2005;30(6):1204–1215.•• Large study involving patients with mild cognitive impairment.
-
(2005)
Neuropsychopharmacology
, vol.30
, Issue.6
, pp. 1204-1215
-
-
Thal, L.J.1
Ferris, S.H.2
Kirby, L.3
-
48
-
-
0345830739
-
Rofecoxib: no effect on Alzheimer’s disease in a 1-year, randomized, blinded, controlled study
-
Reines SA, Block GA, Morris JC, et al. Rofecoxib:no effect on Alzheimer’s disease in a 1-year, randomized, blinded, controlled study. Neurology. 2004;62(1):66–71.
-
(2004)
Neurology
, vol.62
, Issue.1
, pp. 66-71
-
-
Reines, S.A.1
Block, G.A.2
Morris, J.C.3
-
49
-
-
84903883286
-
-
Available from:, Mar
-
Advisory Committee Briefing Document Celecoxib and Valdecoxib Cardiovascular Safety. FDA.gov. [cited 2015 Mar6].Available from: http://www.fda.gov/ohrms/dockets/ac/05/briefing/2005-4090B1_03_Pfizer-Celebrex-Bextra.pdf
-
FDA.gov.
-
-
-
50
-
-
33845803191
-
Long-term efficacy and safety of celecoxib in Alzheimer’s disease
-
Soininen H, West C, Robbins J, et al. Long-term efficacy and safety of celecoxib in Alzheimer’s disease. Dement Geriatr Cogn Disord. 2007;23(1):8–21.
-
(2007)
Dement Geriatr Cogn Disord
, vol.23
, Issue.1
, pp. 8-21
-
-
Soininen, H.1
West, C.2
Robbins, J.3
-
51
-
-
58149379766
-
Cognitive and cerebral metabolic effects of celecoxib versus placebo in people with age-related memory loss: randomized controlled study
-
Small GW, Siddarth P, Silverman DH, et al. Cognitive and cerebral metabolic effects of celecoxib versus placebo in people with age-related memory loss:randomized controlled study. Am J Geriatr Psychiatry. 2008;16(12):999–1009.
-
(2008)
Am J Geriatr Psychiatry
, vol.16
, Issue.12
, pp. 999-1009
-
-
Small, G.W.1
Siddarth, P.2
Silverman, D.H.3
-
52
-
-
0033551547
-
A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer’s disease
-
Scharf S, Mander A, Ugoni A, et al. A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer’s disease. Neurology. 1999;53(1):197–201.
-
(1999)
Neurology
, vol.53
, Issue.1
, pp. 197-201
-
-
Scharf, S.1
Mander, A.2
Ugoni, A.3
-
53
-
-
0037046179
-
Randomized pilot study of nimesulide treatment in Alzheimer’s disease
-
Aisen PS, Schmeidler J, Pasinetti GM. Randomized pilot study of nimesulide treatment in Alzheimer’s disease. Neurology. 2002;58(7):1050–1054.
-
(2002)
Neurology
, vol.58
, Issue.7
, pp. 1050-1054
-
-
Aisen, P.S.1
Schmeidler, J.2
Pasinetti, G.M.3
-
54
-
-
43249085300
-
A randomized, double-blind, placebo controlled-trial of triflusal in mild cognitive impairment: the TRIMCI study
-
Gomez-Isla T, Blesa R, Boada M, et al. A randomized, double-blind, placebo controlled-trial of triflusal in mild cognitive impairment:the TRIMCI study. Alzheimer Dis Assoc Disord. 2008;22(1):21–29.
-
(2008)
Alzheimer Dis Assoc Disord
, vol.22
, Issue.1
, pp. 21-29
-
-
Gomez-Isla, T.1
Blesa, R.2
Boada, M.3
-
55
-
-
0034620538
-
A randomized controlled trial of prednisone in Alzheimer’s disease. Alzheimer’s disease cooperative study
-
Aisen PS, Davis KL, Berg JD, et al. A randomized controlled trial of prednisone in Alzheimer’s disease. Alzheimer’s disease cooperative study. Neurology. 2000;54(3):588–593.
-
(2000)
Neurology
, vol.54
, Issue.3
, pp. 588-593
-
-
Aisen, P.S.1
Davis, K.L.2
Berg, J.D.3
-
56
-
-
0035845325
-
Effect of hydroxychloroquine on progression of dementia in early Alzheimer’s disease: an 18-month randomised, double-blind, placebo-controlled study
-
Van Gool WA, Weinstein HC, Scheltens P, et al. Effect of hydroxychloroquine on progression of dementia in early Alzheimer’s disease:an 18-month randomised, double-blind, placebo-controlled study. Lancet. 2001;358(9280):455–460.
-
(2001)
Lancet
, vol.358
, Issue.9280
, pp. 455-460
-
-
Van Gool, W.A.1
Weinstein, H.C.2
Scheltens, P.3
-
57
-
-
85004096552
-
-
Available from:, Mar Disease: Phase 2 Trial Results Reported by Immune Network…-a092852880
-
Alzheimer Disease:Phase 2 Trial Results Reported by Immune Network Ltd. The Free Library [cited 2016 Mar6]. Available from: http://www.thefreelibrary.com/Alzheimer Disease:Phase 2 Trial Results Reported by Immune Network…-a092852880
-
The Free Library
-
-
-
58
-
-
43249122280
-
Efficacy and safety of tarenflurbil in mild to moderate Alzheimer’s disease: a randomised phase II trial
-
Wilcock GK, Black SE, Hendrix SB, et al. Efficacy and safety of tarenflurbil in mild to moderate Alzheimer’s disease:a randomised phase II trial. Lancet Neurol. 2008;7(6):483–493.
-
(2008)
Lancet Neurol
, vol.7
, Issue.6
, pp. 483-493
-
-
Wilcock, G.K.1
Black, S.E.2
Hendrix, S.B.3
-
59
-
-
72549105935
-
Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial
-
Green RC, Schneider LS, Amato DA, et al. Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease:a randomized controlled trial. JAMA. 2009;302(23):2557–2564.• Failed phase III study of tarenflurbil, which showed promise in phase II studies.
-
(2009)
JAMA
, vol.302
, Issue.23
, pp. 2557-2564
-
-
Green, R.C.1
Schneider, L.S.2
Amato, D.A.3
-
60
-
-
33749633921
-
Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial
-
Freund-Levi Y, Eriksdotter-Jonhagen M, Cederholm T, et al. Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease:OmegAD study:a randomized double-blind trial. Arch Neurol. 2006;63(10):1402–1408.
-
(2006)
Arch Neurol
, vol.63
, Issue.10
, pp. 1402-1408
-
-
Freund-Levi, Y.1
Eriksdotter-Jonhagen, M.2
Cederholm, T.3
-
61
-
-
78650254199
-
Why docosahexaenoic acid and aspirin supplementation could be useful in women as a primary prevention therapy against Alzheimer’s disease?
-
Pomponi MF, Gambassi G, Pomponi M, et al. Why docosahexaenoic acid and aspirin supplementation could be useful in women as a primary prevention therapy against Alzheimer’s disease? Ageing Res Rev. 2011;10(1):124–131.
-
(2011)
Ageing Res Rev
, vol.10
, Issue.1
, pp. 124-131
-
-
Pomponi, M.F.1
Gambassi, G.2
Pomponi, M.3
-
62
-
-
84861314593
-
Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer’s disease
-
Jaturapatporn D, Isaac MG, McCleery J, et al. Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer’s disease. Cochrane Database Syst Rev. 2012;2:CD006378.
-
(2012)
Cochrane Database Syst Rev
, vol.2
, pp. CD006378
-
-
Jaturapatporn, D.1
Isaac, M.G.2
McCleery, J.3
-
63
-
-
84861191690
-
Effects of omega-3 fatty acids on cognitive performance: a meta-analysis
-
Mazereeuw G, Lanctot KL, Chau SA, et al. Effects of omega-3 fatty acids on cognitive performance:a meta-analysis. Neurobiol Aging. 2012;33(7):1482, e1417–1429.
-
(2012)
Neurobiol Aging
, vol.33
, Issue.7
, pp. e1417-e1429
-
-
Mazereeuw, G.1
Lanctot, K.L.2
Chau, S.A.3
-
64
-
-
78049407029
-
Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial
-
Quinn JF, Raman R, Thomas RG, et al. Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease:a randomized trial. JAMA. 2010;304(17):1903–1911.
-
(2010)
JAMA
, vol.304
, Issue.17
, pp. 1903-1911
-
-
Quinn, J.F.1
Raman, R.2
Thomas, R.G.3
-
66
-
-
34249058674
-
Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial
-
ADAPT Research Group, Lyketsos CG, Breitner JC, et al. Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial. Neurology. 2007; 68(21):1800–1808.•• Initial results of the ADAPT primary prevention trial.
-
(2007)
Neurology
, vol.68
, Issue.21
, pp. 1800-1808
-
-
Lyketsos, C.G.1
Breitner, J.C.2
-
67
-
-
47549107705
-
Cognitive function over time in the Alzheimer’s Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib
-
ADAPT Research Group, Martin BK, Szekely C, et al. Cognitive function over time in the Alzheimer’s Disease Anti-inflammatory Prevention Trial (ADAPT):results of a randomized, controlled trial of naproxen and celecoxib. Arch Neurol. 2008;65(7):896–905.
-
(2008)
Arch Neurol
, vol.65
, Issue.7
, pp. 896-905
-
-
Martin, B.K.1
Szekely, C.2
-
68
-
-
79960769591
-
Extended results of the Alzheimer’s disease anti-inflammatory prevention trial
-
Breitner JC, Baker LD, Montine TJ, et al. Extended results of the Alzheimer’s disease anti-inflammatory prevention trial. Alzheimers Dement. 2011;7(4):402–411.
-
(2011)
Alzheimers Dement
, vol.7
, Issue.4
, pp. 402-411
-
-
Breitner, J.C.1
Baker, L.D.2
Montine, T.J.3
-
69
-
-
84933675711
-
Follow-up evaluation of cognitive function in the randomized Alzheimer’s disease anti-inflammatory prevention trial and its follow-up study
-
ADAPT-FS Research Group. Follow-up evaluation of cognitive function in the randomized Alzheimer’s disease anti-inflammatory prevention trial and its follow-up study. Alzheimers Dement. 2015;11(2):216–225e211.• Results of the ADAPT follow-up study, which reports data on cognitive measures.
-
(2015)
Alzheimers Dement
, vol.11
, Issue.2
, pp. 216-225e211
-
-
-
70
-
-
84887479509
-
Results of a follow-up study to the randomized Alzheimer’s Disease Anti-inflammatory Prevention Trial (ADAPT)
-
ADAPT Trial Research Group. Results of a follow-up study to the randomized Alzheimer’s Disease Anti-inflammatory Prevention Trial (ADAPT). Alzheimers Dement. 2013;9(6):714–723.
-
(2013)
Alzheimers Dement
, vol.9
, Issue.6
, pp. 714-723
-
-
-
71
-
-
84888861145
-
Statins and cognition: a systematic review and meta-analysis of short- and long-term cognitive effects
-
Swiger KJ, Manalac RJ, Blumenthal RS, et al. Statins and cognition:a systematic review and meta-analysis of short- and long-term cognitive effects. Mayo Clin Proc. 2013;88(11):1213–1221.
-
(2013)
Mayo Clin Proc
, vol.88
, Issue.11
, pp. 1213-1221
-
-
Swiger, K.J.1
Manalac, R.J.2
Blumenthal, R.S.3
-
72
-
-
67650128395
-
Therapeutic potential of statins in Alzheimer’s disease
-
Kandiah N, Feldman HH. Therapeutic potential of statins in Alzheimer’s disease. J Neurol Sci. 2009;283(1–2):230–234.
-
(2009)
J Neurol Sci
, vol.283
, Issue.1-2
, pp. 230-234
-
-
Kandiah, N.1
Feldman, H.H.2
-
74
-
-
85003911056
-
-
updated 2009 Feb 11; cited 2016, Available from:, Mar
-
Trial of Simvastatin in Amnestic Mild Cognitive Impairment (MCI) Patients (SIMaMCI). ClinicaTrials.gov. [updated 2009 Feb 11; cited 2016 Mar6]. Available from: https://www.clinicaltrials.gov/ct2/show/record/NCT00842920
-
ClinicaTrials.gov.
-
-
-
75
-
-
77956252410
-
Semisynthesis of novel monacolin J derivatives: hypocholesterolemic and neuroprotective activities
-
Campoy S, Sierra S, Suarez B, et al. Semisynthesis of novel monacolin J derivatives:hypocholesterolemic and neuroprotective activities. J Antibiot (Tokyo). 2010;63(8):499–505.
-
(2010)
J Antibiot (Tokyo)
, vol.63
, Issue.8
, pp. 499-505
-
-
Campoy, S.1
Sierra, S.2
Suarez, B.3
-
76
-
-
85047691727
-
NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo
-
Eriksen JL, Sagi SA, Smith TE, et al. NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J Clin Invest. 2003;112(3):440–449.
-
(2003)
J Clin Invest
, vol.112
, Issue.3
, pp. 440-449
-
-
Eriksen, J.L.1
Sagi, S.A.2
Smith, T.E.3
-
77
-
-
68049148021
-
Why did tarenflurbil fail in Alzheimer’s disease?
-
Imbimbo BP. Why did tarenflurbil fail in Alzheimer’s disease? J Alzheimers Dis. 2009;17(4):757–760.
-
(2009)
J Alzheimers Dis
, vol.17
, Issue.4
, pp. 757-760
-
-
Imbimbo, B.P.1
-
78
-
-
77954512014
-
CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer’s disease
-
Imbimbo BP, Giardino L, Sivilia S, et al. CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer’s disease. J Alzheimers Dis. 2010;20(1):159–173.
-
(2010)
J Alzheimers Dis
, vol.20
, Issue.1
, pp. 159-173
-
-
Imbimbo, B.P.1
Giardino, L.2
Sivilia, S.3
-
79
-
-
84939228242
-
CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid
-
Porrini V, Lanzillotta A, Branca C, et al. CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid. Neuroscience. 2015;302:112–120.
-
(2015)
Neuroscience
, vol.302
, pp. 112-120
-
-
Porrini, V.1
Lanzillotta, A.2
Branca, C.3
-
80
-
-
84888267995
-
CHF5074 reduces biomarkers of neuroinflammation in patients with mild cognitive impairment: a 12-week, double-blind, placebo-controlled study
-
Ross J, Sharma S, Winston J, et al. CHF5074 reduces biomarkers of neuroinflammation in patients with mild cognitive impairment:a 12-week, double-blind, placebo-controlled study. Curr Alzheimer Res. 2013;10(7):742–753.
-
(2013)
Curr Alzheimer Res
-
-
Ross, J.1
Sharma, S.2
Winston, J.3
-
81
-
-
84864249514
-
Mechanisms underlying the rapid peroxisome proliferator-activated receptor-gamma-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer’s disease
-
Mandrekar-Colucci S, Karlo JC, Landreth GE. Mechanisms underlying the rapid peroxisome proliferator-activated receptor-gamma-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer’s disease. J Neurosci. 2012;32(30):10117–10128.
-
(2012)
J Neurosci
, vol.32
, Issue.30
, pp. 10117-10128
-
-
Mandrekar-Colucci, S.1
Karlo, J.C.2
Landreth, G.E.3
-
82
-
-
84925496945
-
Peroxisome proliferator-activated receptor-gamma agonists for Alzheimer’s disease and amnestic mild cognitive impairment: a systematic review and meta-analysis
-
Liu J, Wang LN, Jia JP. Peroxisome proliferator-activated receptor-gamma agonists for Alzheimer’s disease and amnestic mild cognitive impairment:a systematic review and meta-analysis. Drugs Aging. 2015;32(1):57–65.
-
(2015)
Drugs Aging
, vol.32
, Issue.1
, pp. 57-65
-
-
Liu, J.1
Wang, L.N.2
Jia, J.P.3
-
83
-
-
84954241702
-
The peroxisome proliferators activated receptor-gamma agonists as therapeutics for the treatment of Alzheimer’s disease and mild-to-moderate Alzheimer’s disease: a meta-analysis
-
Cheng H, Shang Y, Jiang L, et al. The peroxisome proliferators activated receptor-gamma agonists as therapeutics for the treatment of Alzheimer’s disease and mild-to-moderate Alzheimer’s disease:a meta-analysis. Int J Neurosci. 2016;126(4):299–307.
-
(2016)
Int J Neurosci
, vol.126
, Issue.4
, pp. 299-307
-
-
Cheng, H.1
Shang, Y.2
Jiang, L.3
-
84
-
-
84878653016
-
-
updated 2013 Aug 25; cited 2016, Available from:, Mar
-
Biomarker Qualification for Risk of Mild Cognitive Impairment (MCI) Due to Alzheimer’s Disease (AD) and Safety and Efficacy Evaluation of Pioglitazone in Delaying Its Onset (TOMMORROW). ClinicalTrials.gov. [updated 2013 Aug 25; cited 2016 Mar6]. Available from: https://clinicaltrials.gov/ct2/show/NCT01931566
-
ClinicalTrials.gov.
-
-
-
85
-
-
84960111185
-
T3D-959: A multi-faceted disease remedial drug candidate for the treatment of Alzheimer’s disease
-
Tong M, Deochand C, Didsbury J, et al. T3D-959:A multi-faceted disease remedial drug candidate for the treatment of Alzheimer’s disease. J Alzheimer’s Dis. 2016;51:123–138.
-
(2016)
J Alzheimer’s Dis
, vol.51
, pp. 123-138
-
-
Tong, M.1
Deochand, C.2
Didsbury, J.3
-
86
-
-
85003983618
-
Available from
-
Mar
-
Feasibility Study in Subjects With Mild to Moderate Alzheimer’s Disease. ClinicalTrails.gov. [updated 2015 Jul 28; cited 2016 Mar6]. Available from:https://clinicaltrials.gov/ct2/show/NCT02560753
-
ClinicalTrails.gov.
-
-
-
87
-
-
84939876636
-
Pan-PPAR modulation effectively protects APP/PS1 mice from amyloid deposition and cognitive deficits
-
Kummer MP, Schwarzenberger R, Sayah-Jeanne S, et al. Pan-PPAR modulation effectively protects APP/PS1 mice from amyloid deposition and cognitive deficits. Mol Neurobiol. 2015;51(2):661–671.
-
(2015)
Mol Neurobiol
, vol.51
, Issue.2
, pp. 661-671
-
-
Kummer, M.P.1
Schwarzenberger, R.2
Sayah-Jeanne, S.3
-
88
-
-
84898938661
-
Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway
-
Zhao J, Fu Y, Liu CC, et al. Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway. J Biol Chem. 2014;289(16):11282–11292.
-
(2014)
J Biol Chem
, vol.289
, Issue.16
, pp. 11282-11292
-
-
Zhao, J.1
Fu, Y.2
Liu, C.C.3
-
89
-
-
84862777666
-
ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models
-
Cramer PE, Cirrito JR, Wesson DW, et al. ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models. Science. 2012;335(6075):1503–1506.
-
(2012)
Science
, vol.335
, Issue.6075
, pp. 1503-1506
-
-
Cramer, P.E.1
Cirrito, J.R.2
Wesson, D.W.3
-
90
-
-
84956952788
-
Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimer’s disease
-
Cummings JL, Zhong K, Kinney JW, et al. Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimer’s disease. Alzheimers Res Ther. 2016;8(1):4.
-
(2016)
Alzheimers Res Ther
, vol.8
, Issue.1
, pp. 4
-
-
Cummings, J.L.1
Zhong, K.2
Kinney, J.W.3
-
91
-
-
84944878466
-
Resveratrol decreases the insoluble Abeta1-42 level in hippocampus and protects the integrity of the blood-brain barrier in AD rats
-
Zhao HF, Li N, Wang Q, et al. Resveratrol decreases the insoluble Abeta1-42 level in hippocampus and protects the integrity of the blood-brain barrier in AD rats. Neuroscience. 2015;310:641–649.
-
(2015)
Neuroscience
, vol.310
, pp. 641-649
-
-
Zhao, H.F.1
Li, N.2
Wang, Q.3
-
92
-
-
84944790420
-
A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease
-
Turner RS, Thomas RG, Craft S, et al. A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology. 2015;85(16):1383–1391.
-
(2015)
Neurology
, vol.85
, Issue.16
, pp. 1383-1391
-
-
Turner, R.S.1
Thomas, R.G.2
Craft, S.3
-
93
-
-
49949104408
-
Rapid improvement in verbal fluency and aphasia following perispinal etanercept in Alzheimer’s disease
-
Tobinick EL, Gross H. Rapid improvement in verbal fluency and aphasia following perispinal etanercept in Alzheimer’s disease. BMC Neurol. 2008;8:27.
-
(2008)
BMC Neurol
, vol.8
, pp. 27
-
-
Tobinick, E.L.1
Gross, H.2
-
94
-
-
84929937549
-
Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trial
-
Butchart J, Brook L, Hopkins V, et al. Etanercept in Alzheimer disease:A randomized, placebo-controlled, double-blind, phase 2 trial. Neurology. 2015;84(21):2161–2168.
-
(2015)
Neurology
, vol.84
, Issue.21
, pp. 2161-2168
-
-
Butchart, J.1
Brook, L.2
Hopkins, V.3
-
95
-
-
84878653016
-
-
Available from:, Mar
-
Short Term Efficacy and Safety of Perispinal Administration of Etanercept in Mild to Moderate Alzheimer’s Disease. ClinicalTrials.gov. [updated 2012 Oct 5; cited 2016 Mar6]. Available from: https://clinicaltrials.gov/ct2/show/study/NCT01716637
-
ClinicalTrials.gov.
-
-
-
96
-
-
84940970904
-
Selective Brain-Targeted Antagonism of p38 MAPKalpha reduces hippocampal IL-1beta levels and improves morris water maze performance in aged rats
-
Alam JJ. Selective Brain-Targeted Antagonism of p38 MAPKalpha reduces hippocampal IL-1beta levels and improves morris water maze performance in aged rats. J Alzheimers Dis. 2015;48(1):219–227.
-
(2015)
J Alzheimers Dis
, vol.48
, Issue.1
, pp. 219-227
-
-
Alam, J.J.1
-
97
-
-
84878653016
-
-
Available from:, Mar
-
Clinical Pharmacology of p38 MAP Kinase Inhibitor, VX-745, in Mild Cognitive Impairment Due to Alzheimer’s Disease (AD) or Mild AD. ClinicalTrials.gov. [updated 2015 Apr 3; cited 2016 Mar6]. Available from: https://clinicaltrials.gov/ct2/show/record/NCT02423200
-
ClinicalTrials.gov.
-
-
-
98
-
-
84873087532
-
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
-
Heneka MT, Kummer MP, Stutz A, et al. NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice. Nature. 2013;493(7434):674–678.
-
(2013)
Nature
, vol.493
, Issue.7434
, pp. 674-678
-
-
Heneka, M.T.1
Kummer, M.P.2
Stutz, A.3
-
99
-
-
84924415042
-
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
-
Coll RC, Robertson AA, Chae JJ, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015;21(3):248–255.
-
(2015)
Nat Med
, vol.21
, Issue.3
, pp. 248-255
-
-
Coll, R.C.1
Robertson, A.A.2
Chae, J.J.3
-
100
-
-
84936891385
-
IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases
-
Teng MW, Bowman EP, McElwee JJ, et al. IL-12 and IL-23 cytokines:from discovery to targeted therapies for immune-mediated inflammatory diseases. Nat Med. 2015;21(7):719–729.
-
(2015)
Nat Med
, vol.21
, Issue.7
, pp. 719-729
-
-
Teng, M.W.1
Bowman, E.P.2
McElwee, J.J.3
-
101
-
-
84870932482
-
Inhibition of IL-12/IL-23 signaling reduces Alzheimer’s disease-like pathology and cognitive decline
-
Vom Berg J, Prokop S, Miller KR, et al. Inhibition of IL-12/IL-23 signaling reduces Alzheimer’s disease-like pathology and cognitive decline. Nat Med. 2012;18(12):1812–1819.
-
(2012)
Nat Med
, vol.18
, Issue.12
, pp. 1812-1819
-
-
Vom Berg, J.1
Prokop, S.2
Miller, K.R.3
-
102
-
-
84866106602
-
Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease
-
Hu WT, Holtzman DM, Fagan AM, et al. Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease. Neurology. 2012;79(9):897–905.
-
(2012)
Neurology
, vol.79
, Issue.9
, pp. 897-905
-
-
Hu, W.T.1
Holtzman, D.M.2
Fagan, A.M.3
-
103
-
-
44949173099
-
Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology
-
Town T, Laouar Y, Pittenger C, et al. Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nat Med. 2008;14(6):681–687.
-
(2008)
Nat Med
, vol.14
, Issue.6
, pp. 681-687
-
-
Town, T.1
Laouar, Y.2
Pittenger, C.3
-
104
-
-
33750591957
-
Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer’s pathology
-
Tesseur I, Zou K, Esposito L, et al. Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer’s pathology. J Clin Invest. 2006;116(11):3060–3069.
-
(2006)
J Clin Invest
, vol.116
, Issue.11
, pp. 3060-3069
-
-
Tesseur, I.1
Zou, K.2
Esposito, L.3
-
106
-
-
84922064574
-
IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior
-
Chakrabarty P, Li A, Ceballos-Diaz C, et al. IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior. Neuron. 2015;85(3):519–533.
-
(2015)
Neuron
, vol.85
, Issue.3
, pp. 519-533
-
-
Chakrabarty, P.1
Li, A.2
Ceballos-Diaz, C.3
-
107
-
-
84957431867
-
PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer’s disease
-
Baruch K, Deczkowska A, Rosenzweig N, et al. PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer’s disease. Nat Med. 2016;22(2):135–137.• Pre-clinical report on the effect of PD-1 inhibitors in Alzheimer’s disease.
-
(2016)
Nat Med
, vol.22
, Issue.2
, pp. 135-137
-
-
Baruch, K.1
Deczkowska, A.2
Rosenzweig, N.3
-
108
-
-
84939490054
-
Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer’s disease pathology
-
Baruch K, Rosenzweig N, Kertser A, et al. Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer’s disease pathology. Nat Commun. 2015;6:7967.
-
(2015)
Nat Commun
, vol.6
, pp. 7967
-
-
Baruch, K.1
Rosenzweig, N.2
Kertser, A.3
-
109
-
-
84962204899
-
Regulatory T cells delay disease progression in Alzheimer-like pathology
-
Dansokho C, Ait Ahmed D, Aid S, et al. Regulatory T cells delay disease progression in Alzheimer-like pathology. Brain. 2016;139(4):1237–1251.
-
(2016)
Brain
-
-
Dansokho, C.1
Ait Ahmed, D.2
Aid, S.3
-
110
-
-
84928591321
-
The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases
-
Klatzmann D, Abbas AK. The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases. Nat Rev Immunol. 2015;15(5):283–294.
-
(2015)
Nat Rev Immunol
, vol.15
, Issue.5
, pp. 283-294
-
-
Klatzmann, D.1
Abbas, A.K.2
-
111
-
-
84964632197
-
Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology
-
Olmos-Alonso A, Schetters ST, Sri S, et al. Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology. Brain. 2016;139(Pt 3):891–907.
-
(2016)
Brain
, vol.139
, pp. 891-907
-
-
Olmos-Alonso, A.1
Schetters, S.T.2
Sri, S.3
-
112
-
-
84964433785
-
Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-beta pathology
-
Spangenberg EE, Lee RJ, Najafi AR, et al. Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-beta pathology. Brain. 2016;139(4):1265–1281.
-
(2016)
Brain
-
-
Spangenberg, E.E.1
Lee, R.J.2
Najafi, A.R.3
-
113
-
-
84920841382
-
NFkappaB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer’s disease
-
Lian H, Yang L, Cole A, et al. NFkappaB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer’s disease. Neuron. 2015;85(1):101–115.
-
(2015)
Neuron
, vol.85
, Issue.1
, pp. 101-115
-
-
Lian, H.1
Yang, L.2
Cole, A.3
-
114
-
-
84954326957
-
Astrocyte-microglia cross talk through complement activation modulates amyloid pathology in mouse models of Alzheimer’s disease
-
Lian H, Litvinchuk A, Chiang AC, et al. Astrocyte-microglia cross talk through complement activation modulates amyloid pathology in mouse models of Alzheimer’s disease. J Neurosci. 2016;36(2):577–589.
-
(2016)
J Neurosci
, vol.36
, Issue.2
, pp. 577-589
-
-
Lian, H.1
Litvinchuk, A.2
Chiang, A.C.3
-
115
-
-
24344461844
-
The C3a receptor antagonist SB 290157 has agonist activity
-
Mathieu MC, Sawyer N, Greig GM, et al. The C3a receptor antagonist SB 290157 has agonist activity. Immunol Lett. 2005;100(2):139–145.
-
(2005)
Immunol Lett
, vol.100
, Issue.2
, pp. 139-145
-
-
Mathieu, M.C.1
Sawyer, N.2
Greig, G.M.3
-
116
-
-
85004087711
-
Preclinical characterization of RO4602522, a novel, selective and orally active monoamine oxidase type B inhibitor for the treatment of Alzheimer’s disease
-
Borroni E, Wyler R, Messer J, et al. Preclinical characterization of RO4602522, a novel, selective and orally active monoamine oxidase type B inhibitor for the treatment of Alzheimer’s disease. Alzheimers Dement. 2013;9(4):P818.
-
(2013)
Alzheimers Dement
, vol.9
, Issue.4
, pp. P818
-
-
Borroni, E.1
Wyler, R.2
Messer, J.3
-
117
-
-
85003801620
-
Sembragiline in moderate Alzheimer’s disease dementia: results of a Phase 2 trial (Mayflower Road)
-
Nave S, Doody RS, Boada Rovira M, et al. Sembragiline in moderate Alzheimer’s disease dementia:results of a Phase 2 trial (Mayflower Road). J Prev Alz Dis. 2015;2(4):276–277.
-
(2015)
J Prev Alz Dis
, vol.2
, Issue.4
, pp. 276-277
-
-
Nave, S.1
Doody, R.S.2
Boada Rovira, M.3
-
118
-
-
84924589138
-
Scanning ultrasound removes amyloid-beta and restores memory in an Alzheimer’s disease mouse model
-
Leinenga G, Gotz J. Scanning ultrasound removes amyloid-beta and restores memory in an Alzheimer’s disease mouse model. Sci Transl Med. 2015;7(278):278ra233.
-
(2015)
Sci Transl Med
, vol.7
, Issue.278
, pp. 278ra233
-
-
Leinenga, G.1
Gotz, J.2
-
119
-
-
84925464993
-
TREM2 lipid sensing sustains the microglial response in an Alzheimer’s disease model
-
Wang Y, Cella M, Mallinson K, et al. TREM2 lipid sensing sustains the microglial response in an Alzheimer’s disease model. Cell. 2015;160(6):1061–1071.
-
(2015)
Cell
, vol.160
, Issue.6
, pp. 1061-1071
-
-
Wang, Y.1
Cella, M.2
Mallinson, K.3
-
120
-
-
85027946081
-
Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer’s disease
-
Jiang T, Tan L, Zhu XC, et al. Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer’s disease. Neuropsychopharmacology. 2014;39(13):2949–2962.
-
(2014)
Neuropsychopharmacology
, vol.39
, Issue.13
, pp. 2949-2962
-
-
Jiang, T.1
Tan, L.2
Zhu, X.C.3
-
121
-
-
84924737031
-
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models
-
Jay TR, Miller CM, Cheng PJ, et al. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models. J Exp Med. 2015;212(3):287–295.
-
(2015)
J Exp Med
, vol.212
, Issue.3
, pp. 287-295
-
-
Jay, T.R.1
Miller, C.M.2
Cheng, P.J.3
-
122
-
-
84954422340
-
TREM2 overexpression has no improvement on neuropathology and cognitive impairment in aging APPswe/PS1dE9 mice
-
Jiang T, Wan Y, Zhang YD, et al. TREM2 overexpression has no improvement on neuropathology and cognitive impairment in aging APPswe/PS1dE9 mice. Mol Neurobiol. 2016.doi:10.1007/s12035-016-9704-x. [Epub ahead of print]
-
(2016)
Mol Neurobiol
-
-
Jiang, T.1
Wan, Y.2
Zhang, Y.D.3
-
123
-
-
84959118543
-
TREM2 variants: new keys to decipher Alzheimer disease pathogenesis
-
Colonna M, Wang Y. TREM2 variants:new keys to decipher Alzheimer disease pathogenesis. Nat Rev Neurosci. 2016;17:201–207.• Good overview paper of the role of TREM2 in AD pathogenesis, which is currently under investigation. This paper provides thorough mechanistic explanations.
-
(2016)
Nat Rev Neurosci
, vol.17
, pp. 201-207
-
-
Colonna, M.1
Wang, Y.2
-
124
-
-
84969286765
-
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
-
Wang Y, Ulland TK, Ulrich JD, et al. TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques. J Exp Med. 2016;213(5):667–675.
-
(2016)
J Exp Med
, vol.213
, Issue.5
, pp. 667-675
-
-
Wang, Y.1
Ulland, T.K.2
Ulrich, J.D.3
-
125
-
-
84968764145
-
TREM2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy
-
Yuan P, Condello C, Keene CD, et al. TREM2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy. Neuron. 2016;90(4):724–739.
-
(2016)
Neuron
, vol.90
, Issue.4
, pp. 724-739
-
-
Yuan, P.1
Condello, C.2
Keene, C.D.3
-
126
-
-
84878433339
-
Alzheimer’s disease risk gene CD33 inhibits microglial uptake of amyloid beta
-
Griciuc A, Serrano-Pozo A, Parrado AR, et al. Alzheimer’s disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron. 2013;78(4):631–643.
-
(2013)
Neuron
, vol.78
, Issue.4
, pp. 631-643
-
-
Griciuc, A.1
Serrano-Pozo, A.2
Parrado, A.R.3
-
127
-
-
77951647591
-
RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer’s disease
-
Fang F, Lue LF, Yan S, et al. RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer’s disease. Faseb J. 2010;24(4):1043–1055.
-
(2010)
Faseb J
, vol.24
, Issue.4
, pp. 1043-1055
-
-
Fang, F.1
Lue, L.F.2
Yan, S.3
-
128
-
-
84902173668
-
Clinical trial of an inhibitor of RAGE-Abeta interactions in Alzheimer disease
-
Galasko D, Bell J, Mancuso JY, et al. Clinical trial of an inhibitor of RAGE-Abeta interactions in Alzheimer disease. Neurology. 2014;82(17):1536–1542.
-
(2014)
Neurology
, vol.82
, Issue.17
, pp. 1536-1542
-
-
Galasko, D.1
Bell, J.2
Mancuso, J.Y.3
-
129
-
-
84899516443
-
Effect of TTP488 in patients with mild to moderate Alzheimer’s disease
-
Burstein AH, Grimes I, Galasko DR, et al. Effect of TTP488 in patients with mild to moderate Alzheimer’s disease. BMC Neurol. 2014;14:12.
-
(2014)
BMC Neurol
, vol.14
, pp. 12
-
-
Burstein, A.H.1
Grimes, I.2
Galasko, D.R.3
-
130
-
-
84878653016
-
-
Available from:, Mar
-
Evaluation of the Efficacy and Safety of Azeliragon (TTP488) in Patients With Mild Alzheimer’s Disease (STEADFAST). ClinicalTrials.gov. [updated 2014 Feb 25; cited 2016 Mar6]. Available from: https://www.clinicaltrials.gov/show/NCT02080364
-
ClinicalTrials.gov.
-
-
-
131
-
-
0033153519
-
Confounding by indication: an example of variation in the use of epidemiologic terminology
-
Salas M, Hofman A, Stricker BH. Confounding by indication:an example of variation in the use of epidemiologic terminology. Am J Epidemiol. 1999;149(11):981–983.
-
(1999)
Am J Epidemiol
, vol.149
, Issue.11
, pp. 981-983
-
-
Salas, M.1
Hofman, A.2
Stricker, B.H.3
-
132
-
-
77949892665
-
Non-steroidal anti-inflammatory drugs and Alzheimer’s disease: the epidemiological evidence
-
Szekely CA, Zandi PP. Non-steroidal anti-inflammatory drugs and Alzheimer’s disease:the epidemiological evidence. CNS Neurol Disord Drug Targets. 2010;9(2):132–139.
-
(2010)
CNS Neurol Disord Drug Targets
, vol.9
, Issue.2
, pp. 132-139
-
-
Szekely, C.A.1
Zandi, P.P.2
-
133
-
-
0035936004
-
Nonsteroidal antiinflammatory drugs and the risk of Alzheimer’s disease
-
In T’ Veld BA, Ruitenberg A, Hofman A, et al. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer’s disease. N Engl J Med. 2001;345(21):1515–1521.
-
(2001)
N Engl J Med
, vol.345
, Issue.21
, pp. 1515-1521
-
-
In T’ Veld, B.A.1
Ruitenberg, A.2
Hofman, A.3
-
134
-
-
43149102747
-
Protective effects of NSAIDs on the development of Alzheimer disease
-
Vlad SC, Miller DR, Kowall NW, et al. Protective effects of NSAIDs on the development of Alzheimer disease. Neurology. 2008;70(19):1672–1677.•• A large-scale case-control study on the use of NSAIDs and incidence of Alzheimer’s disease in the Veterans Affair Health Care system.
-
(2008)
Neurology
, vol.70
, Issue.19
, pp. 1672-1677
-
-
Vlad, S.C.1
Miller, D.R.2
Kowall, N.W.3
-
135
-
-
66649131390
-
Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort
-
Breitner JC, Haneuse SJ, Walker R, et al. Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort. Neurology. 2009;72(22):1899–1905.
-
(2009)
Neurology
, vol.72
, Issue.22
, pp. 1899-1905
-
-
Breitner, J.C.1
Haneuse, S.J.2
Walker, R.3
-
136
-
-
44949084672
-
Relation of NSAIDs to incident AD, change in cognitive function, and AD pathology
-
Arvanitakis Z, Grodstein F, Bienias JL, et al. Relation of NSAIDs to incident AD, change in cognitive function, and AD pathology. Neurology. 2008;70(23):2219–2225.
-
(2008)
Neurology
, vol.70
, Issue.23
, pp. 2219-2225
-
-
Arvanitakis, Z.1
Grodstein, F.2
Bienias, J.L.3
-
137
-
-
37849044699
-
NSAID use and dementia risk in the cardiovascular health study: role of APOE and NSAID type
-
Szekely CA, Breitner JC, Fitzpatrick AL, et al. NSAID use and dementia risk in the cardiovascular health study:role of APOE and NSAID type. Neurology. 2008;70(1):17–24.
-
(2008)
Neurology
, vol.70
, Issue.1
, pp. 17-24
-
-
Szekely, C.A.1
Breitner, J.C.2
Fitzpatrick, A.L.3
-
138
-
-
34249982140
-
Amyloid β42-level lowering non-steroidal anti-inflammatory drugs and the risk of Alzheimer’s disease
-
Haag MD, Van Oijen M, De Jong FJ, et al. Amyloid β42-level lowering non-steroidal anti-inflammatory drugs and the risk of Alzheimer’s disease. Alzheimers Dement. 2006;2(Suppl1):S43.
-
(2006)
Alzheimers Dement
, vol.2
, pp. S43
-
-
Haag, M.D.1
Van Oijen, M.2
De Jong, F.J.3
-
139
-
-
1842840885
-
Aspirin, NSAIDs, risk of dementia, and influence of the apolipoprotein E epsilon 4 allele in an elderly population
-
Cornelius C, Fastbom J, Winblad B, et al. Aspirin, NSAIDs, risk of dementia, and influence of the apolipoprotein E epsilon 4 allele in an elderly population. Neuroepidemiology. 2004;23(3):135–143.
-
(2004)
Neuroepidemiology
, vol.23
, Issue.3
, pp. 135-143
-
-
Cornelius, C.1
Fastbom, J.2
Winblad, B.3
-
140
-
-
84963992024
-
Mechanisms of peroxisome proliferator activated receptor gamma regulation by non-steroidal anti-inflammatory drugs
-
Puhl AC, Milton FA, Cvoro A, et al. Mechanisms of peroxisome proliferator activated receptor gamma regulation by non-steroidal anti-inflammatory drugs. Nucl Recept Signal. 2015;13:e004.
-
(2015)
Nucl Recept Signal
, vol.13
, pp. e004
-
-
Puhl, A.C.1
Milton, F.A.2
Cvoro, A.3
-
141
-
-
84973763248
-
-
Available from:, Mar
-
FDA Drug Safety Communication:FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) can cause heart attacks or strokes. U.S. Food and Drug Administration [cited 2016 Mar6]. Available from: http://www.fda.gov/Drugs/DrugSafety/ucm451800.htm
-
U.S. Food and Drug Administration
-
-
-
142
-
-
84962883667
-
ADCOMS: a composite clinical outcome for prodromal Alzheimer’s disease trials
-
Wang J, Logovinsky V, Hendrix SB, et al. ADCOMS:a composite clinical outcome for prodromal Alzheimer’s disease trials. J Neurol Neurosurg Psychiatry. 2016. doi:10.1136/jnnp-2015-312383. [Epub ahead of print]
-
(2016)
J Neurol Neurosurg Psychiatry
-
-
Wang, J.1
Logovinsky, V.2
Hendrix, S.B.3
|