NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer's Disease

Neuron

Volumn 85, Issue 1, 2015, Pages 101-115

  Lian, Hong ^a,b   Yang, Li ^a   Cole, Allysa ^a   Sun, Lu ^a   Chiang, Angie C A ^c   Fowler, Stephanie W ^c   Shim, David J ^a,c   Rodriguez Rivera, Jennifer ^a   Taglialatela, Giulio ^d   Jankowsky, Joanna L ^a,c   Lu, Hui Chen ^c,e   Zheng, Hui ^a,b,c  

^a Huffington Center on Aging   (United States)

^b Department of Molecular and Human Genetics ^*  (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d University of Texas Medical Branch School of Medicine   (United States)

^e TEXAS CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ADENOSINE TRIPHOSPHATE; COMPLEMENT COMPONENT C3; GLUCOSE; GLUTAMIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 2; NESTIN; TUMOR NECROSIS FACTOR ALPHA; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; COMPLEMENT C3A RECEPTOR; COMPLEMENT RECEPTOR;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN FUNCTION; BRAIN TISSUE; CELL INTERACTION; CELL STRUCTURE; COCULTURE; COGNITIVE DEFECT; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN TISSUE; MACROGLIA; MOUSE; NERVE CELL; NERVE DEGENERATION; NONHUMAN; PROTEIN DEGRADATION; SYNAPSE; SYNAPTIC TRANSMISSION; TRANSGENIC MOUSE; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; CONFOCAL MICROSCOPY; GENETICS; METABOLISM; PATHOLOGY; SECRETION (PROCESS); SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ASTROCYTES; BRAIN; COMPLEMENT C3; HUMANS; MICE; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; NEURONS; NF-KAPPA B; RECEPTORS, COMPLEMENT; SIGNAL TRANSDUCTION;

EID: 84920841382     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2014.11.018     Document Type: Article

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