Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology

Brain

Volumn 139, Issue 4, 2016, Pages 1265-1281

  Spangenberg, Elizabeth E ^a   Lee, Rafael J ^a   Najafi, Allison R ^a   Rice, Rachel A ^a   Elmore, Monica R P ^a   Blurton Jones, Mathew ^a   West, Brian L ^b   Green, Kim N ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b PLEXXIKON INC   (United States)

Author keywords

Alzheimer's disease; amyloid; cognition; inflammation; microglia

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-38]; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; COLONY STIMULATING FACTOR 1; COLONY STIMULATING FACTOR 1 RECEPTOR; PLX 3397; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

5XFAD MOUSE; ADULT; AGED; ALZHEIMER DISEASE; AMYGDALA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CORTEX; CELL ACTIVATION; CELL COUNT; CELL LOSS; CONTROLLED STUDY; DENDRITIC SPINE; FEMALE; GENETIC TRANSCRIPTION; HIPPOCAMPUS; INTRACELLULAR SIGNALING; MALE; MEMORY DISORDER; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; THALAMUS; TREATMENT DURATION; 129 MOUSE; ANIMAL; BRAIN; C57BL MOUSE; METABOLISM; NERVE CELL; PATHOLOGY; PLAQUE, AMYLOID; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; FEMALE; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROGLIA; NEURONS; PLAQUE, AMYLOID;

EID: 84964433785     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/aww016     Document Type: Article

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