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Volumn 51, Issue 2, 2015, Pages 661-671

Pan-PPAR Modulation Effectively Protects APP/PS1 Mice from Amyloid Deposition and Cognitive Deficits

Author keywords

Alzheimer; Amyloid; Behavior; Inflammation; PPAR

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; AMYLOID PRECURSOR PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; PRESENILIN 1;

EID: 84939876636     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-8743-4     Document Type: Article
Times cited : (44)

References (46)
  • 1
    • 75449102536 scopus 로고    scopus 로고
    • Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3cXht1aqt7s%3D, PID: 20107219
    • Querfurth HW, LaFerla FM (2010) Alzheimer’s disease. N Engl J Med 362:329–344. doi:10.1056/NEJMra0909142
    • (2010) N Engl J Med , vol.362 , pp. 329-344
    • Querfurth, H.W.1    LaFerla, F.M.2
  • 2
    • 84872379077 scopus 로고    scopus 로고
    • Tracking pathophysiological processes in Alzheimer’s disease: an updated hypothetical model of dynamic biomarkers
    • COI: 1:CAS:528:DC%2BC3sXhslCht7o%3D, PID: 23332364
    • Jack CR Jr, Knopman DS, Jagust WJ et al (2013) Tracking pathophysiological processes in Alzheimer’s disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol 12:207–216. doi:10.1016/S1474-4422(12)70291-0
    • (2013) Lancet Neurol , vol.12 , pp. 207-216
    • Jack, C.R.1    Knopman, D.S.2    Jagust, W.J.3
  • 3
    • 77954132249 scopus 로고    scopus 로고
    • Amyloid-β induced neuronal dysfunction in Alzheimer’s disease: from synapses toward neural networks
    • COI: 1:CAS:528:DC%2BC3cXnvFSgtr0%3D, PID: 20581818
    • Palop JJ, Mucke L (2010) Amyloid-β induced neuronal dysfunction in Alzheimer’s disease: from synapses toward neural networks. Nat Neurosci 13:812–818. doi:10.1038/nn.2583
    • (2010) Nat Neurosci , vol.13 , pp. 812-818
    • Palop, J.J.1    Mucke, L.2
  • 4
    • 84857642949 scopus 로고    scopus 로고
    • The toxic Aβ oligomer and Alzheimer’s disease: an emperor in need of clothes
    • COI: 1:CAS:528:DC%2BC38XhtlOltrc%3D, PID: 22286176
    • Benilova I, Karran E, De Strooper B (2012) The toxic Aβ oligomer and Alzheimer’s disease: an emperor in need of clothes. Nat Neurosci 15:349–357. doi:10.1038/nn.3028
    • (2012) Nat Neurosci , vol.15 , pp. 349-357
    • Benilova, I.1    Karran, E.2    De Strooper, B.3
  • 5
    • 0035936004 scopus 로고    scopus 로고
    • Nonsteroidal antiinflammatory drugs and the risk of Alzheimer’s disease
    • PID: 11794217
    • In t’ Veld BA, Ruitenberg A, Hofman A et al (2001) Nonsteroidal antiinflammatory drugs and the risk of Alzheimer’s disease. N Engl J Med 345:1515–1521. doi:10.1056/NEJMoa010178
    • (2001) N Engl J Med , vol.345 , pp. 1515-1521
    • In t’ Veld, B.A.1    Ruitenberg, A.2    Hofman, A.3
  • 6
    • 0035132169 scopus 로고    scopus 로고
    • Role for peroxisome proliferator-activated receptor-gamma in Alzheimer’s disease
    • COI: 1:STN:280:DC%2BD3M7otFOmsw%3D%3D, PID: 11220752
    • Heneka MT, Landreth GE, Feinstein DL (2001) Role for peroxisome proliferator-activated receptor-gamma in Alzheimer’s disease. Ann Neurol 49:276
    • (2001) Ann Neurol , vol.49 , pp. 276
    • Heneka, M.T.1    Landreth, G.E.2    Feinstein, D.L.3
  • 7
    • 0031013395 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs
    • COI: 1:CAS:528:DyaK2sXhtFeltLc%3D, PID: 9013583
    • Lehmann JM, Lenhard JM, Oliver BB et al (1997) Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 272:3406–3410
    • (1997) J Biol Chem , vol.272 , pp. 3406-3410
    • Lehmann, J.M.1    Lenhard, J.M.2    Oliver, B.B.3
  • 8
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
    • COI: 1:CAS:528:DyaK1cXktVSgug%3D%3D, PID: 9422509
    • Jiang C, Ting AT, Seed B (1998) PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 391:82–86. doi:10.1038/34184
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 9
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
    • COI: 1:CAS:528:DyaK1cXktVShtQ%3D%3D, PID: 9422508
    • Ricote M, Li AC, Willson TM et al (1998) The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391:79–82. doi:10.1038/34178
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3
  • 10
    • 34547673325 scopus 로고    scopus 로고
    • PPARs in the brain
    • COI: 1:CAS:528:DC%2BD2sXovFegu7Y%3D, PID: 17569578
    • Heneka MT, Landreth GE (2007) PPARs in the brain. Biochim Biophys Acta 1771:1031–1045. doi:10.1016/j.bbalip.2007.04.016
    • (2007) Biochim Biophys Acta , vol.1771 , pp. 1031-1045
    • Heneka, M.T.1    Landreth, G.E.2
  • 11
    • 0041921071 scopus 로고    scopus 로고
    • Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD3sXmvFaisLg%3D
    • Yan Q, Zhang J, Liu H et al (2003) Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer’s disease. J Neurosci Off J Soc Neurosci 23:7504–7509
    • (2003) J Neurosci Off J Soc Neurosci , vol.23 , pp. 7504-7509
    • Yan, Q.1    Zhang, J.2    Liu, H.3
  • 12
    • 20444499367 scopus 로고    scopus 로고
    • Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice
    • Heneka MT, Sastre M, Dumitrescu-Ozimek L et al (2005) Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. Brain J Neurol 128:1442–1453. doi:10.1093/brain/awh452
    • (2005) Brain J Neurol , vol.128 , pp. 1442-1453
    • Heneka, M.T.1    Sastre, M.2    Dumitrescu-Ozimek, L.3
  • 13
    • 0034651101 scopus 로고    scopus 로고
    • Inflammatory mechanisms in Alzheimer’s disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists
    • COI: 1:CAS:528:DC%2BD3cXhtF2hsLk%3D
    • Combs CK, Johnson DE, Karlo JC et al (2000) Inflammatory mechanisms in Alzheimer’s disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists. J Neurosci Off J Soc Neurosci 20:558–567
    • (2000) J Neurosci Off J Soc Neurosci , vol.20 , pp. 558-567
    • Combs, C.K.1    Johnson, D.E.2    Karlo, J.C.3
  • 14
    • 0037150792 scopus 로고    scopus 로고
    • Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: associated with iNOS and COX-2
    • COI: 1:CAS:528:DC%2BD38XjvVSgsrY%3D, PID: 12031542
    • Kim EJ, Kwon KJ, Park JY et al (2002) Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: associated with iNOS and COX-2. Brain Res 941:1–10
    • (2002) Brain Res , vol.941 , pp. 1-10
    • Kim, E.J.1    Kwon, K.J.2    Park, J.Y.3
  • 15
    • 20444398490 scopus 로고    scopus 로고
    • Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation
    • COI: 1:CAS:528:DC%2BD2MXks1eltrw%3D, PID: 15817469
    • Luna-Medina R, Cortes-Canteli M, Alonso M et al (2005) Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation. J Biol Chem 280:21453–21462. doi:10.1074/jbc.M414390200
    • (2005) J Biol Chem , vol.280 , pp. 21453-21462
    • Luna-Medina, R.1    Cortes-Canteli, M.2    Alonso, M.3
  • 16
    • 0242609178 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase
    • COI: 1:CAS:528:DC%2BD3sXovVKis7w%3D
    • Sastre M, Dewachter I, Landreth GE et al (2003) Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. J Neurosci Off J Soc Neurosci 23:9796–9804
    • (2003) J Neurosci Off J Soc Neurosci , vol.23 , pp. 9796-9804
    • Sastre, M.1    Dewachter, I.2    Landreth, G.E.3
  • 17
    • 31044445398 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma
    • COI: 1:CAS:528:DC%2BD28XpsVSluw%3D%3D, PID: 16407166
    • Sastre M, Dewachter I, Rossner S et al (2006) Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. Proc Natl Acad Sci U S A 103:443–448. doi:10.1073/pnas.0503839103
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 443-448
    • Sastre, M.1    Dewachter, I.2    Rossner, S.3
  • 18
    • 33748755428 scopus 로고    scopus 로고
    • Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer’s disease
    • De la Monte SM, Tong M, Lester-Coll N et al (2006) Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer’s disease. J Alzheimers Dis JAD 10:89–109
    • (2006) J Alzheimers Dis JAD , vol.10 , pp. 89-109
    • De la Monte, S.M.1    Tong, M.2    Lester-Coll, N.3
  • 19
    • 77955057772 scopus 로고    scopus 로고
    • PPARalpha: an emerging therapeutic target in diabetic microvascular damage
    • COI: 1:CAS:528:DC%2BC3cXpt1Crsr4%3D, PID: 20567246
    • Hiukka A, Maranghi M, Matikainen N, Taskinen M-R (2010) PPARalpha: an emerging therapeutic target in diabetic microvascular damage. Nat Rev Endocrinol 6:454–463. doi:10.1038/nrendo.2010.89
    • (2010) Nat Rev Endocrinol , vol.6 , pp. 454-463
    • Hiukka, A.1    Maranghi, M.2    Matikainen, N.3    Taskinen, M.-R.4
  • 20
    • 79952189004 scopus 로고    scopus 로고
    • Vascular PPARδ protects against stroke-induced brain injury
    • COI: 1:CAS:528:DC%2BC3MXitVOgur0%3D, PID: 21205987
    • Yin K-J, Deng Z, Hamblin M et al (2011) Vascular PPARδ protects against stroke-induced brain injury. Arterioscler Thromb Vasc Biol 31:574–581. doi:10.1161/ATVBAHA.110.221267
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 574-581
    • Yin, K.-J.1    Deng, Z.2    Hamblin, M.3
  • 21
    • 25844473319 scopus 로고    scopus 로고
    • Protective effects of a peroxisome proliferator-activated receptor-beta/delta agonist in experimental autoimmune encephalomyelitis
    • COI: 1:CAS:528:DC%2BD2MXhtVynt7bJ, PID: 16098614
    • Polak PE, Kalinin S, Dello Russo C et al (2005) Protective effects of a peroxisome proliferator-activated receptor-beta/delta agonist in experimental autoimmune encephalomyelitis. J Neuroimmunol 168:65–75. doi:10.1016/j.jneuroim.2005.07.006
    • (2005) J Neuroimmunol , vol.168 , pp. 65-75
    • Polak, P.E.1    Kalinin, S.2    Dello Russo, C.3
  • 22
    • 70249113348 scopus 로고    scopus 로고
    • A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD1MXhtFChtrvJ, PID: 19874267
    • Kalinin S, Richardson JC, Feinstein DL (2009) A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer’s disease. Curr Alzheimer Res 6:431–437
    • (2009) Curr Alzheimer Res , vol.6 , pp. 431-437
    • Kalinin, S.1    Richardson, J.C.2    Feinstein, D.L.3
  • 23
    • 33847169097 scopus 로고    scopus 로고
    • Neuroprotective efficacy of the peroxisome proliferator-activated receptor delta-selective agonists in vitro and in vivo
    • COI: 1:CAS:528:DC%2BD2sXis1WgtLY%3D, PID: 17167170
    • Iwashita A, Muramatsu Y, Yamazaki T et al (2007) Neuroprotective efficacy of the peroxisome proliferator-activated receptor delta-selective agonists in vitro and in vivo. J Pharmacol Exp Ther 320:1087–1096. doi:10.1124/jpet.106.115758
    • (2007) J Pharmacol Exp Ther , vol.320 , pp. 1087-1096
    • Iwashita, A.1    Muramatsu, Y.2    Yamazaki, T.3
  • 24
    • 77951039604 scopus 로고    scopus 로고
    • Evidence for the role of peroxisome proliferator-activated receptor-beta/delta in the development of spinal cord injury
    • COI: 1:CAS:528:DC%2BC3cXlsFKhtb8%3D, PID: 20176685
    • Paterniti I, Esposito E, Mazzon E et al (2010) Evidence for the role of peroxisome proliferator-activated receptor-beta/delta in the development of spinal cord injury. J Pharmacol Exp Ther 333:465–477. doi:10.1124/jpet.110.165605
    • (2010) J Pharmacol Exp Ther , vol.333 , pp. 465-477
    • Paterniti, I.1    Esposito, E.2    Mazzon, E.3
  • 25
    • 0035049961 scopus 로고    scopus 로고
    • Co-expression of multiple transgenes in mouse CNS: a comparison of strategies
    • COI: 1:CAS:528:DC%2BD3MXktlGrs7c%3D, PID: 11337275
    • Jankowsky JL, Slunt HH, Ratovitski T et al (2001) Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng 17:157–165
    • (2001) Biomol Eng , vol.17 , pp. 157-165
    • Jankowsky, J.L.1    Slunt, H.H.2    Ratovitski, T.3
  • 26
    • 77956225289 scopus 로고    scopus 로고
    • Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits
    • COI: 1:CAS:528:DC%2BC3cXhtFamtLbE, PID: 20144675
    • Jardanhazi-Kurutz D, Kummer MP, Terwel D et al (2010) Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits. Neurochem Int 57:375–382. doi:10.1016/j.neuint.2010.02.001
    • (2010) Neurochem Int , vol.57 , pp. 375-382
    • Jardanhazi-Kurutz, D.1    Kummer, M.P.2    Terwel, D.3
  • 27
    • 70450219526 scopus 로고    scopus 로고
    • Alpha-secretase mediated conversion of the Amyloid Precursor Protein derived membrane stub C99 to C83 limits Abeta generation
    • PID: 19804379
    • Jäger S, Leuchtenberger S, Martin A et al (2009) Alpha-secretase mediated conversion of the Amyloid Precursor Protein derived membrane stub C99 to C83 limits Abeta generation. J Neurochem. doi:10.1111/j.1471-4159.2009.06420.x
    • (2009) J Neurochem
    • Jäger, S.1    Leuchtenberger, S.2    Martin, A.3
  • 28
    • 0036707494 scopus 로고    scopus 로고
    • Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative
    • COI: 1:CAS:528:DC%2BD38XnslentbY%3D, PID: 12230326
    • Klunk WE, Bacskai BJ, Mathis CA et al (2002) Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J Neuropathol Exp Neurol 61:797–805
    • (2002) J Neuropathol Exp Neurol , vol.61 , pp. 797-805
    • Klunk, W.E.1    Bacskai, B.J.2    Mathis, C.A.3
  • 29
    • 33845407472 scopus 로고    scopus 로고
    • GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide
    • COI: 1:CAS:528:DC%2BD2sXpvVU%3D
    • Wahle T, Thal DR, Sastre M et al (2006) GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide. J Neurosci Off J Soc Neurosci 26:12838–12846. doi:10.1523/JNEUROSCI.1982-06.2006
    • (2006) J Neurosci Off J Soc Neurosci , vol.26 , pp. 12838-12846
    • Wahle, T.1    Thal, D.R.2    Sastre, M.3
  • 30
    • 79956311751 scopus 로고    scopus 로고
    • Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis
    • COI: 1:CAS:528:DC%2BC3MXmsVKrt78%3D
    • Terwel D, Steffensen KR, Verghese PB et al (2011) Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis. J Neurosci Off J Soc Neurosci 31:7049–7059. doi:10.1523/JNEUROSCI.6546-10.2011
    • (2011) J Neurosci Off J Soc Neurosci , vol.31 , pp. 7049-7059
    • Terwel, D.1    Steffensen, K.R.2    Verghese, P.B.3
  • 31
    • 84862777666 scopus 로고    scopus 로고
    • ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models
    • COI: 1:CAS:528:DC%2BC38XktFWksbY%3D, PID: 22323736
    • Cramer PE, Cirrito JR, Wesson DW et al (2012) ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models. Science 335:1503–1506. doi:10.1126/science.1217697
    • (2012) Science , vol.335 , pp. 1503-1506
    • Cramer, P.E.1    Cirrito, J.R.2    Wesson, D.W.3
  • 32
    • 0036499074 scopus 로고
    • (2002) Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitis
    • Diab A, Deng C, Smith JD et al (1950) (2002) Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitis. J Immunol Baltim Md 168:2508–2515
    • (1950) J Immunol Baltim Md , vol.168 , pp. 2508-2515
    • Diab, A.1    Deng, C.2    Smith, J.D.3
  • 33
    • 0347087323 scopus 로고    scopus 로고
    • Protection by pioglitazone in the MPTP model of Parkinson’s disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation
    • COI: 1:CAS:528:DC%2BD2cXntlWjug%3D%3D, PID: 14690537
    • Dehmer T, Heneka MT, Sastre M et al (2004) Protection by pioglitazone in the MPTP model of Parkinson’s disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation. J Neurochem 88:494–501
    • (2004) J Neurochem , vol.88 , pp. 494-501
    • Dehmer, T.1    Heneka, M.T.2    Sastre, M.3
  • 34
    • 84884930937 scopus 로고    scopus 로고
    • The cardiovascular safety of diabetes drugs—insights from the rosiglitazone experience
    • COI: 1:CAS:528:DC%2BC3sXhsF2ksb7E, PID: 23992603
    • Hiatt WR, Kaul S, Smith RJ (2013) The cardiovascular safety of diabetes drugs—insights from the rosiglitazone experience. N Engl J Med 369:1285–1287. doi:10.1056/NEJMp1309610
    • (2013) N Engl J Med , vol.369 , pp. 1285-1287
    • Hiatt, W.R.1    Kaul, S.2    Smith, R.J.3
  • 35
    • 0034813586 scopus 로고    scopus 로고
    • Regulation of beta-amyloid stimulated proinflammatory responses by peroxisome proliferator-activated receptor alpha
    • COI: 1:CAS:528:DC%2BD3MXntVymu7Y%3D, PID: 11578780
    • Combs CK, Bates P, Karlo JC, Landreth GE (2001) Regulation of beta-amyloid stimulated proinflammatory responses by peroxisome proliferator-activated receptor alpha. Neurochem Int 39:449–457
    • (2001) Neurochem Int , vol.39 , pp. 449-457
    • Combs, C.K.1    Bates, P.2    Karlo, J.C.3    Landreth, G.E.4
  • 36
    • 84870226700 scopus 로고    scopus 로고
    • PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice
    • COI: 1:CAS:528:DC%2BC38XhslOqtLvP
    • Yamanaka M, Ishikawa T, Griep A et al (2012) PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice. J Neurosci Off J Soc Neurosci 32:17321–17331. doi:10.1523/JNEUROSCI.1569-12.2012
    • (2012) J Neurosci Off J Soc Neurosci , vol.32 , pp. 17321-17331
    • Yamanaka, M.1    Ishikawa, T.2    Griep, A.3
  • 37
    • 78650678688 scopus 로고    scopus 로고
    • Decreased clearance of CNS β-amyloid in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3cXhsF2jtbrF, PID: 21148344
    • Mawuenyega KG, Sigurdson W, Ovod V et al (2010) Decreased clearance of CNS β-amyloid in Alzheimer’s disease. Science 330:1774. doi:10.1126/science.1197623
    • (2010) Science , vol.330 , pp. 1774
    • Mawuenyega, K.G.1    Sigurdson, W.2    Ovod, V.3
  • 38
    • 70349323417 scopus 로고    scopus 로고
    • CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation
    • COI: 1:CAS:528:DC%2BD1MXht1ertb3E
    • Reed-Geaghan EG, Savage JC, Hise AG, Landreth GE (2009) CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation. J Neurosci Off J Soc Neurosci 29:11982–11992. doi:10.1523/JNEUROSCI.3158-09.2009
    • (2009) J Neurosci Off J Soc Neurosci , vol.29 , pp. 11982-11992
    • Reed-Geaghan, E.G.1    Savage, J.C.2    Hise, A.G.3    Landreth, G.E.4
  • 39
    • 27644595378 scopus 로고    scopus 로고
    • Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice
    • PID: 16212664
    • Heneka MT, Sastre M, Dumitrescu-Ozimek L et al (2005) Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice. J Neuroinflammation 2:22. doi:10.1186/1742-2094-2-22
    • (2005) J Neuroinflammation , vol.2 , pp. 22
    • Heneka, M.T.1    Sastre, M.2    Dumitrescu-Ozimek, L.3
  • 40
    • 80052410564 scopus 로고    scopus 로고
    • Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation
    • COI: 1:CAS:528:DC%2BC3MXhtFKjtLvL, PID: 21903077
    • Kummer MP, Hermes M, Delekarte A et al (2011) Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation. Neuron 71:833–844. doi:10.1016/j.neuron.2011.07.001
    • (2011) Neuron , vol.71 , pp. 833-844
    • Kummer, M.P.1    Hermes, M.2    Delekarte, A.3
  • 41
    • 0036779687 scopus 로고    scopus 로고
    • Emerging roles of PPARs in inflammation and immunity
    • COI: 1:CAS:528:DC%2BD38XnsVGqsbY%3D, PID: 12360213
    • Daynes RA, Jones DC (2002) Emerging roles of PPARs in inflammation and immunity. Nat Rev Immunol 2:748–759. doi:10.1038/nri912
    • (2002) Nat Rev Immunol , vol.2 , pp. 748-759
    • Daynes, R.A.1    Jones, D.C.2
  • 42
    • 0029661982 scopus 로고    scopus 로고
    • The PPARalpha-leukotriene B4 pathway to inflammation control
    • COI: 1:CAS:528:DyaK28XmvVWrtL8%3D, PID: 8900274
    • Devchand PR, Keller H, Peters JM et al (1996) The PPARalpha-leukotriene B4 pathway to inflammation control. Nature 384:39–43. doi:10.1038/384039a0
    • (1996) Nature , vol.384 , pp. 39-43
    • Devchand, P.R.1    Keller, H.2    Peters, J.M.3
  • 43
    • 30744460411 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta (PPARdelta) activation protects H9c2 cardiomyoblasts from oxidative stress-induced apoptosis
    • COI: 1:CAS:528:DC%2BD28Xls1ajsg%3D%3D, PID: 16337160
    • Pesant M, Sueur S, Dutartre P et al (2006) Peroxisome proliferator-activated receptor delta (PPARdelta) activation protects H9c2 cardiomyoblasts from oxidative stress-induced apoptosis. Cardiovasc Res 69:440–449. doi:10.1016/j.cardiores.2005.10.019
    • (2006) Cardiovasc Res , vol.69 , pp. 440-449
    • Pesant, M.1    Sueur, S.2    Dutartre, P.3
  • 44
    • 84869428385 scopus 로고    scopus 로고
    • Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein
    • D’ Uscio LV, Das P, Santhanam AVR et al (2012) Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein. Cardiovasc Res 96:504–512. doi:10.1093/cvr/cvs266
    • (2012) Cardiovasc Res , vol.96 , pp. 504-512
    • D’ Uscio, L.V.1    Das, P.2    Santhanam, A.V.R.3
  • 45
    • 0030978998 scopus 로고    scopus 로고
    • Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein
    • COI: 1:CAS:528:DyaK2sXjsF2gtbg%3D, PID: 9168112
    • Nalbantoglu J, Tirado-Santiago G, Lahsaini A et al (1997) Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein. Nature 387:500–505. doi:10.1038/387500a0
    • (1997) Nature , vol.387 , pp. 500-505
    • Nalbantoglu, J.1    Tirado-Santiago, G.2    Lahsaini, A.3
  • 46
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    • COI: 1:CAS:528:DC%2BD38XivVOntL8%3D, PID: 11932745
    • Walsh DM, Klyubin I, Fadeeva JV et al (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416:535–539. doi:10.1038/416535a
    • (2002) Nature , vol.416 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3


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