CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid

Neuroscience

Volumn 302, Issue , 2015, Pages 112-120

  Porrini, V ^a,b   Lanzillotta, A ^a   Branca, C ^a   Benarese, M ^a   Parrella, E ^a   Lorenzini, L ^c   Calza L ^c,d   Flaibani, R ^b   Spano, P F ^a,b   Imbimbo, B P ^e   Pizzi, M ^a,b  

^a UNIVERSITY OF BRESCIA   (Italy)

^b IRCCS SAN CAMILLO HOSPITAL   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d IRET Foundation   (Italy)

^e Research and Development   (Italy)

Author keywords

Alzheimer's disease; CHF5074; CSP 1103; Microglia; Neuroinflammation; Tg2576

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; CENTRAL NERVOUS SYSTEM AGENTS; CHF 5074; CHITINASE; CHITINASE 3 LIKE 3; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MANNOSE RECEPTOR TYPE C 1; MEMBRANE PROTEIN; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 1-(3',4'-DICHLORO-2-FLUORO(1,1'-BIPHENYL)-4-YL)CYCLOPROPANECARBOXYLIC ACID; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CYCLOPROPANE DERIVATIVE; CYTOKINE; FLURBIPROFEN; NEUROLEPTIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL ACTIVATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG RESPONSE; FEMALE; GENE; GENE FUNCTION; GENE IDENTIFICATION; GENETIC TRANSCRIPTION; HIPPOCAMPUS; LONG TERM POTENTIATION; M1 GENE; MICROGLIA; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; ALZHEIMER DISEASE; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN; C57BL MOUSE; CASE CONTROL STUDY; CELL CULTURE; DISEASE MODEL; DRUG EFFECTS; GENETICS; GLIA; HUMAN; MALE; METABOLISM; MUTATION; NEWBORN; PATHOLOGY; TIME FACTOR; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANIMALS, NEWBORN; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIPSYCHOTIC AGENTS; BRAIN; CASE-CONTROL STUDIES; CELLS, CULTURED; CYCLOPROPANES; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; FLURBIPROFEN; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; NEUROGLIA; NITRIC OXIDE SYNTHASE TYPE II; TIME FACTORS;

EID: 84939228242     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.10.029     Document Type: Article

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