Microglia in alzheimer's disease: It's all about context

International Journal of Alzheimer's Disease

Volumn , Issue , 2012, Pages

  Weitz, Tara M ^a   Town, Terrence ^a,b  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 132; MICRORNA 16; MITOGEN ACTIVATED PROTEIN KINASE 1; RNA INDUCED SILENCING COMPLEX; TAU PROTEIN;

ALZHEIMER DISEASE; DISEASE COURSE; ENZYME PHOSPHORYLATION; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVIEW; RNA SPLICING;

EID: 84863672009     PISSN: None     EISSN: 20900252     Source Type: Journal    
DOI: 10.1155/2012/314185     Document Type: Review

References (72)

1. Wisniewski H., Wegiel J., Wang K., Kujawa M., Lach B., Ultrastructural studies of the cells forming amyloid fibers in classical plaques Canadian Journal of Neurological Sciences 1989 16 4 535 542 (Pubitemid 19278365)
2. Wisniewski H., Wegiel J., Wang K. C., Lach B., Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's disease Acta Neuropathologica 1992 84 2 117 127
3. Frackowiak J., Wisniewski H., Wegiel J., Merz G., Iqbal K., Wang K. C., Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce -amyloid fibrils Acta Neuropathologica 1992 84 3 225 233
4. Wisniewski H., Barcikowska M., Kida E., Phagocytosis of /A4 amyloid fibrils of the neuritic neocortical plaques Acta Neuropathologica 1991 81 5 588 590
5. Akiyama H., Kondo H., Mori H., Kametani F., Nishimura T., Ikeda K., Kato M., McGeer P. L., The amino-terminally truncated forms of amyloid -protein in brain macrophages in the ischemic lesions of Alzheimer's disease patients Neuroscience Letters 1996 219 2 115 118 (Pubitemid 26396328)
6. Yong V. W., Rivest S., Taking advantage of the systemic immune system to cure brain diseases Neuron 2009 64 1 55 60
7. Rezai-Zadeh K., Gate D., Town T., CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease? Journal of Neuroimmune Pharmacology 2009 4 4 462 475
8. Gate D., Rezai-Zadeh K., Jodry D., Rentsendorj A., Town T., Macrophages in Alzheimer's disease: the blood-borne identity Journal of Neural Transmission 2010 117 8 961 970
9. Ransohoff R. M., Kiviskk P., Kidd G., Three or more routes for leukocyte migration into the central nervous system Nature Reviews Immunology 2003 3 7 569 581 (Pubitemid 37328676)
10. Hawkes C. A., McLaurin J., Selective targeting of perivascular macrophages for clearance of -amyloid in cerebral amyloid angiopathy Proceedings of the National Academy of Sciences of the United States of America 2009 106 4 1261 1266
11. Town T., Nikolic V., Tan J., The microglial activation continuum: from innate to adaptive responses Journal of Neuroinflammation 2005 2 1, article 2
12. Colton C. A., Mott R. T., Sharpe H., Xu Q., Van Nostrand W. E., Vitek M. P., Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD Journal of Neuroinflammation 2006 3 1, article 27
13. Colton C. A., Heterogeneity of microglial activation in the innate immune response in the brain Journal of Neuroimmune Pharmacology 2009 4 4 399 418
14. Colton C., Wilcock D., Assessing activation states in microglia CNS and Neurological Disorders 2010 9 2 174 191
15. Meda L., Cassatella M. A., Szendrei G. I., Otvos L., Baron P., Villalba M., Ferrari D., Rossi F., Activation of microglial cells by -amyloid protein and interferon- Nature 1995 374 6523 647 650
16. Tan J., Town T., Paris D., Mori T., Suo Z., Crawford F., Mattson M. P., Flavell R. A., Mullan M., Microglial activation resulting from CD40-CD40l interaction after -amyloid stimulation Science 1999 286 5448 2352 2355 (Pubitemid 30016899)
17. McGeer P. L., McGeer E., Inflammation and the degenerative diseases of aging Annals of the New York Academy of Sciences 2004 1035 1 104 116 (Pubitemid 40362329)
18. McGeer P., McGeer E., Rogers J., Sibley J., Anti-inflammatory drugs and Alzheimer disease The Lancet 1990 335 8696 1037 (Pubitemid 20148621)
19. McGeer P., Rogers J., Anti-inflammatory agents as a therapeutic approach to Alzheimer's disease Neurology 1992 42 2 447 449
20. McGeer P., Schulzer M., McGeer E. G., Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies Neurology 1996 47 2 425 432 (Pubitemid 26324038)
21. Mackenzie I., Munoz D., Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging Neurology 1998 50 4 986 990 (Pubitemid 28212826)
22. Weggen S., Eriksen J. L., Das P., Sagi S. A., Wang R., Pietrzik C. U., Findlay K. A., Smith T. E., Murphy M. P., Bulter T., Kang D. E., Marquez-Sterling N., Golde T. E., Koo E. H., A subset of NSAIDs lower amyloidogenic A 42 independently of cyclooxygenase activity Nature 2001 414 6860 212 216 (Pubitemid 33051236)
23. Szekely C. A., Thorne J. E., Zandi P. P., Ek M., Messias E., Breitner J. C. S., Goodman S. N., Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic review Neuroepidemiology 2004 23 4 159 169 (Pubitemid 38980441)
24. Lim G., Yang F., Chu T., Chen P., Beech W., Teter B., Tran T., Ubeda O., Ashe K. H., Frautschy S. A., Cole G. M., Ibuprofen suppresses plaque pathology and inflammation in a mouse model for alzheimer's disease Journal of Neuroscience 2000 20 15 5709 5714 (Pubitemid 30636898)
25. Jantzen P. T., Connor K. E., DiCarlo G., Wenk G. L., Wallace J. L., Rojiani A. M., Coppola D., Morgan D., Gordon M. N., Microglial activation and -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice The Journal of Neuroscience 2002 22 6 2246 2254 (Pubitemid 35386524)
26. Yan Q., Zhang J., Liu H., Babu-Khan S., Vassar R., Biere A. L., Citron M., Landreth G., Anti-inflammatory drug therapy alters -amyloid processing and deposition in an animal model of Alzheimer's disease Journal of Neuroscience 2003 23 20 7504 7509 (Pubitemid 37034066)
27. Heneka M. T., Sastre M., Dumitrescu-Ozimek L., Hanke A., Dewachter I., Kuiperi C., O'Banion K., Klockgether T., Van Leuven F., Landreth G. E., Acute treatment with the PPAR agonist pioglitazone and ibuprofen reduces glial inflammation and A 1-42 levels in APPV717I transgenic mice Brain 2005 128 6 1442 1453 (Pubitemid 40826196)
28. Wilcock D. M., Jantzen P. T., Li Q., Morgan D., Gordon M. N., Amyloid- vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid Neuroscience 2007 144 3 950 960 (Pubitemid 46019842)
29. Kukar T., Murphy M. P., Eriksen J. L., Sagi S. A., Weggen S., Smith T. E., Ladd T., Khan M. A., Kache R., Beard J., Dodson M., Merit S., Ozols V. V., Anastasiadis P. Z., Das P., Fauq A., Koo E. H., Golde T. E., Diverse compounds mimic Alzheimer disease-causing mutations by augmenting A 42 production Nature Medicine 2005 11 5 545 550 (Pubitemid 40685978)
30. Tan J., Town T., Crawford F., Mori T., DelleDonne A., Crescentini R., Obregon D., Flavel R. A., Mullan M. J., Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice Nature Neuroscience 2002 5 12 1288 1293 (Pubitemid 35417763)
31. Townsend K. P., Town T., Mori T., Lue L. F., Shytle D., Sanberg P. R., Morgan D., Fernandez F., Flavell R. A., Tan J., CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid -peptide European Journal of Immunology 2005 35 3 901 910 (Pubitemid 40425546)
32. Qiao X., Cummins D. J., Paul S. M., Neuroinflammation-induced acceleration of amyloid deposition in the APPV717F transgenic mouse European Journal of Neuroscience 2001 14 3 474 482 (Pubitemid 34203455)
33. Mori T., Koyama N., Arendash G. W., Horikoshi-Sakuraba Y., Tan J., Town T., Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease GLIA 2010 58 3 300 314
34. Fuhrmann M., Bittner T., Jung C. K. E., Burgold S., Page R. M., Mitteregger G., Haass C., Laferla F. M., Kretzschmar H., Herms J., Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease Nature Neuroscience 2010 13 4 411 413
35. Oddo S., Caccamo A., Shepherd J. D., Murphy M. P., Golde T. E., Kayed R., Metherate R., Mattson M. P., Akbari Y., LaFerla F. M., Triple-transgenic model of Alzheimer's Disease with plaques and tangles: intracellular A and synaptic dysfunction Neuron 2003 39 3 409 421 (Pubitemid 36937044)
36. Lee S., Varvel N. H., Konerth M. E., Xu G., Cardona A. E., Ransohoff R. M., Lamb B. T., CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models American Journal of Pathology 2010 177 5 2549 2562
37. Patrick G. N., Zukerberg L., Nikolic M., De La Monte S., Dikkes P., Tsai L. H., Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration Nature 1999 402 6762 615 622 (Pubitemid 129516324)
38. Sundaram J. R., Chan E. S., Poore C. P., Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration Journal of Neuroscience 2012 32 3 1020 1034
39. Golde T. E., Inflammation takes on Alzheimer disease Nature Medicine 2002 8 9 936 938 (Pubitemid 35033689)
40. Group A. R., Lyketsos C., Breitner J., Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial Neurology 2007 68 21 1800 1808 (Pubitemid 46791392)
41. Martin B. K., Szekely C., Brandt J., Piantadosi S., Breitner J. C. S., Craft S., Evans D., Green R., Mullan M., Cognitive function over time in the Alzheimer's disease anti-inflammatory prevention trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib Archives of Neurology 2008 65 7 896 905 (Pubitemid 352008472)
42. McGeer P. L., McGeer E. G., NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies Neurobiology of Aging 2007 28 5 639 647 (Pubitemid 46349357)
43. Breitner J. C., Baker L. D., Montine T. J., Meinert C. L., Lyketsos C. G., Ashe K. H., Brandt J., Craft S., Evans D. E., Green R. C., Ismail M. S., Martin B. K., Mullan M. J., Sabbagh M., Tariot P. N., Extended results of the Alzheimer's disease anti-inflammatory prevention trial Alzheimer's and Dementia 2011 7 4 402 411
44. Holmes C., Cunningham C., Zotova E., Woolford J., Dean C., Kerr S., Culliford D., Perry V. H., Systemic inflammation and disease progression in Alzheimer disease Neurology 2009 73 10 768 774
45. Schenk D., Barbour R., Dunn W., Gordon G., Grajeda H., Guldo T., Hu K., Huang J., Johnson-Wood K., Khan K., Kholodenko D., Lee M., Liao Z., Lieberburg I., Motter R., Mutter L., Soriano F., Shopp G., Vasquez N., Vandevert C., Walker S., Wogulis M., Yednock T., Games D., Seubert P., Immunization with amyloid- attenuates Alzheimer disease-like pathology in the PDAPP mouse Nature 1999 400 6740 173 177 (Pubitemid 29327547)
46. Janus C., Pearson J., McLaurin J., Mathews P. M., Jiang Y., Schmidt S. D., Chishti M. A., Horne P., Heslin D., French J., Mount H. T. J., Nixon R. A., Mercken M., Bergeron C., Fraser P. E., St George-Hyslop P., Westaway D., A peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease Nature 2000 408 6815 979 982 (Pubitemid 32101644)
47. Morgan D., Diamond D. M., Gottschall P. E., Ugen K. E., Dickey C., Hardy J., Duff K., Jantzen P., DiCarlo G., Wilcock D., Connor K., Hatcher J., Hope C., Gordon M., Arendash G. W., A peptide vaccination prevents memory loss in an animal model of Alzheimer's disease Nature 2000 408 6815 982 985 (Pubitemid 32101645)
48. Bard F., Cannon C., Barbour R., Burke R. L., Games D., Grajeda H., Guido T., Hu K., Huang J., Johnson-Wood K., Khan K., Kholodenko D., Lee M., Lieberburg I., Motter R., Nguyen M., Soriano F., Vasquez N., Weiss K., Welch B., Seubert P., Schenk D., Yednock T., Peripherally administered antibodies against amyloid -peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease Nature Medicine 2000 6 8 916 919 (Pubitemid 30644751)
49. Check E., Nerve inflammation halts trial for Alzheimer's drug Nature 2002 415 6871 462 (Pubitemid 34130572)
50. Nicolll J. A. R., Wilkinson D., Holmes C., Steart P., Markham H., Weller R. O., Neuropathology of human Alzheimer disease after immunization with amyloid- peptide: a case report Nature Medicine 2003 9 4 448 452 (Pubitemid 36460079)
51. Holmes C., Boche D., Wilkinson D., Yadegarfar G., Hopkins V., Bayer A., Jones R. W., Bullock R., Love S., Neal J. W., Zotova E., Nicoll J. A., Long-term effects of A 42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial The Lancet 2008 372 9634 216 223 (Pubitemid 351978111)
52. Masliah E., Mallory M., Hansen L., Alford M., Albright T., Terry R., Shapiro Sundsmo P. M., Saitoh T., Immunoreactivity of CD45, a protein phosphotyrosine phosphatase, in Alzheimer's disease Acta Neuropathologica 1991 83 1 12 20
53. Tan J., Town T., Mori T., Wu Y., Saxe M., Crawford F., Mullan M., CD45 opposes -amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase Journal of Neuroscience 2000 20 20 7587 7594
54. Zhu Y., Hou H., Rezai-Zadeh K., Giunta B., Ruscin A., Gemma C., Jin J., Dragicevic N., Bradshaw P., Rasool S., Glabe C. G., Ehrhart J., Bickford P., Mori T., Obregon D., Town T., Tan J., CD45 deficiency drives amyloid- peptide oligomers and neuronal loss in Alzheimer's disease mice Journal of Neuroscience 2011 31 4 1355 1365
55. Shaftel S. S., Kyrkanides S., Olschowka J. A., Miller J. N. H., Johnson R. E., O'Banion M. K., Sustained hippocampal IL-1 overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology Journal of Clinical Investigation 2007 117 6 1595 1604 (Pubitemid 46871344)
56. Chakrabarty P., Ceballos-Diaz C., Beccard A., Janus C., Dickson D., Golde T. E., Das P., IFN- promotes complement expression and attenuates amyloid plaque deposition in amyloid precursor protein transgenic mice Journal of Immunology 2010 184 9 5333 5343
57. Chakrabarty P., Jansen-West K., Beccard A., Ceballos-Diaz C., Levites Y., Verbeeck C., Zubair A. C., Dickson D., Golde T. E., Das P., Massive gliosis induced by interleukin-6 suppresses A deposition in vivo: evidence against inflammation as a driving force for amyloid deposition FASEB Journal 2010 24 2 548 559
58. Chakrabarty P., Herring A., Ceballos-Diaz C., Das P., Golde T. E., Hippocampal expression of murine TNF results in attenuation of amyloid deposition in vivo Molecular Neurodegeneration 2011 6 1, article 16
59. DiCarlo G., Wilcock D., Henderson D., Gordon M., Morgan D., Intrahippocampal LPS injections reduce A load in APP+PS1 transgenic mice Neurobiology of Aging 2001 22 6 1007 1012 (Pubitemid 34066568)
60. Wilcock D. M., Lewis M. R., van Nostrand W. E., Davis J., Previti M. L., Gharkholonarehe N., Vitek M. P., Colton C. A., Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2 Journal of Neuroscience 2008 28 7 1537 1545 (Pubitemid 351287042)
61. Town T., Nikolic V., Tan J., The microglial activation continuum: from innate to adaptive responses Journal of Neuroinflammation 2005 2, article 24
62. Colton C. A., Mott R. T., Sharpe H., Xu Q., van Nostrand W. E., Vitek M. P., Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD Journal of Neuroinflammation 2006 3, article 27
63. Colton C. A., Wilcock D. M., Assessing activation states in microglia CNS and Neurological Disorders 2010 9 2 174 191
64. Grathwohl S. A., Klin R. E., Bolmont T., Prokop S., Winkelmann G., Kaeser S. A., Odenthal J., Radde R., Eldh T., Gandy S., Aguzzi A., Staufenbiel M., Mathews P. M., Wolburg H., Heppner F. L., Jucker M., Formation and maintenance of Alzheimer's disease -amyloid plaques in the absence of microglia Nature neuroscience 2009 12 11 1361 1363
65. Stalder A. K., Ermini F., Bondolfi L., Krenger W., Burbach G. J., Deller T., Coomaraswamy J., Staufenbiel M., Landmann R., Jucker M., Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice Journal of Neuroscience 2005 25 48 11125 11132 (Pubitemid 43089557)
66. Simard A. R., Soulet D., Gowing G., Julien J. P., Rivest S., Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease Neuron 2006 49 4 489 502 (Pubitemid 43221886)
67. El Khoury J., Toft M., Hickman S. E., Means T. K., Terada K., Geula C., Luster A. D., Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease Nature Medicine 2007 13 4 432 438 (Pubitemid 46559828)
68. Laouar Y., Town T., Jeng D., Tran E., Wan Y., Kuchroo V. K., Flavell R. A., TGF- signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis Proceedings of the National Academy of Sciences of the United States of America 2008 105 31 10865 10870
69. Town T., Laouar Y., Pittenger C., Mori T., Szekely C. A., Tan J., Duman R. S., Flavell R. A., Blocking TGF- -Smad2/3 innate immune signaling mitigates Alzheimer-like pathology Nature Medicine 2008 14 6 681 687 (Pubitemid 351809551)
70. Geissmann F., Jung S., Littman D. R., Blood monocytes consist of two principal subsets with distinct migratory properties Immunity 2003 19 1 71 82 (Pubitemid 36859902)
71. Sunderktter C., Nikolic T., Dillon M. J., Van Rooijen N., Stehling M., Drevets D. A., Leenen P. J. M., Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response Journal of Immunology 2004 172 7 4410 4417 (Pubitemid 38375256)
72. Lim G. P., Chu T., Yang F., Beech W., Frautschy S. A., Cole G. M., The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse Journal of Neuroscience 2001 21 21 8370 8377 (Pubitemid 33051435)