RAGE-dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease

FASEB Journal

Volumn 24, Issue 4, 2010, Pages 1043-1055

  Fang, ^a   Lue, Lih Fen ^b   Yan, Shiqiang ^a,c   Xu, Hongwei ^a,f   Luddy, John S ^a   Chen, Doris ^a   Walker, Douglas G ^b   Stern, David M ^d   Yan, Shifang ^a   Schmidt, Ann Marie ^a   Chen, John X ^e   Yan, Shirley ShiDu ^a  

^a Columbia University ^*  (United States)

^b SUN HEALTH RESEARCH INSTITUTE   (United States)

^c Langzhou University   (China)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^e MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^f HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

A binding protein; Animal model; Cytokine; Microglia neuron interaction

Indexed keywords

ACETYLCHOLINESTERASE; ADVANCED GLYCATION END PRODUCT RECEPTOR; AMYLOID BETA PROTEIN; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; RAGE PROTEIN, HUMAN; RAGE PROTEIN, MOUSE; TUMOR ANTIGEN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL INFILTRATION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; INFLAMMATION; LEARNING DISORDER; MEMORY DISORDER; MICROGLIA; MOUSE; NERVE FUNCTION; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; ANIMAL; DISEASE MODEL; GENETICS; LEARNING; MEMORY; METABOLISM; MUTATION; NERVE CELL; PATHOLOGY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; ANTIGENS, NEOPLASM; ASTROCYTES; DISEASE MODELS, ANIMAL; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; LEARNING; MEMORY; MICE; MICE, TRANSGENIC; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; NEURONS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; MUS MUSCULUS;

EID: 77951647591     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.09-139634     Document Type: Article

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